R M Maizels

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi request reprint Molecular helminthology: an integrated approach
    Philip T LoVerde
    School of Medicine and Biomedical Sciences, State University of New York at Buffalo, 14214, USA
    Am J Trop Med Hyg 66:346-7. 2002
  2. ncbi request reprint Regulatory T cells induced by parasites and the modulation of allergic responses
    Mark S Wilson
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK
    Chem Immunol Allergy 90:176-95. 2006
  3. ncbi request reprint F4/80+ alternatively activated macrophages control CD4+ T cell hyporesponsiveness at sites peripheral to filarial infection
    Matthew D Taylor
    Institute of Immunology and Infection Research, Ashworth Laboratories, University of Edinburgh, Edinburgh, United Kingdom
    J Immunol 176:6918-27. 2006
  4. pmc Immuno-epidemiology of human Schistosoma haematobium infection: preferential IgG3 antibody responsiveness to a recombinant antigen dependent on age and parasite burden
    Francisca Mutapi
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Rd, Edinburgh, EH9 3J, UK
    BMC Infect Dis 6:96. 2006
  5. pmc Suppression of allergic airway inflammation by helminth-induced regulatory T cells
    Mark S Wilson
    Institute of Immunology and Infection Research, University of Edinburgh, UK
    J Exp Med 202:1199-212. 2005
  6. pmc Helminth-induced CD19+CD23hi B cells modulate experimental allergic and autoimmune inflammation
    Mark S Wilson
    Centre for Immunity, Infection and Evolution, and Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 40:1682-96. 2010
  7. pmc Helminths and immunological tolerance
    Chris J C Johnston
    1 Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK 2 MRC Centre for Inflammation Research, University of Edinburgh, Queens Medical Research Institute, Edinburgh, UK 3 Address correspondence to Rick M Maizels, Institute of Immunology and Infection Research, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, UK
    Transplantation 97:127-32. 2014
  8. pmc Secretion of protective antigens by tissue-stage nematode larvae revealed by proteomic analysis and vaccination-induced sterile immunity
    James P Hewitson
    Institute of Immunology and Infection Research, Ashworth Laboratories, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Pathog 9:e1003492. 2013
  9. pmc A transcriptomic analysis of Echinococcus granulosus larval stages: implications for parasite biology and host adaptation
    John Parkinson
    Program in Molecular Structure and Function, Hospital for Sick Children, University of Toronto, Toronto, Canada
    PLoS Negl Trop Dis 6:e1897. 2012
  10. pmc Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus
    Lisa A Reynolds
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, EH9 3JT, UK
    Semin Immunopathol 34:829-46. 2012

Collaborators

Detail Information

Publications73

  1. ncbi request reprint Molecular helminthology: an integrated approach
    Philip T LoVerde
    School of Medicine and Biomedical Sciences, State University of New York at Buffalo, 14214, USA
    Am J Trop Med Hyg 66:346-7. 2002
  2. ncbi request reprint Regulatory T cells induced by parasites and the modulation of allergic responses
    Mark S Wilson
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK
    Chem Immunol Allergy 90:176-95. 2006
    ..Third, the down-modulation of allergy in both human and experimental infections is consistent with the activity of T regulatory (Treg) cell populations, which suppress effector mechanisms of both Th1 and Th2 type...
  3. ncbi request reprint F4/80+ alternatively activated macrophages control CD4+ T cell hyporesponsiveness at sites peripheral to filarial infection
    Matthew D Taylor
    Institute of Immunology and Infection Research, Ashworth Laboratories, University of Edinburgh, Edinburgh, United Kingdom
    J Immunol 176:6918-27. 2006
    ..Filarial immunosuppression, therefore, evolves over time at sites increasingly distal to infection, and the mechanisms of filarial down-regulation are dependent on proximity to the infection site...
  4. pmc Immuno-epidemiology of human Schistosoma haematobium infection: preferential IgG3 antibody responsiveness to a recombinant antigen dependent on age and parasite burden
    Francisca Mutapi
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Rd, Edinburgh, EH9 3J, UK
    BMC Infect Dis 6:96. 2006
    ..The aim of this study was to identify a single antigen from adult Schistosoma haematobium worms and subsequently use this antigen to study the development of schistosome-acquired immunity in a human population...
