Research Topics
Species | Thomas M MacDonaldSummaryAffiliation: University of Dundee Country: UK Publications
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Publications
The effects of lumiracoxib 100 mg once daily vs. ibuprofen 600 mg three times daily on the blood pressure profiles of hypertensive osteoarthritis patients taking different classes of antihypertensive agentsT M MacDonald
Hypertension Research Centre, Division of Medicine and Therapeutics, Ninewells Hospital, Dundee DD1 9SY, UK
Int J Clin Pract 64:746-55. 2010..To examine whether the blood pressure (BP) profiles of lumiracoxib and high-dose ibuprofen differed in patients treated with different classes of antihypertensive medications...
A European's perspective of COX-2 drug safetyThomas M MacDonald
Medicines Monitoring Unit MEMO and Hypertension Research Centre, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
J Cardiovasc Pharmacol 47:S92-7. 2006..This paper discusses the safety of cyclooxygenase-2 inhibitors and describes the sort of studies that could be carried out to gather better safety information on their use versus standard nonsteroidal anti-inflammatory drugs...- Is there an interaction between the cardiovascular protective effects of low-dose aspirin and ibuprofen?Thomas M MacDonald
Medicines Monitoring Unit MEMO, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, Scotland, UK
Basic Clin Pharmacol Toxicol 98:275-80. 2006..This interaction is more likely in those who take ibuprofen chronically and is more important in those at high cardiovascular risk. Thus, a reasonable strategy might be to advise aspirin takers to avoid chronic ibuprofen... - Channelling of patients taking NSAIDs or cyclooxygenase-2-specific inhibitors and its effect on interpretation of outcomesT M MacDonald
Department of Clinical Pharmacology and Therapeuitcs, Ninewells Hospital and Medical School, Dundee, UK
Rheumatology (Oxford) 42:iii3-10. 2003.... - Prevalence and treatment of isolated and concurrent hypertension and hypercholesterolaemia in the United KingdomThomas M MacDonald
Division of Medicine and Therapeutics, University of Dundee Ninewells Hospital and Medical School, Dundee, UK
Br J Clin Pharmacol 65:775-86. 2008..Major changes in the reimbursement of primary care for the management of both hypertension and hypercholesterolaemia have occurred in the UK... - Effect of ibuprofen on cardioprotective effect of aspirinT M MacDonald
Medicines Monitoring Unit, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, DD1 9SY, Dundee, UK
Lancet 361:573-4. 2003..73, 1.05-2.84, p=0.0305). Our finding lends support to the hypothesis that ibuprofen may interact with the cardioprotective effects of aspirin, at least in patients with established cardiovascular disease... 
Effect on blood pressure of lumiracoxib versus ibuprofen in patients with osteoarthritis and controlled hypertension: a randomized trialThomas M MacDonald
Hypertension Research Centre, Division of Medicine and Therapeutics, Ninewells Hospital, Dundee, UK
J Hypertens 26:1695-702. 2008....- Valsartan improves endothelial dysfunction in hypertension: a randomized, double-blind studyNikolaos Tzemos
Hypertension Research Centre, Division of Medicine and Therapeutics, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
Cardiovasc Ther 27:151-8. 2009..05) enhanced only with valsartan. Valsartan reserved peripheral endothelial dysfunction through both NO-dependent and -independent pathways, while for the same degree of BP control, amlodipine had only a partial effect on NO bioactivity... - Application of a propensity score to adjust for channelling bias with NSAIDsS V Morant
Medicines Monitoring Unit, Department of Medicine and Therapeutics, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
Pharmacoepidemiol Drug Saf 13:345-53. 2004..To compare the relative risks of upper GI haemorrhage (UGIH) in users of Newer versus Older, non-specific NSAIDs when adjusted for channelling bias by regression on individual covariates, a propensity score and both... - Persistence, adherence and outcomes with antiplatelet regimens following cerebral infarction in the Tayside Stroke CohortRobert W V Flynn
Medicines Monitoring Unit, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
Cerebrovasc Dis 33:190-7. 2012..The objectives of this study were: (1) to describe postdischarge prescribing of antiplatelet regimens, (2) to measure patient persistence with different antiplatelet regimens, and (3) to measure whether persistence impacts on outcomes... - Systematic review of observational research studying the long-term use of antithrombotic medicines following intracerebral hemorrhageRobert W V Flynn
Medicines Monitoring Unit MEMO, Division of Medical Sciences, University of Dundee, Dundee, Scotland, UK
Cardiovasc Ther 28:177-84. 2010.... - Treatment of osteoarthritis in hypertensive patientsIsla S Mackenzie
University of Dundee, Ninewells Hospital, Hypertension Research Centre and Medicines Monitoring Unit, Level 7, Dundee DD1 9SY, UK
Expert Opin Pharmacother 11:393-403. 2010..NSAIDs may also increase cardiovascular risk due to mechanisms other than by raising blood pressure... 
