N J Maitland

Summary

Affiliation: University of York
Country: UK

Publications

  1. ncbi Prospective identification of tumorigenic prostate cancer stem cells
    Anne T Collins
    Yorkshire Cancer Research Unit, Department of Biology, University of York, York, United Kingdom
    Cancer Res 65:10946-51. 2005
  2. ncbi Regulation of protein kinase B activity by PTEN and SHIP2 in human prostate-derived cell lines
    R Michael Sharrard
    YCR Cancer Research Unit, Department of Biology, University of York, Heslington, York YO10 5DD, UK
    Cell Signal 19:129-38. 2007
  3. ncbi Prostate cancer stem cells: a new target for therapy
    Norman J Maitland
    YCR Cancer Research Unit, Department of Biology, University of York, Heslinton, York, YO10 5YW, United Kingdom
    J Clin Oncol 26:2862-70. 2008
  4. ncbi Regulation of the stem cell marker CD133 is independent of promoter hypermethylation in human epithelial differentiation and cancer
    Davide Pellacani
    YCR Cancer Research Unit, Department of Biology, University of York, UK
    Mol Cancer 10:94. 2011
  5. ncbi Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions
    Richard Birnie
    Pro Cure Therapeutics Ltd, The Biocentre, Innovation Way, York Science Park, Heslington, York, UK
    Genome Biol 9:R83. 2008
  6. ncbi Targeting gene therapy for prostate cancer
    N J Maitland
    YCR Cancer Research Unit, Department of Biology Area 13, University of York, Heslington, York, YO10 5DD, UK
    Curr Pharm Des 10:531-55. 2004
  7. ncbi A tumour stem cell hypothesis for the origins of prostate cancer
    Norman J Maitland
    YCR Cancer Research Unit, Department of Biology, University of York, York, UK
    BJU Int 96:1219-23. 2005
  8. ncbi Exploitation of prostate gene expression to develop targeted therapies
    Norman J Maitland
    YCR Cancer Research Unit, Department of Biology, University of York, PO Box 373, York YO1 5YW, U.K
    Acta Biomed 74:105-6. 2003
  9. ncbi Inflammation as the primary aetiological agent of human prostate cancer: a stem cell connection?
    Norman J Maitland
    YCR Cancer Research Unit, Deparment of Biology, University of York, York YO10 5YW, United Kingdom
    J Cell Biochem 105:931-9. 2008
  10. ncbi Prostate cancer stem cells: a target for new therapies
    N J Maitland
    Department of Biology, YCR Cancer Research Unit, University of York, YO10 5YW York, UK
    Ernst Schering Found Symp Proc 5:155-79. 2006

