H M Macdonald

Summary

Affiliation: University of Aberdeen
Country: UK

Publications

  1. ncbi request reprint Nutritional associations with bone loss during the menopausal transition: evidence of a beneficial effect of calcium, alcohol, and fruit and vegetable nutrients and of a detrimental effect of fatty acids
    Helen M Macdonald
    Department of Medicine and Therapeutics, University of Aberdeen, United Kingdom
    Am J Clin Nutr 79:155-65. 2004
  2. doi request reprint Contributions of sunlight and diet to vitamin D status
    Helen M Macdonald
    Musculoskeletal Research, Health Sciences Building, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Calcif Tissue Int 92:163-76. 2013
  3. doi request reprint Vitamin D3 supplementation has no effect on conventional cardiovascular risk factors: a parallel-group, double-blind, placebo-controlled RCT
    Adrian D Wood
    School of Medicine and Dentistry, Health Sciences Building, University of Aberdeen, and Grampian Osteoporosis Service, Woolmanhill Hospital, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    J Clin Endocrinol Metab 97:3557-68. 2012
  4. doi request reprint Dietary silicon interacts with oestrogen to influence bone health: evidence from the Aberdeen Prospective Osteoporosis Screening Study
    Helen M Macdonald
    Musculoskeletal Research Programme, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Bone 50:681-7. 2012
  5. doi request reprint Vitamin D status in postmenopausal women living at higher latitudes in the UK in relation to bone health, overweight, sunlight exposure and dietary vitamin D
    Helen M Macdonald
    Department of Medicine and Therapeutics, University of Aberdeen, Medical School Buildings, Foresterhill, Aberdeen, AB25 2ZD, UK
    Bone 42:996-1003. 2008
  6. doi request reprint Changes in vitamin biomarkers during a 2-year intervention trial involving increased fruit and vegetable consumption by free-living volunteers
    Helen M Macdonald
    Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Br J Nutr 102:1477-86. 2009
  7. doi request reprint Sunlight and dietary contributions to the seasonal vitamin D status of cohorts of healthy postmenopausal women living at northerly latitudes: a major cause for concern?
    H M Macdonald
    University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Osteoporos Int 22:2461-72. 2011
  8. ncbi request reprint Large-scale population-based study shows no evidence of association between common polymorphism of the VDR gene and BMD in British women
    Helen M Macdonald
    Department of Medicine and Therapeutics, University of Aberdeen, Medical School Buildings, Foresterhill, Aberdeen, United Kingdom
    J Bone Miner Res 21:151-62. 2006
  9. doi request reprint Skin color change in Caucasian postmenopausal women predicts summer-winter change in 25-hydroxyvitamin D: findings from the ANSAViD cohort study
    Helen M Macdonald
    Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    J Clin Endocrinol Metab 96:1677-86. 2011
  10. ncbi request reprint Vitamin K1 intake is associated with higher bone mineral density and reduced bone resorption in early postmenopausal Scottish women: no evidence of gene-nutrient interaction with apolipoprotein E polymorphisms
    Helen M Macdonald
    Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom
    Am J Clin Nutr 87:1513-20. 2008

