Alasdair Mj Maclullich
Affiliation: University of Edinburgh
- Neuroimaging studies of delirium: a systematic reviewRoy L Soiza
Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, Scotland, UK
J Psychosom Res 65:239-48. 2008..The aims were to categorize and summarize the existing literature, and to determine whether this literature provides conclusive information on structural or functional brain predictors, correlates, or consequences of delirium...
- Preoperative cerebrospinal fluid cytokine levels and the risk of postoperative delirium in elderly hip fracture patientsDunja Westhoff
Department of Neurology, Academic Medical Center University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The Netherlands
J Neuroinflammation 10:122. 2013..We examined whether hip fracture patients who develop postoperative delirium have altered levels of inflammatory mediators in cerebrospinal fluid (CSF) prior to surgery...
- The descriptive epidemiology of delirium symptoms in a large population-based cohort study: results from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS)Daniel H J Davis
Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
BMC Geriatr 14:87. 2014....
- New horizons in the pathogenesis, assessment and management of deliriumAlasdair M J MacLullich
Edinburgh Delirium Research Group, Geriatric Medicine Unit, University of Edinburgh, Room S1642, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, UK
Age Ageing 42:667-74. 2013..Nevertheless, the field faces several complex research and clinical challenges. In this article we focus on selected areas of recent progress and/or uncertainty in delirium research and practice. (i)..
- Neck muscle cross-sectional area, brain volume and cognition in healthy older men: a cohort studyAlixe H M Kilgour
Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
BMC Geriatr 13:20. 2013..However, studies investigating these relationships at older ages are lacking and rarely include a measure of muscle size. Here we test whether neck muscle size is positively associated with cognition and brain structure in older men...
- 11β-hydroxysteroid dehydrogenase type 1, brain atrophy and cognitive declineAlasdair M J MacLullich
Endocrinology, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, Scotland, UK
Neurobiol Aging 33:207.e1-8. 2012..55, p = 0.0002) over 6 years. The predictive link between systemic 11β-HSD1 activity and progressive brain atrophy and cognitive decline suggests 11β-HSD1 inhibition as a plausible therapy for brain aging...
- Delirium and long-term cognitive impairmentAlasdair M J MacLullich
Department of Geriatric Medicine, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK
Int Rev Psychiatry 21:30-42. 2009..We conclude with suggestions for future research...
- Unravelling the pathophysiology of delirium: a focus on the role of aberrant stress responsesAlasdair M J MacLullich
Geriatric Medicine MRC Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, Scotland, UK
J Psychosom Res 65:229-38. 2008..We conclude by discussing the implications for future research and the development of new therapies for delirium...
- Diabetes and cognitive decline: are steroids the missing link?Alasdair M J MacLullich
Endocrinology Unit, Centre for Cardiovascular Science, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
Cell Metab 7:286-7. 2008..2008) shows that reducing glucocorticoid levels in rodent diabetes models prevents cognitive deficits and enhances neurogenesis and synaptic plasticity. The clinical relevance of these intriguing findings remains undetermined...
- Intracranial capacity and brain volumes are associated with cognition in healthy elderly menA M J Maclullich
Geriatric Medicine Unit, University of Edinburgh, Edinburgh, Scotland, UK
Neurology 59:169-74. 2002..Brain size and intracranial capacity are correlated with cognitive performance in young healthy adults, but data are lacking on these relationships in older healthy adults...
- Enlarged perivascular spaces are associated with cognitive function in healthy elderly menA M J Maclullich
Geriatric Medicine Unit, The University of Edinburgh, Room SU220, The Chancellor s Building, 49 Little France Crescent, EH16 4SB
J Neurol Neurosurg Psychiatry 75:1519-23. 2004..It is not known whether the extent of EPVS is also associated with cognitive function. We tested the hypothesis that more EPVS would be associated with worse cognitive function...
- Smaller left anterior cingulate cortex volumes are associated with impaired hypothalamic-pituitary-adrenal axis regulation in healthy elderly menAlasdair M J MacLullich
Endocrinology Unit, Center for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, United Kingdom
J Clin Endocrinol Metab 91:1591-4. 2006..Studies in animals suggest that the limbic prefrontal cortex, including the anterior cingulate cortex, is involved in regulation of the hypothalamic-pituitary-adrenal (HPA) axis, but human data are lacking...