Does the aldosterone:renin ratio predict the efficacy of spironolactone over bendroflumethiazide in hypertension? A clinical trial protocol for RENALDO (RENin-ALDOsterone) studyHari K Parthasarathy
Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
BMC Cardiovasc Disord 7:14. 2007....- The Tayside Stroke Cohort: exploiting advanced regional medical informatics to create a region-wide database for studying the pharmacoepidemiology of strokeRobert W V Flynn
Medicines Monitoring Unit, Ninewells Hospital and Medical School, Dundee, UK
Pharmacoepidemiol Drug Saf 19:737-44. 2010..We aimed to generate a region-wide longitudinal register of stroke patients using record-linkage of existing clinical and research datasets... - Spironolactone use and renal toxicity: population based longitudinal analysisLi Wei
Medicines Monitoring Unit MEMO, Division of Medical Sciences, Ninewells Hospital and Medical School, Dundee DD1 9SY
BMJ 340:c1768. 2010..To determine the safety of spironolactone prescribing in the setting of the UK National Health Service... - Effectiveness of two statin prescribing strategies with respect to adherence and cardiovascular outcomes: observational studyL Wei
Medicines Monitoring Unit, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
Pharmacoepidemiol Drug Saf 16:385-92. 2007..We have compared the treat-to-target and fire-and-forget statin prescribing strategies with respect to adherence and cardiovascular outcomes... - Effectiveness of statins on total cholesterol and cardiovascular disease and all-cause mortality in osteoarthritis and rheumatoid arthritisXia Sheng
Medicines Monitoring Unit, Division of Medical Sciences, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland
J Rheumatol 39:32-40. 2012..We examined the effectiveness of statins on total cholesterol (TC), cardiovascular (CV) morbidity, and mortality in patients with OA or RA... - Effect of statins on total cholesterol concentrations and cardiovascular outcomes in patients with diabetes mellitus: a population-based cohort studyXia Sheng
Medicines Monitoring Unit, Division of Medical Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
Eur J Clin Pharmacol 68:1201-8. 2012..We evaluated statin-associated TC concentration change and its impact on cardiovascular (CV) risk reduction in diabetic patients in the setting of usual care... - Prescribing antiplatelet medicine and subsequent events after intracerebral hemorrhageRobert W V Flynn
University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
Stroke 41:2606-11. 2010..Many ICH patients have or will have indications for antiplatelet therapy. This observational study describes the level of antiplatelet prescribing and rate of subsequent events after ICH in Tayside, Scotland... - Impact of allopurinol use on urate concentration and cardiovascular outcomeLi Wei
Medicines Monitoring Unit MEMO, Division of Medical Sciences, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
Br J Clin Pharmacol 71:600-7. 2011..To characterize patients with urate measurements by urate-lowering therapy (ULT) use and to study the impact of allopurinol treatment on cardiovascular and mortality outcomes... - Adherence to statin or aspirin or both in patients with established cardiovascular disease: exploring healthy behaviour vs. drug effects and 10-year follow-up of outcomeLi Wei
Medicines Monitoring Unit MEMO, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
Br J Clin Pharmacol 66:110-6. 2008.... - Spironolactone and risk of incident breast cancer in women older than 55 years: retrospective, matched cohort studyIsla S Mackenzie
Medicines Monitoring Unit, University of Dundee, Dundee DD1 9SY, UK
BMJ 345:e4447. 2012..To investigate whether exposure to spironolactone treatment affects the risk of incident breast cancer in women over 55 years of age... - Statin use in the secondary prevention of coronary heart disease in primary care: cohort study and comparison of inclusion and outcome with patients in randomised trialsLi Wei
Medicines Monitoring Unit, Health Informatics Centre, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee DD1 9SY
BMJ 330:821. 2005..82, 0.71 to 0.95). CONCLUSIONS: The community effectiveness of statins in those groups that were not well represented in clinical trials was similar to the efficacy of statins in these trials... - Channelling of SSRIs and SNRIs use in the Tayside population, ScotlandLi Wei
Medicines Monitoring Unit MEMO, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, Scotland, UK
Pharmacoepidemiol Drug Saf 16:859-66. 2007..To compare the user profiles of the two classes of drug, using the Tayside Medicines Monitoring Unit (MEMO) record-linkage database... - Paracetamol-related deaths in Scotland, 1994-2000Christopher L Sheen
Medicines Monitoring Unit, Department of Gastroenterology, Ninewells Hospital, Dundee, DD1 9SY
