Alasdair Mj Maclullich

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi Neuroimaging studies of delirium: a systematic review
    Roy L Soiza
    Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, Scotland, UK
    J Psychosom Res 65:239-48. 2008
  2. pmc Preoperative cerebrospinal fluid cytokine levels and the risk of postoperative delirium in elderly hip fracture patients
    Dunja Westhoff
    Department of Neurology, Academic Medical Center University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    J Neuroinflammation 10:122. 2013
  3. pmc The descriptive epidemiology of delirium symptoms in a large population-based cohort study: results from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS)
    Daniel H J Davis
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    BMC Geriatr 14:87. 2014
  4. pmc New horizons in the pathogenesis, assessment and management of delirium
    Alasdair M J MacLullich
    Edinburgh Delirium Research Group, Geriatric Medicine Unit, University of Edinburgh, Room S1642, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, UK
    Age Ageing 42:667-74. 2013
  5. pmc Neck muscle cross-sectional area, brain volume and cognition in healthy older men: a cohort study
    Alixe H M Kilgour
    Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    BMC Geriatr 13:20. 2013
  6. pmc 11β-hydroxysteroid dehydrogenase type 1, brain atrophy and cognitive decline
    Alasdair M J MacLullich
    Endocrinology, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, Scotland, UK
    Neurobiol Aging 33:207.e1-8. 2012
  7. ncbi Delirium and long-term cognitive impairment
    Alasdair M J MacLullich
    Department of Geriatric Medicine, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK
    Int Rev Psychiatry 21:30-42. 2009
  8. ncbi Unravelling the pathophysiology of delirium: a focus on the role of aberrant stress responses
    Alasdair M J MacLullich
    Geriatric Medicine MRC Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, Scotland, UK
    J Psychosom Res 65:229-38. 2008
  9. ncbi Diabetes and cognitive decline: are steroids the missing link?
    Alasdair M J MacLullich
    Endocrinology Unit, Centre for Cardiovascular Science, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Cell Metab 7:286-7. 2008
  10. ncbi Intracranial capacity and brain volumes are associated with cognition in healthy elderly men
    A M J Maclullich
    Geriatric Medicine Unit, University of Edinburgh, Edinburgh, Scotland, UK
    Neurology 59:169-74. 2002