- Size of the neocerebellar vermis is associated with cognition in healthy elderly menAlasdair M J MacLullich
Geriatric Medicine Unit, University of Edinburgh, Room SU220, The Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
Brain Cogn 56:344-8. 2004..Total cerebellar volumes correlated significantly with a test of nonverbal reasoning (r=.030, p=.42). These findings suggest a specific association of neocerebellar vermis size with variations in cognitive ability in older adults...
- Cerebrospinal fluid cortisol levels are higher in patients with delirium versus controlsAndrew Pearson
Geriatric Medicine, University of Edinburgh, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, UK
BMC Res Notes 3:33. 2010..abstract:..
- Plasma cortisol levels, brain volumes and cognition in healthy elderly menAlasdair M J MacLullich
Geriatric Medicine, University of Edinburgh, Room SU220, The Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
Psychoneuroendocrinology 30:505-15. 2005..This study examined the hypotheses that higher plasma cortisol levels and altered sensitivity to glucocorticoids are associated with worse cognition and more brain atrophy in elderly men...
- Quantifying the effects of normal ageing on white matter structure using unsupervised tract shape modellingMark E Bastin
Medical and Radiological Sciences Medical Physics, University of Edinburgh, and Western General Hospital, Edinburgh, UK
Neuroimage 51:1-10. 2010..These data therefore suggest that brain atrophy and white matter lesions play a significant role in driving regional patterns of age-related changes in white matter tract shape and integrity...
- Enlarged perivascular spaces on MRI are a feature of cerebral small vessel diseaseFergus N Doubal
MRCP, Division of Clinical Neurosciences, Bramwell Dott Building, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK
Stroke 41:450-4. 2010..They may reflect underlying cerebral small vessel disease. We determined whether enlarged perivascular spaces were associated with lacunar stroke subtype and white matter hyperintensities, markers of established small vessel disease...
- Quantitative and qualitative measures of hippocampal atrophy are not correlated in healthy older menKaren J Ferguson
SFC Brain Imaging Research Centre, Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland
J Neuroimaging 20:157-62. 2010..We therefore examined the relationship between hippocampal qualitative atrophy scores and quantitative volumetric measurements in healthy older men...
- Tract shape modelling provides evidence of topological change in corpus callosum genu during normal ageingMark E Bastin
Medical and Radiological Sciences Medical Physics, University of Edinburgh, UK
Neuroimage 43:20-8. 2008..These data show that it is possible automatically to segment comparable tracts in the brains of older subjects using single seed point tractography, if the seed point is carefully chosen...
- Subjective memory complaints and cognitive impairment in older peopleLouise M Reid
Geriatric Medicine, University of Edinburgh, Edinburgh, UK
Dement Geriatr Cogn Disord 22:471-85. 2006..g. neuroticism. In conclusion, the determinants of SMCs are complex. The utility of SMCs in the diagnosis of pre-dementia states (e.g. mild cognitive impairment) is uncertain and requires further evaluation...
- The European delirium associationAlasdair M J MacLullich
Geriatric Medicine, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, Scotland
J Psychosom Res 62:397-8. 2007
- 11Beta-hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabeticsThekkepat C Sandeep
Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
Proc Natl Acad Sci U S A 101:6734-9. 2004..11beta-HSD1 inhibition may be a new approach to prevent/ameliorate cognitive decline...
- Magnetic resonance spectroscopy and cognitive function in healthy elderly menKaren J Ferguson
Brain Imaging Research Centre for Scotland, Edinburgh, UK
Brain 125:2743-9. 2002..These results suggest that in healthy men aged 65-70 years, metabolite levels relate to cognitive performance. Rising Cr levels may be an early marker of cognitive decline...
- Glycosylated hemoglobin levels in healthy elderly nondiabetic men are negatively associated with verbal memoryAlasdair M J MacLullich
J Am Geriatr Soc 52:848-9. 2004