Br J Clin Pharmacol 54:430-2. 2002..To investigate the death rate due to paracetamol poisoning in Scotland and what effect the reduction in over-the-counter paracetamol pack sizes in 1998 had on the death rate... - Adverse cardiovascular effects of acute salt loading in young normotensive individualsNikolaos Tzemos
Hypertension Research Centre, Division of Medicine and Therapeutics, University of Dundee, Ninewells Hospital and Medical School, United Kingdom
Hypertension 51:1525-30. 2008..02). Salt loading impaired vascular endothelial function, left ventricular mechanical relaxation, and electric repolarization in young healthy normotensives... - A pharmacoeconomic comparison of misoprostol/diclofenac with diclofenacS V Morant
Medicines Monitoring Unit, Department of Clinical Pharmacology, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
Pharmacoepidemiol Drug Saf 11:393-400. 2002..These findings have implications for the management of patients who require treatment with NSAIDs... - Hypersensitivity reactions associated with exposure to naproxen and ibuprofen: a cohort studyA D McMahon
Robertson Centre for Biostatistics, University of Glasgow, Glasgow, Scotland, UK
J Clin Epidemiol 54:1271-4. 2001..63 (0.50, 5.29). The study shows that hypersensitivity reactions associated with NSAID use are rare, and provides no evidence that the risks of hypersensitivity reactions differ between naproxen and ibuprofen... - Cluster randomized trials of prescription medicines or prescribing policy: public and general practitioner opinions in ScotlandIsla S Mackenzie
Medicines Monitoring Unit MEMO, University of Dundee, Dundee, UK
Br J Clin Pharmacol 74:354-61. 2012..To understand public and general practitioner (GP) opinion on the acceptability of randomized policy design (RPD) studies (cluster randomized trials) of prescription medicines in Scotland... - Nitric oxide and cardiovascular effects: new insights in the role of nitric oxide for the management of osteoarthritisIsla S Mackenzie
Hypertension Research Centre, Division of Medicine and Therapeutics, University of Dundee, Dundee DD1 9SY, UK
Arthritis Res Ther 10:S3. 2008..Further studies of the effects of CINODs in humans are required, but these agents represent a potential exciting advance in the management of osteoarthritis... - 'Real-life' reduction in cholesterol with statins, 1993 to 2002Michael J Murphy
Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, Dundee, UK
Br J Clin Pharmacol 65:587-92. 2008..Statins reduce cholesterol concentrations and cardiovascular events in randomized clinical trials. * Much less is known about their impact in the setting of normal care... - Statins and total (not LDL) cholesterol concentration and outcome of myocardial infarction: results from a meta-analysis and an observational studyXia Sheng
Medicines Monitoring Unit, Division of Medical Sciences, University of Dundee, Dundee, UK
Eur J Clin Pharmacol 65:1071-80. 2009.... - Cardiovascular prophylaxis with aspirin: costs of supply and management of upper gastrointestinal and renal toxicityS V Morant
Medicines Monitoring Unit (MEMO, Department of Medicine and Therapeutics, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
Br J Clin Pharmacol 57:188-98. 2004..Serious adverse events were uncommon but despite this aspirin cost the NHS between 6 and 25 times the cost of aspirin tablets due to dispensing costs and the cost of managing adverse effects... - Glaucoma incidence in an unselected cohort of diabetic patients: is diabetes mellitus a risk factor for glaucoma? DARTS/MEMO collaboration. Diabetes Audit and Research in Tayside Study. Medicines Monitoring UnitJ D Ellis
Department of Ophthalmology, Ninewells Hospital and Medical School, Ninewells Road, Dundee DD1 9SY, UK
Br J Ophthalmol 84:1218-24. 2000..To evaluate whether diabetes mellitus is a risk factor for the development of primary open angle glaucoma or ocular hypertension (OHT)... - Exercise blood pressure and endothelial dysfunction in hypertensionN Tzemos
Division of Medicine and Therapeutics, Hypertension Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
Int J Clin Pract 63:202-6. 2009..We hypothesised that such individuals could potentially be identified by an exaggerated systolic blood pressure (BP) response to a submaximal exercise... - Prognosis following first acute myocardial infarction in Type 2 diabetes: a comparative population studyP T Donnan
Medicines Monitoring Unit (MEMO, Department of Clinical Pharmacology, Diabetes Centre, and University Department of Medicine, Ninewells Hospital and Medical School, Dundee, UK
Diabet Med 19:448-55. 2002.... - Impact on mortality following first acute myocardial infarction of distance between home and hospital: cohort studyL Wei
Medicines Monitoring Unit, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
Heart 94:1141-6. 2008..To investigate the effect of distance between home and acute hospital on mortality outcome of patients experiencing an incident myocardial infarction (MI)... - Adverse cardiac effects of salt with fludrocortisone in hypertensionP O Lim
