Research Topics
| P MackinSummaryAffiliation: University of Newcastle Country: UK Publications
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Detail Information
Publications
A four-year naturalistic prospective study of cardiometabolic disease in antipsychotic-treated patientsP Mackin
Academic Psychiatry, Institute of Neuroscience, Newcastle General Hospital, Newcastle University, Westgate Road, Newcastle upon Tyne NE4 6BE, United Kingdom
Eur Psychiatry 27:50-5. 2012..Lipid-lowering therapy is associated with a significant reduction in cardiovascular risk...- Prolactin and smoking status in antipsychotic-treated patientsPaul Mackin
Institute of Neuroscience, Newcastle University, UK
J Psychopharmacol 25:698-703. 2011..2 to 4.7, p = 0.002). In this preliminary, cross-sectional study, there was a robust statistical relationship between cigarette smoking and prolactinaemia. The mechanism(s) underpinning this association needs further investigation... - A prospective study of glycaemic status in anti-psychotic-treated patientsP Mackin
School of Neurology, Neurobiology and Psychiatry, Newcastle University, Newcastle upon Tyne, UK
J Psychopharmacol 22:563-6. 2008..Switching to another agent simply on the basis of the development of IFG may not offer any advantage, especially if the mental state is stable... 
Cardiac side effects of psychiatric drugsPaul Mackin
School of Neurology, Neurobiology and Psychiatry, Newcastle University, Leazes Wing Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne, UK
Hum Psychopharmacol 23:3-14. 2008..These risks need to be seen in the context of the undoubted therapeutic efficacy of the psychotropic armamentarium and the relief that these drugs bring to those suffering from mental disorder...- Metabolic disease and cardiovascular risk in people treated with antipsychotics in the communityPaul Mackin
School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Leazes Wing Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
Br J Psychiatry 191:23-9. 2007..Prevalence of physical comorbidity in severe mental illness is a significant public health concern, but comparative data in people with diagnoses other than schizophrenia are sparse... 
A prospective study of monitoring practices for metabolic disease in antipsychotic-treated community psychiatric patientsPaul Mackin
School of Neurology, Neurobiology and Psychiatry, Newcastle University, Newcastle upon Tyne, UK
BMC Psychiatry 7:28. 2007..A number of recent guidelines and consensus statements recommend stringent monitoring of metabolic function in individuals receiving antipsychotic drugs...- Changes in brain-derived neurotrophic factor following treatment with mifepristone in bipolar disorder and schizophreniaPaul Mackin
School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Leazes Wing Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
Aust N Z J Psychiatry 41:321-6. 2007..The aim of the present study was to investigate BDNF levels in patients with bipolar disorder and schizophrenia before and after treatment with the glucocorticoid receptor antagonist mifepristone... - Culture and assessment of manic symptomsPaul Mackin
School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK
Br J Psychiatry 189:379-80. 2006..001) and between India and UK (P<0.001) rater groups. Overall, differences between India and US rater groups were less marked (P=0.28). These differences suggest that cultural biases influence the interpretation of manic symptoms... - QTc interval measurement and metabolic parameters in psychiatric patients taking typical or atypical antipsychotic drugs: a preliminary studyPaul Mackin
School of Neurology, Neurobiology, and Psychiatry, University of Newcastle upon Tyne, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, United Kingdom
J Clin Psychiatry 66:1386-91. 2005..Abnormalities of glucose homeostasis, which may be more common in individuals with major mood disorders and schizophrenia, also affect the QTc interval... - Prevalence of obesity, glucose homeostasis disorders and metabolic syndrome in psychiatric patients taking typical or atypical antipsychotic drugs: a cross-sectional studyP Mackin
Department of Psychiatry, University of Newcastle upon Tyne, Leazes Wing, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK
Diabetologia 48:215-21. 2005..We investigated the hypothesis that atypical antipsychotics are associated with a greater degree of metabolic dysfunction than typical agents... - Rapid cycling bipolar disorder: historical overview and focus on emerging treatmentsPaul Mackin
School of Neurology, Neurobiology and Psychiatry, Department of Psychiatry, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne, UK
Bipolar Disord 6:523-9. 2004.... - Olanzapine-induced hyperglycaemic coma and neuroleptic malignant syndrome: case report and review of literatureN Ahuja
Wallsend Community Mental Health Team, Sir GB Hunter Hospital, Wallsend, Tyne and Wear, UK
J Psychopharmacol 24:125-30. 2010..These questions are considered in the context of currently available literature... - Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugsL J Hampson
Institute of Cellular Medicine, Newcastle University, The Medical School, Framlington Place, Newcastle upon Tyne, UK
Diabetologia 50:1743-51. 2007..The aims of this study were to determine the direct effects of 5-HT in hepatocytes and to test the hypothesis that atypical antipsychotic drugs that predispose to type 2 diabetes counter-regulate the effects of 5-HT... - Executive and visuospatial sketchpad resources in euthymic bipolar disorder: Implications for visuospatial working memory architectureJill M Thompson
University of Newcastle upon Tyne, UK
Memory 14:437-51. 2006..ANCOVA indicated that impaired executive function underpinned patients' CBT performance. Implications for the interface between executive and slave systems of working memory are discussed... - Significance of microalbuminuria in long-duration type 1 diabetesChankramath S Arun
Department of Medicine, The Medical School, University of Newcastle, Newcastle upon Tyne, UK
Diabetes Care 26:2144-9. 2003..The value of microalbuminuria (MA) in predicting renal disease and premature mortality in longer duration type 1 diabetes is unclear... - Brain-derived neurotrophic factor in patients with remitted depressionPaul Mackin
Am J Psychiatry 162:2399; author reply 2399-400. 2005 - Reply to Dr. J-C Shim and colleagues regarding "Fluoxetine augmentation of haloperidol in chronic schizophrenia" [J Clin Psychopharmacol 2003;23:520-521]Paul Mackin
J Clin Psychopharmacol 24:670. 2004 - Wake-up call for British psychiatryNick Craddock
Department of Psychological Medicine, Medical School, Cardiff University, Heath Park, Cardiff, UK
Br J Psychiatry 193:6-9. 2008..On the 200th birthday of psychiatry, it is fitting to reconsider the specialty's core values and renew efforts to use psychiatric skills for the maximum benefit of patients... - Weight gain and antipsychoticsPaul Mackin
J Clin Psychiatry 66:950-1; author reply 951. 2005 - Reduced plasma levels of NGF and BDNF in patients with acute coronary syndromesPaul Mackin
Int J Cardiol 105:352; author reply 353-4. 2005 
Prognosis in obesity: obesity in severe mental illness poses particular problemsPaul Mackin
BMJ 331:452-3; author reply 453. 2005- Schizophrenia and increased risk of cardiovascular diseasePaul Mackin
Am Heart J 151:e8. 2006