Research Topics
Species | P W MacfarlaneSummaryAffiliation: University of Glasgow Country: UK Publications
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Detail Information
Publications
The design of a prospective study of Pravastatin in the Elderly at Risk (PROSPER). PROSPER Study Group. PROspective Study of Pravastatin in the Elderly at RiskJ Shepherd
University of Glasgow, Scotland
Am J Cardiol 84:1192-7. 1999..Finally, an assessment will be made of the effects of treatment on cognitive function, disability, hospitalization or institutionalization, vascular mortality, and all-cause mortality...
Association between high-density lipoprotein and cognitive impairment in the oldest oldEric van Exel
Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
Ann Neurol 51:716-21. 2002..At least part of the association between high-density lipoprotein cholesterol and cognitive function is independent of atherosclerotic disease...
Heart rate variability fraction--a new reportable measure of 24-hour R-R interval variationMaciej Sosnowski
3rd Division of Cardiology, Silesian Medical School, Ziolowa, Katowice, Poland
Ann Noninvasive Electrocardiol 10:7-15. 2005..The scatterplot of R-R intervals has several unique features. Its numerical evaluation may produce a new useful index of global heart rate variability (HRV) from Holter recordings...
Artificial attenuation of ECG voltage produces shortening of the corresponding QRS duration: clinical implications for patients with edemaJohn E Madias
Mount Sinai School of Medicine, New York University, New York, New York, USA
Pacing Clin Electrophysiol 28:1060-5. 2005..Nowadays, physicians accept QRSd measured by computer techniques. The latter offers the possibility of testing the hypothesis that artificial alteration of the ECGV, simulating effects of PERE, could lead to changes in the QRSd...
Are elevated circulating intercellular adhesion molecule 1 levels more strongly predictive of diabetes than vascular risk? Outcome of a prospective study in the elderlyN Sattar
Faculty of Medicine, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, University Place, Glasgow G12 8TA, UK
Diabetologia 52:235-9. 2009....
Age, sex, and the ST amplitude in health and diseaseP W Macfarlane
University Department of Medical Cardiology, Royal Infirmary, Glasgow, Scotland
J Electrocardiol 34:235-41. 2001..Recommended ECG related criteria, particularly in V1, for administration of thrombolytic therapy appear to be neither age nor sex dependent, which is a significant shortcoming given the foregoing information...
Looking for prognostic information in the ST-T segment--is it really worth it?Peter W Macfarlane
Section of Cardiology and Exercise Medicine, Royal Infirmary, Glasgow, United Kingdom
J Electrocardiol 37:209-13. 2004..The conclusion drawn is that the prognostic value of ECG variables has to be considered carefully in the light of other available data...
Is electrocardiography still useful in the diagnosis of cardiac chamber hypertrophy and dilatation?Peter W Macfarlane
Division of Cardiovascular and Medical Sciences, University of Glasgow, Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, Scotland, UK
Cardiol Clin 24:401-11, ix. 2006..Electrocardiography and echocardiography will continue to live side-by-side for the foreseeable future...
The value of the electrocardiogram in risk assessment in primary prevention: experience from the West of Scotland Coronary Prevention StudyP W Macfarlane
Division of Cardiovascular and Medical Sciences, University of Glasgow, Scotland, UK
J Electrocardiol 40:101-9. 2007..Of 355 incident MIs, 47.3% were silent or unrecognized and detected by ECG only. A simple ECG-based risk prediction equation for fatal and nonfatal MI is introduced...
The Pierre Rijlant lecture 2007: the future of electrocardiographyPeter W Macfarlane
Division of Medical Sciences, University of Glasgow, Glasgow, UK
Anadolu Kardiyol Derg 7:1-4. 2007
Influence of lead selection and population on automated measurement of QT dispersionP W Macfarlane
University of Glasgow P W M, Glasgow, Scotland
Circulation 98:2160-7. 1998..Furthermore, there is still discussion on the extent to which QTd reflects dispersion of measurement. This study addresses these problems...
Modification of ACC/ESC criteria for acute myocardial infarctionPeter W Macfarlane
University of Glasgow, Section of Cardiology and Exercise Medicine, Royal Infirmary, Glasgow G31 2ER
J Electrocardiol 37:98-103. 2004..6% to 99.8%. The conclusion drawn is that while the ACC/ESC criteria are simple to apply, they are not particularly specific and can be improved by being supplemented by other ECG measures and optimized for age and sex...
Inter- and intraobserver variability in LVH and RVH reporting in pediatric ECGsR M Hamilton
University Department of Medical Cardiology, Glasgow G31 2ER, UK
Ann Noninvasive Electrocardiol 10:330-3. 2005..CONCLUSIONS: This study has demonstrated the difficulties in using cardiologists' diagnoses as the gold standard with which to evaluate pediatric ECGs...