Collaborators

Detail Information

Publications41

  1. ncbi Prospective identification of tumorigenic prostate cancer stem cells
    Anne T Collins
    Yorkshire Cancer Research Unit, Department of Biology, University of York, York, United Kingdom
    Cancer Res 65:10946-51. 2005
    ..The identification of a prostate cancer stem cell provides a powerful tool to investigate the tumorigenic process and to develop therapies targeted to the stem cell...
  2. ncbi Regulation of protein kinase B activity by PTEN and SHIP2 in human prostate-derived cell lines
    R Michael Sharrard
    YCR Cancer Research Unit, Department of Biology, University of York, Heslington, York YO10 5DD, UK
    Cell Signal 19:129-38. 2007
    ..Thus SHIP2 substitutes for PTEN in the acute regulation of PKB in PC3 cells but not other prostate cell lines, where PTEN may share this role with further PIP3-degrading mechanisms...
  3. ncbi Prostate cancer stem cells: a new target for therapy
    Norman J Maitland
    YCR Cancer Research Unit, Department of Biology, University of York, Heslinton, York, YO10 5YW, United Kingdom
    J Clin Oncol 26:2862-70. 2008
    ..9% of tumor mass, but paradoxically have a poor tumor-initiating capacity...
  4. ncbi Regulation of the stem cell marker CD133 is independent of promoter hypermethylation in human epithelial differentiation and cancer
    Davide Pellacani
    YCR Cancer Research Unit, Department of Biology, University of York, UK
    Mol Cancer 10:94. 2011
    ..In this study we investigated the role of epigenetic regulation of CD133 in epithelial differentiation and cancer...
  5. ncbi Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions
    Richard Birnie
    Pro Cure Therapeutics Ltd, The Biocentre, Innovation Way, York Science Park, Heslington, York, UK
    Genome Biol 9:R83. 2008
    ..We have compared gene expression in these cells relative to their normal and differentiated (CD133-/alpha2beta1low) counterparts, resulting in an informative cancer stem cell gene-expression signature...
  6. ncbi Targeting gene therapy for prostate cancer
    N J Maitland
    YCR Cancer Research Unit, Department of Biology Area 13, University of York, Heslington, York, YO10 5DD, UK
    Curr Pharm Des 10:531-55. 2004
    ..We also consider the future of prostate cancer gene therapy and the factors that should be taken into account when designing clinical trials, in a field that is expected to impact on clinical management of a common tumour type...
  7. ncbi A tumour stem cell hypothesis for the origins of prostate cancer
    Norman J Maitland
    YCR Cancer Research Unit, Department of Biology, University of York, York, UK
    BJU Int 96:1219-23. 2005
    ....
  8. ncbi Exploitation of prostate gene expression to develop targeted therapies
    Norman J Maitland
    YCR Cancer Research Unit, Department of Biology, University of York, PO Box 373, York YO1 5YW, U.K
    Acta Biomed 74:105-6. 2003
  9. ncbi Inflammation as the primary aetiological agent of human prostate cancer: a stem cell connection?
    Norman J Maitland
    YCR Cancer Research Unit, Deparment of Biology, University of York, York YO10 5YW, United Kingdom
    J Cell Biochem 105:931-9. 2008
    ..The establishment of one or more autocrine signalling loops results in an expansion of these cells in the absence of inflammation, as a potential first stage in the development of the tumour...
  10. ncbi Prostate cancer stem cells: a target for new therapies
    N J Maitland
    Department of Biology, YCR Cancer Research Unit, University of York, YO10 5YW York, UK
    Ernst Schering Found Symp Proc 5:155-79. 2006
    ..The final tumours reexpressed androgen receptor and displayed a histology similar to that of a Gleason 4 cancer...
  11. ncbi Expression patterns of the human papillomavirus type 16 transcription factor E2 in low- and high-grade cervical intraepithelial neoplasia
    N J Maitland
    Department of Biology, University of York, U K
    J Pathol 186:275-80. 1998
    ....
  12. ncbi Targeting therapeutic gene expression to human prostate cancers
    N J Maitland
    YCR Cancer Research Unit, Department of Biology, University of York, Heslington, York, YO10 5YW, UK
    Curr Opin Mol Ther 2:389-99. 2000
    ..To achieve optimal and safe targeting, a combination approach will be necessary, as there are few genes whose expression can provide absolute prostate specificity...
  13. ncbi Cancer stem cells - A therapeutic target?
    Norman J Maitland
    University of York, YCR Cancer Research Unit, Department of Biology, York YO1 5YW, UK
    Curr Opin Mol Ther 12:662-73. 2010
    ..Instead, the ideal therapies targeting CSCs will be directed against functions that contribute to the oncogenic nature of CSCs relative to healthy stem cells, an altogether more challenging task...
  14. ncbi Phenotypic effects of overexpression of the MMAC1 gene in prostate epithelial cells
    R M Sharrard
    YCR Cancer Research Unit, Department of Biology, University of York, York, UK
    Br J Cancer 83:1102-9. 2000
    ....
  15. ncbi In vitro models to study cellular differentiation and function in human prostate cancers
    N J Maitland
    YCR Cancer Research Unit, Department of Biology, University of York, Heslington, York YO105YW, United Kingdom