Collaborators

Detail Information

Publications24

  1. ncbi Neuroimaging studies of delirium: a systematic review
    Roy L Soiza
    Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, Scotland, UK
    J Psychosom Res 65:239-48. 2008
    ..The aims were to categorize and summarize the existing literature, and to determine whether this literature provides conclusive information on structural or functional brain predictors, correlates, or consequences of delirium...
  2. pmc Preoperative cerebrospinal fluid cytokine levels and the risk of postoperative delirium in elderly hip fracture patients
    Dunja Westhoff
    Department of Neurology, Academic Medical Center University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    J Neuroinflammation 10:122. 2013
    ..We examined whether hip fracture patients who develop postoperative delirium have altered levels of inflammatory mediators in cerebrospinal fluid (CSF) prior to surgery...
  3. pmc The descriptive epidemiology of delirium symptoms in a large population-based cohort study: results from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS)
    Daniel H J Davis
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    BMC Geriatr 14:87. 2014
    ....
  4. pmc New horizons in the pathogenesis, assessment and management of delirium
    Alasdair M J MacLullich
    Edinburgh Delirium Research Group, Geriatric Medicine Unit, University of Edinburgh, Room S1642, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, UK
    Age Ageing 42:667-74. 2013
    ..Nevertheless, the field faces several complex research and clinical challenges. In this article we focus on selected areas of recent progress and/or uncertainty in delirium research and practice. (i)..
  5. pmc Neck muscle cross-sectional area, brain volume and cognition in healthy older men: a cohort study
    Alixe H M Kilgour
    Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    BMC Geriatr 13:20. 2013
    ..However, studies investigating these relationships at older ages are lacking and rarely include a measure of muscle size. Here we test whether neck muscle size is positively associated with cognition and brain structure in older men...
  6. pmc 11β-hydroxysteroid dehydrogenase type 1, brain atrophy and cognitive decline
    Alasdair M J MacLullich
    Endocrinology, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, Scotland, UK
    Neurobiol Aging 33:207.e1-8. 2012
    ..55, p = 0.0002) over 6 years. The predictive link between systemic 11β-HSD1 activity and progressive brain atrophy and cognitive decline suggests 11β-HSD1 inhibition as a plausible therapy for brain aging...
  7. ncbi Delirium and long-term cognitive impairment
    Alasdair M J MacLullich
    Department of Geriatric Medicine, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK
    Int Rev Psychiatry 21:30-42. 2009
    ..We conclude with suggestions for future research...
  8. ncbi Unravelling the pathophysiology of delirium: a focus on the role of aberrant stress responses
    Alasdair M J MacLullich
    Geriatric Medicine MRC Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, Scotland, UK
    J Psychosom Res 65:229-38. 2008
    ..We conclude by discussing the implications for future research and the development of new therapies for delirium...
  9. ncbi Diabetes and cognitive decline: are steroids the missing link?
    Alasdair M J MacLullich
    Endocrinology Unit, Centre for Cardiovascular Science, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Cell Metab 7:286-7. 2008
    ..2008) shows that reducing glucocorticoid levels in rodent diabetes models prevents cognitive deficits and enhances neurogenesis and synaptic plasticity. The clinical relevance of these intriguing findings remains undetermined...
  10. ncbi Intracranial capacity and brain volumes are associated with cognition in healthy elderly men
    A M J Maclullich
    Geriatric Medicine Unit, University of Edinburgh, Edinburgh, Scotland, UK
    Neurology 59:169-74. 2002
    ..Brain size and intracranial capacity are correlated with cognitive performance in young healthy adults, but data are lacking on these relationships in older healthy adults...
  11. pmc Enlarged perivascular spaces are associated with cognitive function in healthy elderly men
    A M J Maclullich
    Geriatric Medicine Unit, The University of Edinburgh, Room SU220, The Chancellor s Building, 49 Little France Crescent, EH16 4SB
    J Neurol Neurosurg Psychiatry 75:1519-23. 2004
    ..It is not known whether the extent of EPVS is also associated with cognitive function. We tested the hypothesis that more EPVS would be associated with worse cognitive function...
  12. ncbi Smaller left anterior cingulate cortex volumes are associated with impaired hypothalamic-pituitary-adrenal axis regulation in healthy elderly men
    Alasdair M J MacLullich
    Endocrinology Unit, Center for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, United Kingdom
    J Clin Endocrinol Metab 91:1591-4. 2006
    ..Studies in animals suggest that the limbic prefrontal cortex, including the anterior cingulate cortex, is involved in regulation of the hypothalamic-pituitary-adrenal (HPA) axis, but human data are lacking...
  13. ncbi Size of the neocerebellar vermis is associated with cognition in healthy elderly men
    Alasdair M J MacLullich
    Geriatric Medicine Unit, University of Edinburgh, Room SU220, The Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Brain Cogn 56:344-8. 2004
    ..Total cerebellar volumes correlated significantly with a test of nonverbal reasoning (r=.030, p=.42). These findings suggest a specific association of neocerebellar vermis size with variations in cognitive ability in older adults...
  14. pmc Cerebrospinal fluid cortisol levels are higher in patients with delirium versus controls
    Andrew Pearson
    Geriatric Medicine, University of Edinburgh, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, UK
    BMC Res Notes 3:33. 2010
    ..abstract:..
  15. ncbi Plasma cortisol levels, brain volumes and cognition in healthy elderly men
    Alasdair M J MacLullich
    Geriatric Medicine, University of Edinburgh, Room SU220, The Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Psychoneuroendocrinology 30:505-15. 2005
    ..This study examined the hypotheses that higher plasma cortisol levels and altered sensitivity to glucocorticoids are associated with worse cognition and more brain atrophy in elderly men...
  16. pmc Quantifying the effects of normal ageing on white matter structure using unsupervised tract shape modelling
    Mark E Bastin
    Medical and Radiological Sciences Medical Physics, University of Edinburgh, and Western General Hospital, Edinburgh, UK
    Neuroimage 51:1-10. 2010
    ..These data therefore suggest that brain atrophy and white matter lesions play a significant role in driving regional patterns of age-related changes in white matter tract shape and integrity...
  17. ncbi Enlarged perivascular spaces on MRI are a feature of cerebral small vessel disease
    Fergus N Doubal
    MRCP, Division of Clinical Neurosciences, Bramwell Dott Building, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK
    Stroke 41:450-4. 2010
    ..They may reflect underlying cerebral small vessel disease. We determined whether enlarged perivascular spaces were associated with lacunar stroke subtype and white matter hyperintensities, markers of established small vessel disease...
  18. ncbi Quantitative and qualitative measures of hippocampal atrophy are not correlated in healthy older men
    Karen J Ferguson
    SFC Brain Imaging Research Centre, Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland
    J Neuroimaging 20:157-62. 2010
    ..We therefore examined the relationship between hippocampal qualitative atrophy scores and quantitative volumetric measurements in healthy older men...
  19. ncbi Tract shape modelling provides evidence of topological change in corpus callosum genu during normal ageing
    Mark E Bastin
    Medical and Radiological Sciences Medical Physics, University of Edinburgh, UK
    Neuroimage 43:20-8. 2008
    ..These data show that it is possible automatically to segment comparable tracts in the brains of older subjects using single seed point tractography, if the seed point is carefully chosen...
  20. ncbi Subjective memory complaints and cognitive impairment in older people
    Louise M Reid
    Geriatric Medicine, University of Edinburgh, Edinburgh, UK
    Dement Geriatr Cogn Disord 22:471-85. 2006
    ..g. neuroticism. In conclusion, the determinants of SMCs are complex. The utility of SMCs in the diagnosis of pre-dementia states (e.g. mild cognitive impairment) is uncertain and requires further evaluation...
  21. ncbi The European delirium association
    Alasdair M J MacLullich
    Geriatric Medicine, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, Scotland
    J Psychosom Res 62:397-8. 2007
  22. pmc 11Beta-hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics
    Thekkepat C Sandeep
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    Proc Natl Acad Sci U S A 101:6734-9. 2004
    ..11beta-HSD1 inhibition may be a new approach to prevent/ameliorate cognitive decline...
  23. ncbi Magnetic resonance spectroscopy and cognitive function in healthy elderly men
    Karen J Ferguson
    Brain Imaging Research Centre for Scotland, Edinburgh, UK
    Brain 125:2743-9. 2002
    ..These results suggest that in healthy men aged 65-70 years, metabolite levels relate to cognitive performance. Rising Cr levels may be an early marker of cognitive decline...
  24. ncbi Glycosylated hemoglobin levels in healthy elderly nondiabetic men are negatively associated with verbal memory
    Alasdair M J MacLullich
    J Am Geriatr Soc 52:848-9. 2004