Eleanor A Maguire

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Multi-voxel pattern analysis in human hippocampal subfields
    Heidi M Bonnici
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London London, UK
    Front Hum Neurosci 6:290. 2012
  2. pmc Patient HC with developmental amnesia can construct future scenarios
    Niamh C Hurley
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK
    Neuropsychologia 49:3620-8. 2011
  3. pmc Acquiring "the Knowledge" of London's layout drives structural brain changes
    Katherine Woollett
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, UK
    Curr Biol 21:2109-14. 2011
  4. ncbi request reprint The hippocampus: a manifesto for change
    Eleanor A Maguire
    Wellcome Trust Centre for Neuroimaging
    J Exp Psychol Gen 142:1180-9. 2013
  5. ncbi request reprint Memory consolidation in humans: new evidence and opportunities
    Eleanor A Maguire
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Exp Physiol 99:471-86. 2014
  6. pmc Studying the freely-behaving brain with fMRI
    Eleanor A Maguire
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Neuroimage 62:1170-6. 2012
  7. pmc Impaired spatial and non-spatial configural learning in patients with hippocampal pathology
    Dharshan Kumaran
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Neuropsychologia 45:2699-711. 2007
  8. pmc Navigational expertise may compromise anterograde associative memory
    Katherine Woollett
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, UK
    Neuropsychologia 47:1088-95. 2009
  9. pmc Tracking the emergence of conceptual knowledge during human decision making
    Dharshan Kumaran
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Neuron 63:889-901. 2009
  10. ncbi request reprint Navigation expertise and the human hippocampus: a structural brain imaging analysis
    Eleanor A Maguire
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, United Kingdom
    Hippocampus 13:250-9. 2003

Detail Information

Publications59

  1. pmc Multi-voxel pattern analysis in human hippocampal subfields
    Heidi M Bonnici
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London London, UK
    Front Hum Neurosci 6:290. 2012
    ..We suggest that MVPA in human hippocampal subfields may open up new opportunities to examine how different types of information are represented and processed at this fundamental level...
  2. pmc Patient HC with developmental amnesia can construct future scenarios
    Niamh C Hurley
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK
    Neuropsychologia 49:3620-8. 2011
    ....
  3. pmc Acquiring "the Knowledge" of London's layout drives structural brain changes
    Katherine Woollett
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, UK
    Curr Biol 21:2109-14. 2011
    ....
  4. ncbi request reprint The hippocampus: a manifesto for change
    Eleanor A Maguire
    Wellcome Trust Centre for Neuroimaging
    J Exp Psychol Gen 142:1180-9. 2013
    ..By characterizing the precise relationship between scenes and the hippocampus, we believe a theoretically enriched understanding of its fundamental role and its breakdown in pathology can emerge...
  5. ncbi request reprint Memory consolidation in humans: new evidence and opportunities
    Eleanor A Maguire
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Exp Physiol 99:471-86. 2014
    ..In particular, this prompts new questions about the roles of the hippocampus and ventromedial prefrontal cortex and offers new opportunities to interrogate the elusive memory trace that has for so long confounded neuroscientists. ..
  6. pmc Studying the freely-behaving brain with fMRI
    Eleanor A Maguire
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Neuroimage 62:1170-6. 2012
    ....
  7. pmc Impaired spatial and non-spatial configural learning in patients with hippocampal pathology
    Dharshan Kumaran
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Neuropsychologia 45:2699-711. 2007
    ....
  8. pmc Navigational expertise may compromise anterograde associative memory
    Katherine Woollett
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, UK
    Neuropsychologia 47:1088-95. 2009
    ....
  9. pmc Tracking the emergence of conceptual knowledge during human decision making
    Dharshan Kumaran
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Neuron 63:889-901. 2009
    ..Our study offers neurobiological insights into the remarkable capacity of humans to discover the conceptual structure of related experiences and use this knowledge to solve exacting decision problems...
  10. ncbi request reprint Navigation expertise and the human hippocampus: a structural brain imaging analysis
    Eleanor A Maguire
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, United Kingdom
    Hippocampus 13:250-9. 2003
    ....
  11. ncbi request reprint Navigation around London by a taxi driver with bilateral hippocampal lesions
    Eleanor A Maguire
    Wellcome Department of Imaging Neuroscience, Institute of Neurology University College London, London, UK
    Brain 129:2894-907. 2006
    ....