    Radiat Res 155:133-142. 2001
    ..The properties of this cell line, which remains close to diploid, are similar to those of early prostate cancer cells, and it retains expression of many prostate-associated antigens, such as prostate-specific antigen (PSA)...
  16. ncbi Coculture of prostate cancer cells
    Shona H Lang
    YCR Cancer Research Unit, Department of Biology, University of York, UK
    Methods Mol Med 88:295-302. 2004
  17. ncbi Experimental prostate epithelial morphogenesis in response to stroma and three-dimensional matrigel culture
    S H Lang
    YCR Cancer Research Unit, Department of Biology, University of York, Heslington, York YO10 5YW, UK
    Cell Growth Differ 12:631-40. 2001
    ..Thus, development of a functional and morphologically correct prostate gland in vitro is dependent on extracellular matrix, steroid hormones, and factors from stromal cells and serum...
  18. ncbi In vitro modelling of epithelial and stromal interactions in non-malignant and malignant prostates
    S H Lang
    Department of Biology, University of York, Heslington, UK
    Br J Cancer 82:990-7. 2000
    ....
  19. ncbi Prostate epithelial cell lines form spheroids with evidence of glandular differentiation in three-dimensional Matrigel cultures
    S H Lang
    YCR Cancer Research Unit, University of York, Heslington, York YO10 5YW, UK
    Br J Cancer 85:590-9. 2001
    ..Matrigel also influenced the expression of PSA, PSMA and CD44. These results indicate that Matrigel culture can induce morphological differentiation of prostate cancer cells which initially had a basal phenotype...
  20. ncbi An internal polyadenylation signal substantially increases expression levels of lentivirus-delivered transgenes but has the potential to reduce viral titer in a promoter-dependent manner
    Stefanie Hager
    YCR Cancer Research Unit, Department of Biology, University of York, Heslington, York YO10 5DD, United Kingdom
    Hum Gene Ther 19:840-50. 2008
    ..We therefore conclude that an internal polyadenylation signal in lentiviral vectors has a highly beneficial effect on transgene expression, but reduces viral titer in a promoter-dependent manner...
  21. ncbi In vitro primary cell culture as a physiologically relevant method for preclinical testing of human oncolytic adenovirus
    R E Adamson
    YCR Cancer Research Unit, Department of Biology, University of York, Heslington, York YO10 5DD, United Kingdom
    Hum Gene Ther 23:218-30. 2012
    ..Thus, using a relevant panel of primary human cells provides a convenient and alternative preclinical assay for examining the specificity of conditionally replicating oncolytic adenoviruses in vivo...
  22. ncbi Androgen receptor signalling in prostate: effects of stromal factors on normal and cancer stem cells
    Paul A Berry
    YCR Cancer Research Unit, Department of Biology, University of York, Wentworth Way, York, YO10 5DD, UK
    Mol Cell Endocrinol 288:30-7. 2008
    ..Some of these genes have direct androgen receptor binding ability...
  23. ncbi Preclinical evaluation of innate immunity to baculovirus gene therapy vectors in whole human blood
    Lindsay J Georgopoulos
    YCR Cancer Research Unit, Department of Biology Area 13, University of York, Heslington, York YO10 5DD, UK
    Mol Immunol 46:2911-7. 2009
    ..The use of complement inhibitors for therapeutic viruses should be considered on a patient-specific basis...
  24. ncbi Primary prostate stromal cells modulate the morphology and migration of primary prostate epithelial cells in type 1 collagen gels
    June A Hall
    YCR Cancer Research Unit, Department of Biology, University of York, York YO10 5YW, United Kingdom
    Cancer Res 62:58-62. 2002
    ..This three-dimensional culture system allows closely controlled manipulation and analysis in vitro of interactions between prostatic epithelial and stromal cells...
  25. ncbi Development and limitations of lentivirus vectors as tools for tracking differentiation in prostate epithelial cells
    Fiona M Frame
    YCR Cancer Research Unit, Department of Biology, University of York, Heslington, North Yorkshire, YO10 5DD, UK
    Exp Cell Res 316:3161-71. 2010
    ....
  26. ncbi Differentiation of prostate epithelial cell cultures by matrigel/ stromal cell glandular reconstruction
    Shona H Lang
    YCR Cancer Research Unit, University of York, UK
    In Vitro Cell Dev Biol Anim 42:273-80. 2006
    ..Co-culture of the spheroids with fibroblasts advanced differentiation by inducing androgen receptor expression and epithelial polarization. Our findings indicate that tumor cells can form acinus-like spheroids in Matrigel...
  27. ncbi Enhanced expression of vimentin in motile prostate cell lines and in poorly differentiated and metastatic prostate carcinoma
    Shona H Lang
    YCR Cancer Research Unit, University of York, Heslington, York, United Kingdom
    Prostate 52:253-63. 2002
    ..The metastatic potential of a series of prostate cell lines was analysed by measuring motility and invasiveness, and further correlated to the expression of epithelial differentiation markers...
  28. ncbi Prostate cancer stem cells
    Anne T Collins
