Research Topics
Species | Tryfonia Mainou-FowlerSummaryAffiliation: University of Newcastle Country: UK Publications
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Detail Information
Publications
Interleukin 4 production by peripheral blood lymphocytes in patients with classical Hodgkin lymphomaT Mainou-Fowler
Department of Haematological Sciences, School of Clinical and Laboratory Sciences, Leech Building, Newcastle upon Tyne, NE2 4HH, UK
Leuk Res 28:159-66. 2004..In conclusion, there is increased production of IL4 by PHA-activated PB lymphocytes in HL. The CD3(+)CD8(+) T-cell population appears to be responsible for this increased synthesis...- The levels of TNF alpha, IL4 and IL10 production by T-cells in B-cell chronic lymphocytic leukaemia (B-CLL)T Mainou-Fowler
Department of Haematology, School of Clinical and Laboratory Sciences, Royal Victoria Infirmary, Queen Victoria Road, New Castle upon Tyne, NE1 4 LP, UK
Leuk Res 25:157-63. 2001..The differences observed with some B-CLL cases in the production of TNF alpha, IL4 and IL10 by peripheral blood T-cells may suggest survival mechanisms for the leukaemic cells in these patients... - CD31 density is a novel risk factor for patients with B-cell chronic lymphocytic leukaemiaTryfonia Mainou-Fowler
Academic Haematology, School of Clinical and Laboratory Sciences, William Leech Building, The Medical School, Framlington Place, Newcastle upon Tyne, Tyne and Wear, NE2 4HH, UK
Int J Oncol 33:169-74. 2008..Also, low CD31 density enhances the prognostic power of CD38 density. The interaction between CD31 and CD38 and its clinical significance in B-CLL requires further investigation... - A new subtype-specific monoclonal antibody for IAP-survivin identifies high-risk patients with diffuse large B-cell lymphoma and improves the prognostic value of bcl-2Tryfonia Mainou-Fowler
Department of Haematology, School of Clinical and Laboratory Sciences, William Leech Building, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
Int J Oncol 32:59-68. 2008..Nuclear overexpression of IAP-survivin using this antibody predicts the disease outcome in patients with DLBCL and significantly improves the predictive power of bcl-2 in these patients... - Micro-vessel density and the expression of vascular endothelial growth factor (VEGF) and platelet-derived endothelial cell growth factor (PdEGF) in classical Hodgkin lymphoma (HL)Tryfonia Mainou-Fowler
Academic Haematology, School of Clinical and Laboratory Sciences, Newcastle upon Tyne, UK
Leuk Lymphoma 47:223-30. 2006..The expression of PdEGF increased with disease progression in seven cases. In conclusion, Hodgkin tissue shows prominent vascularization. The increased MVD and PdEGF expression with disease progression merits further investigation... - The prognostic value of CD38 expression and its quantification in B cell chronic lymphocytic leukemia (B-CLL)Tryfonia Mainou-Fowler
Haematological Sciences, School of Clinical and Laboratory Sciences, The Medical School, Leech Building, Farmington Place, Newcastle upon Tyne NE2 4HH, UK
Leuk Lymphoma 45:455-62. 2004..This will assist in identifying Stage A patients who may benfit from early and/or more intensive treatment, as well as Stage B and C patients who may require alternative treatment strategies at the outset... - Expression and production of interleukin 4 in B-cell chronic lymphocytic leukaemiaT Mainou-Fowler
University Department of Haematology, School of Clinical and Laboratory Sciences, Royal Victoria Infirmary, Newcastle upon Tyne, UK
Leuk Lymphoma 42:689-98. 2001..49 and r=0.76, respectively). The significant differences observed in the production of IL4 by B-CLL B- and T-lymphocytes may suggest a paracrine function of IL4 in B-CLL... - Quantification improves the prognostic value of CD38 expression in B-cell chronic lymphocytic leukaemiaTryfonia Mainou-Fowler
University Department of Haematology, School of Clinical and Laboratory Sciences, Royal Victoria Infirmary, Newcastle upon Tyne, UK