  12. pmc Autobiographical memory in semantic dementia: a longitudinal fMRI study
    Eleanor A Maguire
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Neuropsychologia 48:123-36. 2010
    ....
  13. pmc Detecting representations of recent and remote autobiographical memories in vmPFC and hippocampus
    Heidi M Bonnici
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, WC1N 3BG, United Kingdom
    J Neurosci 32:16982-91. 2012
    ..Overall, these findings clarify and extend our view of vmPFC and hippocampus while also informing systems-level consolidation and providing clear targets for future studies...
  14. pmc The effect of hippocampal damage in children on recalling the past and imagining new experiences
    Janine M Cooper
    Developmental Cognitive Neuroscience Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom
    Neuropsychologia 49:1843-50. 2011
    ..We speculate that the paediatric patients' relatively intact semantic memory and/or some functionality in their residual hippocampi may underpin their scene construction ability...
  15. pmc Decoding individual episodic memory traces in the human hippocampus
    Martin J Chadwick
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N3BG, UK
    Curr Biol 20:544-7. 2010
    ..Finally, our data provide further evidence for functional differentiation within the medial temporal lobe, in that we show the hippocampus contains significantly more episodic information than adjacent structures...
  16. pmc Decoding representations of scenes in the medial temporal lobes
    Heidi M Bonnici
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London, United Kingdom
    Hippocampus 22:1143-53. 2012
    ....
  17. pmc Neural substrates of driving behaviour
    Hugo J Spiers
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Neuroimage 36:245-55. 2007
    ..By systematically characterising the brain dynamics underlying naturalistic driving behaviour in a real city, our findings may have implications for how driving competence is considered in the context of neurological damage...
  18. pmc Patients with hippocampal amnesia cannot imagine new experiences
    Demis Hassabis
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, United Kingdom
    Proc Natl Acad Sci U S A 104:1726-31. 2007
    ..Given how closely imagined experiences match episodic memories, the absence of this function mediated by the hippocampus, may also fundamentally affect the ability to vividly re-experience the past...
  19. ncbi request reprint Deconstructing episodic memory with construction
    Demis Hassabis
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London, UK
    Trends Cogn Sci 11:299-306. 2007
    ..In light of this, we re-evaluate our understanding of episodic memory, the processes underpinning it and other related cognitive functions...
  20. pmc Imagining fictitious and future experiences: evidence from developmental amnesia
    Eleanor A Maguire
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK
    Neuropsychologia 48:3187-92. 2010
    ..We speculate that the hippocampal activation during fMRI noted previously in P01 and Jon might indicate some residual hippocampal function which is sufficient to support their preserved ability to imagine fictitious and future scenarios...
  21. ncbi request reprint London taxi drivers and bus drivers: a structural MRI and neuropsychological analysis
    Eleanor A Maguire
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, United Kingdom
    Hippocampus 16:1091-101. 2006
    ....
  22. ncbi request reprint The human hippocampus: cognitive maps or relational memory?
    Dharshan Kumaran
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 25:7254-9. 2005
    ..Our results both advance our understanding of the nature of the hippocampal contribution to memory and provide insights into how social networks are instantiated at the neural level...
  23. ncbi request reprint The brain network associated with acquiring semantic knowledge
    Eleanor A Maguire
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Neuroimage 22:171-8. 2004
    ..We suggest that current or prospective utility of incoming information may be one factor that influences the processes engaged during encoding and the concomitant neuronal responses...
  24. pmc Exploring anterograde associative memory in London taxi drivers
    Katherine Woollett
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK
    Neuroreport 23:885-8. 2012
    ..This resolves an outstanding question in the memory profile of London taxi drivers following hippocampal plasticity, and underlines the close relationship between space and the hippocampus...
  25. pmc Scene construction in amnesia: an FMRI study
    Sinéad L Mullally
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, WC1N 3BG, United Kingdom
    J Neurosci 32:5646-53. 2012
    ....
  26. pmc Retrosplenial cortex codes for permanent landmarks
    Stephen D Auger
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, United Kingdom
    PLoS ONE 7:e43620. 2012
    ..Our findings suggest that a primary function of the RSC may be to process the most stable features in an environment, and this could be a prerequisite for successful navigation...
  27. ncbi request reprint Routes to remembering: the brains behind superior memory
    Eleanor A Maguire
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Nat Neurosci 6:90-5. 2003
    ....
  28. pmc Decoding neuronal ensembles in the human hippocampus
    Demis Hassabis
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Curr Biol 19:546-54. 2009
    ..How activity across millions of hippocampal neurons supports these functions is a fundamental question in neuroscience, wherein the size, sparseness, and organization of the hippocampal neural code are debated...
