W MacNee

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi Pulmonary and systemic oxidant/antioxidant imbalance in chronic obstructive pulmonary disease
    William MacNee
    ELEGI, Colt Research Laboratories, Wilkie Building, Medical School, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    Proc Am Thorac Soc 2:50-60. 2005
  2. ncbi Hemodynamic effects of ibopamine on the pulmonary circulation and right ventricular performance in patients with chronic obstructive pulmonary disease
    K Skwarski
    Department of Medicine, City Hospital, Edinburgh, UK
    Cardiology 80:349-55. 1992
  3. ncbi Inhibition of neutrophil adherence and movement by acute cigarette smoke exposure
    C Selby
    Department of Medicine, City Hospital, Edinburgh, Scotland, UK
    Exp Lung Res 18:813-27. 1992
  4. ncbi Potential role of IL-8, platelet-activating factor and TNF-alpha in the sequestration of neutrophils in the lung: effects on neutrophil deformability, adhesion receptor expression, and chemotaxis
    Ellen M Drost
    Edinburgh Lung and Environmental Group Initiative ELEGI Colt Laboratories, Department of Medical and Radiological Sciences, Wilkie Building, The Medical School, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    Eur J Immunol 32:393-403. 2002
  5. ncbi Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1
    Hazel Jardine
    Edinburgh Lung and the Environment Group Initiative Colt Research Laboratories, Medical Research Council Centre for Inflammation Research, University of Edinburgh Medical School, Edinburgh EH8 9AG, United Kingdom
    J Biol Chem 277:21158-66. 2002
  6. doi Systemic inflammatory biomarkers and co-morbidities of chronic obstructive pulmonary disease
    William MacNee
    ELEGI, Colt Research Laboratories, MRC UoE Centre for Inflammation Research, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH 16 4TJ, UK
    Ann Med 45:291-300. 2013
  7. doi Diagnosis of myocardial infarction following hospitalisation for exacerbation of COPD
    David A McAllister
    ELEGI Colt Laboratories, Queens Medial Research Institute, University of Edinburgh, Edinburgh, UK
    Eur Respir J 39:1097-103. 2012
  8. pmc Characterisation of COPD heterogeneity in the ECLIPSE cohort
    Alvar Agusti
    Thorax Institute, Hospital Clinic, IDIBAPS, Universitat de Barcelona, Spain
    Respir Res 11:122. 2010
  9. pmc Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes
    Wan Seob Cho
    ELEGI Group, Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
    Part Fibre Toxicol 8:27. 2011
  10. pmc Cigarette smoke regulates VEGFR2-mediated survival signaling in rat lungs
    John A Marwick
    National Heart and Lung Institute, Imperial College London, UK
    J Inflamm (Lond) 7:11. 2010

Research Grants

Collaborators

Detail Information

Publications101 found, 100 shown here

  1. ncbi Pulmonary and systemic oxidant/antioxidant imbalance in chronic obstructive pulmonary disease
    William MacNee
    ELEGI, Colt Research Laboratories, Wilkie Building, Medical School, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    Proc Am Thorac Soc 2:50-60. 2005
    ..Moreover, it is appreciated that oxidative stress extends beyond the lung and may, through similar oxidative stress mechanisms as those in the lung, contribute to several of the systemic manifestations in COPD...
  2. ncbi Hemodynamic effects of ibopamine on the pulmonary circulation and right ventricular performance in patients with chronic obstructive pulmonary disease
    K Skwarski
    Department of Medicine, City Hospital, Edinburgh, UK
    Cardiology 80:349-55. 1992
    ....
  3. ncbi Inhibition of neutrophil adherence and movement by acute cigarette smoke exposure
    C Selby
    Department of Medicine, City Hospital, Edinburgh, Scotland, UK
    Exp Lung Res 18:813-27. 1992
    ..These data suggest that acute cigarette smoke may impair the crucial neutrophil functions of adherence and movement. However, the chronic effects of cigarette smoke exposure may clearly differ...
  4. ncbi Potential role of IL-8, platelet-activating factor and TNF-alpha in the sequestration of neutrophils in the lung: effects on neutrophil deformability, adhesion receptor expression, and chemotaxis
    Ellen M Drost
    Edinburgh Lung and Environmental Group Initiative ELEGI Colt Laboratories, Department of Medical and Radiological Sciences, Wilkie Building, The Medical School, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    Eur J Immunol 32:393-403. 2002
    ....
  5. ncbi Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1
    Hazel Jardine
    Edinburgh Lung and the Environment Group Initiative Colt Research Laboratories, Medical Research Council Centre for Inflammation Research, University of Edinburgh Medical School, Edinburgh EH8 9AG, United Kingdom
    J Biol Chem 277:21158-66. 2002
    ..The findings of this study provide important information, which may be used for the modulation of glutathione biosynthesis in inflammation...
  6. doi Systemic inflammatory biomarkers and co-morbidities of chronic obstructive pulmonary disease
    William MacNee
    ELEGI, Colt Research Laboratories, MRC UoE Centre for Inflammation Research, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH 16 4TJ, UK
    Ann Med 45:291-300. 2013
    ..Such biomarkers may be used to assess and manage the systemic effects of COPD, and may guide future development of novel therapeutic interventions to provide a more holistic approach to treating this multi-faceted disease...
  7. doi Diagnosis of myocardial infarction following hospitalisation for exacerbation of COPD
    David A McAllister
    ELEGI Colt Laboratories, Queens Medial Research Institute, University of Edinburgh, Edinburgh, UK
    Eur Respir J 39:1097-103. 2012
    ..Overall, one in 12 patients met the criteria for myocardial infarction. Whether these patients would benefit from further cardiac investigation is unknown...