Detail Information

Publications27

  1. ncbi request reprint Nutritional associations with bone loss during the menopausal transition: evidence of a beneficial effect of calcium, alcohol, and fruit and vegetable nutrients and of a detrimental effect of fatty acids
    Helen M Macdonald
    Department of Medicine and Therapeutics, University of Aberdeen, United Kingdom
    Am J Clin Nutr 79:155-65. 2004
    ..The menopausal transition is characterized by rapid bone loss. Few data exist on the role of nutrition...
  2. doi request reprint Contributions of sunlight and diet to vitamin D status
    Helen M Macdonald
    Musculoskeletal Research, Health Sciences Building, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Calcif Tissue Int 92:163-76. 2013
    ..Although oral vitamin D is potentially toxic with high-dose supplements, there is a wide safety margin. Long-term safety data covering a range of potential adverse outcomes are limited...
  3. doi request reprint Vitamin D3 supplementation has no effect on conventional cardiovascular risk factors: a parallel-group, double-blind, placebo-controlled RCT
    Adrian D Wood
    School of Medicine and Dentistry, Health Sciences Building, University of Aberdeen, and Grampian Osteoporosis Service, Woolmanhill Hospital, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    J Clin Endocrinol Metab 97:3557-68. 2012
    ..Observational studies show an association between low vitamin D status assessed by circulating 25-hydroxyvitamin D and cardiovascular events and mortality. Data from randomized controlled trials are limited...
  4. doi request reprint Dietary silicon interacts with oestrogen to influence bone health: evidence from the Aberdeen Prospective Osteoporosis Screening Study
    Helen M Macdonald
    Musculoskeletal Research Programme, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Bone 50:681-7. 2012
    ..Silicon (Si), as Si(OH)(4), is derived mainly from plant-based foods. Dietary Si is associated with bone mineral density (BMD) in premenopausal but not postmenopausal women...
  5. doi request reprint Vitamin D status in postmenopausal women living at higher latitudes in the UK in relation to bone health, overweight, sunlight exposure and dietary vitamin D
    Helen M Macdonald
    Department of Medicine and Therapeutics, University of Aberdeen, Medical School Buildings, Foresterhill, Aberdeen, AB25 2ZD, UK
    Bone 42:996-1003. 2008
    ..Diet appears to attenuate the seasonal variation of vitamin D status in early postmenopausal women at northerly latitude where quality of sunlight for production of vitamin D is diminished...
  6. doi request reprint Changes in vitamin biomarkers during a 2-year intervention trial involving increased fruit and vegetable consumption by free-living volunteers
    Helen M Macdonald
    Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Br J Nutr 102:1477-86. 2009
    ..Plasma vitamin C and whole-blood folate may be suitable for monitoring intakes in populations but for monitoring compliance the former may be restricted to low intakes of fruit and vegetables and the latter to vegetable intake...
  7. doi request reprint Sunlight and dietary contributions to the seasonal vitamin D status of cohorts of healthy postmenopausal women living at northerly latitudes: a major cause for concern?
    H M Macdonald
    University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Osteoporos Int 22:2461-72. 2011
    ..Sunlight exposure in summer and spring provided 80% total annual intake of vitamin D...
  8. ncbi request reprint Large-scale population-based study shows no evidence of association between common polymorphism of the VDR gene and BMD in British women
    Helen M Macdonald
    Department of Medicine and Therapeutics, University of Aberdeen, Medical School Buildings, Foresterhill, Aberdeen, United Kingdom
    J Bone Miner Res 21:151-62. 2006
    ..Here we studied five common polymorphisms of VDR in relation to calcium intake and vitamin D status in a population-based cohort of 3100 British women, but found no significant association with bone mass, bone loss, or fracture...
  9. doi request reprint Skin color change in Caucasian postmenopausal women predicts summer-winter change in 25-hydroxyvitamin D: findings from the ANSAViD cohort study
    Helen M Macdonald
    Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    J Clin Endocrinol Metab 96:1677-86. 2011
    ..UV radiation is responsible for vitamin D synthesis and skin tanning. Longitudinal data relating skin color to vitamin D status are lacking...
  10. ncbi request reprint Vitamin K1 intake is associated with higher bone mineral density and reduced bone resorption in early postmenopausal Scottish women: no evidence of gene-nutrient interaction with apolipoprotein E polymorphisms
    Helen M Macdonald
    Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom
    Am J Clin Nutr 87:1513-20. 2008
    ..Polymorphisms in the apolipoprotein E (APOE) gene are associated with fracture risk, and a potential mechanism is through vitamin K transport...
  11. ncbi request reprint Methylenetetrahydrofolate reductase polymorphism interacts with riboflavin intake to influence bone mineral density
    H M Macdonald
    Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Bone 35:957-64. 2004
    ..This raises the possibility that riboflavin intake and MTHFR genotype might interact to regulate BMD. Further work is required to determine if this association holds true for other populations and ethnic groups...
  12. ncbi request reprint Influence of weight and weight change on bone loss in perimenopausal and early postmenopausal Scottish women
    Helen M Macdonald
    Department of Medicine and Therapeutics, University of Aberdeen, Medical School Buildings, Foresterhill, Aberdeen, AB25 2ZD, UK
    Osteoporos Int 16:163-71. 2005
    ..Postmenopausal women not taking HRT should be made aware that low body weight or losing weight during this particularly vulnerable period may worsen bone loss...
  13. ncbi request reprint Longitudinal changes in weight in perimenopausal and early postmenopausal women: effects of dietary energy intake, energy expenditure, dietary calcium intake and hormone replacement therapy
    H M Macdonald
    Department of Medicine and Therapeutics, University of Aberdeen, Medical School Buildings, Foresterhill, Aberdeen, UK
    Int J Obes Relat Metab Disord 27:669-76. 2003
    ....