Br J Haematol 118:755-61. 2002..However, quantification of CD38 is superior to the percentage positivity and should be used clinically in conjunction with other variables of predictive value to identify B-CLL patients that are likely to progress... - Intracellular cytokine profiles by peripheral blood CD3+ T-cells in patients with classical Hodgkin lymphomaTryfonia Mainou-Fowler
University Department of Haematology, School of Clinical and Laboratory Sciences, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK
Leuk Lymphoma 44:1325-31. 2003..In conclusion, there is reduced intracellular IL2, TNFalpha and IFNgamma and increased cytoplasmic IL4 production by activated PB T-cells in patients with HL. The CD3+CD8+ sub-population is responsible for the increased levels of IL4... - Quantification of CD38 expression in B-cell chronic lymphocytic leukemia (B-CLL): a comparison between antibody binding capacity (ABC) and relative median fluorescence (RMF)Helen M Dignum
Department of Haematology, Queen Alexandra Hospital, Cosham, Portsmouth PO6 3LY, UK
Leuk Lymphoma 45:1167-73. 2004..1103, = 0.0547, = 0.3399, respectively). We suggest that CD38 RMF could be used clinically as an alternative to ABC to identify patients with B-CLL that are likely to progress and require early treatment... - Immunophenotyping of diffuse large B-cell lymphoma (DLBCL) defines multiple sub-groups of germinal centre-like tumours displaying different survival characteristicsJohn J Anderson
Department of Academic Haematology, Northern Institute for Cancer Research, The University of Newcastle, Newcastle upon Tyne, NE2 4HH, UK
Int J Oncol 35:961-71. 2009.... - A 9 series microRNA signature differentiates between germinal centre and activated B-cell-like diffuse large B-cell lymphoma cell linesRachel E Culpin
Academic Haematology, Northern Institute for Cancer Research, Newcastle University, Newcastle, Tyne and Wear, NE2 4HH, UK
Int J Oncol 37:367-76. 2010..In conclusion, the present study identified a microRNA signature that correctly classified GC and ABC phenotypes in DLBCL cell lines. This signature has yet to be assessed for prediction in clinical samples... 
MicroRNAs are suitable for assessment as biomarkers from formalin-fixed paraffin-embedded tissue, and miR-24 represents an appropriate reference microRNA for diffuse large B-cell lymphoma studiesRachel Emily Culpin
Academic Haematology, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, Tyne and Wear, UK
J Clin Pathol 66:249-52. 2013..001) or DNAse treatment of total RNA (p<0.001). Finally, we validate miR-24 as a suitable reference microRNA for diffuse large B-cell lymphoma (DLBCL) FFPET studies...- Evaluation of treatment outcome in 175 patients with Hodgkin lymphoma aged 60 years or over: the SHIELD studyStephen J Proctor
Academic Haematology, Northern Institute of Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom
Blood 119:6005-15. 2012..In a Cox regression model only, obtaining CR remained significant for OS and CR plus comorbidity and age for PFS. RS-EBV status had no significant effect on outcome... - DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemiaElaine Willmore
Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom
Clin Cancer Res 14:3984-92. 2008..We hypothesized that inhibiting DNA-PK would sensitize CLL cells to drug-induced DNA damage and that this approach could increase the therapeutic index of agents used to treat CLL... - Mitoxantrone in combination with an inhibitor of DNA-dependent protein kinase: a potential therapy for high risk B-cell chronic lymphocytic leukaemiaSarah L Elliott
Newcastle Cancer Centre at the NorthernInstitute for Cancer Research, Medical School, Newcastle University, Newcastle upon Tyne, UK
Br J Haematol 152:61-71. 2011..PRKDC mRNA levels correlated with DNA-PKcs protein expression, which predicted shorter survival. These data confirm the potential of DNA-PK as a therapeutic target in poor prognosis CLL...