Martin Cj Maiden


Affiliation: University of Oxford
Country: UK


  1. Pearce M, Chattaway M, Grant K, Maiden M. A proposed core genome scheme for analyses of the Salmonella genus. Genomics. 2019;: pubmed publisher
    ..0 scheme were present in over 98% of S. enterica subspecies I isolates and should, therefore, continue to be used for subspecies I analyses, while the SalmcgMLSTv1.0 scheme is more appropriate for cross genus investigations. ..
  2. Chen M, Rodrigues C, Harrison O, Zhang C, Tan T, Chen J, et al. Invasive meningococcal disease in Shanghai, China from 1950 to 2016: implications for serogroup B vaccine implementation. Sci Rep. 2018;8:12334 pubmed publisher
    ..At the time of writing, MenB IMD dominated IMD in Shanghai, with isolates potentially beyond coverage with licenced OMV- and protein-based MenB vaccines. ..
  3. Sheppard S, Jolley K, Maiden M. A Gene-By-Gene Approach to Bacterial Population Genomics: Whole Genome MLST of Campylobacter. Genes (Basel). 2012;3:261-77 pubmed publisher
    ..We present a gene-by-gene approach for investigating the genetic basis of phenotypes in diverse bacteria such as Campylobacter, implemented with the BIGSdb software on the website. ..
  4. Pearce M, Alikhan N, Dallman T, Zhou Z, Grant K, Maiden M. Comparative analysis of core genome MLST and SNP typing within a European Salmonella serovar Enteritidis outbreak. Int J Food Microbiol. 2018;274:1-11 pubmed publisher
    ..The cgMLST scheme is therefore shown to be a standardised and scalable typing method, which allows Salmonella outbreaks to be analysed and compared across laboratories and jurisdictions. ..
  5. Lucidarme J, Hill D, Bratcher H, Gray S, du Plessis M, Tsang R, et al. Genomic resolution of an aggressive, widespread, diverse and expanding meningococcal serogroup B, C and W lineage. J Infect. 2015;71:544-52 pubmed publisher
    ..Recent MenC isolates from MSM in France and the UK were closely related but distinct. High resolution 'genomic' multilocus sequence typing is necessary to resolve and monitor the spread of diverse cc11 lineages globally. ..
  6. Jansen van Rensburg M, Swift C, Cody A, Jenkins C, Maiden M. Exploiting Bacterial Whole-Genome Sequencing Data for Evaluation of Diagnostic Assays: Campylobacter Species Identification as a Case Study. J Clin Microbiol. 2016;54:2882-2890 pubmed
  7. Maiden M, Harrison O. Population and Functional Genomics of Neisseria Revealed with Gene-by-Gene Approaches. J Clin Microbiol. 2016;54:1949-55 pubmed publisher
  8. Hill D, Lucidarme J, Gray S, Newbold L, Ure R, Brehony C, et al. Genomic epidemiology of age-associated meningococcal lineages in national surveillance: an observational cohort study. Lancet Infect Dis. 2015;15:1420-8 pubmed publisher
    ..The data revealed information crucial to effective deployment and assessment of vaccines against N meningitidis. Meningitis Research Foundation, Wellcome Trust, Public Health England, European Union. ..
  9. Bratcher H, Corton C, Jolley K, Parkhill J, Maiden M. A gene-by-gene population genomics platform: de novo assembly, annotation and genealogical analysis of 108 representative Neisseria meningitidis genomes. BMC Genomics. 2014;15:1138 pubmed publisher
    ..The method generates novel insights into the biology of the meningococcus and improves our understanding of the whole population structure, not just disease causing lineages. ..

More Information


  1. Diallo K, Gamougam K, Daugla D, Harrison O, Bray J, Caugant D, et al. Hierarchical genomic analysis of carried and invasive serogroup A Neisseria meningitidis during the 2011 epidemic in Chad. BMC Genomics. 2017;18:398 pubmed publisher
  2. Bennett J, Bentley S, Vernikos G, Quail M, Cherevach I, White B, et al. Independent evolution of the core and accessory gene sets in the genus Neisseria: insights gained from the genome of Neisseria lactamica isolate 020-06. BMC Genomics. 2010;11:652 pubmed publisher
    ..It is not possible to define a 'pathogenome' for this group of organisms and the disease causing phenotypes are therefore likely to be complex, polygenic, and different among the various disease-associated phenotypes observed. ..
  3. Bennett J, Jolley K, Sparling P, Saunders N, Hart C, Feavers I, et al. Species status of Neisseria gonorrhoeae: evolutionary and epidemiological inferences from multilocus sequence typing. BMC Biol. 2007;5:35 pubmed
    ..Here, the same seven locus Neisseria scheme was used to characterize a diverse collection of N. gonorrhoeae isolates to investigate whether this method would allow differentiation among isolates, and to distinguish these three species...
  4. Maiden M. The impact of protein-conjugate polysaccharide vaccines: an endgame for meningitis?. Philos Trans R Soc Lond B Biol Sci. 2013;368:20120147 pubmed publisher
    ..To date there is little evidence for the spread of virulent vaccine escape variants of the meningococcus and H. influenzae, although this has been reported in pneumococci. ..
  5. Brehony C, Rodrigues C, Borrow R, Smith A, Cunney R, Moxon E, et al. Distribution of Bexsero® Antigen Sequence Types (BASTs) in invasive meningococcal disease isolates: Implications for immunisation. Vaccine. 2016;34:4690-4697 pubmed publisher
    ..1%, based on genotype-phenotype modelling for 63.7% of serogroup B isolates from 2010/14 in UK and Ireland. While there are many caveats to this estimate, it lies within the range of other published estimates. ..
  6. Maiden M, Frosch M. Can we, should we, eradicate the meningococcus?. Vaccine. 2012;30 Suppl 2:B52-6 pubmed publisher
    ..On balance, the control and possible elimination of disease caused by particular disease-associated meningococcal genotypes is a more achievable and worthwhile goal. ..
  7. Maiden M. Population genomics: diversity and virulence in the Neisseria. Curr Opin Microbiol. 2008;11:467-71 pubmed publisher
    ..These are generic approaches and their application to the Neisseria provides a foretaste for their application to the wider bacterial world...
  8. Maiden M, Ibarz Pavón A, Urwin R, Gray S, Andrews N, Clarke S, et al. Impact of meningococcal serogroup C conjugate vaccines on carriage and herd immunity. J Infect Dis. 2008;197:737-43 pubmed publisher
    ..The impact of this intervention on asymptomatic carriage of meningococci was investigated to establish whether serogroup replacement or protection by herd immunity occurred...