  5. pmc Suppression of allergic airway inflammation by helminth-induced regulatory T cells
    Mark S Wilson
    Institute of Immunology and Infection Research, University of Edinburgh, UK
    J Exp Med 202:1199-212. 2005
    ..These data support the contention that helminth infections elicit a regulatory T cell population able to down-regulate allergen induced lung pathology in vivo...
  6. pmc Helminth-induced CD19+CD23hi B cells modulate experimental allergic and autoimmune inflammation
    Mark S Wilson
    Centre for Immunity, Infection and Evolution, and Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 40:1682-96. 2010
    ..These data expand previous observations and highlight the broad regulatory environment that develops during helminth infections that can abate diverse inflammatory disorders in vivo...
  7. pmc Helminths and immunological tolerance
    Chris J C Johnston
    1 Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK 2 MRC Centre for Inflammation Research, University of Edinburgh, Queens Medical Research Institute, Edinburgh, UK 3 Address correspondence to Rick M Maizels, Institute of Immunology and Infection Research, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, UK
    Transplantation 97:127-32. 2014
    ..Here, we review all existing studies of helminth infection and transplantation, explore the mechanisms involved, and discuss possible avenues for future translation to clinical practice. ..
  8. pmc Secretion of protective antigens by tissue-stage nematode larvae revealed by proteomic analysis and vaccination-induced sterile immunity
    James P Hewitson
    Institute of Immunology and Infection Research, Ashworth Laboratories, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Pathog 9:e1003492. 2013
    ..We have thus defined an extensive and novel repertoire of H. polygyrus proteins closely implicated in immune modulation and protective immunity...
  9. pmc A transcriptomic analysis of Echinococcus granulosus larval stages: implications for parasite biology and host adaptation
    John Parkinson
    Program in Molecular Structure and Function, Hospital for Sick Children, University of Toronto, Toronto, Canada
    PLoS Negl Trop Dis 6:e1897. 2012
    ..granulosus larval stages. We report the salient features of this study with a focus on genes reflecting physiological adaptations of different parasite stages...
  10. pmc Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus
    Lisa A Reynolds
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, EH9 3JT, UK
    Semin Immunopathol 34:829-46. 2012
    ..We discuss the balance between resistance and susceptibility in this model system and highlight new themes in innate and adaptive immunity, immunomodulation, and regulation of responsiveness in helminth infection...
  11. ncbi request reprint Immune modulation and modulators in Heligmosomoides polygyrus infection
    Rick M Maizels
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3JT, UK
    Exp Parasitol 132:76-89. 2012
    ..Proteomic and transcriptomic definition of parasite proteins, combined with biochemical identification of immunogenic molecules in resistant mice, will provide new candidate immunomodulators and vaccine antigens for future research...
  12. pmc C-type lectins from the nematode parasites Heligmosomoides polygyrus and Nippostrongylus brasiliensis
    Yvonne Harcus
    Institute of Immunology and Infection Research, University of Edinburgh, UK
    Parasitol Int 58:461-70. 2009
    ..Hence, live parasites release C-type lectins homologous to some key receptors of the mammalian host immune system, raising the possibility that these products interfere in some manner with immunological recognition or effector function...
  13. pmc Helminth immunoregulation: the role of parasite secreted proteins in modulating host immunity
    James P Hewitson
    Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Mol Biochem Parasitol 167:1-11. 2009
    ....
  14. pmc Dynamics of CD11c(+) dendritic cell subsets in lymph nodes draining the site of intestinal nematode infection
    Adam Balic
    Institute of Immunology and Infection Research, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Immunol Lett 127:68-75. 2009
    ....
  15. pmc Signal sequence analysis of expressed sequence tags from the nematode Nippostrongylus brasiliensis and the evolution of secreted proteins in parasites
    Yvonne M Harcus
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh, EH9 3JT, UK
    Genome Biol 5:R39. 2004
    ..Nippostrongylus brasiliensis is a well-studied model nematode parasite of rodents, which secretes products known to modulate host immunity...
