Rob J Mairs

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi request reprint Applications of gene transfer to targeted radiotherapy
    R J Mairs
    Departments of Radiation Oncology and Child Health, University of Glasgow, CRC Beatson Laboratories, Garscube Estate, Glasgow, G61 1BD, Scotland, UK
    Curr Pharm Des 6:1419-32. 2000
  2. ncbi request reprint Optimizing MIBG therapy of neuroendocrine tumors: preclinical evidence of dose maximization and synergy
    Rob J Mairs
    Department of Radiation Oncology, University of Glasgow, Glasgow, UK
    Nucl Med Biol 35:S9-20. 2008
  3. ncbi request reprint Microsatellite analysis for determination of the mutagenicity of extremely low-frequency electromagnetic fields and ionising radiation in vitro
    Robert J Mairs
    Targeted Therapy Group, Division of Cancer Science and Molecular Pathology, Glasgow University, Cancer Research UK Beatson Laboratories, and Department of Child Health, Yorkhill Hospital, Glasgow, UK
    Mutat Res 626:34-41. 2007
  4. ncbi request reprint Gene manipulation to enhance MIBG-targeted radionuclide therapy
    Robert J Mairs
    Targeted Therapy Group, Centre for Oncology and Applied Pharmacology, Cancer Research UK Beatson Laboratories, University of Glasgow
    Nucl Med Biol 32:749-53. 2005
  5. ncbi request reprint National symposium on low-dose radiation and bystander effects -12 October 2004, Cancer Research UK Beatson Laboratories, Glasgow. Sponsored by Glasgow University School for Cancer Studies, the Department of Health and the National Cancer Research Institu
    R J Mairs
    Targeted Therapy Group, Cancer Research UK Beatson Laboratories, Glasgow, UK
    Int J Radiat Biol 81:259-62. 2005
  6. ncbi request reprint Development of a real-time polymerase chain reaction assay for prediction of the uptake of meta-[(131)I]iodobenzylguanidine by neuroblastoma tumors
    Sean Carlin
    Departments of Radiation Oncology and Child Health, University of Glasgow, Cancer Research UK Beatson Laboratories, Glasgow G61 1BD, United Kingdom
    Clin Cancer Res 9:3338-44. 2003
  7. doi request reprint Preclinical assessment of strategies for enhancement of metaiodobenzylguanidine therapy of neuroendocrine tumors
    Rob J Mairs
    Radiation Oncology, Division of Cancer Science and Molecular Pathology, University of Glasgow, Cancer Research UK, Beatson Laboratories, Glasgow, Scotland
    Semin Nucl Med 41:334-44. 2011
  8. ncbi request reprint [131I]MIBG and topotecan: a rationale for combination therapy for neuroblastoma
    Anthony G McCluskey
    Targeted Therapy Group and Department of Child Health, Cancer Research UK Beatson Laboratories, University of Glasgow, Garscube Estate, Glasgow G61 1BD, UK
    Cancer Lett 228:221-7. 2005
  9. ncbi request reprint Sodium-iodide symporter (NIS)-mediated accumulation of [(211)At]astatide in NIS-transfected human cancer cells
    Sean Carlin
    Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nucl Med Biol 29:729-39. 2002
  10. doi request reprint Radiation quality-dependent bystander effects elicited by targeted radionuclides
    Marie Boyd
    Targeted Therapy Group, Division of Cancer Sciences, Faculty of Medicine, Glasgow University, Cancer Research UK Beatson Laboratories, Glasgow, G61 1BD, UK
    J Pharm Pharmacol 60:951-8. 2008

Detail Information

Publications18

  1. ncbi request reprint Applications of gene transfer to targeted radiotherapy
    R J Mairs
    Departments of Radiation Oncology and Child Health, University of Glasgow, CRC Beatson Laboratories, Garscube Estate, Glasgow, G61 1BD, Scotland, UK
    Curr Pharm Des 6:1419-32. 2000
    ..This review covers aspects of the combination of gene manipulation and targeted radiotherapy, emphasising the potential of gene transfer to facilitate tumour targeting with low molecular weight radiopharmaceuticals...
