Yashwant R Mahida

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. ncbi request reprint Host-bacterial interactions in inflammatory bowel disease
    Yashwant R Mahida
    Institute of Infection, Immunity and Inflammation, University Hospital, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Clin Sci (Lond) 107:331-41. 2004
  2. pmc Primary human colonic myofibroblasts are resistant to Clostridium difficile toxin A-induced, but not toxin B-induced, cell death
    N Mullan
    Institute of Infection, Immunity and Inflammation, University of Nottingham Nottingham, UK
    Infect Immun 79:1623-30. 2011
  3. ncbi request reprint Microbial-gut interactions in health and disease. Epithelial cell responses
    Y R Mahida
    Institute of Infection, Immunity and Inflammation and Division of Gastroenterology, Queen s Medical Centre, University Hospital, Nottingham NG7 2UH, UK
    Best Pract Res Clin Gastroenterol 18:241-53. 2004
  4. ncbi request reprint Host-parasite interactions in rodent nematode infections
    Y R Mahida
    Division of Gastroenterology, University Hospital, Queen s Medical Centre, Nottingham NG7 2UH, UK
    J Helminthol 77:125-31. 2003
  5. doi request reprint Heterogeneity in histone 2B-green fluorescent protein-retaining putative small intestinal stem cells at cell position 4 and their absence in the colon
    Kevin R Hughes
    Institute of Infection, Immunity and Inflammation, C Floor, West Block, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    Am J Physiol Gastrointest Liver Physiol 303:G1188-201. 2012
  6. ncbi request reprint Differential effects of varying concentrations of clostridium difficile toxin A on epithelial barrier function and expression of cytokines
    Shawinder S Johal
    Division of Gastroenterology, University Hospital, Queen s Medical Centre, Nottingham, United Kingdom
    J Infect Dis 189:2110-9. 2004
  7. ncbi request reprint Toxicity of mycophenolate mofetil in patients with inflammatory bowel disease
    Maeve M Skelly
    Division of Gastroenterology, Department of Pathology, University Hospital, Queen s Medical Center, Nottingham, NG7 2UH, England, U K
    Inflamm Bowel Dis 8:93-7. 2002
  8. ncbi request reprint Effects of Trichinella spiralis infection on intestinal pathology in mice lacking interleukin-4 (IL-4) or intestinal trefoil factor (ITF/TFF3)
    Mohammed Shafek Dehlawi
    School of Biological Sciences, University of Nottingham, Nottingham NG7 2RD, UK
    Parasitol Int 55:207-11. 2006
  9. pmc Impaired luminal processing of human defensin-5 in Crohn's disease: persistence in a complex with chymotrypsinogen and trypsin
    David Elphick
    Institute of Infection, Immunity, and Inflammation, University of Nottingham, Nottingham, UK
    Am J Pathol 172:702-13. 2008
  10. ncbi request reprint Expression of alpha5 (CD49e) and alpha6 (CD49f) integrin subunits on T cells in the circulation and the lamina propria of normal and inflammatory bowel disease colonic mucosa
    J E Pilling
    Division of Gastroenterology, Univeristy Hospital, Queens Medical Centre, Nottingham, UK
    Scand J Immunol 48:425-8. 1998

Collaborators

  • Christopher S Potten
  • Christopher J Hawkey
  • Maeve M Skelly
  • D Wakelin
  • A J Ouellette
  • D A Elphick
  • Richard Logan
  • R N Cunliffe
  • Ricardo M C Gândara
  • R Walsh
  • Kevin R Hughes
  • N Mullan
  • S Samuel
  • J Webb
  • P A Sutton
  • M Kamal
  • Mohammed Shafek Dehlawi
  • A S Austin
  • Shawinder S Johal
  • S S Johal
  • Brian C McKaig
  • P D James
  • B C McKaig
  • Hanno Hock
  • Tanvi Javkar
  • Fred Sablitzky
  • K R Hughes
  • A Robins
  • J Behnke
  • R Seth
  • S Li
  • K Solomon
  • J Brazier
  • J E Pilling
  • Kevin Hughes
  • H M Judge
  • R A Robins
  • A Cockayne
  • S Peter Borriello
  • C P Lambert
  • J Hammond
  • S P Borriello
  • Katie Solomon
  • Sue Dodson
  • Daniel McWilliams
  • Sue A Watson
  • F R A J Rose
  • K Hughes
  • P J Tighe
  • J Keyte
  • L Abberley
  • F R Rose
  • A Smith
  • D K Podolsky
  • W C Chan
  • A Galvin
  • A M Robins
  • H F Sewell

