Sandra Macfarlane

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. ncbi request reprint Review article: prebiotics in the gastrointestinal tract
    S Macfarlane
    Dundee University Gut Group, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, Dundee, UK
    Aliment Pharmacol Ther 24:701-14. 2006
  2. ncbi request reprint Intestinal bacteria and ulcerative colitis
    J H Cummings
    Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital Medical School, Dundee DD1 9SY, UK
    Curr Issues Intest Microbiol 4:9-20. 2003
  3. ncbi request reprint Microbial biofilms in the human gastrointestinal tract
    S Macfarlane
    Dundee University Gut Group, Ninewells Hospital Medical School, Dundee, UK
    J Appl Microbiol 102:1187-96. 2007
  4. ncbi request reprint Intestinal bacteria and inflammatory bowel disease
    Sandra Macfarlane
    Microbiology and Gut Biology Group, University of Dundee, Dundee, UK
    Crit Rev Clin Lab Sci 46:25-54. 2009
  5. ncbi request reprint Microbial colonization of the upper gastrointestinal tract in patients with Barrett's esophagus
    Sandra Macfarlane
    Dundee University Gut Group, Ninewells Hospital Medical School, Dundee, United Kingdom
    Clin Infect Dis 45:29-38. 2007
  6. pmc Composition and metabolic activities of bacterial biofilms colonizing food residues in the human gut
    Sandra Macfarlane
    Gut Group, University of Dundee, Level 6, Ninewells Hospital Medical School, Dundee DD1 9SY, United Kingdom
    Appl Environ Microbiol 72:6204-11. 2006
  7. doi request reprint Microbial biofilm communities in the gastrointestinal tract
    Sandra Macfarlane
    Dundee University Gut Group, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, Dundee, UK
    J Clin Gastroenterol 42:S142-3. 2008
  8. pmc Colonization of mucin by human intestinal bacteria and establishment of biofilm communities in a two-stage continuous culture system
    Sandra Macfarlane
    Microbiology and Gut Biology Group, University of Dundee Medical School, Level 6, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, United Kingdom
    Appl Environ Microbiol 71:7483-92. 2005
  9. ncbi request reprint Mucosal bacteria in ulcerative colitis
    S Macfarlane
    Microbiology and Gut Biology Group, University of Dundee, Dundee DD1 9SY, UK
    Br J Nutr 93:S67-72. 2005
  10. ncbi request reprint Chemotaxonomic analysis of bacterial populations colonizing the rectal mucosa in patients with ulcerative colitis
    Sandra Macfarlane
    Microbiology and Gut Biology Group, University of Dundee, Ninewells Hospital Medical School, Dundee, United Kingdom
    Clin Infect Dis 38:1690-9. 2004

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Review article: prebiotics in the gastrointestinal tract
    S Macfarlane
    Dundee University Gut Group, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, Dundee, UK
    Aliment Pharmacol Ther 24:701-14. 2006
    ..It is therefore expected that prebiotics will improve health in a way similar to probiotics, whilst at the same time being cheaper, and carrying less risk and being easier to incorporate into the diet than probiotics...
  2. ncbi request reprint Intestinal bacteria and ulcerative colitis
    J H Cummings
    Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital Medical School, Dundee DD1 9SY, UK
    Curr Issues Intest Microbiol 4:9-20. 2003
    ..There is scope for more work in this area focussing on the mucosal microflora, its interactions with the gut immune system, its metabolic properties and the potential ways of modifying it...
  3. ncbi request reprint Microbial biofilms in the human gastrointestinal tract
    S Macfarlane
    Dundee University Gut Group, Ninewells Hospital Medical School, Dundee, UK
    J Appl Microbiol 102:1187-96. 2007
    ..However, recent work has shown that there is considerable potential to alter the species composition of mucosal biofilms in a beneficial way using synbiotics...
  4. ncbi request reprint Intestinal bacteria and inflammatory bowel disease
    Sandra Macfarlane
    Microbiology and Gut Biology Group, University of Dundee, Dundee, UK
    Crit Rev Clin Lab Sci 46:25-54. 2009
    ....
  5. ncbi request reprint Microbial colonization of the upper gastrointestinal tract in patients with Barrett's esophagus
    Sandra Macfarlane
    Dundee University Gut Group, Ninewells Hospital Medical School, Dundee, United Kingdom
    Clin Infect Dis 45:29-38. 2007
    ..The aim of this study was to characterize microbial communities in esophageal aspirate specimens and on distal esophageal mucosal samples from patients with BE...
