Laura M Machesky

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi request reprint Sharks' teeth and dunes
    Laura M Machesky
    Nature 417:494-7. 2002
  2. pmc N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods
    Xinzi Yu
    The Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, Scotland, UK
    J Cell Biol 199:527-44. 2012
  3. pmc Activated mutant NRas(Q61K) drives aberrant melanocyte signaling, survival, and invasiveness via a Rac1-dependent mechanism
    Ang Li
    The Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
    J Invest Dermatol 132:2610-21. 2012
  4. pmc Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny
    Simon D J Calaminus
    Beatson Institute for Cancer Research, University of Glasgow, Glasgow, United Kingdom
    PLoS ONE 7:e51361. 2012
  5. pmc Cells assemble invadopodia-like structures and invade into matrigel in a matrix metalloprotease dependent manner in the circular invasion assay
    Xinzi Yu
    The Beatson Institute for Cancer Research, Glasgow University College of Medical Veterinary and Life Sciences, Glasgow, United Kingdom
    PLoS ONE 7:e30605. 2012
  6. pmc Phenotypes induced by NM causing alpha-skeletal muscle actin mutants in fibroblasts, Sol 8 myoblasts and myotubes
    Drieke Vandamme
    Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, Baertsoenkaai 3, Gent, Belgium
    BMC Res Notes 2:40. 2009
  7. pmc Arp2/3 complex activity in filopodia of spreading cells
    Simon A Johnston
    University of Birmingham School of Biosciences, Edgbaston, Birmingham, UK
    BMC Cell Biol 9:65. 2008
  8. doi request reprint Lamellipodia and filopodia in metastasis and invasion
    Laura M Machesky
    The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, United Kingdom
    FEBS Lett 582:2102-11. 2008
  9. ncbi request reprint Actin-based protrusions: promoters or inhibitors of cancer invasion?
    Laura M Machesky
    The Beatson Institute for Cancer Research, Garscube Estate, Bearsden, Glasgow, Scotland
    Cancer Cell 16:5-7. 2009
  10. ncbi request reprint Scar/WAVE3 contributes to motility and plasticity of lamellipodial dynamics but not invasion in three dimensions
    Heather J Spence
    The Beatson Institute for Cancer Research, Garscube Estate, Switchback Rd, Bearsden, Glasgow G61 1BD, UK
    Biochem J 448:35-42. 2012

Detail Information

Publications55

  1. ncbi request reprint Sharks' teeth and dunes
    Laura M Machesky
    Nature 417:494-7. 2002
  2. pmc N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods
    Xinzi Yu
    The Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, Scotland, UK
    J Cell Biol 199:527-44. 2012
    ..Thus, N-WASP is crucial for extension of invasive pseudopods into which MT1-MMP traffics and for providing the correct cytoskeletal framework to couple matrix remodeling with protrusive invasion...
  3. pmc Activated mutant NRas(Q61K) drives aberrant melanocyte signaling, survival, and invasiveness via a Rac1-dependent mechanism
    Ang Li
    The Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
    J Invest Dermatol 132:2610-21. 2012
    ....
  4. pmc Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny
    Simon D J Calaminus
    Beatson Institute for Cancer Research, University of Glasgow, Glasgow, United Kingdom
    PLoS ONE 7:e51361. 2012
    ..These results have fundamental implications for the use of the Pf4-Cre mouse model and for our understanding of a possible role for Pf4 in the development of the hematopoietic lineage...
  5. pmc Cells assemble invadopodia-like structures and invade into matrigel in a matrix metalloprotease dependent manner in the circular invasion assay
    Xinzi Yu
    The Beatson Institute for Cancer Research, Glasgow University College of Medical Veterinary and Life Sciences, Glasgow, United Kingdom
    PLoS ONE 7:e30605. 2012
    ..We propose that this is a useful assay for routine and medium throughput analysis of invasion of cancer cells in vitro and the study of cells migrating in a 3D environment...
  6. pmc Phenotypes induced by NM causing alpha-skeletal muscle actin mutants in fibroblasts, Sol 8 myoblasts and myotubes
    Drieke Vandamme
    Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, Baertsoenkaai 3, Gent, Belgium
    BMC Res Notes 2:40. 2009
    ..CONCLUSION: Our results confirm that NM associated alpha-actin mutations induce a range of defects at the biochemical level as well as in cultured fibroblasts and muscle cells...