  8. pmc Characterisation of COPD heterogeneity in the ECLIPSE cohort
    Alvar Agusti
    Thorax Institute, Hospital Clinic, IDIBAPS, Universitat de Barcelona, Spain
    Respir Res 11:122. 2010
    ..Chronic obstructive pulmonary disease (COPD) is a complex condition with pulmonary and extra-pulmonary manifestations. This study describes the heterogeneity of COPD in a large and well characterised and controlled COPD cohort (ECLIPSE)...
  9. pmc Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes
    Wan Seob Cho
    ELEGI Group, Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
    Part Fibre Toxicol 8:27. 2011
    ..Herein, we further investigated the pathological changes induced by ZnONP and their possible mechanism of action...
  10. pmc Cigarette smoke regulates VEGFR2-mediated survival signaling in rat lungs
    John A Marwick
    National Heart and Lung Institute, Imperial College London, UK
    J Inflamm (Lond) 7:11. 2010
    ..However, the VEGFR2-mediated survival signaling in response to oxidants/cigarette smoke (CS) is not known. We hypothesized that CS exposure leads to disruption of VEGFR2-mediated endothelial survival signaling in rat lungs...
  11. doi New paradigms in the pathogenesis of chronic obstructive pulmonary disease I
    William MacNee
    University of Edinburgh, MRC Centre for Inflammation Research, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, UK
    Proc Am Thorac Soc 6:527-31. 2009
    ..These insights provide new beginnings for future investigations in the pathobiology of COPD which may lead to future therapies for this condition...
  12. pmc Chronic obstructive pulmonary disease . 7: Management of COPD
    W MacNee
    University of Edinburgh, Lothian University NHS Trust, Edinburgh, Scotland, UK
    Thorax 58:261-5. 2003
    ..A major problem is the effective implementation of what is already known, and allocation of the resources necessary to make this available to all who might benefit...
  13. ncbi Is oxidative stress central to the pathogenesis of chronic obstructive pulmonary disease?
    W MacNee
    Respiratory Medicine, ELEGI, Colt Research Laboratories, Wilkie Building, Medical School, Teviot Place, EH8 9AG, Edinburgh, UK
    Trends Mol Med 7:55-62. 2001
    ..Antioxidants should therefore not only protect against the direct injurious effects of oxidants, but also may fundamentally alter the inflammatory events which have a central role in the pathogenesis of COPD...
  14. ncbi Right heart function in COPD
    William MacNee
    Department of Respiratory and Environmental Medicine, University of Edinburgh, ELEGI Colt Laboratories, MRC Centre for Inflammation Research, The Queen s Medical Research Institute, Edinburgh, Scotland, United Kingdom
    Semin Respir Crit Care Med 31:295-312. 2010
    ..Further studies are required of more specific pulmonary vasodilators or therapies to improve right ventricular function in these patients...
  15. pmc Cardiovascular injury and repair in chronic obstructive pulmonary disease
    William MacNee
    ELEGI Colt Research Labs, The Queen s Medical Research Institute, The University of Edinburgh, Edinburgh, EH16 4TJ, Scotland, UK
    Proc Am Thorac Soc 5:824-33. 2008
    ..We also discuss alternative hypotheses that the endothelium and connective tissues in the arteries and lungs of patients with COPD and cardiovascular disease have a shared susceptibility to these factors...
  16. ncbi Mechanism of lung injury caused by PM10 and ultrafine particles with special reference to COPD
    W MacNee
    Edinburgh Lung and the Environment Group Initiative Colt Research Laboratories, Dept of Clinical and Radiological Sciences, University of Edinburgh, Medical School, UK
    Eur Respir J Suppl 40:47s-51s. 2003
    ..Understanding the mechanisms of the harmful effects of particulate air pollution in chronic obstructive pulmonary disease may help in risk strategy for individuals who are susceptible to the effects of air pollution...
  17. ncbi Oxidative stress and lung inflammation in airways disease
    W MacNee
    Respiratory Medicine, ELEGI, Colt Research Laboratories, Wilkie Building, Edinburgh, Scotland, UK
    Eur J Pharmacol 429:195-207. 2001
    ..Such drugs are being developed and should in the future allow the hypothesis that oxidative stress is a fundamental factor in the inflammation, which occurs in these airways diseases to be tested...
  18. doi Update in chronic obstructive pulmonary disease 2007
    William MacNee
    ELEGI Colt Research Labs, University of Edinburgh MRC Centre for Inflammation Research, The Queen s Medical Research Institute, Edinburgh, United Kingdom
    Am J Respir Crit Care Med 177:820-9. 2008
  19. ncbi Exacerbations of COPD: environmental mechanisms
    W MacNee
    ELEGI Colt Research Laboratories, University of Edinburgh Medical School, Edinburgh, Scotland
    Chest 117:390S-7S. 2000
    ..Elucidation of the mechanism of the harmful effects of these pollutants should allow improved risk assessment for patients with airways diseases who are be susceptible to the effects of these air pollutants...
  20. pmc Pathogenesis of chronic obstructive pulmonary disease
    William MacNee
    Respiratory Medicine, ELEGI Colt Research Laboratories, Wilkie Building, Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Proc Am Thorac Soc 2:258-66; discussion 290-1. 2005
    ..In addition, it has been proposed that the development of emphysema may involve alveolar cell loss through apoptosis. This mechanism may involve the vascular endothelial growth factor pathway and oxidative stress...
