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Species | Ian MaclennanSummaryAffiliation: University of Birmingham Country: UK Publications
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Publications
The changing preference of T and B cells for partners as T-dependent antibody responses developI C MacLennan
Department of Immunology, University of Birmingham Medical School, United Kingdom
Immunol Rev 156:53-66. 1997..During primary antibody responses T-cell proliferation in follicles produces many times the peak number of T cells found in that site: a substantial proportion of the CD4+ memory T-cell pool may originate from growth in follicles...
Homeostatic cell-cycle control by BLyS: Induction of cell-cycle entry but not G1/S transition in opposition to p18INK4c and p27Kip1Xiangao Huang
Department of Pathology and Graduate Program in Immunology and Microbial Pathogenesis, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 101:17789-94. 2004..Antagonistic cell-cycle regulation by BLyS and p18(INK4c) is functionally linked to apoptotic control and conserved from B cell activation in vitro to antibody response in vivo, further indicating a physiologic role in homeostasis...
Molecular differences between the divergent responses of ovalbumin-specific CD4 T cells to alum-precipitated ovalbumin compared to ovalbumin expressed by SalmonellaKarine Serre
MRC Centre for Immune Regulation, University of Birmingham, Medical School, Birmingham, UK
Mol Immunol 45:3558-66. 2008..Finally, IL-17RB is strongly associated with OVA-specific CD4 T cells responding to alumOVA, suggesting that alum may promote Th2 immune response through a role for the IL-25/IL-17RB pathway...- Extrafollicular antibody responsesIan C M MacLennan
MRC Center for Immune Regulation, University of Birmingham, Birmingham, UK
Immunol Rev 194:8-18. 2003..All types of naïve and memory B cells can be recruited into extrafollicular responses. These responses are associated with immunoglobulin class switching but, at the most, only low-level hypermutation... - Dendritic cells, BAFF, and APRIL: innate players in adaptive antibody responsesIan Maclennan
MRC Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom
Immunity 17:235-8. 2002..While this may be lifesaving in the face of infection, it can predispose to autoantibody production... - Responses to the soluble flagellar protein FliC are Th2, while those to FliC on Salmonella are Th1Adam F Cunningham
MRC Centre for Immune Regulation, University of Birmingham, Birmingham, UK
Eur J Immunol 34:2986-95. 2004.... - Recirculating and germinal center B cells differentiate into cells responsive to polysaccharide antigensCarola G Vinuesa
University of Birmingham, MRC Centre for Immune Regulation, Birmingham, GB
Eur J Immunol 33:297-305. 2003..The differentiation of B cells both from germinal centers and the recirculating pool to the MZ phenotype is likely to make an important contribution to the repertoire of B cells that respond to polysaccharide antigens... - Pinpointing IL-4-independent acquisition and IL-4-influenced maintenance of Th2 activity by CD4 T cellsAdam F Cunningham
The Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham, GB
Eur J Immunol 34:686-94. 2004.... - Th2 activities induced during virgin T cell priming in the absence of IL-4, IL-13, and B cellsAdam F Cunningham
University of Birmingham, Medical Research Council Centre for Immune Regulation, Birmingham, United Kingdom
J Immunol 169:2900-6. 2002..These early events that direct virgin T cells toward Th2 differentiation contrast with the critical later role of Th2 cytokines in selectively expanding Th2 clones and driving further IL-4 synthesis... - IL-4 directs both CD4 and CD8 T cells to produce Th2 cytokines in vitro, but only CD4 T cells produce these cytokines in response to alum-precipitated protein in vivoKarine Serre
MRC Centre for Immune Regulation, The IBR, School of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom
Mol Immunol 47:1914-22. 2010.... - Low-level hypermutation in T cell-independent germinal centers compared with high mutation rates associated with T cell-dependent germinal centersKai Michael Toellner
Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham B15 2TT, United Kingdom
J Exp Med 195:383-9. 2002..It is concluded that efficient activation of hypermutation depends on interaction with T cells, but some hypermutation may be induced without such signals, even outside germinal centers... - B cell clones that sustain long-term plasmablast growth in T-independent extrafollicular antibody responsesMei-Chi Hsu
Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham B15 2TT, United Kingdom
Proc Natl Acad Sci U S A 103:5905-10. 2006..The absence of B2 and T cells confirms that hemopoietic cell chimerism leading to primary lymphopoiesis had not been established... - Critical synergy of CD30 and OX40 signals in CD4 T cell homeostasis and Th1 immunity to SalmonellaFabrina Gaspal
Medical Research Council Centre for Immune Regulation, Division of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom
J Immunol 180:2824-9. 2008..Finally, Salmonella and lymphopenia are shown to act synergistically in selectively depleting CD4 T cells deficient in OX40 and CD30. Collectively these findings identify a novel mechanism by which Th1 responses are sustained... - IFN-{gamma} produced by CD8 T cells induces T-bet-dependent and -independent class switching in B cells in responses to alum-precipitated protein vaccineElodie Mohr
Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom
