Research Topics
| Sandra MacfarlaneSummaryAffiliation: University of Dundee Country: UK Publications
| Collaborators
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Detail Information
Publications
Intestinal bacteria and ulcerative colitisJ H Cummings
Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital Medical School, Dundee DD1 9SY, UK
Curr Issues Intest Microbiol 4:9-20. 2003..There is scope for more work in this area focussing on the mucosal microflora, its interactions with the gut immune system, its metabolic properties and the potential ways of modifying it...- Review article: prebiotics in the gastrointestinal tractS Macfarlane
Dundee University Gut Group, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, Dundee, UK
Aliment Pharmacol Ther 24:701-14. 2006..It is therefore expected that prebiotics will improve health in a way similar to probiotics, whilst at the same time being cheaper, and carrying less risk and being easier to incorporate into the diet than probiotics... 
Composition and metabolic activities of bacterial biofilms colonizing food residues in the human gutSandra Macfarlane
Gut Group, University of Dundee, Level 6, Ninewells Hospital Medical School, Dundee DD1 9SY, United Kingdom
Appl Environ Microbiol 72:6204-11. 2006..Acetate was the principal fermentation product formed by biofilm bacteria, whereas higher levels of butyrate were produced by nonadherent populations, showing that the two communities were metabolically distinct...- Colonization of mucin by human intestinal bacteria and establishment of biofilm communities in a two-stage continuous culture systemSandra Macfarlane
Microbiology and Gut Biology Group, University of Dundee Medical School, Level 6, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, United Kingdom
Appl Environ Microbiol 71:7483-92. 2005..Intestinal bacterial populations growing on mucin surfaces were shown to be phylogenetically and metabolically distinct from their planktonic counterparts... 
Microbial biofilm communities in the gastrointestinal tractSandra Macfarlane
Dundee University Gut Group, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, Dundee, UK
J Clin Gastroenterol 42:S142-3. 2008....- Mucosal bacteria in ulcerative colitisS Macfarlane
Microbiology and Gut Biology Group, University of Dundee, Dundee DD1 9SY, UK
Br J Nutr 93:S67-72. 2005..Results demonstrated that short-term synbiotic treatment resulted in increased bifidobacterial colonisation of the rectal mucosa and induced significant reductions in the expression of molecules that control inflammation in active UC... - Intestinal bacteria and inflammatory bowel diseaseSandra Macfarlane
Microbiology and Gut Biology Group, University of Dundee, Dundee, UK
Crit Rev Clin Lab Sci 46:25-54. 2009.... - Microbial biofilms in the human gastrointestinal tractS Macfarlane
Dundee University Gut Group, Ninewells Hospital Medical School, Dundee, UK
J Appl Microbiol 102:1187-96. 2007..However, recent work has shown that there is considerable potential to alter the species composition of mucosal biofilms in a beneficial way using synbiotics... - Microbial colonization of the upper gastrointestinal tract in patients with Barrett's esophagusSandra Macfarlane
Dundee University Gut Group, Ninewells Hospital Medical School, Dundee, United Kingdom
Clin Infect Dis 45:29-38. 2007..The aim of this study was to characterize microbial communities in esophageal aspirate specimens and on distal esophageal mucosal samples from patients with BE... - Chemotaxonomic analysis of bacterial populations colonizing the rectal mucosa in patients with ulcerative colitisSandra Macfarlane
Microbiology and Gut Biology Group, University of Dundee, Ninewells Hospital Medical School, Dundee, United Kingdom
Clin Infect Dis 38:1690-9. 2004..Interindividual variations in mucosal biofilms made it difficult to assign a role for specific bacteria in UC etiology. However, differences in bifidobacteria and peptostreptococci may implicate these organisms in this disease... - Mucosa-associated bacterial diversity in relation to human terminal ileum and colonic biopsy samplesShakil Ahmed
Dundee University Gut Group, Ninewells Hospital and Medical School, Dundee, Scotland, United Kingdom