  2. ncbi request reprint Optimizing MIBG therapy of neuroendocrine tumors: preclinical evidence of dose maximization and synergy
    Rob J Mairs
    Department of Radiation Oncology, University of Glasgow, Glasgow, UK
    Nucl Med Biol 35:S9-20. 2008
    ..By employing a range of strategies, there are good prospects for the improvement of the [(131)I]MIBG therapy of neuroectodermal tumors...
  3. ncbi request reprint Microsatellite analysis for determination of the mutagenicity of extremely low-frequency electromagnetic fields and ionising radiation in vitro
    Robert J Mairs
    Targeted Therapy Group, Division of Cancer Science and Molecular Pathology, Glasgow University, Cancer Research UK Beatson Laboratories, and Department of Child Health, Yorkhill Hospital, Glasgow, UK
    Mutat Res 626:34-41. 2007
    ..Treatment with 0.3 Gy induced more than 10 times more mutations per unit dose than irradiation with 3 Gy, indicating hypermutability at low dose...
  4. ncbi request reprint Gene manipulation to enhance MIBG-targeted radionuclide therapy
    Robert J Mairs
    Targeted Therapy Group, Centre for Oncology and Applied Pharmacology, Cancer Research UK Beatson Laboratories, University of Glasgow
    Nucl Med Biol 32:749-53. 2005
    ..However, uptake of the drug in malignant sites is insufficient to cure disease. A growing body of experimental evidence indicates exciting possibilities for the integration of gene transfer with [(131)I]MIBG-targeted radiotherapy...
  5. ncbi request reprint National symposium on low-dose radiation and bystander effects -12 October 2004, Cancer Research UK Beatson Laboratories, Glasgow. Sponsored by Glasgow University School for Cancer Studies, the Department of Health and the National Cancer Research Institu
    R J Mairs
    Targeted Therapy Group, Cancer Research UK Beatson Laboratories, Glasgow, UK
    Int J Radiat Biol 81:259-62. 2005
  6. ncbi request reprint Development of a real-time polymerase chain reaction assay for prediction of the uptake of meta-[(131)I]iodobenzylguanidine by neuroblastoma tumors
    Sean Carlin
    Departments of Radiation Oncology and Child Health, University of Glasgow, Cancer Research UK Beatson Laboratories, Glasgow G61 1BD, United Kingdom
    Clin Cancer Res 9:3338-44. 2003
    ..EXPERMENTAL DESIGN: Tumor specimens from 54 neuroblastoma patients were analyzed using real-time PCR, and NAT expression was compared with the corresponding diagnostic scintigrams...
  7. doi request reprint Preclinical assessment of strategies for enhancement of metaiodobenzylguanidine therapy of neuroendocrine tumors
    Rob J Mairs
    Radiation Oncology, Division of Cancer Science and Molecular Pathology, University of Glasgow, Cancer Research UK, Beatson Laboratories, Glasgow, Scotland
    Semin Nucl Med 41:334-44. 2011
    ..With these ploys, it is expected that advances will be made toward the optimization of [(131)I]MIBG therapy of neuroectodermal tumors...
  8. ncbi request reprint [131I]MIBG and topotecan: a rationale for combination therapy for neuroblastoma
    Anthony G McCluskey
    Targeted Therapy Group and Department of Child Health, Cancer Research UK Beatson Laboratories, University of Glasgow, Garscube Estate, Glasgow G61 1BD, UK
    Cancer Lett 228:221-7. 2005
    ..We are investigating various scheduled combinations of topotecan and [131I]MIBG on neuroblastoma cells, and preliminary data suggests that topotecan induces increased accumulation of [131I]MIBG in vitro...
  9. ncbi request reprint Sodium-iodide symporter (NIS)-mediated accumulation of [(211)At]astatide in NIS-transfected human cancer cells
    Sean Carlin
    Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nucl Med Biol 29:729-39. 2002
    ..These studies suggest [(211)At]astatide as a possible alternative radionuclide to [(131)I]iodide for NIS-based endoradiotherapy, and provide a model for the study of [(211)At]astatide behavior at a cellular level...