  16. ncbi request reprint Immunological genomics of Brugia malayi: filarial genes implicated in immune evasion and protective immunity
    R M Maizels
    Institute for Cell, Animal and Population Biology, University of Edinburgh, Edinburgh, UK
    Parasite Immunol 23:327-44. 2001
    ..These gene products provide a fascinating glimpse of the molecular repertoire which helminth parasites have evolved to manipulate and evade the mammalian immune response...
  17. ncbi request reprint Exploring the immunology of parasitism--from surface antigens to the hygiene hypothesis
    R M Maizels
    Centre for Immunity, Infection and Evolution, and Institute of Immunology and Infection Research, University of Edinburgh, West Mains Road, Edinburgh, UK
    Parasitology 136:1549-64. 2009
    ..The review concludes with a forward look to where we may make future advances towards the final eradication of helminth diseases...
  18. pmc Parasite immunomodulation and polymorphisms of the immune system
    Rick M Maizels
    Centre for Immunity, Infection and Evolution, and Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, EH9 3JT, UK
    J Biol 8:62. 2009
    ....
  19. ncbi request reprint Infections and allergy - helminths, hygiene and host immune regulation
    Rick M Maizels
    Institute of Immunology and Infection Research, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Curr Opin Immunol 17:656-61. 2005
    ..Patent allergy in humans is also known to be modulated by helminth infections, suggesting that a similar regulatory network may be controlling immunopathologic disease in man...
  20. ncbi request reprint Helminth parasites--masters of regulation
    Rick M Maizels
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Immunol Rev 201:89-116. 2004
    ....
  21. pmc Regulation of pathogenesis and immunity in helminth infections
    Rick M Maizels
    Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, Scotland, UK
    J Exp Med 206:2059-66. 2009
    ..A recent international meeting focused on how these parasites modulate host immunity and how control of parasitic and immunopathological disease might be achieved...
  22. ncbi request reprint Toxocara canis: genes expressed by the arrested infective larval stage of a parasitic nematode
    R M Maizels
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh, UK
    Int J Parasitol 30:495-508. 2000
    ..Such parasite-specific genes expressed at a high level by a stage that shows remarkable endurance may represent critical products necessary for the success of the parasitic mode of life...
  23. doi request reprint T-cell regulation in helminth parasite infections: implications for inflammatory diseases
    Rick M Maizels
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK
    Chem Immunol Allergy 94:112-23. 2008
    ....
  24. ncbi request reprint Immune evasion genes from filarial nematodes
    R M Maizels
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Int J Parasitol 31:889-98. 2001
    ....
  25. doi request reprint Expression of helminth genes in Leishmania: an experimental transfection system to test immunological function
    R M Maizels
    Institute of Immunology and Infection Research, University of Edinburgh, Ashworth Laboratories, Edinburgh, UK
    Parasite Immunol 30:195-201. 2008
    ..Thus, Leishmania transfection provides a tractable system to analyse helminth gene function within the context of the host immune system...
  26. doi request reprint A macrophage migration inhibitory factor-like tautomerase from Teladorsagia circumcincta (Nematoda: Strongylida)
    A J Nisbet
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Scotland, UK
    Parasite Immunol 32:503-11. 2010
    ..Neither native, purified Tci-MIF nor recombinant Tci-MIF-1 dramatically influenced the in vitro migration of sheep monocytes...
  27. doi request reprint daf-7-related TGF-beta homologues from Trichostrongyloid nematodes show contrasting life-cycle expression patterns
    H J McSorley
    Centre for Immunity, Infection and Evolution, and Institute for Immunology and Infection Research, Ashworth Laboratories, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, Scotland
    Parasitology 137:159-71. 2010
    ..The molecular evolution of this gene family in parasitic nematodes has diversified the pre-protein and life-cycle expression patterns of TGF-beta homologues while conserving the structure of the active domain...
  28. ncbi request reprint Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivo
    Matthew D Taylor
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom
    J Immunol 174:4924-33. 2005
    ..These data suggest that regulatory T cells act, in an IL-10-independent manner, to suppress host immunity to filariasis...
  29. ncbi request reprint Expression and immune recognition of Brugia malayi VAL-1, a homologue of vespid venom allergens and Ancylostoma secreted proteins
    J Murray
    Ashworth Laboratories, Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, EH9 3JT, Edinburgh, UK
    Mol Biochem Parasitol 118:89-96. 2001
    ..The association of Bm-VAL-1 with the infective stage and its recognition by humans exposed to filariasis suggests that further evaluation of this antigen as a vaccine candidate should be performed...
