M J Mackinnon

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi request reprint The evolution of multiple drug resistance in malaria parasites
    M J Mackinnon
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Trans R Soc Trop Med Hyg 92:188-95. 1998
  2. pmc Immunity promotes virulence evolution in a malaria model
    Margaret J Mackinnon
    School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Biol 2:E230. 2004
  3. ncbi request reprint The effects of mosquito transmission and population bottlenecking on virulence, multiplication rate and rosetting in rodent malaria
    M J Mackinnon
    School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Int J Parasitol 35:145-53. 2005
  4. ncbi request reprint Drug resistance models for malaria
    M J Mackinnon
    School of Biological Sciences, University of Edinburgh, West Mains Rd, Edinburgh EH9 3JT, UK
    Acta Trop 94:207-17. 2005
  5. ncbi request reprint Virulence in rodent malaria: host genotype by parasite genotype interactions
    M J Mackinnon
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh, Scotland EH9 3JT, UK
    Infect Genet Evol 1:287-96. 2002
  6. ncbi request reprint The effects of host immunity on virulence-transmissibility relationships in the rodent malaria parasite Plasmodium chabaudi
    M J Mackinnon
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, Scotland
    Parasitology 126:103-12. 2003
  7. ncbi request reprint Plasmodium chabaudi: rosetting in a rodent malaria model
    Margaret J Mackinnon
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Rd, Edinburgh, East Lothian, UK
    Exp Parasitol 101:121-8. 2002
  8. pmc Selection for high and low virulence in the malaria parasite Plasmodium chabaudi
    M J Mackinnon
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Proc Biol Sci 266:741-8. 1999
  9. pmc Virulence in malaria: an evolutionary viewpoint
    Margaret J Mackinnon
    School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, Scotland, UK
    Philos Trans R Soc Lond B Biol Sci 359:965-86. 2004
  10. ncbi request reprint Rodent malaria parasites suffer from the presence of conspecific clones in three-clone Plasmodium chabaudi infections
    J C De Roode
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Road, Edinburgh EH9 3JT, Scotland, UK
    Parasitology 127:411-8. 2003