Hypertension Research Center, Department of Clinical Pharmacology and Therapeutics, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
Hypertension 37:856-61. 2001..This raises the possibility that salt may have BP-independent adverse cardiac effects in susceptible hypertensive subjects... - Use and adherence to beta-blockers for secondary prevention of myocardial infarction: who is not getting the treatment?Li Wei
Medicines Monitoring Unit, Department of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
Pharmacoepidemiol Drug Saf 13:761-6. 2004..To characterise those who receive beta-blocker therapy after MI and to estimate the effect of adherence to beta-blocker use on subsequent mortality and recurrent MI... - An approximate Bayesian risk-analysis for the gastro-intestinal safety of ibuprofenJixian Wang
Medicines Monitoring Unit, Department of Pharmacology and Therapeutics, University of Dundee, Dundee DD1 9SY, Scotland
Pharmacoepidemiol Drug Saf 11:695-701. 2002..The approximate Bayesian bootstrap method was demonstrated to be a robust and easily implemented alternative to the full Bayesian approach to risk analysis whenever data are sparse... - Paracetamol pack size restriction: the impact on paracetamol poisoning and the over-the-counter supply of paracetamol, aspirin and ibuprofenChristopher L Sheen
Medicines Monitoring Unit, Ninewells Hospital, Dundee, Scotland, UK
Pharmacoepidemiol Drug Saf 11:329-31. 2002..In 1998, OTC pack sizes of paracetamol were reduced. We have studied the effect of this pack size restriction on OTC supply of paracetamol, aspirin and ibuprofen... - Practice factors that influence antibiotic prescribing in general practice in TaysideD T Steinke
Medicines Monitoring Unit and Tayside Centre for General Practice, Ninewells Hospital, Dundee DD1 9SY, UK
J Antimicrob Chemother 46:509-12. 2000..Training practice status was the dominant factor associated with significant differences in rates of antibiotic prescribing, in class of antibiotic prescribed and in performance indicators of antibiotic prescribing... - Treatment patterns of hypertension and dyslipidaemia in hypertensive patients at higher and lower risk of cardiovascular disease in primary care in the United KingdomT M MacDonald
Medicines Monitoring Unit, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
J Hum Hypertens 21:925-33. 2007..These findings demonstrate the under-recognition/undertreatment of cardiovascular risk factors in UK primary care among patients at risk of CVD... - Pharmacoepidemiological research at the Medicines Monitoring Unit, Scotland: data protection and confidentialityJ M Evans
Medicines Monitoring Unit MEMO, Department of Clinical Pharmacology, Ninewells Hospital, Dundee DD1 9SY, Scotland
Pharmacoepidemiol Drug Saf 10:669-73. 2001..This involves anonymization of data, seeking specific ethical approval for research studies and obtaining relevant permissions from 'Caldicott Guardians', as described in this article... - The doctor-patient relationship and prescribing patterns. A view from primary careD T Steinke
Medicines Monitoring Unit MEMO, Ninewells Hospital, Dundee, Scotland
Pharmacoeconomics 16:599-603. 1999..The client can make better decisions with the relevant information, thus breaking down the agency relationship that once existed... - Costs associated with symptomatic systolic heart failureP G Davey
MEMO Medicines Monitoring, University Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, Scotland
Pharmacoeconomics 16:399-407. 1999..To investigate whether the extent of systolic dysfunction is a useful predictor of the costs of healthcare and social support for patients with heart failure... - Epidemiology and economic burden of viral hepatitis: an observational population based studyD T Steinke
Medicines Monitoring Unit MEMO, Ninewells Hospital, Dundee, UK
Gut 50:100-5. 2002..To describe the epidemiology and estimate the health resource use of patients with viral hepatitis in Tayside, Scotland, using record linkage techniques... - Prior trimethoprim use and trimethoprim-resistant urinary tract infection: a nested case-control study with multivariate analysis for other risk factorsD T Steinke
Medicines Monitoring Unit MEMO, Department of Clinical Pharmacology and Therapeutics, Level 7, Ninewells Hospital, Dundee DD1 9SY, UK
J Antimicrob Chemother 47:781-7. 2001..Reduction in trimethoprim prescribing alone may not reduce the prevalence of trimethoprim resistance... - Adherence to statin treatment and readmission of patients after myocardial infarction: a six year follow up studyL Wei
Medicines Monitoring Unit, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
Heart 88:229-33. 2002..CONCLUSIONS: Despite the infrequent use of statin during the study period, good adherence to statin treatment was associated with lower risk of recurrent MI... - Presence of bacteriuria caused by trimethoprim resistant bacteria in patients prescribed antibiotics: multilevel model with practice and individual patient dataP T Donnan
Tayside Centre for General Practice, Community Health Sciences, University of Dundee, Dundee DD2 4BF