  10. doi request reprint Radiation quality-dependent bystander effects elicited by targeted radionuclides
    Marie Boyd
    Targeted Therapy Group, Division of Cancer Sciences, Faculty of Medicine, Glasgow University, Cancer Research UK Beatson Laboratories, Glasgow, G61 1BD, UK
    J Pharm Pharmacol 60:951-8. 2008
    ..It is concluded that radiopharmaceutical-induced bystander effects may depend on LET of the decay particles but are independent of site of intracellular concentration of radionuclide...
  11. ncbi request reprint A transfectant mosaic xenograft model for evaluation of targeted radiotherapy in combination with gene therapy in vivo
    Robert J Mairs
    Targeted Therapy Group, Division of Cancer Science and Molecular Pathology, Glasgow University, Cancer Research United Kingdom Beatson Laboratories, Glasgow, United Kingdom
    J Nucl Med 48:1519-26. 2007
    ..To enable the evaluation of targeted radiotherapy combined with gene transfer in vivo, we have developed a transfectant mosaic xenograft (TMX) model...
  12. ncbi request reprint An efficient targeted radiotherapy/gene therapy strategy utilising human telomerase promoters and radioastatine and harnessing radiation-mediated bystander effects
    Marie Boyd
    Department of Radiation Oncology and Targeted Therapy, Glasgow University, Cancer Research UK Beatson Laboratories, Glasgow G61 1BD, Scotland, UK
    J Gene Med 6:937-47. 2004
    ..Combining gene therapy with targeted radiotherapy is attractive because the associated cross-fire irradiation of the latter induces biological bystander effects upon neighbouring cells overcoming low gene transfer efficiency...
  13. ncbi request reprint Comparison of radiohaloanalogues of meta-iodobenzylguanidine (MIBG) for a combined gene- and targeted radiotherapy approach to bladder carcinoma
    Natasha E Fullerton
    Centre for Oncology and Applied Pharmacology, University of Glasgow, Cancer Research, UK
    Med Chem 1:611-8. 2005
    ..We conclude that NAT gene transfer combined with the administration of n.c.a.[131I]MIBG or [211At]MABG, is a promising novel treatment approach for bladder cancer therapy...
  14. ncbi request reprint Radiation-induced biologic bystander effect elicited in vitro by targeted radiopharmaceuticals labeled with alpha-, beta-, and auger electron-emitting radionuclides
    Marie Boyd
    Targeted Therapy Group, Division of Cancer Science and Molecular Pathology, Glasgow University, Cancer Research United Kingdom Beatson Laboratories, Glasgow, United Kingdom
    J Nucl Med 47:1007-15. 2006
    ....
  15. ncbi request reprint Application of targeted radiotherapy/gene therapy to bladder cancer cell lines
    Natasha E Fullerton
    Centre for Oncology and Applied Pharmacology, University of Glasgow, Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
    Eur Urol 47:250-6. 2005
    ..The aim is to decrease side effects from radiation toxicity, while increasing radiation dose to tumour. This tumour cell kill approach is augmented by radiological bystander effects...
  16. ncbi request reprint [131I]meta-iodobenzylguanidine and topotecan combination treatment of tumors expressing the noradrenaline transporter
    Anthony G McCluskey
    Targeted Therapy Group and Department of Child Health, University of Glasgow, Cancer Research UK Beatson Laboratories
    Clin Cancer Res 11:7929-37. 2005
    ..The aim of this study was to investigate the efficacy of [(131)I]MIBG in combination with topotecan in vitro and in vivo...
  17. ncbi request reprint Radioprotective gene therapy through retroviral expression of manganese superoxide dismutase
    Thomas D Southgate
    Cancer Research UK Gene Therapy Group, Paterson Institute for Cancer Research, Wilmslow Road, Manchester M20 4BX, UK
    J Gene Med 8:557-65. 2006
    ..The antioxidant enzyme manganese superoxide dismutase (SOD2) catalyzes the dismutation of the superoxide anions into hydrogen peroxide...