Detail Information

Publications25

  1. ncbi request reprint Host-bacterial interactions in inflammatory bowel disease
    Yashwant R Mahida
    Institute of Infection, Immunity and Inflammation, University Hospital, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Clin Sci (Lond) 107:331-41. 2004
    ..Approaches to alter the intestinal microflora for therapeutic purposes and their potential mechanisms of action are also discussed...
  2. pmc Primary human colonic myofibroblasts are resistant to Clostridium difficile toxin A-induced, but not toxin B-induced, cell death
    N Mullan
    Institute of Infection, Immunity and Inflammation, University of Nottingham Nottingham, UK
    Infect Immun 79:1623-30. 2011
    ..Responses by colonic myofibroblasts may play an important role in mucosal protection, repair, and regeneration in colitis due to C. difficile infection...
  3. ncbi request reprint Microbial-gut interactions in health and disease. Epithelial cell responses
    Y R Mahida
    Institute of Infection, Immunity and Inflammation and Division of Gastroenterology, Queen s Medical Centre, University Hospital, Nottingham NG7 2UH, UK
    Best Pract Res Clin Gastroenterol 18:241-53. 2004
    ..The mechanisms by which epithelial cells may avoid pro-inflammatory responses to resident microorganisms, while retaining the capacity to respond to pathogens, are also being characterized...
  4. ncbi request reprint Host-parasite interactions in rodent nematode infections
    Y R Mahida
    Division of Gastroenterology, University Hospital, Queen s Medical Centre, Nottingham NG7 2UH, UK
    J Helminthol 77:125-31. 2003
    ..There is also increasing appreciation of the contribution of non-bone marrow-derived cells in innate and adaptive host responses in these models...
  5. doi request reprint Heterogeneity in histone 2B-green fluorescent protein-retaining putative small intestinal stem cells at cell position 4 and their absence in the colon
    Kevin R Hughes
    Institute of Infection, Immunity and Inflammation, C Floor, West Block, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    Am J Physiol Gastrointest Liver Physiol 303:G1188-201. 2012
    ....
  6. ncbi request reprint Differential effects of varying concentrations of clostridium difficile toxin A on epithelial barrier function and expression of cytokines
    Shawinder S Johal
    Division of Gastroenterology, University Hospital, Queen s Medical Centre, Nottingham, United Kingdom
    J Infect Dis 189:2110-9. 2004
    ..We investigated epithelial barrier function and expression of interleukin (IL)-8 and transforming growth factor (TGF)-beta in response to varying concentrations of C. difficile toxin A...
  7. ncbi request reprint Toxicity of mycophenolate mofetil in patients with inflammatory bowel disease
    Maeve M Skelly
    Division of Gastroenterology, Department of Pathology, University Hospital, Queen s Medical Center, Nottingham, NG7 2UH, England, U K
    Inflamm Bowel Dis 8:93-7. 2002
    ..Moreover, as patients with UC may be unduly prone to colonic injury, MMF may not be a suitable drug for its treatment...
  8. ncbi request reprint Effects of Trichinella spiralis infection on intestinal pathology in mice lacking interleukin-4 (IL-4) or intestinal trefoil factor (ITF/TFF3)
    Mohammed Shafek Dehlawi
    School of Biological Sciences, University of Nottingham, Nottingham NG7 2RD, UK
    Parasitol Int 55:207-11. 2006
    ..ITF/TFF3 appears not to influence cellular responses and does not alter parasite-induced pathological changes in the small intestine...
  9. pmc Impaired luminal processing of human defensin-5 in Crohn's disease: persistence in a complex with chymotrypsinogen and trypsin
    David Elphick
    Institute of Infection, Immunity, and Inflammation, University of Nottingham, Nottingham, UK
    Am J Pathol 172:702-13. 2008
    ..The persistence of this complex in CD may be attributable to increased luminal levels of proteinase inhibitors such as alpha1-anti-trypsin...
  10. ncbi request reprint Expression of alpha5 (CD49e) and alpha6 (CD49f) integrin subunits on T cells in the circulation and the lamina propria of normal and inflammatory bowel disease colonic mucosa
    J E Pilling
    Division of Gastroenterology, Univeristy Hospital, Queens Medical Centre, Nottingham, UK
    Scand J Immunol 48:425-8. 1998
    ....
  11. pmc Characterization of putative stem cells in isolated human colonic crypt epithelial cells and their interactions with myofibroblasts
    S Samuel
    Institute of Infection, Immunity and Inflammation, C Floor, West Block, Queen s Medical Centre, Nottingham NG72UH, United Kingdom
    Am J Physiol Cell Physiol 296:C296-305. 2009
    ..In conclusion, in preparation of isolated and disaggregated human colonic crypts, cells with stem cell characteristics preferentially adhere to primary human colonic myofibroblasts in a beta(1)-integrin-independent fashion...
  12. ncbi request reprint Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase-1 and -2
    Y R Mahida
    Division of Gastroenterology, University Hospital, Queen s Medical Centre, Nottingham, United Kingdom
    Am J Physiol 273:G1341-8. 1997
    ..Adult human colonic subepithelial myofibroblasts may influence epithelial cell function via products of COX-1 and -2 enzymes, such as PGE2 and secreted ECM proteins...
