Research Topics
| Eleanor A MaguireSummaryAffiliation: University College London Country: UK Publications
| Collaborators |
Detail Information
Publications
Studying the freely-behaving brain with fMRIEleanor A Maguire
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
Neuroimage 62:1170-6. 2012....- Tracking the emergence of conceptual knowledge during human decision makingDharshan Kumaran
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
Neuron 63:889-901. 2009..Our study offers neurobiological insights into the remarkable capacity of humans to discover the conceptual structure of related experiences and use this knowledge to solve exacting decision problems... - Navigational expertise may compromise anterograde associative memoryKatherine Woollett
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, UK
Neuropsychologia 47:1088-95. 2009.... - Impaired spatial and non-spatial configural learning in patients with hippocampal pathologyDharshan Kumaran
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
Neuropsychologia 45:2699-711. 2007.... - Detecting representations of recent and remote autobiographical memories in vmPFC and hippocampusHeidi M Bonnici
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, WC1N 3BG, United Kingdom
J Neurosci 32:16982-91. 2012..Overall, these findings clarify and extend our view of vmPFC and hippocampus while also informing systems-level consolidation and providing clear targets for future studies... 
Deconstructing episodic memory with constructionDemis Hassabis
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London, UK
Trends Cogn Sci 11:299-306. 2007..In light of this, we re-evaluate our understanding of episodic memory, the processes underpinning it and other related cognitive functions...- Imagining fictitious and future experiences: evidence from developmental amnesiaEleanor A Maguire
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK
Neuropsychologia 48:3187-92. 2010..We speculate that the hippocampal activation during fMRI noted previously in P01 and Jon might indicate some residual hippocampal function which is sufficient to support their preserved ability to imagine fictitious and future scenarios... 
Exploring anterograde associative memory in London taxi driversKatherine Woollett
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK
Neuroreport 23:885-8. 2012..This resolves an outstanding question in the memory profile of London taxi drivers following hippocampal plasticity, and underlines the close relationship between space and the hippocampus...- Decoding representations of scenes in the medial temporal lobesHeidi M Bonnici
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London, United Kingdom
Hippocampus 22:1143-53. 2012.... - Decoding individual episodic memory traces in the human hippocampusMartin J Chadwick
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N3BG, UK
Curr Biol 20:544-7. 2010..Finally, our data provide further evidence for functional differentiation within the medial temporal lobe, in that we show the hippocampus contains significantly more episodic information than adjacent structures... - Autobiographical memory in semantic dementia: a longitudinal fMRI studyEleanor A Maguire
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
Neuropsychologia 48:123-36. 2010.... - Retrosplenial cortex codes for permanent landmarksStephen D Auger
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, United Kingdom
PLoS ONE 7:e43620. 2012..Our findings suggest that a primary function of the RSC may be to process the most stable features in an environment, and this could be a prerequisite for successful navigation... - Acquiring "the Knowledge" of London's layout drives structural brain changesKatherine Woollett
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, UK
Curr Biol 21:2109-14. 2011.... - Attenuated boundary extension produces a paradoxical memory advantage in amnesic patientsSinéad L Mullally
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, UK
Curr Biol 22:261-8. 2012..This cognitive phenomenon is revealed by a subsequent memory error when we confidently misremember the extended scene instead of the original. This effect is known as "boundary extension" and is apparent in adults, children, and babies... - Non-spatial expertise and hippocampal gray matter volume in humansKatherine Woollett
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London, United Kingdom
Hippocampus 18:981-4. 2008..Instead it would seem that hippocampal gray matter volume effects are more likely to be observed when the knowledge acquired concerns a complex and detailed large-scale spatial layout... - Using imagination to understand the neural basis of episodic memoryDemis Hassabis
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
J Neurosci 27:14365-74. 2007..We suggest that additional brain regions are co-opted into this core network in a task-specific manner to support functions such as episodic memory that may have additional requirements... - Match mismatch processes underlie human hippocampal responses to associative noveltyDharshan Kumaran
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
J Neurosci 27:8517-24. 2007..More generally, the current study also offers insights into how the hippocampus automatically represents the spatiotemporal context of our experiences, a function that may relate to its role in episodic memory... - Neural substrates of driving behaviourHugo J Spiers
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
Neuroimage 36:245-55. 2007..By systematically characterising the brain dynamics underlying naturalistic driving behaviour in a real city, our findings may have implications for how driving competence is considered in the context of neurological damage... - Decoding information in the human hippocampus: a user's guideMartin J Chadwick
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
Neuropsychologia 50:3107-21. 2012..Overall, we hope to highlight the potential utility of MVPA, when appropriately deployed, and provide some initial guidance to those considering MVPA as a means to investigate the hippocampus... - Scene construction in amnesia: an FMRI studySinéad L Mullally
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, WC1N 3BG, United Kingdom