  6. pmc Composition and metabolic activities of bacterial biofilms colonizing food residues in the human gut
    Sandra Macfarlane
    Gut Group, University of Dundee, Level 6, Ninewells Hospital Medical School, Dundee DD1 9SY, United Kingdom
    Appl Environ Microbiol 72:6204-11. 2006
    ..Acetate was the principal fermentation product formed by biofilm bacteria, whereas higher levels of butyrate were produced by nonadherent populations, showing that the two communities were metabolically distinct...
  7. doi request reprint Microbial biofilm communities in the gastrointestinal tract
    Sandra Macfarlane
    Dundee University Gut Group, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, Dundee, UK
    J Clin Gastroenterol 42:S142-3. 2008
    ....
  8. pmc Colonization of mucin by human intestinal bacteria and establishment of biofilm communities in a two-stage continuous culture system
    Sandra Macfarlane
    Microbiology and Gut Biology Group, University of Dundee Medical School, Level 6, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, United Kingdom
    Appl Environ Microbiol 71:7483-92. 2005
    ..Intestinal bacterial populations growing on mucin surfaces were shown to be phylogenetically and metabolically distinct from their planktonic counterparts...
  9. ncbi request reprint Mucosal bacteria in ulcerative colitis
    S Macfarlane
    Microbiology and Gut Biology Group, University of Dundee, Dundee DD1 9SY, UK
    Br J Nutr 93:S67-72. 2005
    ..Results demonstrated that short-term synbiotic treatment resulted in increased bifidobacterial colonisation of the rectal mucosa and induced significant reductions in the expression of molecules that control inflammation in active UC...
  10. ncbi request reprint Chemotaxonomic analysis of bacterial populations colonizing the rectal mucosa in patients with ulcerative colitis
    Sandra Macfarlane
    Microbiology and Gut Biology Group, University of Dundee, Ninewells Hospital Medical School, Dundee, United Kingdom
    Clin Infect Dis 38:1690-9. 2004
    ..Interindividual variations in mucosal biofilms made it difficult to assign a role for specific bacteria in UC etiology. However, differences in bifidobacteria and peptostreptococci may implicate these organisms in this disease...
  11. ncbi request reprint Characterisation of intestinal bacteria in infant stools using real-time PCR and northern hybridisation analyses
    Mark J Hopkins
    Microbiology and Gut Biology Group, University of Dundee, Ninewells Hospital Medical School, UK
    FEMS Microbiol Ecol 54:77-85. 2005
    ..Both methodologies indicated increased bifidobacteria in breast-fed babies, and higher levels of desulfovibrios in bottle-fed children...
  12. pmc Mucosa-associated bacterial diversity in relation to human terminal ileum and colonic biopsy samples
    Shakil Ahmed
    Dundee University Gut Group, Ninewells Hospital and Medical School, Dundee, Scotland, United Kingdom
    Appl Environ Microbiol 73:7435-42. 2007
    ..0004) and Faecalibacterium prausnitzii (P = 0.001) were dominant in the ascending and descending colon. Site-specific colonization in the gastrointestinal tract may be contributory in the etiology of some diseases of the large intestine...
  13. pmc Longitudinal analyses of gut mucosal microbiotas in ulcerative colitis in relation to patient age and disease severity and duration
    Alemu Fite
    Microbiology and Gut Biology Group, University of Dundee, Dundee, United Kingdom
    J Clin Microbiol 51:849-56. 2013
    ..These findings demonstrated that longitudinal variations in mucosal bacterial populations occur in UC and that bacterial community structure is related to disease severity...
  14. ncbi request reprint Bacteria, colonic fermentation, and gastrointestinal health
    George T Macfarlane
    University of Dundee, Ninewells Hospital Medical School, Microbiology and Gut Biology Group, Dundee DD1 9SY, United Kingdom
    J AOAC Int 95:50-60. 2012
    ..However, as digestive materials move along the gut, carbohydrates become depleted, which may be linked to the increased prevalence of colonic disease in the distal bowel...