BMJ 328:1297. 2004..To look for evidence of a relation between antibiotic resistance and prescribing by general practitioners by analysis of prescribing at both practice and individual patient level... - Paracetamol toxicity: epidemiology, prevention and costs to the health-care systemC L Sheen
Medicines Monitoring Unit, Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, UK
QJM 95:609-19. 2002..The use, abuse and ways of reducing paracetamol toxicity are reviewed, but in view of the potential for harm, serious consideration should be given to changing the legal status of paracetamol, possibly to a prescription-only medicine... - Frequency of blood glucose monitoring in relation to glycaemic control: observational study with diabetes databaseJ M Evans
Medicines Monitoring Unit, Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee DD1 9SY
BMJ 319:83-6. 1999..To investigate patterns of self monitoring of blood glucose concentration in diabetic patients who use insulin and to determine whether frequency of self monitoring is related to glycaemic control... - Selegiline and mortality in subjects with Parkinson's disease: a longitudinal community studyP T Donnan
Medicines Monitoring Unit MEMO, Department of Clinical Pharmacology, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, UK
Neurology 55:1785-9. 2000..To estimate mortality by drug use in a cohort of patients with PD relative to age- and sex-matched comparators... - Impact of type 1 and type 2 diabetes on patterns and costs of drug prescribing: a population-based studyJ M Evans
Department of Medicine, Ninewells Hospital, University of Dundee, Scotland, UK
Diabetes Care 23:770-4. 2000..Utilization and costs of prescription drugs were investigated in diabetic and nondiabetic patients... - Acetaminophen: risk-management urgently requiredT M MacDonald
Division of Medicine and Therapeutics, Medicines Monitoring Unit, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
Pharmacoepidemiol Drug Saf 15:406-9. 2006 - Post exertional broad complex tachycardia in a normotensive patient: a rare presentation of phaeochromocytomaN Tzemos
Hypertension Research Centre, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, DD I 9SY, United Kingdom
Scott Med J 46:14-5. 2001..We report an unusual association between phaeochromocyotoma and post-exertional malignant arrhythmia in a normotensive subject... - Socio-economic status, obesity and prevalence of Type 1 and Type 2 diabetes mellitusJ M Evans
Medicines Monitoring Unit MEMO, University of Dundee, Scotland, UK
Diabet Med 17:478-80. 2000..The influence of socio-economic status on the prevalence of Type 1 and Type 2 diabetes mellitus, and on obesity, was explored using routinely collected healthcare data for the population of Tayside, Scotland... - Prevalence and aetiology of hypothyroidism in the youngI Hunter
Department of Child Health, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
Arch Dis Child 83:207-10. 2000..To define the prevalence of hypothyroid disease in children and young people, and describe its aetiology... - Prescription of acid-suppressing drugs in relation to endoscopic diagnosis: a record-linkage studyA T Prach
Medicines Monitoring Unit, Department of Clinical Pharmacology, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
Aliment Pharmacol Ther 13:397-405. 1999..Although widely used, few data are available on the appropriateness of prescribing of acid-suppressing drugs (ASDs), despite guidelines on the investigation and treatment of dyspeptic patients... - Irbesartan reduces QT dispersion in hypertensive individualsP O Lim
Hypertension Research Centre, Department of Clinical Pharmacology and Therapeutics, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
Hypertension 33:713-8. 1999..In conclusion, irbesartan improved QT dispersion, and this effect may be important in preventing sudden cardiac death in at-risk hypertensive subjects... - Adherence to prescribed oral hypoglycaemic medication in a population of patients with Type 2 diabetes: a retrospective cohort studyP T Donnan
Tayside Centre for General Practice, Department of Clinical Pharmacology, University of Dundee, Dundee, UK
Diabet Med 19:279-84. 2002..In particular, to test the hypothesis that one tablet per day is associated with better adherence than more than one... - ACE inhibitor use is associated with hospitalization for severe hypoglycemia in patients with diabetes. DARTS/MEMO Collaboration. Diabetes Audit and Research in Tayside, Scotland. Medicines Monitoring UnitA D Morris
Department of Medicine, Ninewells Hospital and Medical School, University of Dundee, Scotland, U K
Diabetes Care 20:1363-7. 1997..To evaluate the association between the use of ACE inhibitors and hospital admission for severe hypoglycemia and to explore the effects of potential confounding variables on this relationship... - Factors associated with trimethoprim-resistant bacteria isolated from urine samplesD T Steinke