Appl Environ Microbiol 73:7435-42. 2007..0004) and Faecalibacterium prausnitzii (P = 0.001) were dominant in the ascending and descending colon. Site-specific colonization in the gastrointestinal tract may be contributory in the etiology of some diseases of the large intestine... - Characterisation of intestinal bacteria in infant stools using real-time PCR and northern hybridisation analysesMark J Hopkins
Microbiology and Gut Biology Group, University of Dundee, Ninewells Hospital Medical School, UK
FEMS Microbiol Ecol 54:77-85. 2005..Both methodologies indicated increased bifidobacteria in breast-fed babies, and higher levels of desulfovibrios in bottle-fed children... - Bacteria, colonic fermentation, and gastrointestinal healthGeorge T Macfarlane
University of Dundee, Ninewells Hospital Medical School, Microbiology and Gut Biology Group, Dundee DD1 9SY, United Kingdom
J AOAC Int 95:50-60. 2012..However, as digestive materials move along the gut, carbohydrates become depleted, which may be linked to the increased prevalence of colonic disease in the distal bowel... - Degradation of cross-linked and non-cross-linked arabinoxylans by the intestinal microbiota in childrenMark J Hopkins
MRC Microbiology and Gut Biology Group, University of Dundee, Dundee, United Kingdom
Appl Environ Microbiol 69:6354-60. 2003..In conclusion, in this study we found that the effects of AX and AXF on the microbial ecology and metabolism of intestinal microbiotas are similar in children and adults... - Studies on the effect of system retention time on bacterial populations colonizing a three-stage continuous culture model of the human large gut using FISH techniquesMatthew W Child
Microbiology and Gut Biology Group, University of Dundee, Ninewells Hospital Medical School, Dundee, UK
FEMS Microbiol Ecol 55:299-310. 2006.... - Effect of a synbiotic on microbial community structure in a continuous culture model of the gastric microbiota in enteral nutrition patientsAileen R Smith
Microbiology and Gut Biology Group, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
FEMS Microbiol Ecol 80:135-45. 2012..These results indicate that the use of a synbiotic has the potential to reduce pathogen colonization on PEG tube surfaces in vivo, thereby reducing the incidence of biofilm-related infectious complications... - Bacterial translocation in cirrhosis is not caused by an abnormal small bowel gut microbiotaHelen Steed
Dundee University Gut Group, Ninewells Hospital and Medical School, UK
FEMS Immunol Med Microbiol 63:346-54. 2011.... - Models for intestinal fermentation: association between food components, delivery systems, bioavailability and functional interactions in the gutGeorge T Macfarlane
Gut Group, University of Dundee, Ninewells Hospital Medical School, Dundee DD1 9SY, United Kingdom
Curr Opin Biotechnol 18:156-62. 2007..Recent developments using these systems have enabled modelling of surface colonisation and biofilm development, a hitherto neglected area of study... - Toll-like receptors-2, -3 and -4 expression patterns on human colon and their regulation by mucosal-associated bacteriaElizabeth Furrie
Ninewells Hospital Medical School, University of Dundee, Dundee, UK
Immunology 115:565-74. 2005..In contrast, mature columnar epithelium is able to respond to viral pathogens, which are not part of the normal gut commensal microbiota... - Prebiotics, synbiotics and inflammatory bowel diseaseHelen Steed
Gut Group, University of Dundee, Ninewells Hospital Medical School, Dundee, UK
Mol Nutr Food Res 52:898-905. 2008..More work is needed to understand the effects of prebiotics and synbiotics on microbial communities in the gut, and their interactions with the host's immune system... - Microbiological and immunological effects of enteral feeding on the upper gastrointestinal tractAileen Robertson Smith
1Microbiology and Gut Biology Group, Ninewells Hospital and Medical School, Dundee, UK
J Med Microbiol 60:359-65. 2011..05). These results indicate that EN can lead to significant bacterial overgrowth on upper gastrointestinal tract mucosae and a significantly diminished pro-inflammatory cytokine response... - Comparison of compositions and metabolic activities of fecal microbiotas in young adults and in antibiotic-treated and non-antibiotic-treated elderly subjectsEmma J Woodmansey
Microbiology and Gut Biology Group, University of Dundee, Dundee DD1 9SY, UK
Appl Environ Microbiol 70:6113-22. 2004..Other differences in the intestinal ecosystem in elderly subjects were observed, with alterations in the dominant clostridial species in combination with greater numbers of facultative anaerobes... - Adherence and cytokine induction in Caco-2 cells by bacterial populations from a three-stage continuous-culture model of the large intestineBahram Bahrami