  30. ncbi request reprint Requirement for in vivo production of IL-4, but not IL-10, in the induction of proliferative suppression by filarial parasites
    A S MacDonald
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    J Immunol 160:1304-12. 1998
    ..Thus, IL-4 produced in vivo in response to filarial L3 and adult parasites is essential for the induction of proliferative suppression but is not itself the suppressive factor...
  31. ncbi request reprint Characterisation of Tc-cpl-1, a cathepsin L-like cysteine protease from Toxocara canis infective larvae
    A Loukas
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Mol Biochem Parasitol 92:275-89. 1998
    ..Larger scale studies are underway to investigate the efficacy of rTc-CPL-1 as a diagnostic antigen for human toxocariasis, the current test for which relies on whole excretory/secretory antigens of cultured parasites...
  32. ncbi request reprint A cDNA encoding Tc-MUC-5, a mucin from Toxocara canis larvae identified by expression screening
    A Doedens
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, EH9 3JT, Edinburgh, UK
    Acta Trop 79:211-7. 2001
    ..7%), suggesting that this protein is not part of the TES-120 family of surface coat proteins...
  33. ncbi request reprint Variation and polymorphism in helminth parasites
    R M Maizels
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh E119 3JT, UK
    Parasitology 125:S25-37. 2002
    ..Future work will define whether polymorphisms in these antigens may be driven by exposure to the host immune response or reflect some other facet of parasite biology...
  34. ncbi request reprint A Brugia malayi homolog of macrophage migration inhibitory factor reveals an important link between macrophages and eosinophil recruitment during nematode infection
    F H Falcone
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh, United Kingdom
    J Immunol 167:5348-54. 2001
    ..These data suggest that macrophages may provide a crucial link between helminth parasites, their active cytokine mimics, and the recruitment of eosinophils in infection...
  35. ncbi request reprint Th2 induction by Nippostrongylus secreted antigens in mice deficient in B cells, eosinophils or MHC Class I-related receptors
    Martin J Holland
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Immunol Lett 96:93-101. 2005
    ..Thus, Th2 induction by Nippostrongylus antigens is independent of B cells, or MHC class I presentation, and does not require a sufficiency of eosinophils in vivo...
  36. ncbi request reprint Vaccination against helminth parasites--the ultimate challenge for vaccinologists?
    R M Maizels
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Immunol Rev 171:125-47. 1999
    ..With advances under way in parasite genomics and new vaccine delivery systems offering more rapid assessment and development, there are now excellent opportunities for new antihelminth vaccines...
  37. pmc Chitinase and Fizz family members are a generalized feature of nematode infection with selective upregulation of Ym1 and Fizz1 by antigen-presenting cells
    Meera G Nair
    Ashworth Laboratories, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Infect Immun 73:385-94. 2005
    ..ChaFFs may therefore be important effector or wound-repair molecules at the site of nematode infection, with potential regulatory roles for Ym1 and Fizz1 in the draining lymph nodes...
  38. pmc MIF homologues from a filarial nematode parasite synergize with IL-4 to induce alternative activation of host macrophages
    Lidia Prieto-Lafuente
    Institute of Immunology and Infection Research, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    J Leukoc Biol 85:844-54. 2009
    ..Hence, MIF may accentuate macrophage activation according to the polarity of the environment, thus promoting AAM differentiation in the presence of IL-4-inducing parasitic helminths...
  39. ncbi request reprint Selective maturation of dendritic cells by Nippostrongylus brasiliensis-secreted proteins drives Th2 immune responses
    Adam Balic
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 34:3047-59. 2004
    ....
  40. ncbi request reprint IL-4R signaling is required to induce IL-10 for the establishment of T(h)2 dominance
    Adam Balic
    Institute of Immunology and Infection Research, Ashworth Laboratories, West Mains Road, University of Edinburgh, EH9 3JT, UK
    Int Immunol 18:1421-31. 2006
    ..We conclude that T(h)2 cell development in response to N. brasiliensis antigen requires both IL-4 and IL-10 to act in concert on incipient populations of both T(h)1 and T(h)2 types...