Elevated troponin levels are associated with sympathoadrenal activation in acute ischaemic strokeM Barber
University Division of Cardiovascular and Medical Sciences, Royal Infirmary, Glasgow, UK
Cerebrovasc Dis 23:260-6. 2007..We aimed to determine the factors associated with troponin elevation in ischaemic stroke and the prognostic value of this finding...
The role of myocardial perfusion scanning, heart rate variability and D-dimers in predicting the risk of perioperative cardiac complications after peripheral vascular surgeryN Mamode
Department of Vascular Surgery, Medical Cardiology and Medicine, Glasgow, UK
Eur J Vasc Endovasc Surg 22:499-508. 2001..CONCLUSIONS: Preliminary screening using clinical data has limited value in risk assessment prior to vascular surgery but preoperative heart rate variability, D-dimers and thallium scanning provide modest incremental predictive value...
Long-term follow-up of the West of Scotland Coronary Prevention StudyIan Ford
Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom
N Engl J Med 357:1477-86. 2007..9 to 5.5% (P<0.001) in the treatment group. Extended follow-up data were obtained for approximately 10 years after completion of the trial...
Bedside serial comparison of electrocardiogramsP W Macfarlane
Royal Infirmary, Glasgow, Scotland
J Electrocardiol 21:S159-62. 1988..Serial comparison logic has been incorporated into the diagnostic program inside the 440 and 740 so that immediate serial comparison can be undertaken at the bedside or in the clinic...
Reproducibility of a non-invasive real-time measure of cardiac parasympathetic activityP G Murray
University Department of Medical Cardiology, Glasgow Royal Infirmary, UK
Physiol Meas 22:661-72. 2001..The short-term reproducibility of a 5 minute recording of CIPA is moderate and better than simple time-domain but not frequency-domain measures of HRV...
C-reactive protein and prediction of coronary heart disease and global vascular events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER)Naveed Sattar
Department of Vascular Biochemistry, University of Glasgow, Glasgow, Scotland, UK
Circulation 115:981-9. 2007..The role of C-reactive protein (CRP) in predicting vascular events and response to statin therapy remains uncertain. Additional large prospective studies are required...
Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular diseaseDavid J Stott
Division of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom
Am J Clin Nutr 82:1320-6. 2005..Homocysteine is an independent risk factor for vascular disease and is associated with dementia in older people. Potential mechanisms include altered endothelial and hemostatic function...
Plasma lipoproteins and apolipoproteins as predictors of cardiovascular risk and treatment benefit in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER)Chris J Packard
Department of Vascular Biochemistry, University of Glasgow, Glasgow, Scotland
Circulation 112:3058-65. 2005..We assessed the role of plasma lipoproteins as predictors of risk and of treatment benefit in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER)...
Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention StudyNaveed Sattar
University Department of Pathological Biochemistry, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, Scotland, UK
Circulation 108:414-9. 2003..Information on the prospective association of this definition for coronary heart disease (CHD) and type 2 diabetes is currently limited...
Association between apolipoprotein E4 and cognitive decline in elderly adultsChris J Packard
Department of Vascular Biochemistry, University of Glasgow, Glasgow, Scotland
J Am Geriatr Soc 55:1777-85. 2007..To determine the influence of apolipoprotein E on cognitive decline in a cohort of elderly men and women...
Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studiesNaveed Sattar
Faculty of Medicine, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
Lancet 371:1927-35. 2008..We investigated to what extent metabolic syndrome and its individual components were related to risk for these two diseases in elderly populations...
Leptin predicts diabetes but not cardiovascular disease: results from a large prospective study in an elderly populationPaul Welsh
Faculty of Medicine, University of Glasgow, Scotland, UK
Diabetes Care 32:308-10. 2009..To clarify the association of circulating levels of leptin with risk for cardiovascular disease (CVD) events and new-onset diabetes in men and women...
Lipoprotein-associated phospholipase A(2), inflammatory biomarkers, and risk of cardiovascular disease in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER)Muriel J Caslake
Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G11 6NT, UK
Atherosclerosis 210:28-34. 2010..We evaluated the association of Lp-PLA(2) with vascular events in the elderly where the importance of LDL is diminished as a risk factor for coronary disease...
Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trialsNaveed Sattar
British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
Lancet 375:735-42. 2010..We aimed to establish by a meta-analysis of published and unpublished data whether any relation exists between statin use and development of diabetes...
Are markers of inflammation more strongly associated with risk for fatal than for nonfatal vascular events?Naveed Sattar
Division of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, Scotland, UK
PLoS Med 6:e1000099. 2009..We tested whether interleukin (IL)-6, C-reactive protein (CRP), and fibrinogen more strongly associate with fatal compared to nonfatal myocardial infarction (MI) and stroke...
