Calman A MacLennan

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. pmc Lymphocyte subsets in healthy Malawians: implications for immunologic assessment of HIV infection in Africa
    Wilson L Mandala
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi
    J Allergy Clin Immunol 125:203-8. 2010
  2. pmc Early interferon-γ production in human lymphocyte subsets in response to nontyphoidal Salmonella demonstrates inherent capacity in innate cells
    Tonney S Nyirenda
    Medical Research Council Centre for Immune Regulation and Clinical Immunology Service, Institute of Biomedical Research, School of Immunity and Infection, College of Medicine and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 5:e13667. 2010
  3. pmc Diagnostic accuracy and clinical utility of a simplified low cost method of counting CD4 cells with flow cytometry in Malawi: diagnostic accuracy study
    Calman A MacLennan
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, PO Box 30096, Blantyre 3, Malawi
    BMJ 335:190. 2007
  4. pmc Affordable pediatric CD4 counting by flow cytometry in Malawi
    Calman A MacLennan
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi
    Cytometry B Clin Cytom 74:S90-7. 2008
  5. pmc The neglected role of antibody in protection against bacteremia caused by nontyphoidal strains of Salmonella in African children
    Calman A MacLennan
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi
    J Clin Invest 118:1553-62. 2008
  6. pmc Dysregulated humoral immunity to nontyphoidal Salmonella in HIV-infected African adults
    Calman A MacLennan
    Medical Research Council Centre for Immune Regulation and Clinical Immunology Service, Institute of Biomedical Research, School of Immunity and Infection, University of Birmingham, Birmingham, UK
    Science 328:508-12. 2010
  7. ncbi request reprint Differential timing of antibody-mediated phagocytosis and cell-free killing of invasive African Salmonella allows immune evasion
    Matthew K Siggins
    Medical Research Council Centre for Immune Regulation and Clinical Immunology Service, Institute of Biomedical Research, School of Immunity and Infection, College of Medicine and Dental Sciences, University of Birmingham, Birmingham, UK Novartis Vaccines Institute for Global Health, Siena, Italy
    Eur J Immunol 44:1093-8. 2014
  8. pmc Importance of antibody and complement for oxidative burst and killing of invasive nontyphoidal Salmonella by blood cells in Africans
    Esther N Gondwe
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre 3, Malawi
    Proc Natl Acad Sci U S A 107:3070-5. 2010
  9. pmc Genotypic homogeneity of multidrug resistant S. Typhimurium infecting distinct adult and childhood susceptibility groups in Blantyre, Malawi
    Chisomo L Msefula
    Department of Microbiology, College of Medicine, University of Malawi, Blantyre, Malawi
    PLoS ONE 7:e42085. 2012
  10. pmc Finger-prick blood samples can be used interchangeably with venous samples for CD4 cell counting indicating their potential for use in CD4 rapid tests
    Calman A MacLennan
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi
    AIDS 21:1643-5. 2007