  7. pmc Arp2/3 complex activity in filopodia of spreading cells
    Simon A Johnston
    University of Birmingham School of Biosciences, Edgbaston, Birmingham, UK
    BMC Cell Biol 9:65. 2008
    ..The interplay between filopodial and lamellipodial protrusions is an area of much interest as it is thought to be a key determinant of how cells make motility choices...
  8. doi request reprint Lamellipodia and filopodia in metastasis and invasion
    Laura M Machesky
    The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, United Kingdom
    FEBS Lett 582:2102-11. 2008
    ..As key proteins are uncovered which regulate the assembly of actin-based structures, these need to be considered in light of whether they represent potential invasion and metastasis proteins...
  9. ncbi request reprint Actin-based protrusions: promoters or inhibitors of cancer invasion?
    Laura M Machesky
    The Beatson Institute for Cancer Research, Garscube Estate, Bearsden, Glasgow, Scotland
    Cancer Cell 16:5-7. 2009
    ..This study challenges ideas about the role of actin in cancer invasion...
  10. ncbi request reprint Scar/WAVE3 contributes to motility and plasticity of lamellipodial dynamics but not invasion in three dimensions
    Heather J Spence
    The Beatson Institute for Cancer Research, Garscube Estate, Switchback Rd, Bearsden, Glasgow G61 1BD, UK
    Biochem J 448:35-42. 2012
    ....
  11. pmc Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression
    Ang Li
    The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
    Dev Cell 21:722-34. 2011
    ..Myosin contractility balances the extension of long pseudopods by effecting retraction and allowing force generation for movement through the complex 3D epidermal environment...
  12. doi request reprint Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation
    Yafeng Ma
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
    Development 140:2203-11. 2013
    ..These data indicate that fascin 1 not only promotes cell migration in mouse melanocytes but it also has a role in growth and cell cycle progression...
  13. ncbi request reprint Tissue inducible Lifeact expression allows visualization of actin dynamics in vivo and ex vivo
    Hannah Schachtner
    The Beatson Institute for Cancer Research, Garscube Estate, Bearsden, Glasgow, United Kingdom
    Eur J Cell Biol 91:923-9. 2012
    ..Thus, through use of this mouse model, we were able to gain insights into the actin dynamics of cells that could only previously be studied using fixed specimens or following isolation from their native tissue environment...
  14. doi request reprint Cyclical action of the WASH complex: FAM21 and capping protein drive WASH recycling, not initial recruitment
    Laura Park
    CR UK Beatson Institute for Cancer Research, Glasgow University, Switchback Road, Glasgow G61 1BD, UK
    Dev Cell 24:169-81. 2013
    ..Recycling is driven by FAM21's interaction with capping protein, which couples the WASH complex to dynamic actin on vesicles...
  15. pmc The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion
    Ang Li
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, Scotland, UK
    Curr Biol 20:339-45. 2010
    ..We provide a potential molecular mechanism for how fascin increases the invasiveness of cancer cells, and we compare invadopodia with invasive filopod-like structures in 3D...
  16. pmc Actin on trafficking: could actin guide directed receptor transport?
    Tobias Zech
    Beatson Institute for Cancer Research, Bearsden, UK
    Cell Adh Migr 6:476-81. 2012
    ....
  17. ncbi request reprint Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes
    Ang Li
    CRUK Beatson Institute for Cancer Research, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
    Gastroenterology 146:1386-96.e1-17. 2014
    ..The actin-bundling protein fascin has been identified as a biomarker of invasive and advanced PDAC and regulates cell migration and invasion in vitro. We investigated fascin expression and its role in PDAC progression in mice...
  18. doi request reprint Loss of Scar/WAVE complex promotes N-WASP- and FAK-dependent invasion
    Haoran Tang
    The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK
    Curr Biol 23:107-17. 2013
    ..It is becoming ever more apparent that 2D and 3D migration utilize the actin cytoskeletal machinery differently...
  19. pmc The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration
    Tobias Zech
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK
    J Cell Sci 124:3753-9. 2011
    ..Thus, we implicate WASH and Arp2/3-driven actin nucleation in receptor recycling leading to invasive motility...
  20. doi request reprint Pseudopod growth and evolution during cell movement is controlled through SCAR/WAVE dephosphorylation
    Seiji Ura
    Beatson Institute for Cancer Research, Bearsden, Glasgow, UK
    Curr Biol 22:553-61. 2012
    ..SCAR/WAVE is phosphorylated at multiple sites, but how this affects its biological activity is unclear. Here we show that dephosphorylation of Dictyostelium SCAR controls normal pseudopod dynamics...