  41. ncbi request reprint Regulation of allergy and autoimmunity in helminth infection
    Mark S Wilson
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh, UK
    Clin Rev Allergy Immunol 26:35-50. 2004
    ..Understanding and harnessing the modulatory capacity of helminths may uncover novel therapeutic interventions, mimicking and exploiting their evolution for our benefit...
  42. ncbi request reprint Helminths in the hygiene hypothesis: sooner or later?
    R M Maizels
    Institute for Immunology and Infection Research, Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, UK
    Clin Exp Immunol 177:38-46. 2014
    ..remains - is the influence of parasites on immunity one that acts primarily in early life, and at initiation of the immune response, or in adulthood and when recall responses occur? In short, parasite immunosuppression - sooner or later? ..
  43. ncbi request reprint Parasite immunology: pathways for expelling intestinal helminths
    R M Maizels
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh, EH10 5PB, Scotland, UK
    Curr Biol 8:R711-4. 1998
    ..Recent studies of knockout mice deficient in these mediators or their shared receptor have revealed discrete pathways required for expulsion of different gut parasites...
  44. ncbi request reprint Cloning and characterisation of a prohibitin gene from infective larvae of the parasitic nematode Toxocara canis
    A Loukas
    Institute of Cell, Animal and Population Biology University of Edinburgh, United Kingdom
    DNA Seq 9:323-8. 1998
    ..This report of the first full-length gene encoding prohibitin from a parasitic nematode raises interesting suggestions about the potential role of prohibitin in diapause and in the regulation of moulting in development...
  45. ncbi request reprint Immune regulation by helminth parasites: cellular and molecular mechanisms
    Rick M Maizels
    Institute for Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Nat Rev Immunol 3:733-44. 2003
    ..Long-lived parasites such as the helminths, however, are more remarkable for their ability to downregulate host immunity, protecting themselves from elimination and minimizing severe pathology in the host...
  46. doi request reprint Age-related and infection intensity-related shifts in antibody recognition of defined protein antigens in a schistosome-exposed population
    Francisca Mutapi
    Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    J Infect Dis 198:167-75. 2008
    ..This study compared patterns of recognition of defined Schistosoma haematobium adult worm antigens by serum antibodies from schistosome-exposed Zimbabweans aged 5-18 years...
  47. doi request reprint Early recruitment of natural CD4+ Foxp3+ Treg cells by infective larvae determines the outcome of filarial infection
    Matthew D Taylor
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 39:192-206. 2009
    ..These CD4(+)Foxp3(+) Treg cells are predominantly recruited from the 'natural' regulatory pool and act to inhibit protective immunity over the full course of infection...
  48. ncbi request reprint Expansion of Foxp3+ regulatory T cells in mice infected with the filarial parasite Brugia malayi
    Henry J McSorley
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom
    J Immunol 181:6456-66. 2008
    ..We conclude that filarial infections significantly skew the balance of the host immune system toward Treg expansion and activation, in a manner dependent on live parasites but independent of a concomitant Th2 response...
  49. pmc Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway
    John R Grainger
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3JT, Scotland, UK
    J Exp Med 207:2331-41. 2010
    ..We have therefore identified a novel pathway through which helminth parasites may stimulate T reg cells, which is likely to be a key part of the parasite's immunological relationship with the host...
  50. ncbi request reprint CTLA-4 and CD4+ CD25+ regulatory T cells inhibit protective immunity to filarial parasites in vivo
    Matthew D Taylor
    Institute of Immunology and Infection Research, University of Edinburgh, United Kingdom
    J Immunol 179:4626-34. 2007
    ..This work suggests that during filarial infection CTLA-4 coinhibition and CD4+ CD25+ Treg cells form complementary components of immune regulation that inhibit protective immunity in vivo...
  51. pmc Heterologous expression of the filarial nematode alt gene products reveals their potential to inhibit immune function
    Natalia Gomez-Escobar
    Institute of Immunology and Infection Research, University of Edinburgh, UK
    BMC Biol 3:8. 2005
    ..We investigated two such novel genes from Brugia malayi termed abundant larval transcript (alt), expression of which reaches ~5% of total transcript at the time parasites enter the human host...
