Ian Maclennan

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. ncbi request reprint The changing preference of T and B cells for partners as T-dependent antibody responses develop
    I C MacLennan
    Department of Immunology, University of Birmingham Medical School, United Kingdom
    Immunol Rev 156:53-66. 1997
  2. pmc Homeostatic cell-cycle control by BLyS: Induction of cell-cycle entry but not G1/S transition in opposition to p18INK4c and p27Kip1
    Xiangao Huang
    Department of Pathology and Graduate Program in Immunology and Microbial Pathogenesis, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:17789-94. 2004
  3. doi request reprint Molecular differences between the divergent responses of ovalbumin-specific CD4 T cells to alum-precipitated ovalbumin compared to ovalbumin expressed by Salmonella
    Karine Serre
    MRC Centre for Immune Regulation, University of Birmingham, Medical School, Birmingham, UK
    Mol Immunol 45:3558-66. 2008
  4. pmc Low-level hypermutation in T cell-independent germinal centers compared with high mutation rates associated with T cell-dependent germinal centers
    Kai Michael Toellner
    Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham B15 2TT, United Kingdom
    J Exp Med 195:383-9. 2002
  5. ncbi request reprint Dendritic cells, BAFF, and APRIL: innate players in adaptive antibody responses
    Ian Maclennan
    MRC Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom
    Immunity 17:235-8. 2002
  6. ncbi request reprint Extrafollicular antibody responses
    Ian C M MacLennan
    MRC Center for Immune Regulation, University of Birmingham, Birmingham, UK
    Immunol Rev 194:8-18. 2003
  7. ncbi request reprint Responses to the soluble flagellar protein FliC are Th2, while those to FliC on Salmonella are Th1
    Adam F Cunningham
    MRC Centre for Immune Regulation, University of Birmingham, Birmingham, UK
    Eur J Immunol 34:2986-95. 2004
  8. ncbi request reprint Pinpointing IL-4-independent acquisition and IL-4-influenced maintenance of Th2 activity by CD4 T cells
    Adam F Cunningham
    The Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham, GB
    Eur J Immunol 34:686-94. 2004
  9. ncbi request reprint Recirculating and germinal center B cells differentiate into cells responsive to polysaccharide antigens
    Carola G Vinuesa
    University of Birmingham, MRC Centre for Immune Regulation, Birmingham, GB
    Eur J Immunol 33:297-305. 2003
  10. pmc IL-4 directs both CD4 and CD8 T cells to produce Th2 cytokines in vitro, but only CD4 T cells produce these cytokines in response to alum-precipitated protein in vivo
    Karine Serre
    MRC Centre for Immune Regulation, The IBR, School of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Mol Immunol 47:1914-22. 2010