  21. doi Evaluation of exhaled breath condensate pH as a biomarker for COPD
    William MacNee
    ELEGI Colt Research Labs, MRC Centre for Inflammation Research, The Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK
    Respir Med 105:1037-45. 2011
    ..We also determined short term reproducibility and the response of EBC to oral prednisolone...
  22. ncbi Pathogenesis of chronic obstructive pulmonary disease
    William MacNee
    ELEGI Colt Research Laboratories, MRC Centre for Inflammation Research, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Avenue, Edinburgh EH16 4TJ, Scotland, UK
    Clin Chest Med 28:479-513, v. 2007
    ..This article provides an update on the cellular and molecular mechanisms of these processes in the pathogenesis of COPD...
  23. ncbi Oxidants and COPD
    William MacNee
    ELEGI, Colt Research Laboratories, MRC Centre for Inflammation Research, University of Edinburgh, Medical School, Edinburgh, Scotland, UK
    Curr Drug Targets Inflamm Allergy 4:627-41. 2005
    ..Thus, there is a great need for an effective antioxidant therapy to modulate the oxidative stress in COPD, since this may be an important therapeutic target...
  24. ncbi Oxidants and antioxidants as therapeutic targets in chronic obstructive pulmonary disease
    W MacNee
    Respiratory Medicine, ELEGI and Colt Research Laboratories, University of Edinburgh, Edinburgh, Scotland
    Am J Respir Crit Care Med 160:S58-65. 1999
    ..MacNee W, Rahman I. Oxidants and antioxidants as therapeutic targets in chronic obstructive pulmonary disease...
  25. ncbi Oxidants/antioxidants and COPD
    W MacNee
    Edinburgh Lung Environmental Group Initiative, Colt Research Laboratories, University of Edinburgh, Edinburgh, Scotland, UK
    Chest 117:303S-17S. 2000
    ....
  26. ncbi Activation of NF-kappaB by PM(10) occurs via an iron-mediated mechanism in the absence of IkappaB degradation
    L A Jimenez
    Edinburgh Lung and The Environment Group Initiative ELEGI Colt Research Laboratories, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    Toxicol Appl Pharmacol 166:101-10. 2000
    ..Coincubation of polymixin B, an endotoxin-binding compound, and PM(10) did not inhibit NF-kappaB. In summary, PM(10) activates NF-kappaB in A549 cells by an iron-mediated mechanism in the absence of IkappaB degradation...
  27. ncbi Nanoparticle carbon black driven DNA damage induces growth arrest and AP-1 and NFkappaB DNA binding in lung epithelial A549 cell line
    R M Mroz
    ELEGI Colt Laboratories, MRC University of Edinburgh Center for Inflammation Research, Edinburgh, UK
    J Physiol Pharmacol 58:461-70. 2007
    ..N-acetylcysteine blocked NP driven effects. In conclusion, NPCB and BaP-NPCB induce DNA damage, activating p53, proteins related to DNA repair and proinflammatory transcription factors...
  28. ncbi Regulation of redox glutathione levels and gene transcription in lung inflammation: therapeutic approaches
    I Rahman
    ELEGI and Colt Research Laboratories, Department of Respiratory Medicine, University of Edinburgh Medical School, Edinburgh, Scotland, UK
    Free Radic Biol Med 28:1405-20. 2000
    ..The potential role of thiol antioxidants as a therapeutic approach in inflammatory lung diseases is also discussed...
  29. ncbi Adenoviral E1A primes alveolar epithelial cells to PM(10)-induced transcription of interleukin-8
    P S Gilmour
    Respiratory Section, Edinburgh Lung and The Environment Group Initiative/Colt Laboratories, Department of Medical and Radiological Sciences, The University of Edinburgh Medical School, Edinburgh EH8 9AG, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 281:L598-606. 2001
    ..By this mechanism, susceptibility to exacerbation of COPD in response to particulate air pollution may occur in individuals harboring E1A...
  30. pmc Free radical activity of industrial fibers: role of iron in oxidative stress and activation of transcription factors
    P S Gilmour
    Department of Biological Sciences, Napier University, Edinburgh, United Kingdom
    Environ Health Perspect 105:1313-7. 1997
    ..Although this was not related to iron release or ability to deplete macrophage GSH at 4 hr, GSH does play a role in activation of NF kappa B...
  31. ncbi Molecular mechanism of the regulation of glutathione synthesis by tumor necrosis factor-alpha and dexamethasone in human alveolar epithelial cells
    I Rahman
    Rayne Laboratory, Respiratory Medicine Unit, Department of Medicine RIE, University of Edinburgh, Medical School, Edinburgh EH8 9AG, United Kingdom
    J Biol Chem 274:5088-96. 1999
    ..These data have implications for the oxidant/antioxidant balance in inflammatory lung diseases...
  32. ncbi Oxidants/antioxidants and chronic obstructive pulmonary disease: pathogenesis to therapy
    W MacNee
    ELEGI/Colt Laboratories, Department of Medical and Radiological Sciences, Wilkie Building, University of Edinburgh, Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Novartis Found Symp 234:169-85; discussion 185-8. 2001
    ....
  33. ncbi Lipopolysaccharide-induced alveolar epithelial permeability: the role of nitric oxide
    X Y Li
    Department of Medicine, University of Edinburgh, Royal Infirmary of Edinburgh, Scotland, United Kingdom
    Am J Respir Crit Care Med 157:1027-33. 1998
    ..These data suggest that NO is involved in LPS-induced changes in epithelial integrity. However, other mechanisms should be evoked in addition to NO to explain completely the increased epithelial permeability produced by LPS...