  52. pmc Cytokine responses to Schistosoma haematobium in a Zimbabwean population: contrasting profiles for IFN-gamma, IL-4, IL-5 and IL-10 with age
    Francisca Mutapi
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Rd, Edinburgh, EH9 3JT, UK
    BMC Infect Dis 7:139. 2007
    ..This study determined the cytokine-age profiles of Zimbabweans resident in a Schistosoma haematobium endemic area and further investigated the relationship between the cytokine responses and infection intensity...
  53. pmc Alarming dendritic cells for Th2 induction
    Andrew S MacDonald
    the Institute of Immunology and Infection Research, Ashworth Laboratories, University of Edinburgh, Edinburgh EH9 3JT, Scotland, UK
    J Exp Med 205:13-7. 2008
    ..However, progress is being made with the identification of novel endogenous tissue factors that can enhance Th2 induction by DCs...
  54. ncbi request reprint Praziquantel treatment of individuals exposed to Schistosoma haematobium enhances serological recognition of defined parasite antigens
    Francisca Mutapi
    Institute for Immunology and Infection Research, Ashworth Laboratories, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    J Infect Dis 192:1108-18. 2005
    ..This study aimed to identify and compare proteins recognized by serum samples from schistosome-exposed individuals before and after curative praziquantel treatment...
  55. pmc Ascaris suum-derived products induce human neutrophil activation via a G protein-coupled receptor that interacts with the interleukin-8 receptor pathway
    F H Falcone
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, United Kingdom
    Infect Immun 69:4007-18. 2001
    ..Our results provide the first evidence for a direct interaction between a parasite-derived chemotactic factor and the host's chemotactic network, via a novel G protein-coupled receptor which interacts with the IL-8 receptor pathway...
  56. ncbi request reprint A novel C-type lectin secreted by a tissue-dwelling parasitic nematode
    A Loukas
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh, EH9 3JT, UK
    Curr Biol 9:825-8. 1999
    ..In TES-32, this loop appeared to be less obtrusive, permitting a broader range of ligand binding. The similarity of TES-32 to host immune cell receptors suggests a hitherto unsuspected strategy for parasite immune evasion...
  57. doi request reprint Chitinases and chitinase-like proteins: potential therapeutic targets for the treatment of T-helper type 2 allergies
    T E Sutherland
    Ashworth Laboratories, Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK
    Clin Exp Allergy 39:943-55. 2009
    ....
  58. pmc Acquired immune heterogeneity and its sources in human helminth infection
    C D Bourke
    Institute of Immunology and Infection Research, University of Edinburgh, Ashworth Laboratories, West Mains Road, Edinburgh EH93JT, UK
    Parasitology 138:139-59. 2011
    ..This review summarizes key differences identified in human acquired immune responses to nematode and trematode infections of public health importance and explores the factors contributing to these variations...
  59. ncbi request reprint Abundant larval transcript-1 and -2 genes from Brugia malayi: diversity of genomic environments but conservation of 5' promoter sequences functional in Caenorhabditis elegans
    Natalia Gomez-Escobar
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Mol Biochem Parasitol 125:59-71. 2002
    ..We conclude that the high level of alt transcription in filarial L3s is not due to expression from a multi-copy gene family but to a set of strong promoter elements shared between the two alt genes...
  60. doi request reprint The secretome of the filarial parasite, Brugia malayi: proteomic profile of adult excretory-secretory products
    James P Hewitson
    Institute of Immunology and Infection Research, University of Edinburgh, Ashworth Laboratories, Edinburgh, UK
    Mol Biochem Parasitol 160:8-21. 2008
    ....
  61. pmc Expansion and activation of CD4(+)CD25(+) regulatory T cells in Heligmosomoides polygyrus infection
    Constance A M Finney
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 37:1874-86. 2007
    ....
  62. pmc Differential recognition patterns of Schistosoma haematobium adult worm antigens by the human antibodies IgA, IgE, IgG1 and IgG4
    F Mutapi
    Ashworth Laboratories, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Parasite Immunol 33:181-92. 2011
    ..This may partly explain differences observed in isotype dynamics at a population level. Differential recognition patterns for some isoforms indicated in the study have potential importance for vaccine development...