Collaborators

Detail Information

Publications31

  1. ncbi request reprint The changing preference of T and B cells for partners as T-dependent antibody responses develop
    I C MacLennan
    Department of Immunology, University of Birmingham Medical School, United Kingdom
    Immunol Rev 156:53-66. 1997
    ..During primary antibody responses T-cell proliferation in follicles produces many times the peak number of T cells found in that site: a substantial proportion of the CD4+ memory T-cell pool may originate from growth in follicles...
  2. pmc Homeostatic cell-cycle control by BLyS: Induction of cell-cycle entry but not G1/S transition in opposition to p18INK4c and p27Kip1
    Xiangao Huang
    Department of Pathology and Graduate Program in Immunology and Microbial Pathogenesis, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:17789-94. 2004
    ..Antagonistic cell-cycle regulation by BLyS and p18(INK4c) is functionally linked to apoptotic control and conserved from B cell activation in vitro to antibody response in vivo, further indicating a physiologic role in homeostasis...
  3. doi request reprint Molecular differences between the divergent responses of ovalbumin-specific CD4 T cells to alum-precipitated ovalbumin compared to ovalbumin expressed by Salmonella
    Karine Serre
    MRC Centre for Immune Regulation, University of Birmingham, Medical School, Birmingham, UK
    Mol Immunol 45:3558-66. 2008
    ..Finally, IL-17RB is strongly associated with OVA-specific CD4 T cells responding to alumOVA, suggesting that alum may promote Th2 immune response through a role for the IL-25/IL-17RB pathway...
  4. pmc Low-level hypermutation in T cell-independent germinal centers compared with high mutation rates associated with T cell-dependent germinal centers
    Kai Michael Toellner
    Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham B15 2TT, United Kingdom
    J Exp Med 195:383-9. 2002
    ..It is concluded that efficient activation of hypermutation depends on interaction with T cells, but some hypermutation may be induced without such signals, even outside germinal centers...
  5. ncbi request reprint Dendritic cells, BAFF, and APRIL: innate players in adaptive antibody responses
    Ian Maclennan
    MRC Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom
    Immunity 17:235-8. 2002
    ..While this may be lifesaving in the face of infection, it can predispose to autoantibody production...
  6. ncbi request reprint Extrafollicular antibody responses
    Ian C M MacLennan
    MRC Center for Immune Regulation, University of Birmingham, Birmingham, UK
    Immunol Rev 194:8-18. 2003
    ..All types of naïve and memory B cells can be recruited into extrafollicular responses. These responses are associated with immunoglobulin class switching but, at the most, only low-level hypermutation...
  7. ncbi request reprint Responses to the soluble flagellar protein FliC are Th2, while those to FliC on Salmonella are Th1
    Adam F Cunningham
    MRC Centre for Immune Regulation, University of Birmingham, Birmingham, UK
    Eur J Immunol 34:2986-95. 2004
    ....
  8. ncbi request reprint Pinpointing IL-4-independent acquisition and IL-4-influenced maintenance of Th2 activity by CD4 T cells
    Adam F Cunningham
    The Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham, GB
    Eur J Immunol 34:686-94. 2004
    ....
  9. ncbi request reprint Recirculating and germinal center B cells differentiate into cells responsive to polysaccharide antigens
    Carola G Vinuesa
    University of Birmingham, MRC Centre for Immune Regulation, Birmingham, GB
    Eur J Immunol 33:297-305. 2003
    ..The differentiation of B cells both from germinal centers and the recirculating pool to the MZ phenotype is likely to make an important contribution to the repertoire of B cells that respond to polysaccharide antigens...
  10. pmc IL-4 directs both CD4 and CD8 T cells to produce Th2 cytokines in vitro, but only CD4 T cells produce these cytokines in response to alum-precipitated protein in vivo
    Karine Serre
    MRC Centre for Immune Regulation, The IBR, School of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Mol Immunol 47:1914-22. 2010
    ....
  11. ncbi request reprint Th2 activities induced during virgin T cell priming in the absence of IL-4, IL-13, and B cells
    Adam F Cunningham
    University of Birmingham, Medical Research Council Centre for Immune Regulation, Birmingham, United Kingdom
    J Immunol 169:2900-6. 2002
    ..These early events that direct virgin T cells toward Th2 differentiation contrast with the critical later role of Th2 cytokines in selectively expanding Th2 clones and driving further IL-4 synthesis...
  12. ncbi request reprint Critical synergy of CD30 and OX40 signals in CD4 T cell homeostasis and Th1 immunity to Salmonella
    Fabrina Gaspal
    Medical Research Council Centre for Immune Regulation, Division of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom
    J Immunol 180:2824-9. 2008
    ..Finally, Salmonella and lymphopenia are shown to act synergistically in selectively depleting CD4 T cells deficient in OX40 and CD30. Collectively these findings identify a novel mechanism by which Th1 responses are sustained...
  13. pmc B cell clones that sustain long-term plasmablast growth in T-independent extrafollicular antibody responses
    Mei Chi Hsu
    Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Proc Natl Acad Sci U S A 103:5905-10. 2006
    ..The absence of B2 and T cells confirms that hemopoietic cell chimerism leading to primary lymphopoiesis had not been established...
  14. doi request reprint Early simultaneous production of intranodal CD4 Th2 effectors and recirculating rapidly responding central-memory-like CD4 T cells
    Karine Serre
    MRC Centre for Immune Regulation, The IBR, Department of Immunology, University of Birmingham, Birmingham, UK
    Eur J Immunol 39:1573-86. 2009
    ..Thus intranodal effector cells and recirculating, rapidly responding central-memory-like cells emerged simultaneously from the third day of a primary Th2 response...