  34. doi Vascular dysfunction in chronic obstructive pulmonary disease
    John D Maclay
    Centre for Inflammation Research, Edinburgh University, Edinburgh, United Kingdom
    Am J Respir Crit Care Med 180:513-20. 2009
    ..It is unclear whether such associations relate to the presence of COPD or prior smoking habit...
  35. ncbi Histone acetylation regulates epithelial IL-8 release mediated by oxidative stress from environmental particles
    Peter S Gilmour
    Edinburgh Lung and the Environment Group Initiative Colt Laboratory, The University of Edinburgh, Department of Medicine and Radiological Sciences, Medical School, Edinburgh EH8 9AG, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 284:L533-40. 2003
    ..Acetylation of H4 mediated by PM(10) was associated with the promoter region of the IL-8 gene. These data suggest that remodeling of chromatin by histone acetylation plays a role in PM(10)-mediated responses in the lungs...
  36. ncbi Localization of gamma-glutamylcysteine synthetase messenger rna expression in lungs of smokers and patients with chronic obstructive pulmonary disease
    I Rahman
    Respiratory Medicine Unit, ELEGI Laboratories, University of Edinburgh, Medical School, Edinburgh, Scotland, UK
    Free Radic Biol Med 28:920-5. 2000
    ..This suggests a specific role for enhanced GSH synthesis as a mechanism to provide an adaptive response against oxidative stress in patients with COPD...
  37. ncbi Aluminium lactate treatment of DQ12 quartz inhibits its ability to cause inflammation, chemokine expression, and nuclear factor-kappaB activation
    R Duffin
    ELEGI/Colt Laboratories, Department of Respiratory Medicine, University of Edinburgh, Edinburgh, United Kingdom
    Toxicol Appl Pharmacol 176:10-7. 2001
    ....
  38. ncbi PM(10)-exposed macrophages stimulate a proinflammatory response in lung epithelial cells via TNF-alpha
    L A Jimenez
    Edinburgh Lung and the Environment Group Initiative Colt Laboratories, Department of Medical and Radiological Sciences, University of Edinburgh, Edinburgh EH8 9AG, Scotland, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 282:L237-48. 2002
    ..These data suggest that PM(10)-activated macrophages may amplify the inflammatory response by enhancing IL-8 release from lung epithelial cells, in part, via elaboration of TNF-alpha...
  39. ncbi Cardiovascular risk in chronic obstructive pulmonary disease
    John D Maclay
    Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
    Respirology 12:634-41. 2007
    ..Finally, we review those studies that have investigated therapeutic interventions in COPD that may modify cardiovascular risk...
  40. ncbi Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs
    John A Marwick
    MRC Centre for Inflammation Research, Department of Environmental Medicine, University of Edinburgh, UK
    Am J Respir Cell Mol Biol 31:633-42. 2004
    ..These findings suggest a possible molecular mechanism by which cigarette smoke drives proinflammatory gene transcription and an inflammatory response in the lungs...
  41. ncbi Regulation of lipopolysaccharide-mediated interleukin-1beta release by N-acetylcysteine in THP-1 cells
    M Parmentier
    Dept of Medicine, University of Edinburgh Medical School, UK
    Eur Respir J 16:933-9. 2000
    ..These data indicate that N-acetyl-L-cysteine modulates interleukin-1kappa release by increasing levels of the homo- and heterodimeric forms of nuclear factor-kappaB...
  42. pmc Oxidative stress and airway inflammation in severe exacerbations of COPD
    E M Drost
    ELEGI Laboratory, MRC Centre for Inflammation Research, University of Edinburgh, Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Thorax 60:293-300. 2005
    ..Two sites within the lungs were compared: the large airways (in sputum) and the peripheral airways (by bronchoalveolar lavage (BAL))...
  43. pmc The procoagulant potential of environmental particles (PM10)
    P S Gilmour
    Edinburgh Lung and the Environment Group Initiative ELEGI Colt Laboratory, The University of Edinburgh, Department of Medicine and Radiological Sciences, Medical School, Wilkie Building, Teviot Place, Edinburgh, UK
    Occup Environ Med 62:164-71. 2005
    ..It was hypothesised that PM10 exposure would result in an inflammatory response and enhance the activation of the extrinsic coagulation mechanisms in pulmonary and vascular cells in culture...
  44. ncbi Oxidant-mediated lung epithelial cell tolerance: the role of intracellular glutathione and nuclear factor-kappaB
    I Rahman
    Respiratory Medicine Unit, ELEGI and Colt Research Laboratory, Wilkie Building, Medical School, University of Edinburgh, Teviot Place, EH8 9AG, Edinburgh, UK
    Biochem Pharmacol 62:787-94. 2001
    ..Thus, increasing intracellular glutathione may be of therapeutic relevance if able to modulate NF-kappaB activation and hence attenuate inflammation...
  45. pmc Free radical activity of PM10: iron-mediated generation of hydroxyl radicals
    K Donaldson
    Department of Biological Sciences, Napier University, Edinburgh, United Kingdom
    Environ Health Perspect 105:1285-9. 1997
    ..We conclude, therefore, that the free radical activity is derived either from a fraction that is not centrifugeable on a bench centrifuge, or that the radical generating system is released into solution...