J Neurosci 32:5646-53. 2012.... - Differential engagement of brain regions within a 'core' network during scene constructionJennifer J Summerfield
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
Neuropsychologia 48:1501-9. 2010..This task offers a potentially useful tool for breaking down scene construction, a process that may be key to a range of cognitive functions such as episodic memory, future thinking and navigation... - Patient HC with developmental amnesia can construct future scenariosNiamh C Hurley
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK
Neuropsychologia 49:3620-8. 2011.... - Talent in the taxi: a model system for exploring expertiseKatherine Woollett
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
Philos Trans R Soc Lond B Biol Sci 364:1407-16. 2009.... - A navigational guidance system in the human brainHugo J Spiers
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
Hippocampus 17:618-26. 2007..In addition, these findings may also have wider implications for how the brain monitors and integrates different types of information in the service of goal-directed behavior in general... - Decoding human brain activity during real-world experiencesHugo J Spiers
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London, WC1N 3BG, UK
Trends Cogn Sci 11:356-65. 2007.... - Novelty signals: a window into hippocampal information processingDharshan Kumaran
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
Trends Cogn Sci 13:47-54. 2009..More generally, we suggest that a renewed emphasis on the information processing qualities of the human hippocampus offers the promise of a long awaited union between theoretical and empirical research across species... - London taxi drivers and bus drivers: a structural MRI and neuropsychological analysisEleanor A Maguire
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, United Kingdom
Hippocampus 16:1091-101. 2006.... - Multi-voxel pattern analysis in human hippocampal subfieldsHeidi M Bonnici
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London London, UK
Front Hum Neurosci 6:290. 2012..We suggest that MVPA in human hippocampal subfields may open up new opportunities to examine how different types of information are represented and processed at this fundamental level... - Decoding neuronal ensembles in the human hippocampusDemis Hassabis
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
Curr Biol 19:546-54. 2009..How activity across millions of hippocampal neurons supports these functions is a fundamental question in neuroscience, wherein the size, sparseness, and organization of the hippocampal neural code are debated... - A new role for the parahippocampal cortex in representing spaceSinéad L Mullally
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
J Neurosci 31:7441-9. 2011.... - Cortical midline involvement in autobiographical memoryJennifer J Summerfield
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK
Neuroimage 44:1188-200. 2009.... - Exploring the parahippocampal cortex response to high and low spatial frequency spacesPeter Zeidman
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK
Neuroreport 23:503-7. 2012..We suggest that coding for the presence of space may be a core function of PHC, and could explain its engagement in a range of tasks, including scene processing, where space is always present... - The dynamics of hippocampal activation during encoding of overlapping sequencesDharshan Kumaran
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, United Kingdom
Neuron 49:617-29. 2006.... - Spontaneous mentalizing during an interactive real world task: an fMRI studyHugo J Spiers
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
Neuropsychologia 44:1674-82. 2006.... - An unexpected sequence of events: mismatch detection in the human hippocampusDharshan Kumaran
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, United Kingdom
PLoS Biol 4:e424. 2006..The present study also offers broader insights into the nature of essential computations carried out by the hippocampus, which may also underpin its unique contribution to episodic memory... - Patients with hippocampal amnesia cannot imagine new experiencesDemis Hassabis
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, United Kingdom
Proc Natl Acad Sci U S A 104:1726-31. 2007..Given how closely imagined experiences match episodic memories, the absence of this function mediated by the hippocampus, may also fundamentally affect the ability to vividly re-experience the past... - The construction system of the brainDemis Hassabis
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK
Philos Trans R Soc Lond B Biol Sci 364:1263-71. 2009..Here, we selectively review this fast-growing literature and consider some implications for remembering the past and predicting the future... - Decoding overlapping memories in the medial temporal lobes using high-resolution fMRIMartin J Chadwick
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
Learn Mem 18:742-6. 2011..The hippocampus also contained representations of spatial contexts that were shared across different memories, consistent with a specialized role in processing space... - Which computational mechanisms operate in the hippocampus during novelty detection?Dharshan Kumaran
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, United Kingdom
Hippocampus 17:735-48. 2007.... - Thoughts, behaviour, and brain dynamics during navigation in the real worldHugo J Spiers
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
Neuroimage 31:1826-40. 2006.... - Exploring the role of space-defining objects in constructing and maintaining imagined scenesSinéad L Mullally
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
Brain Cogn 82:100-7. 2013..SD objects therefore enjoy a privileged role in scene construction and maintenance, and appear to be an essential building block of scenes... - The human hippocampus: cognitive maps or relational memory?Dharshan Kumaran
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
J Neurosci 25:7254-9. 2005..Our results both advance our understanding of the nature of the hippocampal contribution to memory and provide insights into how social networks are instantiated at the neural level...