  15. pmc Degradation of cross-linked and non-cross-linked arabinoxylans by the intestinal microbiota in children
    Mark J Hopkins
    MRC Microbiology and Gut Biology Group, University of Dundee, Dundee, United Kingdom
    Appl Environ Microbiol 69:6354-60. 2003
    ..In conclusion, in this study we found that the effects of AX and AXF on the microbial ecology and metabolism of intestinal microbiotas are similar in children and adults...
  16. ncbi request reprint Studies on the effect of system retention time on bacterial populations colonizing a three-stage continuous culture model of the human large gut using FISH techniques
    Matthew W Child
    Microbiology and Gut Biology Group, University of Dundee, Ninewells Hospital Medical School, Dundee, UK
    FEMS Microbiol Ecol 55:299-310. 2006
    ....
  17. doi request reprint Effect of a synbiotic on microbial community structure in a continuous culture model of the gastric microbiota in enteral nutrition patients
    Aileen R Smith
    Microbiology and Gut Biology Group, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    FEMS Microbiol Ecol 80:135-45. 2012
    ..These results indicate that the use of a synbiotic has the potential to reduce pathogen colonization on PEG tube surfaces in vivo, thereby reducing the incidence of biofilm-related infectious complications...
  18. doi request reprint Bacterial translocation in cirrhosis is not caused by an abnormal small bowel gut microbiota
    Helen Steed
    Dundee University Gut Group, Ninewells Hospital and Medical School, UK
    FEMS Immunol Med Microbiol 63:346-54. 2011
    ....
  19. ncbi request reprint Models for intestinal fermentation: association between food components, delivery systems, bioavailability and functional interactions in the gut
    George T Macfarlane
    Gut Group, University of Dundee, Ninewells Hospital Medical School, Dundee DD1 9SY, United Kingdom
    Curr Opin Biotechnol 18:156-62. 2007
    ..Recent developments using these systems have enabled modelling of surface colonisation and biofilm development, a hitherto neglected area of study...
  20. pmc Toll-like receptors-2, -3 and -4 expression patterns on human colon and their regulation by mucosal-associated bacteria
    Elizabeth Furrie
    Ninewells Hospital Medical School, University of Dundee, Dundee, UK
    Immunology 115:565-74. 2005
    ..In contrast, mature columnar epithelium is able to respond to viral pathogens, which are not part of the normal gut commensal microbiota...
  21. doi request reprint Prebiotics, synbiotics and inflammatory bowel disease
    Helen Steed
    Gut Group, University of Dundee, Ninewells Hospital Medical School, Dundee, UK
    Mol Nutr Food Res 52:898-905. 2008
    ..More work is needed to understand the effects of prebiotics and synbiotics on microbial communities in the gut, and their interactions with the host's immune system...
  22. doi request reprint Microbiological and immunological effects of enteral feeding on the upper gastrointestinal tract
    Aileen Robertson Smith
    1Microbiology and Gut Biology Group, Ninewells Hospital and Medical School, Dundee, UK
    J Med Microbiol 60:359-65. 2011
    ..05). These results indicate that EN can lead to significant bacterial overgrowth on upper gastrointestinal tract mucosae and a significantly diminished pro-inflammatory cytokine response...
  23. pmc Comparison of compositions and metabolic activities of fecal microbiotas in young adults and in antibiotic-treated and non-antibiotic-treated elderly subjects
    Emma J Woodmansey
    Microbiology and Gut Biology Group, University of Dundee, Dundee DD1 9SY, UK
    Appl Environ Microbiol 70:6113-22. 2004
    ..Other differences in the intestinal ecosystem in elderly subjects were observed, with alterations in the dominant clostridial species in combination with greater numbers of facultative anaerobes...
  24. pmc Adherence and cytokine induction in Caco-2 cells by bacterial populations from a three-stage continuous-culture model of the large intestine
    Bahram Bahrami
    Microbiology and Gut Biology Group, University of Dundee, Dundee, United Kingdom
    Appl Environ Microbiol 77:2934-42. 2011
    ..This study demonstrates that environmental determinants regulate the adherence properties of intestinal bacteria and their abilities to regulate cytokine synthesis...