Collaborators

Detail Information

Publications25

  1. ncbi request reprint The evolution of multiple drug resistance in malaria parasites
    M J Mackinnon
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Trans R Soc Trop Med Hyg 92:188-95. 1998
    ..Reductions in fitness of the mutant in the absence of drugs (i.e., a fitness cost to resistance) and the degree of epistasis and the mode of gene action of the drugs do not alter these conclusions...
  2. pmc Immunity promotes virulence evolution in a malaria model
    Margaret J Mackinnon
    School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Biol 2:E230. 2004
    ..Thus, immune selection accelerated the rate of virulence evolution, rendering parasites more dangerous to naïve hosts. These results argue for further consideration of the evolutionary consequences for pathogen virulence of vaccination...
  3. ncbi request reprint The effects of mosquito transmission and population bottlenecking on virulence, multiplication rate and rosetting in rodent malaria
    M J Mackinnon
    School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Int J Parasitol 35:145-53. 2005
    ....
  4. ncbi request reprint Drug resistance models for malaria
    M J Mackinnon
    School of Biological Sciences, University of Edinburgh, West Mains Rd, Edinburgh EH9 3JT, UK
    Acta Trop 94:207-17. 2005
    ..A simple population dynamics model that captures the epidemiological effects of drug treatment and resistance, as opposed to a population genetics model that does not, is presented in order to illustrate the main conclusions...
  5. ncbi request reprint Virulence in rodent malaria: host genotype by parasite genotype interactions
    M J Mackinnon
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh, Scotland EH9 3JT, UK
    Infect Genet Evol 1:287-96. 2002
    ..Both mortality and morbidity-related factors might therefore influence the upper limit on virulence of malaria parasites...
  6. ncbi request reprint The effects of host immunity on virulence-transmissibility relationships in the rodent malaria parasite Plasmodium chabaudi
    M J Mackinnon
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, Scotland
    Parasitology 126:103-12. 2003
    ..These results support the basic assumption underlying our theory that predicts that anti-disease vaccines will select for higher virulence in those microparasites for which virulence is integrally linked to transmission...
  7. ncbi request reprint Plasmodium chabaudi: rosetting in a rodent malaria model
    Margaret J Mackinnon
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Rd, Edinburgh, East Lothian, UK
    Exp Parasitol 101:121-8. 2002
    ..The molecular basis of rosetting in P. chabaudi is unknown at present, but the results suggest that the molecules involved may differ from those in human-infecting species...
  8. pmc Selection for high and low virulence in the malaria parasite Plasmodium chabaudi
    M J Mackinnon
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Proc Biol Sci 266:741-8. 1999
    ..Thus, we found evidence of the factors assumed to drive evolution of increased virulence, but not those thought to counter this selection...
  9. pmc Virulence in malaria: an evolutionary viewpoint
    Margaret J Mackinnon
    School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, Scotland, UK
    Philos Trans R Soc Lond B Biol Sci 359:965-86. 2004
    ..One implication of this evolutionary view of virulence is that parasite populations are expected to evolve new levels of virulence in response to medical interventions such as vaccines and drugs...
  10. ncbi request reprint Rodent malaria parasites suffer from the presence of conspecific clones in three-clone Plasmodium chabaudi infections
    J C De Roode
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Road, Edinburgh EH9 3JT, Scotland, UK
    Parasitology 127:411-8. 2003
    ..These results suggest that in-host competition reduces both growth rate and probability of transmission for individual parasite clones...
  11. ncbi request reprint Population dynamics of Plasmodium falciparum in an unstable malaria area of eastern Sudan
    H A Babiker
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Scotland, UK
    Parasitology 120:105-11. 2000
    ..A higher frequency of inbreeding was estimated among the parasites that survived the dry season compared to the wet season...
  12. pmc Antimalarial drugs clear resistant parasites from partially immune hosts
    P Cravo
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Rd, Edinburgh EH9 3JT, United Kingdom
    Antimicrob Agents Chemother 45:2897-901. 2001
    ..In this study, using the rodent malaria model Plasmodium chabaudi, we show that drug-resistant parasites can be cleared by drugs when the host is partially immune...
  13. ncbi request reprint Imperfect vaccines and the evolution of pathogen virulence
    S Gandon
    Institute of Cell, Animal and Population Biology, The University of Edinburgh, Edinburgh EH9 3JT, UK
    Nature 414:751-6. 2001
    ..These findings have policy implications for the development and use of vaccines that are not expected to provide full immunity, such as candidate vaccines for malaria...
  14. ncbi request reprint Mosquito mortality and the evolution of malaria virulence
    H M Ferguson
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Evolution 57:2792-804. 2003
    ....
  15. ncbi request reprint The emergence of drug-resistant malaria
    I M Hastings
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Parasitology 117:411-7. 1998
    ..These factors are discussed in relation to the practical implementation of drug control programmes...
  16. pmc Low multiplication rates of African Plasmodium falciparum isolates and lack of association of multiplication rate and red blood cell selectivity with malaria virulence
    Anne Marie Deans
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    Am J Trop Med Hyg 74:554-63. 2006
    ..This raises the possibility of differences in the mechanisms of malaria virulence between sub-Saharan Africa and Asia...
  17. pmc A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria
    Ian A Cockburn
    Institute of Cell Animal and Population Biology, Ashworth Laboratories, King s Buildings, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Proc Natl Acad Sci U S A 101:272-7. 2004
    ..We have therefore identified CR1 as a new malaria resistance gene and provided compelling evidence that rosetting is an important parasite virulence phenotype that should be a target for drug and vaccine development...
  18. doi request reprint Differential antibody responses to Plasmodium falciparum merozoite proteins in Malawian children with severe malaria
    Carlota Dobano
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland
    J Infect Dis 197:766-74. 2008
    ..005; for MSP-2, P< .05) or SMA (for MSP-1 and MSP-2, P<.001; for AMA-1, P< .005). These distinct IgG patterns might reflect differences in age, exposure to P. falciparum, and/or genetic factors affecting immune responses...
  19. pmc Heritability of malaria in Africa
    Margaret J Mackinnon
    School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Med 2:e340. 2005
    ..While many individual genes have been identified that confer protection against malaria, the overall impact of host genetics on malarial risk remains unknown...
  20. ncbi request reprint Drug resistance-virulence relationship in Plasmodium falciparum causing severe malaria in an area of seasonal and unstable transmission
    Hayder A Giha
    Malaria Research Centre MalRC, Department of Biochemistry, Faculty of Medicine, University of Khartoum, P O Box 102, Khartoum, Sudan
    Acta Trop 97:181-7. 2006
    ..There was a trend towards a higher gametocyte rate among severe malaria patients compared with uncomplicated malaria cases. These results are discussed in relation to the fitness of drug resistant parasites...
  21. ncbi request reprint Increased density but not prevalence of gametocytes following drug treatment of Plasmodium falciparum
    Eltayeb Ali
    Sudan Atomic Energy Commission, Khartoum, Sudan
    Trans R Soc Trop Med Hyg 100:176-83. 2006
    ..Infections with drug-resistant parasites tended to have higher gametocyte prevalence than drug-sensitive infections...
  22. ncbi request reprint Drug resistance in malaria: its population biology and implications for control
    Hamza A Babiker
    Acta Trop 94:161-2. 2005
  23. ncbi request reprint Evolution of drug-resistance genes in Plasmodium falciparum in an area of seasonal malaria transmission in Eastern Sudan
    Abdel Muhsin A Abdel-Muhsin
    Tropical Medicine Research Institute, National Institute for Research, and Department of Biochemistry, Faculty of Medicine, University of Khartoum, Khartoum, Sudan
    J Infect Dis 189:1239-44. 2004
    ..This cyclical fluctuation in drug-resistance genes most likely reflects seasonal variation in drug pressure and differences in the fitness of resistant and sensitive parasites...
  24. pmc Breadth and magnitude of antibody responses to multiple Plasmodium falciparum merozoite antigens are associated with protection from clinical malaria
    Faith H A Osier
    KEMRI Centre for Geographic Medicine Research, Coast, P O Box 230 80108, Kilifi, Kenya
    Infect Immun 76:2240-8. 2008
    ....
  25. ncbi request reprint Genetic complexity of Plasmodium falciparum in two ethnic groups of Burkina Faso with marked differences in susceptibility to malaria
    Giacomo M Paganotti
    Instituto Pasteur, Fondazione Cenci Bolognetti, and Dipartimento di Scienze di Sanità Pubblica, Sezione di Parassitologia, Universita di Roma La Sapienza, Rome, Italy
    Am J Trop Med Hyg 71:173-8. 2004
    ..This effect was especially marked in older children. These differences can most probably be attributed to genetic differences in immune responsiveness to malaria between the two ethnic groups...