  13. pmc Mucosal T cells regulate Paneth and intermediate cell numbers in the small intestine of T. spiralis-infected mice
    M Kamal
    Division of Gastroenterology, University of Nottingham, UK
    Clin Exp Immunol 126:117-25. 2001
    ..In conclusion, a unique, likely thymic-independent population of mucosal T cells modulates innate small intestinal host defense in mice by increasing the number of Paneth and intermediate cells in response to T. spiralis infection...
  14. pmc Expression of antimicrobial neutrophil defensins in epithelial cells of active inflammatory bowel disease mucosa
    R N Cunliffe
    Division of Gastroenterology, University Hospital, Queen s Medical Centre, Nottingham NG7 2UH, UK
    J Clin Pathol 55:298-304. 2002
    ..The aim of this study was to investigate the expression of HNP 1-3 and lysozyme in normal and active inflammatory bowel disease (IBD) mucosa...
  15. doi request reprint Regional differences in stem and transit cell proliferation and apoptosis in the terminal ileum and colon of mice after 12 Gy
    Ricardo M C Gândara
    Institute of Infection, Immunity and Inflammation, Queens Medical Centre, University of Nottingham, Nottingham, UK
    Int J Radiat Oncol Biol Phys 82:e521-8. 2012
    ..We aimed to investigate stem cell-dependent characteristics of cell proliferation, apoptosis, and crypt size in terminal ileum and different regions of the colon...
  16. ncbi request reprint Differential expression of TGF-beta isoforms by normal and inflammatory bowel disease intestinal myofibroblasts
    B C McKaig
    Division of Gastroenterology, University Hospital, Nottingham NG7 2UH, United Kingdom
    Am J Physiol Cell Physiol 282:C172-82. 2002
    ....
  17. pmc Colonic IgA producing cells and macrophages are reduced in recurrent and non-recurrent Clostridium difficile associated diarrhoea
    S S Johal
    Division of Gastroenterology, University Hospital, Nottingham NG7 2UH, UK
    J Clin Pathol 57:973-9. 2004
    ..In Clostridium difficile associated diarrhoea (CDAD), histological changes in the colonic mucosa range from minimal inflammation to pseudomembranous colitis (PMC). The disease also recurs in a considerable proportion of patients...
  18. ncbi request reprint Defensins and mucosal protection
    Y R Mahida
    Division of Gastroenterology, Institute of Infection, Immunity and Inflammation, University of Nottingham and University Hospital, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Novartis Found Symp 263:71-7; discussion 77-84, 211-8. 2004
    ..HBDs have also been shown to be chemotactic for immature dendritic cells and memory T cells. Thus, they may not only mediate innate immunity, but also regulate adaptive immune responses in inflammatory bowel disease...
  19. pmc Epithelial stem cell-related alterations in Trichinella spiralis-infected small intestine
    R Walsh
    Institute of Infection, Immunity and Inflammation, University of Nottingham, Nottingham, UK
    Cell Prolif 42:394-403. 2009
    ..This model has been used to explore changes in the epithelial proliferative cell population and expression of transforming growth factor-beta (TGF-beta)...
  20. pmc Essential role of toxin A in C. difficile 027 and reference strain supernatant-mediated disruption of Caco-2 intestinal epithelial barrier function
    P A Sutton
    Institute of Infection, Immunity and Inflammation, University of Nottingham, Nottingham, UK
    Clin Exp Immunol 153:439-47. 2008
    ..difficile, toxin A is required for the initial injury that leads to loss of barrier function...
  21. pmc Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease
    Brian C McKaig
    Division of Gastroenterology, University Hospital, Queen s Medical Centre, Nottingham, United Kingdom
    Am J Pathol 162:1355-60. 2003
    ..These studies illustrate a potential mechanism by which differential expression of isoforms of TGF-beta may lead to excessive deposition of extracellular matrix and stricture formation via TIMP-1-mediated inhibition of MMP activity...
  22. pmc Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease
    R N Cunliffe
    Division of Gastroenterology, University of Nottingham, UK
    Gut 48:176-85. 2001
    ....
  23. ncbi request reprint Expression and regulation of antimicrobial peptides in the gastrointestinal tract
    R N Cunliffe
    Institute of Infection, Immunity and Inflammation and Division of Gastroenterology, University of Nottingham, United Kingdom
    J Leukoc Biol 75:49-58. 2004
    ..The ability of these peptides to act as chemoattractants for cells of the innate- and adaptive-immune system may also play an important role in perpetuating chronic inflammation in the GI tract...
  24. pmc Paneth cells: their role in innate immunity and inflammatory disease
    D A Elphick
    Institute of Infection, Immunity, and Inflammation, C Floor, West Block, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Gut 54:1802-9. 2005
  25. ncbi request reprint Responses to free lipopolysaccharide and Escherichia coli by normal human intestinal macrophages, following their migration out of the lamina propria
    A S Austin
    Institute of Infection, Immunity and Inflammation, University of Nottingham, Nottingham, UK
    Scand J Immunol 61:575-84. 2005
    ..These cells respond to free LPS and E. coli, as demonstrated by the expression of TNF-alpha...