Medicines Monitoring Unit MEMO, University of Dundee, UK
J Antimicrob Chemother 43:841-3. 1999..There were no associations found for diabetes or prior corticosteroid exposure. Community controls were found to be inappropriate controls for the study of trimethoprim-resistant bacteria in urine samples... - The multiple propensity score for analysis of dose-response relationships in drug safety studiesJ Wang
Department of Clinical Pharmacology Ninewells Hospital and Medical School, University of Dundee, UK
Pharmacoepidemiol Drug Saf 10:105-11. 2001..We found that the unadjusted risk ratios were biased downwards due to confounders and that this bias was reduced by using stratification based on the multiple propensity score... - Raised aldosterone to renin ratio predicts antihypertensive efficacy of spironolactone: a prospective cohort follow-up studyP O Lim
Hypertension Research Centre, Department of Clinical Pharmacology and Therapeutics, and Department of Endocrinology and Diabetes, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
Br J Clin Pharmacol 48:756-60. 1999..To assess the blood pressure response to oral spironolactone in hypertensive patients with primary aldosteronism identified with raised aldosterone to renin ratio... - The influence of physical activity on the variability of ambulatory blood pressureA C Leary
Department of Clinical Pharmacology, National University of Ireland, Cork, UK
Am J Hypertens 13:1067-73. 2000..Correlation is strongest between BP and average activity integrated over the previous 15 min. Much of the variance in blood pressure remains unexplained... - Channelling bias and the incidence of gastrointestinal haemorrhage in users of meloxicam, coxibs, and older, non-specific non-steroidal anti-inflammatory drugsT M MacDonald
Medicines Monitoring Unit, Department of Clinical Pharmacology and Therapeutics, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
Gut 52:1265-70. 2003.... - Physical activity level is an independent predictor of the diurnal variation in blood pressureA C Leary
Department of Clinical Pharmacology and Therapeutics, National University of Ireland, Cork
J Hypertens 18:405-10. 2000..The aim of this study was to define the relationship between physical activity and the magnitude of the percentage fall in blood pressure at night (nocturnal dip)... - Effect of allopurinol on mortality and hospitalisations in chronic heart failure: a retrospective cohort studyA D Struthers
Department of Clinical Pharmacology and Therapeutics, and the Medicines Monitoring Unit, Ninewells Hospital, Dundee DD1 9SY, UK
Heart 87:229-34. 2002..This hypothesis is based on previous data that a high urate concentration is independently associated with mortality with a risk ratio of 4.23 in CHF... - Nebivolol reverses endothelial dysfunction in essential hypertension: a randomized, double-blind, crossover studyN Tzemos
Hypertension Research Centre, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, United Kingdom
Circulation 104:511-4. 2001..We hypothesized that nebivolol, a vasodilating beta-blocker, could improve endothelial dysfunction. We tested this hypothesis by comparing the effects of nebivolol and atenolol on endothelial function... - Diabetes and lower-limb amputations in the community. A retrospective cohort study. DARTS/MEMO Collaboration. Diabetes Audit and Research in Tayside Scotland/Medicines Monitoring UnitA D Morris
University Department of Medicine, Ninewells Hospital and Medical School, Dundee, Scotland, U K
Diabetes Care 21:738-43. 1998..There are few U.K. data on the incidence rates of amputation in diabetic subjects compared with the nondiabetic population... - The comparative effectiveness of statin therapy in selected chronic diseases compared with the remaining populationXia Sheng
Medicines Monitoring Unit, Division of Medical Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK
BMC Public Health 12:712. 2012.... - Influenza H1N1 (swine flu) vaccination: a safety surveillance feasibility study using self-reporting of serious adverse events and pregnancy outcomesIsla S Mackenzie
Medicines Monitoring Unit, Division of Medical Sciences, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
Br J Clin Pharmacol 73:801-11. 2012.... - Drug treatment discontinuation and achievement of target blood pressure and cholesterol in United Kingdom primary careThomas M MacDonald
Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, UK
Curr Med Res Opin 23:2765-74. 2007..This cohort study evaluated medication discontinuation and target achievement in a United Kingdom primary care setting... - Serum thyroid-stimulating hormone concentration and morbidity from cardiovascular disease and fractures in patients on long-term thyroxine therapyRobert W Flynn
Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
J Clin Endocrinol Metab 95:186-93. 2010..For patients on T(4) replacement, the dose is guided by serum TSH concentrations, but some patients request higher doses due to adverse symptoms... - Promoting public awareness of randomised clinical trials using the media: the 'Get Randomised' campaignIsla S Mackenzie
