Andrew S MacDonald

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc TLR-4 ligation of dendritic cells is sufficient to drive pathogenic T cell function in experimental autoimmune encephalomyelitis
    Richard J Mellanby
    Medical Research Council University of Edinburgh Centre for Inflammation Research, Centre for Multiple Sclerosis Research and Centre for Immunity Infection and Evolution, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    J Neuroinflammation 9:248. 2012
  2. pmc Alarming dendritic cells for Th2 induction
    Andrew S MacDonald
    the Institute of Immunology and Infection Research, Ashworth Laboratories, University of Edinburgh, Edinburgh EH9 3JT, Scotland, UK
    J Exp Med 205:13-7. 2008
  3. pmc Th2 responses to helminth parasites can be therapeutically enhanced by, but are not dependent upon, GITR-GITR ligand costimulation in vivo
    Nienke Van Der Werf
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    J Immunol 187:1411-20. 2011
  4. doi request reprint A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivo
    Georgia Perona-Wright
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    J Immunol 182:2808-15. 2009
  5. pmc ICOS controls Foxp3(+) regulatory T-cell expansion, maintenance and IL-10 production during helminth infection
    Stephen A Redpath
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 43:705-15. 2013
  6. pmc Alternatively activated dendritic cells regulate CD4+ T-cell polarization in vitro and in vivo
    Peter C Cook
    Institute of Immunology and Infection Research, Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, Scotland, United Kingdom
    Proc Natl Acad Sci U S A 109:9977-82. 2012
  7. pmc Concurrent bacterial stimulation alters the function of helminth-activated dendritic cells, resulting in IL-17 induction
    Georgia Perona-Wright
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    J Immunol 188:2350-8. 2012
  8. ncbi request reprint Full development of Th2 immunity requires both innate and adaptive sources of CD154
    Stephen J Jenkins
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    J Immunol 180:8083-92. 2008
  9. ncbi request reprint Distinct sources and targets of IL-10 during dendritic cell-driven Th1 and Th2 responses in vivo
    Georgia Perona-Wright
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 36:2367-75. 2006
  10. pmc CD11c depletion severely disrupts Th2 induction and development in vivo
    Alexander T Phythian-Adams
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, EH9 3JT Scotland, UK
    J Exp Med 207:2089-96. 2010