  46. ncbi Lung glutathione and oxidative stress: implications in cigarette smoke-induced airway disease
    I Rahman
    Department of Respiratory Medicine, Medical School, University of Edinburgh, Edinburgh EH8 9AG, United Kingdom
    Am J Physiol 277:L1067-88. 1999
    ..This review outlines 1) the regulation of cellular GSH levels and gamma-GCS expression under oxidative stress and 2) the evidence for lung oxidant stress and the potential role of GSH in the pathogenesis of COPD...
  47. ncbi Soluble transition metals in welding fumes cause inflammation via activation of NF-kappaB and AP-1
    J D McNeilly
    ELEGI Colt Laboratories, Centre for Inflammation Research, Wilkie Building, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
    Toxicol Lett 158:152-7. 2005
    ....
  48. pmc Ambient particle inhalation and the cardiovascular system: potential mechanisms
    K Donaldson
    Biomedicine Research Group, School of Life Sciences, Napier University, Edinburgh, Scotland
    Environ Health Perspect 109:523-7. 2001
    ..In this present review, we consider the likely interactions between the ultrafine particles the acute phase response and cardiovascular disease...
  49. pmc Asthma and PM10
    K Donaldson
    Biomedicine Research Group, School of Life Sciences, Napier University, Edinburgh, UK
    Respir Res 1:12-5. 2000
    ....
  50. ncbi The effect of smoking on the transcriptional regulation of lung inflammation in patients with chronic obstructive pulmonary disease
    Patryk Szulakowski
    ELEGI Colt Laboratories, MRC Centre for Inflammation Research, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, United Kingdom
    Am J Respir Crit Care Med 174:41-50. 2006
    ..Chronic obstructive pulmonary disease (COPD) is believed to result from an abnormal inflammatory response in the lungs to noxious particles and gases usually found in cigarette smoke...
  51. doi NiO and Co3O4 nanoparticles induce lung DTH-like responses and alveolar lipoproteinosis
    W S Cho
    ELEGI Colt Laboratory, Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
    Eur Respir J 39:546-57. 2012
    ..These findings have implications for the risk management of occupational NP exposure and provide evidence that haptenic metal oxide NPs can induce chronic progressive lung immune responses via a DTH-like mechanism...
  52. ncbi Extent of pulmonary emphysema in man and its relation to the loss of elastic recoil
    M Gugger
    Rayne Laboratory, Department of Medicine RIE, University of Edinburgh, Scotland, U K
    Clin Sci (Lond) 80:353-8. 1991
    ....
  53. ncbi Computed tomographic emphysema distribution: relationship to clinical features in a cohort of smokers
    G Mair
    Medical Research Council Centre for Inflammation Research, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, UK
    Eur Respir J 33:536-42. 2009
    ..Increased age and female sex were related to disease distribution independent of emphysema severity. These findings may be related to differences in development of emphysema...
  54. ncbi Permeability, inflammation and oxidant status in airspace epithelium exposed to ozone
    Douglas Morrison
    Respiratory Medicine Unit, Department of Medicine, University of Edinburgh, Medical School, Teviot Place, Edinburgh EH3 9YW, Scotland, UK
    Respir Med 100:2227-34. 2006
    ..Ozone exposure did not increase epithelial permeability, but was associated with neutrophil influx into the airspaces, without evidence of increased oxidative stress...
  55. pmc The pro-inflammatory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: the role of surface area
    Claire Monteiller
    Institute of Occupational Medicine, Research Park North, Edinburgh, UK
    Occup Environ Med 64:609-15. 2007
    ....
  56. ncbi Nacystelyn inhibits oxidant-mediated interleukin-8 expression and NF-kappaB nuclear binding in alveolar epithelial cells
    Frank Antonicelli
    Department of Medical and Radiological Sciences, Respiratory Medicine Unit, ELEGI Colt Research Laboratories, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    Free Radic Biol Med 32:492-502. 2002
    ..These data indicate that NAL may be used to modulate pro-inflammatory process by inhibiting cytokine release in the lungs and thus has therapeutic potential in inflammatory lung diseases...
  57. ncbi Nanoparticle-driven DNA damage mimics irradiation-related carcinogenesis pathways
    R M Mroz
    ELEGI Colt Laboratories, University of Edinburgh, Edinburgh, Scotland, UK
    Eur Respir J 31:241-51. 2008
    ..In conclusion, nanoparticles and reactive oxidative species induce DNA damage, activating p53 and proteins related to DNA repair, mimicking irradiation-related carcinogenesis pathways...
  58. ncbi Role of inflammation in cardiopulmonary health effects of PM
    Ken Donaldson
    ELEGI Colt Laboratory, University of Edinburgh, Medical School, Teviot Place, Edinburgh EH9 8AG, Scotland, UK
    Toxicol Appl Pharmacol 207:483-8. 2005
    ..Thirdly, inflammation could affect the autonomic nervous system activity in ways that could lead to alterations in the control of heart rhythm which could culminate in fatal dysrhythmia...
  59. pmc Arterial stiffness is independently associated with emphysema severity in patients with chronic obstructive pulmonary disease
    David A McAllister
    ELEGI Colt Laboratories, MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, EH164SB UK
    Am J Respir Crit Care Med 176:1208-14. 2007
    ....
  60. ncbi Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM10)
    Ken Donaldson
    Colt ELEGI Laboratories, Centre for Inflammation Research, The University of Edinburgh Medical School, Edinburgh EH8 9AG, Scotland, UK
    Free Radic Biol Med 34:1369-82. 2003
    ..Oxidative stress from particles is also likely to play an important role in the carcinogenic effects associated with PM(10) and hydroxyl radicals from PM(10) cause DNA damage in vitro...