Collaborators

Detail Information

Publications16

  1. pmc Lymphocyte subsets in healthy Malawians: implications for immunologic assessment of HIV infection in Africa
    Wilson L Mandala
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi
    J Allergy Clin Immunol 125:203-8. 2010
    ..There is currently a lack of comprehensive immunophenotyping data from African populations to guide the immunologic assessment of HIV infection...
  2. pmc Early interferon-γ production in human lymphocyte subsets in response to nontyphoidal Salmonella demonstrates inherent capacity in innate cells
    Tonney S Nyirenda
    Medical Research Council Centre for Immune Regulation and Clinical Immunology Service, Institute of Biomedical Research, School of Immunity and Infection, College of Medicine and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 5:e13667. 2010
    ..This report identifies the lymphocyte subsets that produce IFNγ early in Salmonella infection...
  3. pmc Diagnostic accuracy and clinical utility of a simplified low cost method of counting CD4 cells with flow cytometry in Malawi: diagnostic accuracy study
    Calman A MacLennan
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, PO Box 30096, Blantyre 3, Malawi
    BMJ 335:190. 2007
    ..To assess the diagnostic accuracy and clinical utility of a simplified low cost method for measuring absolute and percentage CD4 counts with flow cytometry...
  4. pmc Affordable pediatric CD4 counting by flow cytometry in Malawi
    Calman A MacLennan
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi
    Cytometry B Clin Cytom 74:S90-7. 2008
    ..There is a need for this technology to transfer to government laboratories run by local staff, and to be validated in children, where %CD4/lymphocyte values are required...
  5. pmc The neglected role of antibody in protection against bacteremia caused by nontyphoidal strains of Salmonella in African children
    Calman A MacLennan
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi
    J Clin Invest 118:1553-62. 2008
    ..This finding and the age-incidence of NTS bacteremia suggest that antibody protects against NTS bacteremia and support the development of vaccines against NTS that induce protective antibody...
  6. pmc Dysregulated humoral immunity to nontyphoidal Salmonella in HIV-infected African adults
    Calman A MacLennan
    Medical Research Council Centre for Immune Regulation and Clinical Immunology Service, Institute of Biomedical Research, School of Immunity and Infection, University of Birmingham, Birmingham, UK
    Science 328:508-12. 2010
    ....
  7. ncbi request reprint Differential timing of antibody-mediated phagocytosis and cell-free killing of invasive African Salmonella allows immune evasion
    Matthew K Siggins
    Medical Research Council Centre for Immune Regulation and Clinical Immunology Service, Institute of Biomedical Research, School of Immunity and Infection, College of Medicine and Dental Sciences, University of Birmingham, Birmingham, UK Novartis Vaccines Institute for Global Health, Siena, Italy
    Eur J Immunol 44:1093-8. 2014
    ....
  8. pmc Importance of antibody and complement for oxidative burst and killing of invasive nontyphoidal Salmonella by blood cells in Africans
    Esther N Gondwe
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre 3, Malawi
    Proc Natl Acad Sci U S A 107:3070-5. 2010
    ..These findings increase the likelihood that an antibody-inducing vaccine will protect against invasive nontyphoidal Salmonella disease in African children...
  9. pmc Genotypic homogeneity of multidrug resistant S. Typhimurium infecting distinct adult and childhood susceptibility groups in Blantyre, Malawi
    Chisomo L Msefula
    Department of Microbiology, College of Medicine, University of Malawi, Blantyre, Malawi
    PLoS ONE 7:e42085. 2012
    ..These data suggest that the MDR bacterial population is not static, but is undergoing microevolution which might result in further epidemiology change...
  10. pmc Finger-prick blood samples can be used interchangeably with venous samples for CD4 cell counting indicating their potential for use in CD4 rapid tests
    Calman A MacLennan
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi
    AIDS 21:1643-5. 2007
    ..7 and 63.7 cells/microl) for absolute counts and 0.71% (limits of agreement -2.07 and 3.48%) for %CD4/lymphocyte suggesting that finger-prick blood samples can be used interchangeably with venous samples for CD4 cell counting...
  11. pmc The stability of complement-mediated bactericidal activity in human serum against Salmonella
    Colette M O'Shaughnessy
    Medical Research Council Centre for Immune Regulation and Clinical Immunology Service, Institute of Biomedical Research, School of Immunity and Infection, College of Medicine and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 7:e49147. 2012
    ..The study provides a scheme for determining the requirements for serum handling in relation to functional activity of complement in other systems...
  12. doi request reprint Absent bactericidal activity of mouse serum against invasive African nontyphoidal Salmonella results from impaired complement function but not a lack of antibody
    Matthew K Siggins
    Medical Research Council Centre for Immune Regulation and Clinical Immunology Service, Institute of Biomedical Research, School of Immunity and Infection, College of Medicine and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Immunol 186:2365-71. 2011
    ..This difference in Ab-dependent immunity to Salmonella in mice and men must be considered when applying findings from the mouse model of Salmonella disease and vaccination response to man...
  13. pmc The capsular polysaccharide Vi from Salmonella typhi is a B1b antigen
    Jennifer L Marshall
    Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, Institute for Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Immunol 189:5527-32. 2012
    ..This work therefore suggests that, in mice, B1b cells contribute to the protection induced by Vi Ag, and targeting non-Vi Ags as subunit vaccines may offer an attractive strategy to augment current Vi-based vaccine strategies...
  14. doi request reprint Purification of antibodies to O antigen of Salmonella Typhimurium from human serum by affinity chromatography
    Colette M O'Shaughnessy
    Novartis Vaccines Institute for Global Health, Via Fiorentina 1, 53100 Siena, Italy
    J Immunol Methods 387:199-210. 2013
    ..This method offers the potential to purify antibodies to Salmonella OAg from polyclonal serum following vaccination or natural exposure to Salmonella and so investigate the functionality and diversity of the antibody response to OAg...
  15. doi request reprint Measurement of antibodies to pneumococcal, meningococcal and haemophilus polysaccharides, and tetanus and diphtheria toxoids using a 19-plexed assay
    Alison M E Whitelegg
    Medical Research Council Centre for Immune Regulation and Clinical Immunology Service, Institute of Biomedical Research, School of Immunity and Infection, College of Medicine and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK
    J Immunol Methods 377:37-46. 2012
    ..It is suitable for use in standard clinical practice to assess the in vivo immune response to test vaccinations and measure absolute antibody levels to these antigens...
  16. pmc SadA, a trimeric autotransporter from Salmonella enterica serovar Typhimurium, can promote biofilm formation and provides limited protection against infection
    Dhaarini Raghunathan
    School of Immunity and Infection, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Infect Immun 79:4342-52. 2011
    ..Therefore, despite SadA having pleiotropic functions, it is not a dominant, protective antigen for antibody-mediated protection against Salmonella...