Medicines Monitoring Unit MEMO, University of Dundee, Dundee and Health Services Research Unit, University of Aberdeen, Aberdeen, UK
Br J Clin Pharmacol 69:128-35. 2010..8, 3.1%; P= 0.92]. CONCLUSIONS It is possible to raise public awareness of clinical research using the media, but further efforts may be required to influence individuals' decisions to take part in clinical research... - The epidemiology of liver disease in Tayside database: a population-based record-linkage studyDouglas T Steinke
ELDIT Medicines Monitoring Unit MEMO, Ninewells Hospital, Dundee, UK
J Biomed Inform 35:186-93. 2002..The epidemiology of liver disease in Tayside (ELDIT) is a specially built register of liver disease for a well-defined geographical area of Scotland... - The Walker Project: a longitudinal study of 48,000 children born 1952-1966 (aged 36-50 years in 2002) and their familiesGillian Libby
Medicines Monitoring Unit MEMO, University of Dundee, Scotland, UK
Paediatr Perinat Epidemiol 18:302-12. 2004..The number of birth records available and linkage to current databases make this a unique birth cohort with huge potential for the investigation of the fetal origins of adult disease... - Managing security and privacy concerns over data storage in healthcare researchIsla S Mackenzie
Medicines Monitoring Unit MEMO, University of Dundee, Dundee, UK
Pharmacoepidemiol Drug Saf 20:885-93. 2011..We discuss holistic measures, involving both information technology and people, taken to improve the security and privacy of data storage... - The safety of drugs for OTC use: what evidence is required for an NSAID switch?Thomas M MacDonald
Medicines Monitoring Unit, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
Pharmacoepidemiol Drug Saf 11:577-84. 2002..2 with at least 90% power for an event rate of 5%. An example of a possible pharmacy-based randomized study design to demonstrate safety equivalence of OTC analgesics is given... - Influence of a single dose of 20 mg tadalafil, a phosphodiesterase 5 inhibitor, on ambulatory blood pressure in subjects with hypertensionDean Patterson
Department of Medicine, Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
Br J Clin Pharmacol 62:280-7. 2006..To test the non-inferiority of a single dose of tadalafil 20 mg compared with placebo with respect to 26-h mean ambulatory systolic and diastolic blood pressure in treated and untreated hypertensive subjects... - Mineralocorticoid receptor antagonistsHari Krishnan Parthasarathy
Hypertension Research Centre, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, DD1 9SY, UK
Curr Hypertens Rep 9:45-52. 2007..The re-emergence of mineralocorticoid receptor antagonists has provided clinicians with an important tool towards complete blockade of the renin-angiotensin-aldosterone axis... - Record-linkage methodology for prescribing researchG Libby
Medicines Monitoring Unit (MEMO, University of Dundee, Ninewells Hospital, Dundee, UK
J Clin Pharm Ther 26:241-6. 2001..We draw upon the work of the Medicines Monitoring Unit (MEMO), University of Dundee, to illustrate its contribution to prescribing research... - Isolated diastolic heart failure as a cause of breathlessness in the community: the Arbroath studyR J MacFadyen
Department of Clinical Pharmacology and Therapeutics, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
Eur J Heart Fail 3:243-8. 2001..The patients in this group have adverse cardiovascular risk profiles. Obesity was a common co-morbidity which may impair detailed 2-D echocardiographic assessment... - Association between allopurinol and mortality in heart failure patients: a long-term follow-up studyL Wei
Medicines Monitoring Unit MEMO, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
Int J Clin Pract 63:1327-33. 2009..The aim of the study was to explore the long-term effect of allopurinol on mortality and cardiovascular hospitalisations in heart failure (HF) patients... - The thyroid epidemiology, audit, and research study: thyroid dysfunction in the general populationR W V Flynn
Medicines Monitoring Unit, Ninewells Hospital and Medical School, Dundee, DD1 9SY, United Kingdom
J Clin Endocrinol Metab 89:3879-84. 2004..The midyear point prevalence of all-cause hypothyroidism rose from 2.2% in 1993 to 3.0% in 1996.The level of thyroid dysfunction in Tayside, Scotland is higher than previously reported, and it increased from 1993 to 1996... - Blood pressure determinants of left ventricular wall thickness and mass index in hypertension: comparing office, ambulatory and exercise blood pressuresP O Lim
Hypertension Research Centre, Department of Clinical Pharmacology and Therapeutics, and Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
J Hum Hypertens 15:627-33. 2001..The exercise BP should perhaps be normalised in hypertension management to optimise regression of LV hypertrophy... - Appendicectomy is associated with increased pregnancy rate: a cohort studyLi Wei