  21. pmc Mtss1 promotes cell-cell junction assembly and stability through the small GTPase Rac1
    John C Dawson
    Beatson Institute for Cancer Research, Glasgow, United Kingdom
    PLoS ONE 7:e31141. 2012
    ..We thus propose that Mtss1 promotes Rac1 activation and actin recruitment driving junction maintenance. We suggest that the observed loss of Mtss1 in cancers may compromise junction stability and thus promote EMT and metastasis...
  22. pmc SCAR knockouts in Dictyostelium: WASP assumes SCAR's position and upstream regulators in pseudopods
    Douwe M Veltman
    Beatson Institute for Cancer Research, Glasgow G61 1BD, Scotland, UK
    J Cell Biol 198:501-8. 2012
    ..We conclude that WASP and SCAR can regulate pseudopod actin using similar mechanisms...
  23. ncbi request reprint Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane
    Hannah Schachtner
    University of Glasgow College of Medical, Veterinary and Life Sciences and Beatson Institute for Cancer Research, Bearsden, Glasgow, UK
    Blood 121:2542-52. 2013
    ....
  24. ncbi request reprint Podosomes in adhesion, migration, mechanosensing and matrix remodeling
    Hannah Schachtner
    CRUK Beatson Institute for Cancer Research and College of Medical, Veterinary and Life Sciences, Glasgow University, Garscube Campus, Switchback Rd, Bearsden, Glasgow, United Kingdom
    Cytoskeleton (Hoboken) 70:572-89. 2013
    ..We also discuss the emerging idea that podosomes can sense matrix stiffness and enable cells to respond to their environment...
  25. pmc P-Rex1 is required for efficient melanoblast migration and melanoma metastasis
    Colin R Lindsay
    The Beatson Institute for Cancer Research, Glasgow G61 1BD, UK
    Nat Commun 2:555. 2011
    ..We conclude that P-Rex1 has an important role in melanoblast migration and cancer progression to metastasis in mice and humans...
  26. pmc Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis
    Michael Carnell
    Cancer Research UK Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, Scotland, UK
    J Cell Biol 193:831-9. 2011
    ..Our data imply a new mechanism, actin-mediated sorting, in which WASH and the Arp2/3 complex polymerize actin on vesicles to drive the separation and recycling of proteins such as the V-ATPase...
  27. doi request reprint Actin dynamics at the leading edge: from simple machinery to complex networks
    Robert H Insall
    CRUK Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, Scotland
    Dev Cell 17:310-22. 2009
    ..Future progress depends on connecting these processes and components to the dynamic behavior of the whole cell in three dimensions...
  28. doi request reprint Functional analysis of Dictyostelium IBARa reveals a conserved role of the I-BAR domain in endocytosis
    Douwe M Veltman
    Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, UK
    Biochem J 436:45-52. 2011
    ..The results from the present study suggest that I-BAR-containing proteins help generate the membrane curvature required for endocytosis and implies an unexpected role for IRSp53 family proteins in vesicle trafficking...
  29. pmc Loss of reelin expression in breast cancer is epigenetically controlled and associated with poor prognosis
    Torsten Stein
    Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, Department of Pathology, Western Infirmary, University of Glasgow, Glasgow, G11 6NT, UK
    Am J Pathol 177:2323-33. 2010
    ..We conclude that reelin may play an important role in controlling invasiveness and metastatic potential of breast cancer cells and that its expression is controlled by promoter methylation...
  30. pmc Myopathy-causing actin mutations promote defects in serum-response factor signalling
    Balazs Visegrady
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G611BD, U K
    Biochem J 427:41-8. 2010
    ..We propose that altered serum-response factor signalling could be a major factor in actin-based nemaline myopathy, and that this area could be exploited to develop therapies for sufferers...
  31. ncbi request reprint Src-dependent phosphorylation of Scar1 promotes its association with the Arp2/3 complex
    Hazel Ardern
    The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow G61 1BD, United Kingdom
    Cell Motil Cytoskeleton 63:6-13. 2006
    ..Thus, Src may act as an intermediary to regulate the activity of the Arp2/3 complex in response to external stimuli, via modulation of its interaction with WAVE/Scar proteins...