  29. pmc A navigational guidance system in the human brain
    Hugo J Spiers
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    Hippocampus 17:618-26. 2007
    ..In addition, these findings may also have wider implications for how the brain monitors and integrates different types of information in the service of goal-directed behavior in general...
  30. ncbi request reprint The effect of adult-acquired hippocampal damage on memory retrieval: an fMRI study
    Eleanor A Maguire
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Neuroimage 27:146-52. 2005
    ..We speculate that it may relate to the age at which hippocampal damage occurred reflecting plasticity within the developing brain, or to cognitive differences between VC, the developmental amnesic patient, and the control subjects...
  31. pmc The hippocampus extrapolates beyond the view in scenes: an fMRI study of boundary extension
    Martin J Chadwick
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK
    Cortex 49:2067-79. 2013
    ..This suggests that the anticipation and construction of scenes is a pervasive and important aspect of our online perception, with the HC playing a central role. ..
  32. pmc Attenuated boundary extension produces a paradoxical memory advantage in amnesic patients
    Sinéad L Mullally
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, UK
    Curr Biol 22:261-8. 2012
    ..This cognitive phenomenon is revealed by a subsequent memory error when we confidently misremember the extended scene instead of the original. This effect is known as "boundary extension" and is apparent in adults, children, and babies...
  33. pmc Non-spatial expertise and hippocampal gray matter volume in humans
    Katherine Woollett
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London, United Kingdom
    Hippocampus 18:981-4. 2008
    ..Instead it would seem that hippocampal gray matter volume effects are more likely to be observed when the knowledge acquired concerns a complex and detailed large-scale spatial layout...
  34. pmc Using imagination to understand the neural basis of episodic memory
    Demis Hassabis
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 27:14365-74. 2007
    ..We suggest that additional brain regions are co-opted into this core network in a task-specific manner to support functions such as episodic memory that may have additional requirements...
  35. pmc Match mismatch processes underlie human hippocampal responses to associative novelty
    Dharshan Kumaran
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 27:8517-24. 2007
    ..More generally, the current study also offers insights into how the hippocampus automatically represents the spatiotemporal context of our experiences, a function that may relate to its role in episodic memory...
  36. ncbi request reprint Lateral asymmetry in the hippocampal response to the remoteness of autobiographical memories
    Eleanor A Maguire
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 23:5302-7. 2003
    ..The current results indicate that consideration of lateral asymmetry may help to broaden the scope of theoretical interpretations concerning hippocampal involvement in remote memory...
  37. pmc Decoding information in the human hippocampus: a user's guide
    Martin J Chadwick
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Neuropsychologia 50:3107-21. 2012
    ..Overall, we hope to highlight the potential utility of MVPA, when appropriately deployed, and provide some initial guidance to those considering MVPA as a means to investigate the hippocampus...
  38. pmc Differential engagement of brain regions within a 'core' network during scene construction
    Jennifer J Summerfield
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Neuropsychologia 48:1501-9. 2010
    ..This task offers a potentially useful tool for breaking down scene construction, a process that may be key to a range of cognitive functions such as episodic memory, future thinking and navigation...
  39. ncbi request reprint Decoding human brain activity during real-world experiences
    Hugo J Spiers
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London, WC1N 3BG, UK
    Trends Cogn Sci 11:356-65. 2007
    ....
  40. pmc Talent in the taxi: a model system for exploring expertise
    Katherine Woollett
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Philos Trans R Soc Lond B Biol Sci 364:1407-16. 2009
    ....
  41. pmc A new role for the parahippocampal cortex in representing space
    Sinéad L Mullally
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 31:7441-9. 2011
    ....
  42. ncbi request reprint The dynamics of hippocampal activation during encoding of overlapping sequences
    Dharshan Kumaran
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, United Kingdom
    Neuron 49:617-29. 2006
    ....
  43. ncbi request reprint Thoughts, behaviour, and brain dynamics during navigation in the real world
    Hugo J Spiers
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Neuroimage 31:1826-40. 2006
    ....
  44. pmc An unexpected sequence of events: mismatch detection in the human hippocampus
    Dharshan Kumaran
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, United Kingdom
    PLoS Biol 4:e424. 2006
    ..The present study also offers broader insights into the nature of essential computations carried out by the hippocampus, which may also underpin its unique contribution to episodic memory...