Medicines Monitoring Unit, School of Medicine, Division of Medical Sciences, Centre for Academic Clinical Practice, Division of Clinical and Population Sciences and Education, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland
Ann Surg 256:1039-44. 2012..This study was carried out to determine whether pregnancy rate is reduced after appendicitis or appendicectomy... - Cardiovascular safety of lumiracoxib: a meta-analysis of randomised controlled trials in patients with osteoarthritisIsla S Mackenzie
Medicines Monitoring Unit MEMO and Hypertension Research Centre HRC, Division of Medical Sciences, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
Eur J Clin Pharmacol 69:133-41. 2013..To re-evaluate the cardiovascular risk of lumiracoxib compared with other non-steroidal anti-inflammatory drugs (NSAIDs) or placebo in patients with osteoarthritis... - Pioglitazone and bladder cancer: a propensity score matched cohort studyLi Wei
Medicines Monitoring Unit, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, Scotland, UK
Br J Clin Pharmacol 75:254-9. 2013..To examine whether exposure to pioglitazone use is associated with increased incidence of bladder cancer in patients with type 2 diabetes mellitus... - Taking glucocorticoids by prescription is associated with subsequent cardiovascular diseaseLi Wei
Ninewells Hospital and Medical School, Dundee, Scotland, United Kingdom
Ann Intern Med 141:764-70. 2004..56 (CI, 2.18 to 2.99). LIMITATIONS: Because the data were observational, residual confounding cannot be excluded. CONCLUSION: Treatment with high-dose glucocorticoids seemed to be associated with increased risk for cardiovascular disease... - Variation at the aldosterone synthase (CYP11B2) locus contributes to hypertension in subjects with a raised aldosterone-to-renin ratioPitt O Lim
Hypertension Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
J Clin Endocrinol Metab 87:4398-402. 2002..This study supports the notion that there is a genetic component that regulates aldosterone production and that hyperaldosteronism might develop over time in susceptible individuals... - Automated data capture from free-text radiology reports to enhance accuracy of hospital inpatient stroke codesRobert W V Flynn
Medicines Monitoring Unit, University of Dundee, Dundee, UK
Pharmacoepidemiol Drug Saf 19:843-7. 2010..We aimed to increase the number of stroke-type-specific diagnoses by augmenting SMR01 with data derived from CRIS reports and to assess the accuracy of this methodology... - Review of aldosterone- and angiotensin II-induced target organ damage and preventionAllan D Struthers
Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Tayside DD1 9SY, Dundee, UK
Cardiovasc Res 61:663-70. 2004.... - Is exercise blood pressure a marker of vascular endothelial function?N Tzemos
Hypertension Research Centre, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
QJM 95:423-9. 2002 - Reversible hypertension following coeliac disease treatment: the role of moderate hyperhomocysteinaemia and vascular endothelial dysfunctionP O Lim
Hypertension Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
J Hum Hypertens 16:411-5. 2002..This highlights the need to resolve co-existing vascular risk factors in patients with hypertension... - Why not prescribe the best drugs for hypertension now?S Y S Wong
Department of Clinical Pharmacology, Hypertension Research Centre, Ninewells Hospital and Medical School, Dundee, UK
J Hum Hypertens 17:505-11. 2003.... - Gastrointestinal side effects of NSAIDs - pharmacoeconomic implicationsChristopher L Sheen
Medicines Monitoring Unit, Ninewells Hospital, Dundee, UK
Expert Opin Pharmacother 3:265-9. 2002..It also highlights the variability in risk and the impact of newer drugs. Risk stratification and the subsequent guided use of NSAIDs is likely to limit the pharmacoeconomic implications... - Vitamin A and lung function in CFFiona K Aird
Division of Maternal and Child Health Sciences, University of Dundee, Ninewells Hospital and Medical School, Scotland, DD1 9SY, UK
J Cyst Fibros 5:129-31. 2006..Serum vitamin D and vitamin E concentrations were also measured but did not show any significant correlations with lung function... - Does a prolonged QT peak identify left ventricular hypertrophy in hypertension?K Y K Wong
The Cardiovascular Research Group, Ninewells Hospital, Dundee, UK
Int J Cardiol 89:179-86. 2003..start of QRS to peak of T wave) is easier to measure. Therefore, we tested the hypothesis that long QT peak was associated with left ventricular hypertrophy and assessed its cost-effectiveness at diagnosing left ventricular hypertrophy... - The association between coeliac disease and cardiovascular diseaseL Wei
Medicines Monitoring Unit, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
Aliment Pharmacol Ther 27:514-9. 2008..Coeliac disease is more prevalent than was previously thought. The association between coeliac disease and cardiovascular outcome is not clear...