  32. pmc Fascin regulates the migration of subventricular zone-derived neuroblasts in the postnatal brain
    Martina Sonego
    Wolfson Centre for Age Related Diseases, King s College London, Guy s Campus, London SE1 1UL, United Kingdom
    J Neurosci 33:12171-85. 2013
    ..We propose that a tightly regulated phospho/dephospho-fascin cycle modulated by extracellular signals is required for the polarized morphology and migration in neuroblasts, thus contributing to efficient neurogenesis. ..
  33. ncbi request reprint Linked regulation of motility and integrin function in activated migrating neutrophils revealed by interference in remodelling of the cytoskeleton
    Stephen I Anderson
    Department of Physiology, The Medical School, The University of Birmingham, Birmingham B15 2TT, UK
    Cell Motil Cytoskeleton 54:135-46. 2003
    ..They also suggest a role of the Arp2/3 complex and WASP-family in co-ordinating actin polymerisation and integrin function in migrating neutrophils...
  34. ncbi request reprint Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B
    Guillaume Bompard
    School of Biosciences, Division of Molecular Cell Biology, University of Birmingham, Edgbaston, Birmingham, B15 2TT UK
    J Cell Sci 118:5393-403. 2005
    ..Thus, MIM-B is unlikely to be a metastasis suppressor but acts as a scaffold protein that interacts with Rac, actin and actin-associated proteins to modulate lamellipodia formation...
  35. ncbi request reprint Regulation of WASP: PIP2 Pipped by Toca-1?
    Robert H Insall
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Cell 118:140-1. 2004
    ..This discovery changes our picture of how small GTPases and multiple other signals converge to stimulate actin polymerization and cell motility...
  36. ncbi request reprint The WASP-Arp2/3 pathway: genetic insights
    Maria K Vartiainen
    Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, Transcription Laboratory, London, WC2A 3PX, UK
    Curr Opin Cell Biol 16:174-81. 2004
    ..It has also become clear that precise regulation of both Scar and WASP activity is of the utmost importance for their physiological functions...
  37. ncbi request reprint Identification of the p16-Arc subunit of the Arp 2/3 complex as a substrate of MAPK-activated protein kinase 2 by proteomic analysis
    Saurabh Singh
    Department of Biochemistry and Molecular Biology, Medicine, and Pharmacology, University of Louisville, KY 40202, USA
    J Biol Chem 278:36410-7. 2003
    ..The ability of MAPKAPK2 to phosphorylate one isoform of p16-Arc suggests a possible mechanism by which the p38 MAPK cascade regulates remodeling of the actin cytoskeleton...
  38. pmc Involvement of the Arp2/3 complex and Scar2 in Golgi polarity in scratch wound models
    Juana Magdalena
    School of Biosciences, University of Birmingham, Edgbaston, United Kingdom
    Mol Biol Cell 14:670-84. 2003
    ..Furthermore, in NIH 3T3 cells, Scar2 and the Arp2/3 complex appear to be involved in the establishment and maintenance of Golgi polarity during directed migration...
  39. ncbi request reprint Expression of WASP and Scar1/WAVE1 actin-associated proteins is differentially modulated during differentiation of HL-60 cells
    Sophie Launay
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    Cell Motil Cytoskeleton 54:274-85. 2003
    ..These observations show for the first time that modulation of Scar1 and WASP expression is a component of the differentiation program of myeloid precursors and indicate that WASP and Scar1 have different roles in mature myeloid cells...
  40. pmc MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta
    Jacquelyn A Woodings
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Biochem J 371:463-71. 2003
    ..We postulate that MIM-B may be a regulator of actin assembly downstream of tyrosine kinase signalling and that this activity may explain the involvement of MIM in the metastasis of cancer cells...
  41. ncbi request reprint Microtubule involvement in NIH 3T3 Golgi and MTOC polarity establishment
    Juana Magdalena
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    J Cell Sci 116:743-56. 2003
    ..In addition, this study indicates that MTOC and Golgi polarization events are separately controlled...
  42. ncbi request reprint Cell structure and dynamics
    Laura M Machesky
    Curr Opin Cell Biol 15:2-5. 2003
  43. ncbi request reprint WAVE/Scars in platelets
    Atsushi Oda
    Laboratory of Environmental Biology, Department of Preventive Medicine, Hokkaido University School of Medicine, Kitaku, Sapporo, 060 8638, Japan
    Blood 105:3141-8. 2005
    ..These data suggest that the 3 WAVE isoforms exhibit common and distinct features and may potentially be involved in the regulation of actin cytoskeleton in platelets...