  61. doi Accelerated lung aging: a novel pathogenic mechanism of chronic obstructive pulmonary disease (COPD)
    William MacNee
    MRC Centre for Inflammation Research, The Queen s Medical Research Institute Level 2, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Biochem Soc Trans 37:819-23. 2009
    ..The processes involved in accelerated aging may provide novel targets for therapy in COPD. The present article reviews the evidence for accelerated aging as a mechanism in the pathogenesis of COPD...
  62. doi Adverse cardiovascular effects of air pollution
    Nicholas L Mills
    Centre for Cardiovascular Science, University of Edinburgh, UK
    Nat Clin Pract Cardiovasc Med 6:36-44. 2009
    ..An increased understanding of the mediators and mechanisms of these processes is necessary if we are to develop strategies to protect individuals at risk and reduce the effect of air pollution on cardiovascular disease...
  63. ncbi Regulation of LPS-mediated inflammation in vivo and in vitro by the thiol antioxidant Nacystelyn
    Frank Antonicelli
    Edinburgh Lung and Environment Group Initiative Colt Research Laboratories, Department of Medical and Radiological Sciences, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Am J Physiol Lung Cell Mol Physiol 286:L1319-27. 2004
    ....
  64. ncbi Soluble transition metals cause the pro-inflammatory effects of welding fumes in vitro
    Jane D McNeilly
    Respiratory Medicine Unit, ELEGI Colt Laboratories, University of Edinburgh, Edinburgh EH8 9AG, UK
    Toxicol Appl Pharmacol 196:95-107. 2004
    ..These results support the hypothesis that the enhanced pro-inflammatory responses of welding fume particulates are mediated by soluble transition metal components via an oxidative stress mechanism...
  65. pmc Exposure to concentrated ambient particles does not affect vascular function in patients with coronary heart disease
    Nicholas L Mills
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
    Environ Health Perspect 116:709-15. 2008
    ..Exposure to fine particulate air pollution is associated with increased cardiovascular morbidity and mortality. We previously demonstrated that exposure to dilute diesel exhaust causes vascular dysfunction in humans...
  66. ncbi Cigarette smoke-induced oxidative stress and TGF-beta1 increase p21waf1/cip1 expression in alveolar epithelial cells
    John A Marwick
    Respiratory Medicine Unit, ELEGI and Colt Laboratory, University of Edinburgh, Medical School, Edinburgh, UK
    Ann N Y Acad Sci 973:278-83. 2002
    ..This may be important in the growth arrest and cell survival of alveolar type II cells in the G(1) phase...
  67. ncbi 4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease
    Irfan Rahman
    Respiratory Medicine Unit, ELEGI Laboratory, University of Edinburgh Medical School, Wilkie Building, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    Am J Respir Crit Care Med 166:490-5. 2002
    ..01). The elevated levels of 4-HNE may play a role in the signaling events in lung inflammation leading to the imbalance of the expression of both proinflammatory mediators and protective antioxidant genes in COPD...
  68. ncbi The pulmonary toxicology of ultrafine particles
    Ken Donaldson
    The Biomedicine Research Group, School of Life Sciences, Napier University, 10 Colinton Road, Edinburgh EH10 5DT, Scotland, United Kingdom
    J Aerosol Med 15:213-20. 2002
    ..Ultrafine particles can also impair the ability of macrophages to phagocytose and clear other particles, and this may be pro-inflammogenic...
  69. ncbi Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis
    Nicholas L Mills
    Centre for Cardiovascular Science, Edinburgh University, Edinburgh, Scotland
    Circulation 112:3930-6. 2005
    ..The study aim was to investigate the effects of diesel exhaust inhalation on vascular and endothelial function in humans...
  70. ncbi Do inhaled carbon nanoparticles translocate directly into the circulation in humans?
    Nicholas L Mills
    Centre for Cardiovascular Science, The University of Edinburgh, Chancellor s Building, Edinburgh EH16 4SB, UK
    Am J Respir Crit Care Med 173:426-31. 2006
    ..It has been suggested that the nanoparticulate component of PM(10) is capable of translocating into the circulation with the potential for direct effects on the vasculature...
  71. ncbi Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells: potential mechanism in gene transcription in lung inflammation
    Irfan Rahman
    ELEGI Colt Research Laboratory, University of Edinburgh, Medical School, Scotland, UK
    Mol Cell Biochem 234:239-48. 2002
    ..This indicates a mechanism for the pro-inflammatory effects of oxidative stress...
  72. pmc Living and dying with severe chronic obstructive pulmonary disease: multi-perspective longitudinal qualitative study
    Hilary Pinnock
    Centre for Population Health Sciences GP Section, University of Edinburgh, UK
    BMJ 342:d142. 2011
    ..To understand the perspectives of people with severe chronic obstructive pulmonary disease (COPD) as their illness progresses, and of their informal and professional carers, to inform provision of care for people living and dying with COPD...
  73. ncbi Pulmonary and systemic effects of short-term inhalation exposure to ultrafine carbon black particles
    Peter S Gilmour
    Edinburgh Lung and the Environment Group Initiative ELEGI Colt Laboratory, The MRC Centre for Inflammation Research, Medical School, The University of Edinburgh, Edinburgh EH8 9AG, UK
    Toxicol Appl Pharmacol 195:35-44. 2004
    ..The data show that there is a small but consistent significant proinflammatory effect of this exposure to ultrafine particles that is greater than the effect of the same exposure to fine CB...