  25. ncbi request reprint Bacterial diversity in the human gut
    Sandra Macfarlane
    Microbiology and Gut Biology Group, University of Dundee, Dundee DD1 9SY, United Kingdom
    Adv Appl Microbiol 54:261-89. 2004
  26. ncbi request reprint Regulation of short-chain fatty acid production
    Sandra Macfarlane
    University of Dundee, MRC Microbiology and Gut Biology Group, Ninewells Hospital Medical School, Dundee DD1 9SY, UK
    Proc Nutr Soc 62:67-72. 2003
    ..In the latter organism acetate and succinate are the major fermentation products when substrate is abundant, whereas succinate is decarboxylated to produce propionate when C and energy sources are limiting...
  27. ncbi request reprint The gut microbiota in inflammatory bowel disease
    G T Macfarlane
    Microbiology and Gut Biology Group, University of Dundee, Dundee DD1 9SY, UK
    Curr Pharm Des 15:1528-36. 2009
    ....
  28. ncbi request reprint Bacterial milieu and mucosal bacteria in ulcerative colitis
    G T Macfarlane
    University of Dundee MRC Microbiology and Gut Biology Group, Ninewells Hospital Medical School, Dundee DD1 9SY, UK
    Novartis Found Symp 263:57-64; discussion 64-70, 211-8. 2004
    ....
  29. pmc Systemic antibodies towards mucosal bacteria in ulcerative colitis and Crohn's disease differentially activate the innate immune response
    E Furrie
    MRC Microbiology and Gut Biology Group, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    Gut 53:91-8. 2004
    ..This would provide an explanation for this chronic inflammatory condition...
  30. doi request reprint Bacterial metabolism and health-related effects of galacto-oligosaccharides and other prebiotics
    G T Macfarlane
    Dundee University Gut Group, Ninewells Hospital Medical School, Dundee, UK
    J Appl Microbiol 104:305-44. 2008
    ..In many instances, prebiotics seem to be more effective when used as part of a synbiotic combination...
  31. pmc Synbiotic therapy (Bifidobacterium longum/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomised controlled pilot trial
    E Furrie
    Microbiology and Gut Biology Group, University of Dundee, Ninewells Hospital Medical School, Dundee DD1 9SY, UK
    Gut 54:242-9. 2005
    ..Therefore, modulation of bacterial communities on the gut mucosa, through the use of probiotics and prebiotics, may be used to modify the disease state...
  32. pmc Identification and quantitation of mucosal and faecal desulfovibrios using real time polymerase chain reaction
    A Fite
    MRC Microbiology and Gut Biology Group, University of Dundee, Dundee, UK
    Gut 53:523-9. 2004
    ..These bacteria have previously been linked to ulcerative colitis. Traditional methods of culturing these organisms are slow, and often unreliable, while molecular approaches are either non-quantitative or lack sensitivity...
  33. doi request reprint Fermentation in the human large intestine: its physiologic consequences and the potential contribution of prebiotics
    George T Macfarlane
    Microbiology and Gut Biology Group, Ninewells Hospital Medical School, University of Dundee, UK
    J Clin Gastroenterol 45:S120-7. 2011
    ..Many of these phenomena can be linked to their digestion and SCFA production by bacteria in the large gut...
  34. pmc Effects of antibiotics on bacterial species composition and metabolic activities in chemostats containing defined populations of human gut microorganisms
    Dorothy F Newton
    University of Dundee Microbiology and Gut Biology Group, Level 6, Ninewells Hospital and Medical School, Dundee, United Kingdom
    Antimicrob Agents Chemother 57:2016-25. 2013
    ..The growth of antibiotic-resistant bifidobacteria in the large bowel may enable them to occupy ecological niches left vacant after antibiotic administration, preventing colonization by pathogenic species...
  35. ncbi request reprint Risk factors for yeast superinfection in the treatment of suspected exit site infections: a case-control study
    L Oliveira
    Department of Medicine, University of Ottawa, Ottawa Hospital, Ottawa, Ontario, Canada
    J Vasc Access 9:35-8. 2008
    ..The purpose of our study was to determine if the use of polysporin double in the treatment of exit site infections was associated with the emergence of yeast positive exit site cultures...
  36. doi request reprint Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial
    Lars Lannfelt
    Department of Public Health and Geriatrics, Uppsala University Hospital, Uppsala, Sweden
    Lancet Neurol 7:779-86. 2008
    ..Strong preclinical efficacy data and the completion of early, clinical safety studies have preceded this phase IIa study, the aim of which was to assess the effects of PBT2 on safety, efficacy, and biomarkers of AD...