  44. ncbi request reprint Congenital myopathies: diseases of the actin cytoskeleton
    Emilie Clarkson
    School of Biosciences, University of Birmingham, Birmingham, B15 2TT, UK
    J Pathol 204:407-17. 2004
    ..There are no existing cures for congenital myopathies, although improvements can be made to both the standard of living and the life expectancy of the patient through various therapies...
  45. pmc Studies on the actin-binding protein HS1 in platelets
    Steven G Thomas
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    BMC Cell Biol 8:46. 2007
    ..The Arp2/3 complex is highly regulated by a number of actin-binding proteins including the haematopoietic-specific protein HS1 and its homologue cortactin. The present study investigates the role of HS1 in platelets using HS1-/- mice...
  46. ncbi request reprint MIM: a multifunctional scaffold protein
    Laura M Machesky
    School of Biosciences, University of Birmingham, Birmingham, B15 2TT, UK
    J Mol Med (Berl) 85:569-76. 2007
    ..How this multifunctional protein and its close relative ABBA-1 regulate cellular behaviour is still very much an open question...
  47. ncbi request reprint Actin dynamics at sites of extracellular matrix degradation
    Massimiliano Baldassarre
    Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, Via Nazionale 8a, I 66030 S Maria Imbaro, Chieti, Italy
    Eur J Cell Biol 85:1217-31. 2006
    ..In conclusion, invadopodia-associated actin comets are a striking example of consistently arising, spontaneous expression of actin-driven propulsion events that also represent a valuable experimental paradigm...
  48. ncbi request reprint Characterisation of IRTKS, a novel IRSp53/MIM family actin regulator with distinct filament bundling properties
    Thomas H Millard
    School of Biosciences, University of Birmingham, Birmingham, B15 2TT, UK
    J Cell Sci 120:1663-72. 2007
    ..Lastly, we could not detect actin monomer sequestration by the Ct extension of IRTKS as would be expected with a conventional WH2 motif, but it did interact with actin filaments...
  49. ncbi request reprint Bar domain proteins: a role in tubulation, scission and actin assembly in clathrin-mediated endocytosis
    John C Dawson
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
    Trends Cell Biol 16:493-8. 2006
    ..We describe three classes of BAR domains, BAR, N-BAR and F-BAR, providing examples of each discussing and how they function in linking membranes to the actin cytoskeleton in endocytosis...
  50. pmc Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization
    Jean Paul ten Klooster
    The Netherlands Cancer Institute, Division of Cell Biology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Biochem J 397:39-45. 2006
    ..This 'self-amplifying' signalling module involving Tiam1, Rac and the Arp2/3 complex could thus drive actin polymerization at specific sites in cells that are required for dynamic morphological changes...
  51. ncbi request reprint Arabidopsis group Ie formins localize to specific cell membrane domains, interact with actin-binding proteins and cause defects in cell expansion upon aberrant expression
    Michael J Deeks
    The Integrative Cell Biology Laboratory, School of Biological and Biomedical Sciences, University of Durham, Science Laboratories, South Road, Durham DH1 3LE, UK
    New Phytol 168:529-40. 2005
    ..Taken together, these data suggest that the group Ie formins act with profilin to regulate actin polymerization at specific sites associated with the cell membrane...
  52. pmc Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow
    Owen J T McCarty
    Centre for Cardiovascular Sciences, The Institute of Biomedical Research, School of Biosciences, University of Birmingham, United Kingdom
    J Biol Chem 280:39474-84. 2005
    ....
  53. pmc Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53
    Thomas H Millard
    School of Biosciences, The University of Birmingham, Edgbaston, Birmingham, UK
    EMBO J 24:240-50. 2005
    ..This study promotes an expanded view of IRSp53 as an actin regulator that integrates scaffolding and effector functions...
  54. ncbi request reprint MRL proteins: leading Ena/VASP to Ras GTPases
    John A Legg
    Nat Cell Biol 6:1015-7. 2004
  55. ncbi request reprint Identification of the insulin-responsive tyrosine phosphorylation sites on IRSp53
    Man Yeung Heung
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Eur J Cell Biol 87:699-708. 2008
    ..Furthermore, the tyrosine phosphorylation status does not appear to affect the cell morphology and production of filopod-like structures upon expression of IRSp53...