  74. ncbi Acute exacerbations of COPD
    W MacNee
    Respiratory Medicine Unit, Royal Infirmary of Edinburgh, Scotland, UK
    Swiss Med Wkly 133:247-57. 2003
    ..Early or immediate supported discharge for selected patients has been shown to be effective in the management of patients with COPD...
  75. ncbi What's new in COPD?
    J J Miller
    ELEGI Colt Research Laboratories, The University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4SB, United Kingdom
    Scott Med J 52:36-41; quiz 42, 57. 2007
  76. ncbi Increased arterial stiffness in patients with chronic obstructive pulmonary disease: a mechanism for increased cardiovascular risk
    N L Mills
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
    Thorax 63:306-11. 2008
    ..The mechanisms responsible for this association are not clear and appear to be independent of smoking history...
  77. doi Oral antioxidant supplementation does not prevent acute mountain sickness: double blind, randomized placebo-controlled trial
    J K Baillie
    Department of Anaesthesia, Critical Care and Pain Medicine, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK
    QJM 102:341-8. 2009
    ..Acute mountain sickness may be caused by cerebrovascular fluid leakage due to oxidative damage to the endothelium. This may be reduced by oral antioxidant supplementation...
  78. ncbi Cigarette smoke prevents apoptosis through inhibition of caspase activation and induces necrosis
    Julie A Wickenden
    ELEGI Colt Research Laboratories, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Am J Respir Cell Mol Biol 29:562-70. 2003
    ..Therefore, unlike previous studies, cell death in response to cigarette smoke by necrosis and not apoptosis may be responsible for the loss of alveolar walls and inflammation observed in emphysema...
  79. ncbi Increased platelet activation in patients with stable and acute exacerbation of COPD
    John D Maclay
    ELEGI Colt Laboratories, Centre for Inflammation Research, Edinburgh University, Edinburgh, UK
    Thorax 66:769-74. 2011
    ..Interaction between inflammatory cells and activated platelets is important in the pathogenesis of atherothrombosis and may contribute to cardiovascular risk in patients with COPD...
  80. pmc Efficacy of simple short-term in vitro assays for predicting the potential of metal oxide nanoparticles to cause pulmonary inflammation
    Senlin Lu
    University of Edinburgh, Edinburgh, UK
    Environ Health Perspect 117:241-7. 2009
    ..There has been concern regarding risks from inhalation exposure to nanoparticles (NPs). The large number of particles requiring testing means that alternative approaches to animal testing are needed...
  81. ncbi Inflammatory lung secretions inhibit dendritic cell maturation and function via neutrophil elastase
    Ali Roghanian
    Medical Research Council MRC Centre for Inflammation Research CIR, The Queen s Medical Research Institute, Edinburgh University Medical School, Edinburgh, Scotland, United Kingdom
    Am J Respir Crit Care Med 174:1189-98. 2006
    ..Therefore, we hypothesized that inflammatory mediators, such as neutrophil elastase (NE) released into the lung, may be able to modulate their activity...
  82. ncbi Proposal for a multidimensional staging system for chronic obstructive pulmonary disease
    Bartolome R Celli
    Department of Pulmonary and Critical Care Medicine, Tufts University, Boston, MA 02135, USA
    Respir Med 99:1546-54. 2005
    ..Although the staging boundaries were based on existing literature, they have proven useful in predicting survival. We conclude that a multidimensional grading system is useful to assess the impact of COPD...
  83. ncbi Cigarette smoke disrupts VEGF165-VEGFR-2 receptor signaling complex in rat lungs and patients with COPD: morphological impact of VEGFR-2 inhibition
    John A Marwick
    Department of Environmental Medicine, University of Rochester Medical Center, Box 850, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 290:L897-908. 2006
    ..However, targeted therapies to restore VEGF(165)-VEGFR-2 complex may promote endothelial cell survival and help to ameliorate emphysema...
  84. pmc Airways inflammation and treatment during acute exacerbations of COPD
    Erik Bathoorn
    Groningen Research Institute for Asthma and COPD GRIAC, Department of Pulmonology, University Medical Center Groningen, The Netherlands
    Int J Chron Obstruct Pulmon Dis 3:217-29. 2008
    ..It is important to focus on inflammation since it gives insight into the pathological changes causing an exacerbation, thereby possibly providing directions for future therapies which modify inflammation...
  85. ncbi Persistent endothelial dysfunction in humans after diesel exhaust inhalation
    Håkan Törnqvist
    Department of Respiratory Medicine and Allergy, Umea University Hospital, SE 901 85 Umea, Sweden
    Am J Respir Crit Care Med 176:395-400. 2007
    ..We have previously demonstrated that inhalation of diesel exhaust causes an immediate (within 2 h) impairment of vascular and endothelial function in humans...
  86. ncbi Lack of systemic oxidative stress during PAF challenge in mild asthma
    Andrés L Echazarreta
    Servei de Pneumologia, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Universitat de Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Respir Med 99:519-23. 2005
    ..Unlike PAF, L-PAF-induced changes were negligible. We conclude that there is no systemic oxidant-antioxidant imbalance during acute bronchoconstriction induced by PAF in these patients with mild asthma...
  87. ncbi [Pathogenesis of chronic obstructive pulmonary disease. Molecular mechanisms (part II)]
    Patryk Szulakowski
    Z ELEGI Colt Laboratories, Centre for Inflammation Research, The University of Edinburgh, Edynburg, Wielka Brytania
    Wiad Lek 59:250-4. 2006
    ..Furthermore, histone acetylation seems to be a potential mechanism exclusive to smokers with susceptibility to COPD based on the transcription of specific pro- and anti-inflammatory cytokine combinations...