Microbiology and Gut Biology Group, University of Dundee, Dundee, United Kingdom
Appl Environ Microbiol 77:2934-42. 2011..This study demonstrates that environmental determinants regulate the adherence properties of intestinal bacteria and their abilities to regulate cytokine synthesis... - Longitudinal analyses of gut mucosal microbiotas in ulcerative colitis in relation to patient age and disease severity and durationAlemu Fite
Microbiology and Gut Biology Group, University of Dundee, Dundee, United Kingdom
J Clin Microbiol 51:849-56. 2013..These findings demonstrated that longitudinal variations in mucosal bacterial populations occur in UC and that bacterial community structure is related to disease severity... - Bacterial diversity in the human gutSandra Macfarlane
Microbiology and Gut Biology Group, University of Dundee, Dundee DD1 9SY, United Kingdom
Adv Appl Microbiol 54:261-89. 2004 - Regulation of short-chain fatty acid productionSandra Macfarlane
University of Dundee, MRC Microbiology and Gut Biology Group, Ninewells Hospital Medical School, Dundee DD1 9SY, UK
Proc Nutr Soc 62:67-72. 2003..In the latter organism acetate and succinate are the major fermentation products when substrate is abundant, whereas succinate is decarboxylated to produce propionate when C and energy sources are limiting... - Systemic antibodies towards mucosal bacteria in ulcerative colitis and Crohn's disease differentially activate the innate immune responseE Furrie
MRC Microbiology and Gut Biology Group, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
Gut 53:91-8. 2004..This would provide an explanation for this chronic inflammatory condition... - Synbiotic therapy (Bifidobacterium longum/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomised controlled pilot trialE Furrie
Microbiology and Gut Biology Group, University of Dundee, Ninewells Hospital Medical School, Dundee DD1 9SY, UK
Gut 54:242-9. 2005..Therefore, modulation of bacterial communities on the gut mucosa, through the use of probiotics and prebiotics, may be used to modify the disease state... - The gut microbiota in inflammatory bowel diseaseG T Macfarlane
Microbiology and Gut Biology Group, University of Dundee, Dundee DD1 9SY, UK
Curr Pharm Des 15:1528-36. 2009.... - Bacterial milieu and mucosal bacteria in ulcerative colitisG T Macfarlane
University of Dundee MRC Microbiology and Gut Biology Group, Ninewells Hospital Medical School, Dundee DD1 9SY, UK
Novartis Found Symp 263:57-64; discussion 64-70, 211-8. 2004.... - Bacterial metabolism and health-related effects of galacto-oligosaccharides and other prebioticsG T Macfarlane
Dundee University Gut Group, Ninewells Hospital Medical School, Dundee, UK
J Appl Microbiol 104:305-44. 2008..In many instances, prebiotics seem to be more effective when used as part of a synbiotic combination... - Identification and quantitation of mucosal and faecal desulfovibrios using real time polymerase chain reactionA Fite
MRC Microbiology and Gut Biology Group, University of Dundee, Dundee, UK
Gut 53:523-9. 2004.... - Fermentation in the human large intestine: its physiologic consequences and the potential contribution of prebioticsGeorge T Macfarlane
Microbiology and Gut Biology Group, Ninewells Hospital Medical School, University of Dundee, UK
J Clin Gastroenterol 45:S120-7. 2011..Many of these phenomena can be linked to their digestion and SCFA production by bacteria in the large gut... - Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trialLars Lannfelt
Department of Public Health and Geriatrics, Uppsala University Hospital, Uppsala, Sweden
Lancet Neurol 7:779-86. 2008..Strong preclinical efficacy data and the completion of early, clinical safety studies have preceded this phase IIa study, the aim of which was to assess the effects of PBT2 on safety, efficacy, and biomarkers of AD... - Risk factors for yeast superinfection in the treatment of suspected exit site infections: a case-control studyL Oliveira
Department of Medicine, University of Ottawa, Ottawa Hospital, Ottawa, Ontario, Canada
J Vasc Access 9:35-8. 2008..The purpose of our study was to determine if the use of polysporin double in the treatment of exit site infections was associated with the emergence of yeast positive exit site cultures...