Automated electrocardiogram interpretation programs versus cardiologists' triage decision making based on teletransmitted data in patients with suspected acute coronary syndromeElaine N Clark
Institute of Cardiovascular and Medical Sciences, University of Glasgow, Scotland, United Kingdom
Am J Cardiol 106:1696-702. 2010..02) and the cardiologists (p = 0.004). Triage decisions were effective, with good agreement between cardiologists' decisions and discharge diagnoses...
Elevated alanine aminotransferase predicts new-onset type 2 diabetes independently of classical risk factors, metabolic syndrome, and C-reactive protein in the west of Scotland coronary prevention studyNaveed Sattar
Division of Cardiovascular and Medical Sciences, Universityof Glasgow, Glasgow Royal Infirmary, Glasgow G31 2ER, Scotland, UK
Diabetes 53:2855-60. 2004..The simplicity of ALT measurement and its availability in routine clinical practice suggest that this enzyme activity could be included in future diabetes prediction algorithms...
Clinical Trials: Minimising source data queries to streamline endpoint adjudication in a large multi-national trialElizabeth P Tolmie
Glasgow Clinical Research Facility, Tennent Building, Western Infirmary, Glasgow, UK
Trials 12:112. 2011..The purpose of the review was to identify areas that could be improved for future clinical trials. The results are reported in this paper...
Evaluation of the electrocardiographic criteria for left ventricular hypertrophyIain Morrison
Division of Medical Sciences, University of Glasgow, Glasgow, UK
Anadolu Kardiyol Derg 7:159-63. 2007....
Can cardiac vagal tone be estimated from the 10-second ECG?Ruth M Hamilton
University Section of Cardiology and Exercise Medicine, Queen Elizabeth Building, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, UK
Int J Cardiol 95:109-15. 2004..The aim of this study, therefore, was to discover whether indices of HRV calculated over 10 s could predict cardiac vagal tone (CVT) recorded over a 5-min period by the NeuroScope, a new instrument that selectively measures vagal tone...
Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approachPaul Welsh
Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
J Clin Endocrinol Metab 95:93-9. 2010..Associations between adiposity and circulating inflammation markers are assumed to be causal, although the direction of the relationship has not been proven...
CPR '98: a practical multimedia computer-based guide to cardiopulmonary resuscitation for medical studentsL J Clark
The Microcomputer Cluster, Level 1, Glasgow Royal Infirmary, Glasgow, UK
Resuscitation 44:109-17. 2000..It was found that students who used the package performed significantly better in theoretical assessments than those who did not...
Evaluation of pediatric electrocardiogram diagnosis of ventricular hypertrophy by computer program compared with cardiologistsR M Hamilton
University Section of Cardiology, Division of Cardiovascular and Medical Sciences, Queen Elizabeth Building, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow, G31 2ER UK
Pediatr Cardiol 26:373-8. 2005..Subsequent discussion revealed that if the cardiologists had disagreed with one another initially, their consensus opinion was twice as likely to be in agreement with the program...
Localization of accessory pathways in the Wolff-Parkinson-White pattern--physician versus computer interpretation of the same algorithmAndrew D McGavigan
Department of Cardiology, Glasgow Royal Infirmary, Glasgow, UK
Pacing Clin Electrophysiol 30:998-1002. 2007..We compared the utility of a computerized program in identifying pathway location from the ECG using the algorithm published by Fitzpatrick and coworkers(3) against physician assessment with the same algorithm...
Diagnosis of acute myocardial ischaemia using probabilistic methodsJodat M Seyal
Department of Medical Cardiology, Royal Infirmary, Glasgow, Scotland
J Cardiovasc Risk 9:115-21. 2002..CONCLUSION: The study suggests that equations for the diagnosis of acute cardiac ischaemia developed in one centre may not readily translate elsewhere, possibly due to varying interpretations of the clinical and ECG criteria used...
Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trialJames Shepherd
University Department of Pathological Biochemistry, University of Glasgow, Royal Infirmary, Scotland, Glasgow, UK
Lancet 360:1623-30. 2002..Our aim was to test the benefits of pravastatin treatment in an elderly cohort of men and women with, or at high risk of developing, cardiovascular disease and stroke...
A comparison of commonly used QT correction formulae: the effect of heart rate on the QTc of normal ECGsShen Luo
Burdick Quinton Cardiology Systems Inc, Deerfield, WI 53531, USA
J Electrocardiol 37:81-90. 2004..It was also noted that QT has a linear trend with HR but not with RR...
Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. 1995James Shepherd
Atheroscler Suppl 5:91-7. 2004
The microsomal triglyceride transfer protein gene-493T variant lowers cholesterol but increases the risk of coronary heart diseaseHelena Ledmyr
King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden
Circulation 109:2279-84. 2004..We hypothesize that this polymorphism impacts on coronary heart disease (CHD) risk...
The additional value of routine electrocardiograms in cardiovascular risk management of older peopleWouter de Ruijter
Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
Scand J Prim Health Care 26:147-53. 2008..To evaluate whether routinely performed ECGs in older people from the general population have added value for cardiovascular risk management beyond the information that is already available from their medical records...
Gender and effects of a common genetic variant in the NOS1 regulator NOS1AP on cardiac repolarization in 3761 individuals from two independent populationsMartin D Tobin
Department of Health Sciences, University of Leicester, UK
Int J Epidemiol 37:1132-41. 2008..We investigated the association between rs10494366 in NOS1AP and QTc, and assessed gender-specific NOS1AP associations with QTc during rest and after exercise...
Can the lessons learned from the assessment of automated electrocardiogram analysis in the Common Standards for quantitative Electrocardiography study benefit measurement of delayed contrast-enhanced magnetic resonance images?Jocelyne Fayn
Methodologies of Information Processing in Cardiology, INSERM, INSA Lyon, Universite Lyon 1, France
J Electrocardiol 40:246-50. 2007
Markers of autonomic tone on a standard ECG are predictive of mortality in old ageThomas van Bemmel
Section of Gerontology and Geriatrics, Department of Internal Medicine, C1 R, Leiden University Medical Center, Leiden, The Netherlands
Int J Cardiol 107:36-41. 2006..To investigate markers of autonomic tone on a standard electrocardiogram in relation to mortality in old age...
Age-adjustment of HRV measures and its prognostic value for risk assessment in patients late after myocardial infarctionMaciej Sosnowski
3rd Division of Cardiology, Silesian Medical School, Ziolowa Street 47 40635, Katowice, Poland
Int J Cardiol 86:249-58. 2002....
The routine electrocardiogram for cardiovascular risk stratification in old age: the Leiden 85-plus studyWouter de Ruijter
Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
J Am Geriatr Soc 55:872-7. 2007..To explore the prognostic value of signs of prior myocardial infarction (MI) and atrial fibrillation (AF) on routine electrocardiograms (ECGs) at the age of 85 with respect to mortality and changes in functional status...
Practice standards for electrocardiographic monitoring in hospital settings: an American Heart Association scientific statement from the Councils on Cardiovascular Nursing, Clinical Cardiology, and Cardiovascular Disease in the Young: endorsed by the InteBarbara J Drew
Circulation 110:2721-46. 2004..Currently available ECG lead systems are described, and recommendations related to staffing, training, and methods to improve quality are provided...
The assessment of autonomic function in chronic atrial fibrillation: description of a non-invasive technique based on circadian rhythm of atrioventricular nodal functional refractory periodsAleem U Khand
Academic Unit of Cardiology, University of Hull, Hull, UK
Europace 8:927-34. 2006..Atrial fibrillation (AF) is the commonest sustained arrhythmia and is particularly prevalent in heart failure. We have developed a simple index to assess autonomic function in patients with chronic AF...
Metabolic syndrome and diabetes mellitusW E Feeman
Circulation 109:E23. 2004
Myocardial infarction in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)Saskia A J Lesnik Oberstein
Department of Clinical Genetics, Leiden University Medical Center, The Netherlands
Medicine (Baltimore) 82:251-6. 2003..To our knowledge, this is the first study showing that NOTCH3 mutation carriers may be at increased risk of early acute myocardial infarction, expanding CADASIL disease expression beyond the central nervous system to include the heart...
Association between chronic diseases and disability in elderly subjects with low and high income: the Leiden 85-plus StudyAnnetje Bootsma-van der Wiel
Department of Gerontology and Geriatrics, Leiden University Medical Center, The Netherlands
Eur J Public Health 15:494-7. 2005..CONCLUSIONS: We conclude that ADL-disability is more prevalent in elderly with low income. Neither prevalence of chronic diseases nor the association with disability could explain this...
AHA scientific statement: practice standards for electrocardiographic monitoring in hospital settings: an American Heart Association Scientific Statement from the Councils on Cardiovascular Nursing, Clinical Cardiology, and Cardiovascular Disease in the YBarbara J Drew
J Cardiovasc Nurs 20:76-106. 2005..Currently available ECG lead systems are described, and recommendations related to staffing, training, and methods to improve quality are provided...
Effect of controlling hyperglycemia with diet on QT abnormalities in newly diagnosed patients with type 2 diabetesRajeev Kumar
Diabetes Care 27:2767-8. 2004