    University of York, YCR Cancer Research Unit, Department of Biology, Heslington, York YO10 5DD, UK
    Eur J Cancer 42:1213-8. 2006
    ....
  29. ncbi Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer
    Stephanie L Swift
    YCR Cancer Research Unit, Department of Biology, University of York, Heslington, United Kingdom
    Cancer Res 70:347-56. 2010
    ..Our findings support the use of NTRs as tools for therapeutic targeting in prostate cancers composed of both poorly differentiated and/or well-differentiated cells...
  30. ncbi Molecular analysis of the interaction between HPV type 16 E6 and human E6-associated protein
    P R Daniels
    YCRC Cancer Research Unit, University of York, UK
    FEBS Lett 416:6-10. 1997
    ....
  31. ncbi A microdissection approach to detect molecular markers during progression of prostate cancer
    P Berthon
    Department of Biology, University of York, Heslington, UK
    Br J Cancer 72:946-51. 1995
    ..By targeting recognised tumour cells we can find DNA mutations which are undetectable using the standard technique of whole-tissue DNA extraction, particularly in a heterogeneous tumour such as carcinoma of the prostate...
  32. ncbi Alternative splicing of the human PTEN/MMAC1/TEP1 gene
    R M Sharrard
    YCR Cancer Research Unit, Department of Biology, University of York, Heslington, York YO10 5DD, UK
    Biochim Biophys Acta 1494:282-5. 2000
    ..Cultured tumour and non-tumour cell lines show similar splicing patterns...
  33. ncbi Structure of the human S100A12-copper complex: implications for host-parasite defence
    O V Moroz
    Department of Chemistry, University of York, York YO10 5YW, England
    Acta Crystallogr D Biol Crystallogr 59:859-67. 2003
    ..The results suggest that copper binding may be essential for the functional role of S100A12 and probably the other calgranulins in the early immune response...
  34. ncbi Immortalization of human prostate cells with the human papillomavirus type 16 E6 gene
    Norman J Maitland
    YCR Cancer Research Unit, Department of Biology, University of York, UK
    Methods Mol Med 88:275-85. 2004
  35. ncbi Dimerization of the human papillomavirus type 16 E2 N terminus results in DNA looping within the upstream regulatory region
    Elena E Hernandez-Ramon
    YCR Cancer Research Unit, Department of Biology Area 13, University of York, Heslington, York, YO10 5DD United Kingdom
    J Virol 82:4853-61. 2008
    ..Our results suggest that N-terminal dimerization plays a role in E2-mediated transactivation, probably via DNA looping, a common mechanism for remote regulation of gene transcription...
  36. ncbi Phenotypic effects of HPV-16 E2 protein expression in human keratinocytes
    Julie E Burns
    YCR Cancer Research Unit, Department of Biology Area 13, University of York, PO Box 373, York YO105YW, UK
    Virology 401:314-21. 2010
    ..This provides the first evidence of a role for E2 in stimulation of the normal epithelial differentiation programme, which would promote the progression of the HPV life cycle...
  37. ncbi CD133, a novel marker for human prostatic epithelial stem cells
    Gavin D Richardson
    Prostate Research Group, Surgical Oncology, Medical School, Framlington Place, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
    J Cell Sci 117:3539-45. 2004
    ..alpha(2)beta(1)(hi)/CD133(+) cells exhibit two important attributes of epithelial stem cells: they possess a high in vitro proliferative potential and can reconstitute prostatic-like acini in immunocompromised male nude mice...
  38. ncbi Optimization of a synthetic beta-catenin-dependent promoter for tumor-specific cancer gene therapy
    Kai S Lipinski
    ML Research, Keele University Science Park, Keele, Staffordshire ST5 5SP, UK
    Mol Ther 10:150-61. 2004
    ..CTP4 should be the promoter of choice for Ad-based gene therapies of tumors deregulated for beta-catenin. We provide preliminary evidence that these may include prostate and ovarian as well as colorectal cancer...
  39. ncbi Expression and localization of endothelin-converting enzyme-1 in human prostate cancer
    Louise A Dawson
    Proteolysis Research Group, School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, United Kingdom
    Exp Biol Med (Maywood) 231:1106-10. 2006
    ..The upregulation of the ECE-1c isoform in PC cell lines is being investigated further...
  40. ncbi Differential expression of neutral endopeptidase-24.11 (neprilysin) and endothelin-converting enzyme in human prostate cancer cell lines
    Badar A Usmani
    School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, U K
    Clin Sci (Lond) 103:314S-317S. 2002
    ..A differential profile of ECE and NEP could contribute to an abundance of mitogenic peptides aiding the progression of androgen-independent prostate cancer...
  41. ncbi Seeding drug discovery: integrating telomerase cancer biology and cellular senescence to uncover new therapeutic opportunities in targeting cancer stem cells
    W Nicol Keith
    Centre for Oncology and Applied Pharmacology, University of Glasgow, Cancer Research UK Beatson Laboratories, Alexander Stone Building, Garscube Estate, Switchback Road, Bearsden, Glasgow, UK
    Drug Discov Today 12:611-21. 2007
    ....