  15. doi request reprint Dendritic cells and monocyte/macrophages that create the IL-6/APRIL-rich lymph node microenvironments where plasmablasts mature
    Elodie Mohr
    Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, United Kingdom
    J Immunol 182:2113-23. 2009
    ..The distribution of these myeloid cell subsets correlates with a gradient of AFC maturation assessed by progressive loss of Ki67 as AFC pass from the B cell follicle along the perivascular areas to the medullary cords...
  16. pmc Dysregulated humoral immunity to nontyphoidal Salmonella in HIV-infected African adults
    Calman A MacLennan
    Medical Research Council Centre for Immune Regulation and Clinical Immunology Service, Institute of Biomedical Research, School of Immunity and Infection, University of Birmingham, Birmingham, UK
    Science 328:508-12. 2010
    ....
  17. ncbi request reprint Salmonella induces a switched antibody response without germinal centers that impedes the extracellular spread of infection
    Adam F Cunningham
    Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom
    J Immunol 178:6200-7. 2007
    ..These results may explain why attenuated Salmonella-induced B cell responses are protective in secondary, but not primary infections...
  18. pmc IFN-{gamma} produced by CD8 T cells induces T-bet-dependent and -independent class switching in B cells in responses to alum-precipitated protein vaccine
    Elodie Mohr
    Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Proc Natl Acad Sci U S A 107:17292-7. 2010
    ..Thus, T-bet dependence identifies distinct transcriptional pathways in B cells that regulate IFN-γ-induced switching to different IgG isotypes...
  19. pmc The porin OmpD from nontyphoidal Salmonella is a key target for a protective B1b cell antibody response
    Cristina Gil-Cruz
    School of Immunity and Infection and Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Proc Natl Acad Sci U S A 106:9803-8. 2009
    ..OmpD is a strong candidate vaccine target and may, in part, explain the lack of cross-protection between Salmonella Typhi and STm infections...
  20. ncbi request reprint Germinal centers still hold secrets
    Ian C M MacLennan
    MRC Centre for Immune Regulation, University of Birmingham, United Kingdom
    Immunity 22:656-7. 2005
    ..Wang and Carter (2005) highlight this in the current issue of Immunity in a study of germinal center development in mice with impaired CD19 signaling...
  21. ncbi request reprint Levels of autoantibodies, unlike antibodies to all extrinsic antigen groups, fall following B cell depletion with Rituximab
    Alastair J Ferraro
    MRC Centre for Immune Regulation, Medical School, University of Birmingham, UK
    Eur J Immunol 38:292-8. 2008
    ....
  22. ncbi request reprint CDK inhibitor p18(INK4c) is required for the generation of functional plasma cells
    Michelle R Tourigny
    Department of Pathology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Immunity 17:179-89. 2002
    ..Cell cycle arrest mediated by p18(INK4C) is therefore requisite for the generation of functional plasma cells...
  23. ncbi request reprint Analysis of B cell memory formation using DNA microarrays
    Carola G Vinuesa
    Medical Genome Centre, John Curtin School of Medical Research, Australian National University, ACT, Australia
    Ann N Y Acad Sci 975:33-45. 2002
    ..This model demonstrates how genome-scale technology can be adapted to investigate specific aspects of B cell biology...
  24. ncbi request reprint Plasmodium chabaudi chabaudi infection in mice induces strong B cell responses and striking but temporary changes in splenic cell distribution
    Ariel H Achtman
    Division of Parasitology, National Institute for Medical Research, London, United Kingdom
    J Immunol 171:317-24. 2003
    ..These results show that the changes in splenic cell distribution are linked to the presence of parasites and do not seem to interfere with the development of the humoral response...
  25. ncbi request reprint NF-kappa B1 p50 is required for BLyS attenuation of apoptosis but dispensable for processing of NF-kappa B2 p100 to p52 in quiescent mature B cells
    Eunice N Hatada
    Department of Pathology, Cornell Rockefeller University Sloan Kettering Institute Tri Institutional MD PhD Program, Weill Medical College of Cornell University, New York, NY, 10021, USA
    J Immunol 171:761-8. 2003
    ..These results suggest that BLyS mediates its survival signals in metabolically restricted quiescent B cells, at least in part, through coordinated activation of both NF-kappaB pathways and selective downstream antiapoptotic genes...
  26. pmc microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells
    Elena Vigorito
    Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, CB22 3AT, UK
    Immunity 27:847-59. 2007
    ..1 regulation is a contributing factor to the miR-155-deficient phenotype. Our results implicate post-transcriptional regulation of gene expression for establishing the terminal differentiation program of B cells...
  27. ncbi request reprint Axon growth and guidance genes identify T-dependent germinal centre B cells
    Di Yu
    Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, Canberra, Australia
    Immunol Cell Biol 86:3-14. 2008
    ..Finally we show some of the axon growth genes upregulated in TD-GC B cells including Basp1, Shh, Sult4alpha, Sc4mol are also preferentially expressed in post-GC B cell neoplasms...
  28. ncbi request reprint Recirculating CD4 memory T cells mount rapid secondary responses without major contributions from follicular CD4 effectors and B cells
    Sanjiv A Luther
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Eur J Immunol 37:1476-84. 2007
    ..Accelerated memory CD4 T cell responses were also seen in B cell-deficient mice...
  29. doi request reprint B cells: the follicular dimension of the marginal zone
    Ian C M MacLennan
    Immunol Cell Biol 86:219-20. 2008