  45. ncbi request reprint Which computational mechanisms operate in the hippocampus during novelty detection?
    Dharshan Kumaran
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, United Kingdom
    Hippocampus 17:735-48. 2007
    ....
  46. pmc Exploring the role of space-defining objects in constructing and maintaining imagined scenes
    Sinéad L Mullally
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Brain Cogn 82:100-7. 2013
    ..SD objects therefore enjoy a privileged role in scene construction and maintenance, and appear to be an essential building block of scenes...
  47. pmc Exploring the parahippocampal cortex response to high and low spatial frequency spaces
    Peter Zeidman
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK
    Neuroreport 23:503-7. 2012
    ..We suggest that coding for the presence of space may be a core function of PHC, and could explain its engagement in a range of tasks, including scene processing, where space is always present...
  48. doi request reprint Novelty signals: a window into hippocampal information processing
    Dharshan Kumaran
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Trends Cogn Sci 13:47-54. 2009
    ..More generally, we suggest that a renewed emphasis on the information processing qualities of the human hippocampus offers the promise of a long awaited union between theoretical and empirical research across species...
  49. pmc Cortical midline involvement in autobiographical memory
    Jennifer J Summerfield
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK
    Neuroimage 44:1188-200. 2009
    ....
  50. pmc Assessing hippocampal functional reserve in temporal lobe epilepsy: a multi-voxel pattern analysis of fMRI data
    Heidi M Bonnici
    Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, 12 Queen Square, London WC1N 3BG, United Kingdom
    Epilepsy Res 105:140-9. 2013
    ..These findings suggest that MVPA in fMRI memory studies of TLE can indicate hippocampal functional reserve and may be useful to predict the effects of hippocampal resection in individual patients...
  51. pmc The construction system of the brain
    Demis Hassabis
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK
    Philos Trans R Soc Lond B Biol Sci 364:1263-71. 2009
    ..Here, we selectively review this fast-growing literature and consider some implications for remembering the past and predicting the future...
  52. pmc Decoding overlapping memories in the medial temporal lobes using high-resolution fMRI
    Martin J Chadwick
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    Learn Mem 18:742-6. 2011
    ..The hippocampus also contained representations of spatial contexts that were shared across different memories, consistent with a specialized role in processing space...
  53. ncbi request reprint Spontaneous mentalizing during an interactive real world task: an fMRI study
    Hugo J Spiers
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Neuropsychologia 44:1674-82. 2006
    ....
  54. ncbi request reprint Aging affects the engagement of the hippocampus during autobiographical memory retrieval
    Eleanor A Maguire
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, UCL, 12 Queen Square, London WC1N 3BG, UK
    Brain 126:1511-23. 2003
    ..Understanding this relationship may aid prognosis, as well as providing insights into plasticity in the anatomy of memory...
  55. ncbi request reprint The well-worn route and the path less traveled: distinct neural bases of route following and wayfinding in humans
    Tom Hartley
    Institute of Cognitive Neuroscience and Department of Anatomy and Developmental Biology, University College London, University College London, London, United Kingdom
    Neuron 37:877-88. 2003
    ..We argue that the type of representation used influences both performance and concomitant fMRI activation patterns...
  56. ncbi request reprint Scene construction in developmental amnesia: an fMRI study
    Sinéad L Mullally
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London, WC1N 3BG, UK
    Neuropsychologia 52:1-10. 2014
    ..Our results show that a type of non-hippocampal dependent scene construction is possible and occurs in DA, perhaps mediated by semantic memory, which does not appear to involve the vivid visualisation of imagined scenes. ..
  57. ncbi request reprint Representations of recent and remote autobiographical memories in hippocampal subfields
    Heidi M Bonnici
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, United Kingdom
    Hippocampus 23:849-54. 2013
    ..Thus, the hippocampal subfields are differentially involved in the representation of recent and remote autobiographical memories during vivid recall...
  58. pmc Assessing the mechanism of response in the retrosplenial cortex of good and poor navigators
    Stephen D Auger
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK
    Cortex 49:2904-13. 2013
    ..This mechanism may represent a key building block for spatial and scene representations that are central to episodic memories and imagining the future, and could also be a prerequisite for successful navigation. ..
  59. ncbi request reprint The human hippocampus and spatial and episodic memory
    Neil Burgess
    Institute of Cognitive Neuroscience and Department of Anatomy and Developmental Biology, University College London, 17 Queen Square, London, United Kingdom
    Neuron 35:625-41. 2002
    ....