Proc Natl Acad Sci U S A 107:17292-7. 2010..Thus, T-bet dependence identifies distinct transcriptional pathways in B cells that regulate IFN-γ-induced switching to different IgG isotypes... - Dendritic cells and monocyte/macrophages that create the IL-6/APRIL-rich lymph node microenvironments where plasmablasts matureElodie Mohr
Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, United Kingdom
J Immunol 182:2113-23. 2009..The distribution of these myeloid cell subsets correlates with a gradient of AFC maturation assessed by progressive loss of Ki67 as AFC pass from the B cell follicle along the perivascular areas to the medullary cords... - Early simultaneous production of intranodal CD4 Th2 effectors and recirculating rapidly responding central-memory-like CD4 T cellsKarine Serre
MRC Centre for Immune Regulation, The IBR, Department of Immunology, University of Birmingham, Birmingham, UK
Eur J Immunol 39:1573-86. 2009..Thus intranodal effector cells and recirculating, rapidly responding central-memory-like cells emerged simultaneously from the third day of a primary Th2 response... - Salmonella induces a switched antibody response without germinal centers that impedes the extracellular spread of infectionAdam F Cunningham
Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom
J Immunol 178:6200-7. 2007..These results may explain why attenuated Salmonella-induced B cell responses are protective in secondary, but not primary infections... - Dysregulated humoral immunity to nontyphoidal Salmonella in HIV-infected African adultsCalman A MacLennan
Medical Research Council Centre for Immune Regulation and Clinical Immunology Service, Institute of Biomedical Research, School of Immunity and Infection, University of Birmingham, Birmingham, UK
Science 328:508-12. 2010.... - The porin OmpD from nontyphoidal Salmonella is a key target for a protective B1b cell antibody responseCristina Gil-Cruz
School of Immunity and Infection and Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham B15 2TT, United Kingdom
Proc Natl Acad Sci U S A 106:9803-8. 2009..OmpD is a strong candidate vaccine target and may, in part, explain the lack of cross-protection between Salmonella Typhi and STm infections... - Germinal centers still hold secretsIan C M MacLennan
MRC Centre for Immune Regulation, University of Birmingham, United Kingdom
Immunity 22:656-7. 2005..Wang and Carter (2005) highlight this in the current issue of Immunity in a study of germinal center development in mice with impaired CD19 signaling... - Levels of autoantibodies, unlike antibodies to all extrinsic antigen groups, fall following B cell depletion with RituximabAlastair J Ferraro
MRC Centre for Immune Regulation, Medical School, University of Birmingham, UK
Eur J Immunol 38:292-8. 2008.... - CDK inhibitor p18(INK4c) is required for the generation of functional plasma cellsMichelle R Tourigny
Department of Pathology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
Immunity 17:179-89. 2002..Cell cycle arrest mediated by p18(INK4C) is therefore requisite for the generation of functional plasma cells... - Analysis of B cell memory formation using DNA microarraysCarola G Vinuesa
Medical Genome Centre, John Curtin School of Medical Research, Australian National University, ACT, Australia
Ann N Y Acad Sci 975:33-45. 2002..This model demonstrates how genome-scale technology can be adapted to investigate specific aspects of B cell biology... - microRNA-155 regulates the generation of immunoglobulin class-switched plasma cellsElena Vigorito
Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, CB22 3AT, UK
Immunity 27:847-59. 2007..1 regulation is a contributing factor to the miR-155-deficient phenotype. Our results implicate post-transcriptional regulation of gene expression for establishing the terminal differentiation program of B cells... - Axon growth and guidance genes identify T-dependent germinal centre B cellsDi Yu
Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, Canberra, Australia
Immunol Cell Biol 86:3-14. 2008..Finally we show some of the axon growth genes upregulated in TD-GC B cells including Basp1, Shh, Sult4alpha, Sc4mol are also preferentially expressed in post-GC B cell neoplasms... - Recirculating CD4 memory T cells mount rapid secondary responses without major contributions from follicular CD4 effectors and B cellsSanjiv A Luther
Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
Eur J Immunol 37:1476-84. 2007..Accelerated memory CD4 T cell responses were also seen in B cell-deficient mice... - Plasmodium chabaudi chabaudi infection in mice induces strong B cell responses and striking but temporary changes in splenic cell distributionAriel H Achtman
Division of Parasitology, National Institute for Medical Research, London, United Kingdom
J Immunol 171:317-24. 2003..These results show that the changes in splenic cell distribution are linked to the presence of parasites and do not seem to interfere with the development of the humoral response... - NF-kappa B1 p50 is required for BLyS attenuation of apoptosis but dispensable for processing of NF-kappa B2 p100 to p52 in quiescent mature B cellsEunice N Hatada
Department of Pathology, Cornell Rockefeller University Sloan Kettering Institute Tri Institutional MD PhD Program, Weill Medical College of Cornell University, New York, NY, 10021, USA
J Immunol 171:761-8. 2003..These results suggest that BLyS mediates its survival signals in metabolically restricted quiescent B cells, at least in part, through coordinated activation of both NF-kappaB pathways and selective downstream antiapoptotic genes... - B cells: the follicular dimension of the marginal zoneIan C M MacLennan
Immunol Cell Biol 86:219-20. 2008