  14. ncbi request reprint Effect of potassium citrate supplementation or increased fruit and vegetable intake on bone metabolism in healthy postmenopausal women: a randomized controlled trial
    Helen M Macdonald
    University of Aberdeen, Aberdeen, United Kingdom
    Am J Clin Nutr 88:465-74. 2008
    ..Alkali provision may explain why fruit and vegetables benefit bone health...
  15. ncbi request reprint COL1A1 Sp1 polymorphism predicts perimenopausal and early postmenopausal spinal bone loss
    H M Macdonald
    Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill, United Kingdom
    J Bone Miner Res 16:1634-41. 2001
    ..0%), weight (5.0%), and baseline BMD (2.8%). We conclude that women homozygous for the Sp1 polymorphism are at significantly increased risk of excess rates of bone loss at the spine, but this effect may be nullified by the use of HRT...
  16. doi request reprint Seasonal 25-hydroxyvitamin D changes in British postmenopausal women at 57 degrees N and 51 degrees N: a longitudinal study
    A Mavroeidi
    Bone and Musculoskeletal Research Programme, University of Aberdeen, UK
    J Steroid Biochem Mol Biol 121:459-61. 2010
    ..The extent of vitamin D deficiency in Asian women residing in the South of England is of concern...
  17. pmc Association of oestrogen receptor alpha gene polymorphisms with postmenopausal bone loss, bone mass, and quantitative ultrasound properties of bone
    O M E Albagha
    The Bone Research Group, Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen AB25 2ZD, UK
    J Med Genet 42:240-6. 2005
    ..The gene encoding oestrogen receptor alpha (ESR1) appears to regulate bone mineral density (BMD) and other determinants of osteoporotic fracture risk...
  18. doi request reprint Physical activity and dietary calcium interactions in bone mass in Scottish postmenopausal women
    A Mavroeidi
    School of Medical Sciences, University of Aberdeen, Aberdeen, UK
    Osteoporos Int 20:409-16. 2009
    ..At low and/or medium Ca intakes BMD was higher amongst the most active people...
  19. doi request reprint Dietary patterns, bone resorption and bone mineral density in early post-menopausal Scottish women
    A C Hardcastle
    Bone and Musculoskeletal Research Programme, Division of Applied Medicine, University of Aberdeen, Aberdeen, UK
    Eur J Clin Nutr 65:378-85. 2011
    ..Dietary patterns may provide insights into which foods are important and how nutrition affects bone health. The aim of this study was to investigate the associations between dietary patterns, bone turnover and bone mineral density (BMD)...
  20. doi request reprint A parallel group double-blind RCT of vitamin D3 assessing physical function: is the biochemical response to treatment affected by overweight and obesity?
    A D Wood
    School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen, AB252ZD, UK
    Osteoporos Int 25:305-15. 2014
    ..In a double-blind, randomised, placebo-controlled trial, we found that vitamin D3 supplementation (400 or 1,000 I.U. vs. placebo daily for 1 year with bimonthly study visits) does not improve grip strength or reduce falls...
  21. ncbi request reprint Large-scale population-based study shows no association between common polymorphisms of the TGFB1 gene and BMD in women
    Fiona E A McGuigan
    Department of Medicine and Therapeutics, University of Aberdeen, UK
    J Bone Miner Res 22:195-202. 2007
    ..We studied five common polymorphisms of TGFB1 in relation to osteoporosis-related phenotypes in a population-based cohort of 2975 British women, but found no significant association with bone mass, bone loss, bone markers, or fracture...
  22. doi request reprint The functional ACTN3 577X variant increases the risk of falling in older females: results from two large independent cohort studies
    Robert N Judson
    Musculoskeletal Research Programme, Division of Applied Medicine, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK
    J Gerontol A Biol Sci Med Sci 66:130-5. 2011
    ..We investigated whether a common functional variant of skeletal muscle α-actinin-3 (ACTN3 p. R577X) previously associated with impairments in muscle strength, power, and physical functioning represents a risk factor for falls...
  23. ncbi request reprint Longitudinal changes in dietary intake in Scottish women around the menopause: changes in dietary pattern result in minor changes in nutrient intake
    Helen M Macdonald
    Centre for Nutrition and Food Safety, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK
    Public Health Nutr 8:409-16. 2005
    ..To examine dietary change that has occurred over 5 to 6 years...
  24. doi request reprint Associations between dietary flavonoid intakes and bone health in a Scottish population
    Antonia C Hardcastle
    Bone and Musculoskeletal Research Programme, University of Aberdeen, Foresterhill, Aberdeen, Scotland
    J Bone Miner Res 26:941-7. 2011
    ..057, p ≤ .001). These associations were still seen after adjusting for confounders. It is concluded that dietary flavonoid intakes are associated with BMD, supporting the evidence from animal and cellular studies...
  25. ncbi request reprint Low dietary potassium intakes and high dietary estimates of net endogenous acid production are associated with low bone mineral density in premenopausal women and increased markers of bone resorption in postmenopausal women
    Helen M Macdonald
    Department of Medicine and Therapeutics, University of Aberdeen, Medical School Buildings, Aberdeen, United Kingdom
    Am J Clin Nutr 81:923-33. 2005
    ..Algorithms based on dietary intakes of key nutrients can be used to approximate net endogenous acid production (NEAP) and to explore the association between dietary acidity and bone health...
  26. ncbi request reprint Lower estimates of net endogenous non-carbonic acid production are positively associated with indexes of bone health in premenopausal and perimenopausal women
    Susan A New
    Centre for Nutrition and Food Safety, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, United Kingdom
    Am J Clin Nutr 79:131-8. 2004
    ..Estimation of the net rate of endogenous non-carbonic acid production (NEAP) from dietary protein and potassium content enables exploration of the effects of dietary acidity or alkalinity on bone...
  27. ncbi request reprint Standardizing terminology for estimating the diet-dependent net acid load to the metabolic system
    Lynda A Frassetto
    University of California San Francisco, CA 94143, USA
    J Nutr 137:1491-2. 2007