  63. ncbi request reprint Homologues of human macrophage migration inhibitory factor from a parasitic nematode. Gene cloning, protein activity, and crystal structure
    Xingxing Zang
    Institute of Cell, Animal and Population Biology, University of Edinburgh, United Kingdom
    J Biol Chem 277:44261-7. 2002
    ..The strength of the similarity implies that MIF-mediated pathways play an important role in nematode immune evasion strategies...
  64. doi request reprint Four abundant novel transcript genes from Toxocara canis with unrelated coding sequences share untranslated region tracts implicated in the control of gene expression
    Deborah M Callister
    Institute of Immunology and Infection Research, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Mol Biochem Parasitol 162:60-70. 2008
    ..elegans micro-RNA lin-4. While infective stage parasites stockpile high levels of the ant transcripts, we suggest that translation is repressed, possibly by a mechanism involving 3' UTR motifs shared by the four genes...
  65. ncbi request reprint O-methylated glycans from Toxocara are specific targets for antibody binding in human and animal infections
    Irma Schabussova
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3JT, UK
    Int J Parasitol 37:97-109. 2007
    ..However, DC-SIGN did not bind the synthetic glycans, indicating additional non-methylated carbohydrates may also play a role in the interaction between T. canis and its host...
  66. ncbi request reprint A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivo
    Georgia Perona-Wright
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    J Immunol 182:2808-15. 2009
    ..Our data delineate sequential requirements for DC expression of CD40 and production of IL-6 during Th17 polarization in vitro and in vivo, and reveal distinct costimulatory requirements for Th1 vs Th17 generation...
  67. ncbi request reprint Cystatins from filarial parasites: evolution, adaptation and function in the host-parasite relationship
    William F Gregory
    Institute of Immunology and Infection Research, Ashworth Laboratories, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Int J Biochem Cell Biol 40:1389-98. 2008
    ..Hence, we hypothesise that CPI-2 has evolved to block mammalian proteases (including the antigen-processing enzyme AEP) while CPI-1 and -3 function in the milieu of the mosquito vector necessary for transmission of the parasite...
  68. ncbi request reprint Bm-CPI-2, a cystatin from Brugia malayi nematode parasites, differs from Caenorhabditis elegans cystatins in a specific site mediating inhibition of the antigen-processing enzyme AEP
    Janice Murray
    Institute of Immunology and Infection Research, Ashworth Laboratories, University of Edinburgh, West Mains Road, Scotland EH9 3JT, UK
    Mol Biochem Parasitol 139:197-203. 2005
    ..6) and Ce-CPI-2 (R01B10.1), both of which block cathepsins and neither of which possess the ability to block AEP. Thus, Brugia CPI-2 may have convergently evolved to inhibit an enzyme important only in the mammalian environment...
  69. ncbi request reprint Resistance to helminth infection: the case for interleukin-5-dependent mechanisms
    Rick M Maizels
    J Infect Dis 190:427-9. 2004
  70. ncbi request reprint Molecular and cellular biology of helminth parasites IV
    Murray E Selkirk
    Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, UK
    Int J Parasitol 36:615-6. 2006
  71. ncbi request reprint Comparison of IgG-ELISA and IgG4-ELISA for Toxocara serodiagnosis
    Rahmah Noordin
    Institute for Research in Molecular Medicine, Suite 110, Eureka Complex, Universiti Sains Malaysia, 11800 Penang, Malaysia
    Acta Trop 93:57-62. 2005
    ..An IgG4 immunoassay would also be useful in the secondary screening of antigen clones in the effort to develop improved serological tests for toxocariasis...
  72. ncbi request reprint Lymphatic filariasis and Brugia timori: prospects for elimination
    Peter Fischer
    Department of Helminthology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359 Hamburg, Germany
    Trends Parasitol 20:351-5. 2004
    ..Therefore, elimination of B. timori appears to be achievable...
  73. pmc Characterization of a UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase with an unusual lectin domain from the platyhelminth parasite Echinococcus granulosus
    Teresa Freire
    Departamento de Bioquimica, Facultad de Medicina, Universidad de la Republica, Av Gral Flores 2125, Montevideo CP 11800, Uruguay
    Biochem J 382:501-10. 2004
    ..Therefore it could participate in the biosynthesis of O-glycosylated parasite proteins exposed at the interface between E. granulosus and its hosts...