Collaborators

Detail Information

Publications23

  1. pmc TLR-4 ligation of dendritic cells is sufficient to drive pathogenic T cell function in experimental autoimmune encephalomyelitis
    Richard J Mellanby
    Medical Research Council University of Edinburgh Centre for Inflammation Research, Centre for Multiple Sclerosis Research and Centre for Immunity Infection and Evolution, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    J Neuroinflammation 9:248. 2012
    ..We sought to test the feasibility of this approach and whether activation of the DC by toll-like receptor (TLR)-4 ligation was a sufficient stimulus to drive EAE...
  2. pmc Alarming dendritic cells for Th2 induction
    Andrew S MacDonald
    the Institute of Immunology and Infection Research, Ashworth Laboratories, University of Edinburgh, Edinburgh EH9 3JT, Scotland, UK
    J Exp Med 205:13-7. 2008
    ..However, progress is being made with the identification of novel endogenous tissue factors that can enhance Th2 induction by DCs...
  3. pmc Th2 responses to helminth parasites can be therapeutically enhanced by, but are not dependent upon, GITR-GITR ligand costimulation in vivo
    Nienke Van Der Werf
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    J Immunol 187:1411-20. 2011
    ....
  4. doi request reprint A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivo
    Georgia Perona-Wright
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    J Immunol 182:2808-15. 2009
    ..Our data delineate sequential requirements for DC expression of CD40 and production of IL-6 during Th17 polarization in vitro and in vivo, and reveal distinct costimulatory requirements for Th1 vs Th17 generation...
  5. pmc ICOS controls Foxp3(+) regulatory T-cell expansion, maintenance and IL-10 production during helminth infection
    Stephen A Redpath
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 43:705-15. 2013
    ..Thus, ICOS regulates Type 2 immunity in a tissue-specific manner, and plays a key role in driving Foxp3 Treg-cell expansion and function during helminth infections...
  6. pmc Alternatively activated dendritic cells regulate CD4+ T-cell polarization in vitro and in vivo
    Peter C Cook
    Institute of Immunology and Infection Research, Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, Scotland, United Kingdom
    Proc Natl Acad Sci U S A 109:9977-82. 2012
    ..Together, these data highlight the significant impact that IL-4 and RELMα can have on DC activation and function in the context of either bacterial or helminth pathogens...
  7. pmc Concurrent bacterial stimulation alters the function of helminth-activated dendritic cells, resulting in IL-17 induction
    Georgia Perona-Wright
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    J Immunol 188:2350-8. 2012
    ....
  8. ncbi request reprint Full development of Th2 immunity requires both innate and adaptive sources of CD154
    Stephen J Jenkins
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    J Immunol 180:8083-92. 2008
    ..These data help define the costimulatory interactions that occur during the generation of Th2 immunity, and challenge the widely held view that CD154 expressing T cells are the sole contributors in this process...
  9. ncbi request reprint Distinct sources and targets of IL-10 during dendritic cell-driven Th1 and Th2 responses in vivo
    Georgia Perona-Wright
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 36:2367-75. 2006
    ..Surprisingly, the critical source of IL-10 in this process is neither T nor B cells. These data illustrate the distinct actions of IL-10 during differently polarised, pathogen-focussed, DC-driven immune responses in vivo...
  10. pmc CD11c depletion severely disrupts Th2 induction and development in vivo
    Alexander T Phythian-Adams
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, EH9 3JT Scotland, UK
    J Exp Med 207:2089-96. 2010
    ....
  11. doi request reprint Chronic helminth infection promotes immune regulation in vivo through dominance of CD11cloCD103- dendritic cells
    Katherine A Smith
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    J Immunol 186:7098-109. 2011
    ..Thus, the proregulatory environment of chronic intestinal helminth infection is associated with the in vivo predominance of a newly defined phenotype of CD11c(lo) tolerogenic DCs...
  12. doi request reprint Dendritic cell expression of the Notch ligand jagged2 is not essential for Th2 response induction in vivo
    Alan G F Worsley
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 38:1043-9. 2008
    ..These data suggest that, although involved in Th2 direction in vitro, jagged2 is not fundamentally required for Th2 induction by SEA-activated dendritic cells in vivo...
  13. pmc Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation
    Stephen J Jenkins
    Centre for Immunity, Infection and Evolution, and the Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK
    Science 332:1284-8. 2011
    ..Thus, expansion of innate cells necessary for pathogen control or wound repair can occur without recruitment of potentially tissue-destructive inflammatory cells...
  14. ncbi request reprint Dendritic cell activation and function in response to Schistosoma mansoni
    Georgia Perona-Wright
    Institute of Immunology and Infection Research, University of Edinburgh, 212B Ashworth Labs, King s Buildings, West Mains Road, Edinburgh EH9 3JT, Scotland, UK
    Int J Parasitol 36:711-21. 2006
    ....
  15. ncbi request reprint Cytokine-dependent inflammatory cell recruitment patterns in the peritoneal cavity of mice exposed to the parasitic nematode Brugia malayi
    Andrew S MacDonald
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Med Microbiol Immunol 192:33-40. 2003
    ..Surprisingly, the absence of T cells failed to influence inflammatory cell recruitment indicating that recruitment signals are provided by other cell types...
  16. ncbi request reprint Cutting edge: polarized Th cell response induction by transferred antigen-pulsed dendritic cells is dependent on IL-4 or IL-12 production by recipient cells
    Andrew S MacDonald
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Immunol 168:3127-30. 2002
    ..These data help delineate the source and importance of IL-4 and IL-12 in the process of induction of polarized T cell responses by DC...
  17. ncbi request reprint Impaired Th2 development and increased mortality during Schistosoma mansoni infection in the absence of CD40/CD154 interaction
    Andrew S MacDonald
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Immunol 168:4643-9. 2002
    ..These data indicate that CD40/CD154 interaction is required to allow development of a Th2-dominated immune response to S. mansoni and support the view that failure to develop such a response can have fatal consequences...
  18. ncbi request reprint Cutting edge: Th2 response induction by dendritic cells: a role for CD40
    Andrew S MacDonald
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Immunol 168:537-40. 2002
    ..acnes. CD40-CD154 interaction can therefore play a major role in Th2 response induction...
  19. ncbi request reprint Lack of C3 affects Th2 response development and the sequelae of chemotherapy in schistosomiasis
    Anne Camille La Flamme
    Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA
    J Immunol 170:470-6. 2003
    ..Together these results indicate that C3 enhances Th2 responses during schistosome infection, potentiates PZQ-mediated parasite clearance, and reduces chemotherapy-induced proinflammatory mediator production...
  20. ncbi request reprint CD154 plays a central role in regulating dendritic cell activation during infections that induce Th1 or Th2 responses
    Amy D Straw
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia 19104, USA
    J Immunol 170:727-34. 2003
    ..However, the ability of this activation pathway to induce IL-12 production by DC is restrained in S. mansoni-infected, but not T. gondii-infected, mice by Ag-responsive CD11c(-) cells...
  21. ncbi request reprint Dendritic cell expression of OX40 ligand acts as a costimulatory, not polarizing, signal for optimal Th2 priming and memory induction in vivo
    Stephen J Jenkins
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    J Immunol 179:3515-23. 2007
    ..These data define a critical role for DC-derived OX40L in the induction and development of Th2 responses in vivo...
  22. ncbi request reprint Cutting edge: dendritic cells copulsed with microbial and helminth antigens undergo modified maturation, segregate the antigens to distinct intracellular compartments, and concurrently induce microbe-specific Th1 and helminth-specific Th2 responses
    Laura Cervi
    Departments of Pathobiology and Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 172:2016-20. 2004
    ....
  23. ncbi request reprint Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infection
    Devon J Shedlock
    Department of Microbiology, School of Medicine, University of Pennsylvania, 3610 Hamilton Walk, Philadelphia, PA 19104 6076, USA
    J Immunol 170:2053-63. 2003
    ....