  88. ncbi Allergic rhinitis, asthma, airway biology, and chronic obstructive pulmonary disease in AJRCCM in 2004
    Leonardo Fabbri
    Medical, Oncological, and Radiological Sciences, University of Modena, Modena, Italy
    Am J Respir Crit Care Med 171:686-98. 2005
  89. ncbi High-dose acetylcysteine in idiopathic pulmonary fibrosis
    Maurits Demedts
    University Hospital, Katholieke Universiteit Leuven, Leuven, Belgium
    N Engl J Med 353:2229-42. 2005
    ..Idiopathic pulmonary fibrosis is a chronic progressive disorder with a poor prognosis...
  90. ncbi Cryptic haplotypes of SERPINA1 confer susceptibility to chronic obstructive pulmonary disease
    Sally Chappell
    Division of Clinical Chemistry, Molecular Medical Sciences, Institute of Genetics, University Hospital, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom
    Hum Mutat 27:103-9. 2006
    ..In contrast, no haplotype associations for SERPINA3 were identified...
  91. ncbi Glutathione prevents inhibition of fibroblast-mediated collagen gel contraction by cigarette smoke
    Hui Jung Kim
    Pulmonary Division, Department of Internal Medicine, Seoul Adventist Hospital, Seoul 130 650, Korea
    Am J Physiol Lung Cell Mol Physiol 283:L409-17. 2002
    ..In conclusion, smoke inhibition of fibroblast repair, as reflected by collagen gel contraction and fibronectin production, may be modulated by intracellular GSH levels...
  92. ncbi Prescription of oxygen: still problems after all these years
    William MacNee
    Am J Respir Crit Care Med 172:517-8. 2005
  93. ncbi Interstitial lung disease, lung cancer, lung transplantation, pulmonary vascular disorders, and sleep-disordered breathing in AJRCCM in 2004
    T Douglas Bradley
    Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 171:675-85. 2005
  94. ncbi [Pathogenesis of chronic obstructive pulmonary disease. Cellular mechanisms (part I)]
    Robert M Mroz
    ELEGI Colt Laboratories, Centre for Inflammation Research, The University of Edinburgh, Edynburg, Wielka Brytania
    Wiad Lek 59:92-6. 2006
    ..kappaB phosphoinositide-3-kinase gamma, TGF-beta, NOS synthase, serine proteinases and matrix metalloproteinases...
  95. pmc The SERPINE2 gene and chronic obstructive pulmonary disease
    Sally Chappell
    Am J Hum Genet 79:184-6; author reply 186-7. 2006
  96. ncbi Cystic fibrosis, pediatrics, control of breathing, pulmonary physiology and anatomy, and surfactant biology in AJRCCM in 2004
    Andrew Bush
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box C272, Room 5503, Denver, CO 80262 0001, USA
    Am J Respir Crit Care Med 171:545-53. 2005
  97. ncbi Critical care in AJRCCM 2004
    Derek Angus
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box C272, Room 5503, Denver, CO 80262 0001, USA
    Am J Respir Crit Care Med 171:537-44. 2005
  98. ncbi Haplotypes of the alpha-1 antitrypsin gene in healthy controls and Z deficiency patients
    Sally Chappell
    Division of Clinical Chemistry, Institute of Genetics, University of Nottingham, Nottingham, United Kingdom
    Hum Mutat 24:535-6. 2004
    ..In addition to the haplotype information, we present evidence for a functional effect of a SNP in intron 1...
  99. pmc Guidelines for chronic obstructive pulmonary disease
    William MacNee
    BMJ 329:361-3. 2004
  100. ncbi Expression of adhesion molecules during apoptosis of circulating neutrophils in COPD
    Aina Noguera
    Serveis de Analisis Cliniques, Hospital Universitari Son Dureta, Palma de Mallorca, Spain
    Chest 125:1837-42. 2004
    ..Dysregulation of neutrophil apoptosis may contribute to the latter. This study investigated the potential abnormalities of the apoptotic process in COPD patients...
  101. ncbi Ultrafine carbon black particles inhibit human lung fibroblast-mediated collagen gel contraction
    Huijung Kim
    Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5125, USA
    Am J Respir Cell Mol Biol 28:111-21. 2003
    ..Taken together, these results demonstrate the ability of ultrafine particles to contribute to altered tissue repair and extend the known mechanisms by which these biologically active particles exert their effects...

Research Grants4

  1. Biomarkers of oxidative stress and inflammation in COPD
    William MacNee; Fiscal Year: 2005
    ..Such information will allow the identification of novel biomarkers and the fingerprints themselves may represent a mechanism to stratify COPD patients and allow the assessment of novel therapies. ..
  2. Biomarkers of oxidative stress and inflammation in COPD
    William MacNee; Fiscal Year: 2002
    ..Such information will allow the identification of novel biomarkers and the fingerprints themselves may represent a mechanism to stratify COPD patients and allow the assessment of novel therapies. ..
  3. Biomarkers of oxidative stress and inflammation in COPD
    William MacNee; Fiscal Year: 2003
    ..Such information will allow the identification of novel biomarkers and the fingerprints themselves may represent a mechanism to stratify COPD patients and allow the assessment of novel therapies. ..
  4. Biomarkers of oxidative stress and inflammation in COPD
    William MacNee; Fiscal Year: 2004
    ..Such information will allow the identification of novel biomarkers and the fingerprints themselves may represent a mechanism to stratify COPD patients and allow the assessment of novel therapies. ..