Neil A Mabbott

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc An expression atlas of human primary cells: inference of gene function from coexpression networks
    Neil A Mabbott
    The Roslin Institute and Royal Dick School of Veterinary Studies, The University of Edinburgh, Easter Bush, Midlothian, Edinburgh EH25 9RG, UK
    BMC Genomics 14:632. 2013
  2. pmc Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium
    N A Mabbott
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Easter Bush, Midlothian, Scotland, UK
    Mucosal Immunol 6:666-77. 2013
  3. pmc Prion pathogenesis and secondary lymphoid organs (SLO): tracking the SLO spread of prions to the brain
    Neil A Mabbott
    The Roslin Institute and Royal Dick School of Veterinary Studies, Midlothian, UK
    Prion 6:322-33. 2012
  4. doi request reprint Meta-analysis of lineage-specific gene expression signatures in mouse leukocyte populations
    Neil A Mabbott
    The Roslin Institute and Royal Dick School of Veterinary Studies, The University of Edinburgh, Roslin Biocentre, Roslin, Midlothian, UK
    Immunobiology 215:724-36. 2010
  5. pmc Expression of mesenchyme-specific gene signatures by follicular dendritic cells: insights from the meta-analysis of microarray data from multiple mouse cell populations
    Neil A Mabbott
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Easter Bush, Midlothian, UK
    Immunology 133:482-98. 2011
  6. doi request reprint Determining the role of mononuclear phagocytes in prion neuroinvasion from the skin
    Gwennaelle J Wathne
    University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK
    J Leukoc Biol 91:817-28. 2012
  7. pmc The effects of host age on the transport of complement-bound complexes to the spleen and the pathogenesis of intravenous scrapie infection
    Karen L Brown
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Roslin, Midlothian, United Kingdom
    J Virol 86:25-35. 2012
  8. pmc Ablation of the cellular prion protein, PrPC, specifically on follicular dendritic cells has no effect on their maturation or function
    Laura McCulloch
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Midlothian, UK
    Immunology 138:246-57. 2013
  9. pmc Identification of novel genes selectively expressed in the follicle-associated epithelium from the meta-analysis of transcriptomics data from multiple mouse cell and tissue populations
    Atsushi Kobayashi
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK
    DNA Res 19:407-22. 2012
  10. doi request reprint The effects of host age on follicular dendritic cell status dramatically impair scrapie agent neuroinvasion in aged mice
    Karen L Brown
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Roslin, United Kingdom
    J Immunol 183:5199-207. 2009

Collaborators

Detail Information

Publications20

  1. pmc An expression atlas of human primary cells: inference of gene function from coexpression networks
    Neil A Mabbott
    The Roslin Institute and Royal Dick School of Veterinary Studies, The University of Edinburgh, Easter Bush, Midlothian, Edinburgh EH25 9RG, UK
    BMC Genomics 14:632. 2013
    ..Here we have combined a large number of publically available microarray datasets derived from human primary cells and analysed large correlation graphs of these data...
  2. pmc Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium
    N A Mabbott
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Easter Bush, Midlothian, Scotland, UK
    Mucosal Immunol 6:666-77. 2013
    ....
  3. pmc Prion pathogenesis and secondary lymphoid organs (SLO): tracking the SLO spread of prions to the brain
    Neil A Mabbott
    The Roslin Institute and Royal Dick School of Veterinary Studies, Midlothian, UK
    Prion 6:322-33. 2012
    ....
  4. doi request reprint Meta-analysis of lineage-specific gene expression signatures in mouse leukocyte populations
    Neil A Mabbott
    The Roslin Institute and Royal Dick School of Veterinary Studies, The University of Edinburgh, Roslin Biocentre, Roslin, Midlothian, UK
    Immunobiology 215:724-36. 2010
    ....
  5. pmc Expression of mesenchyme-specific gene signatures by follicular dendritic cells: insights from the meta-analysis of microarray data from multiple mouse cell populations
    Neil A Mabbott
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Easter Bush, Midlothian, UK
    Immunology 133:482-98. 2011
    ..Together, these data suggest FDC are a specialized mesenchymal cell population within the germinal centres of lymphoid tissues...
  6. doi request reprint Determining the role of mononuclear phagocytes in prion neuroinvasion from the skin
    Gwennaelle J Wathne
    University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK
    J Leukoc Biol 91:817-28. 2012
    ..Therefore, together, these data suggest that the propagation of prions from the skin to the draining LN occurs via dermal classical DCs, independently of langerin(+) cells...
  7. pmc The effects of host age on the transport of complement-bound complexes to the spleen and the pathogenesis of intravenous scrapie infection
    Karen L Brown
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Roslin, Midlothian, United Kingdom
    J Virol 86:25-35. 2012
    ..This study is the first to suggest that the effects of aging on the microarchitecture and the function of the splenic marginal zone significantly influence the pathogenesis of an important pathogen...
  8. pmc Ablation of the cellular prion protein, PrPC, specifically on follicular dendritic cells has no effect on their maturation or function
    Laura McCulloch
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Midlothian, UK
    Immunology 138:246-57. 2013
    ..These data clearly demonstrate that PrP(C) expression is dispensable for the functional maturation of FDC and their ability to maintain antigen-specific antibody responses and affinity maturation...
  9. pmc Identification of novel genes selectively expressed in the follicle-associated epithelium from the meta-analysis of transcriptomics data from multiple mouse cell and tissue populations
    Atsushi Kobayashi
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK
    DNA Res 19:407-22. 2012
    ..This study provides new insight into the FAE transcriptome. Further characterization of the candidate genes identified here will aid the identification of novel regulators of cell function in the FAE...
  10. doi request reprint The effects of host age on follicular dendritic cell status dramatically impair scrapie agent neuroinvasion in aged mice
    Karen L Brown
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Roslin, United Kingdom
    J Immunol 183:5199-207. 2009
    ..Furthermore, the inefficient neuroinvasion in aged individuals may lead to significant levels of subclinical TSE disease in the population...
  11. doi request reprint Defining the anatomical localisation of subsets of the murine mononuclear phagocyte system using integrin alpha X (Itgax, CD11c) and colony stimulating factor 1 receptor (Csf1r, CD115) expression fails to discriminate dendritic cells from macrophages
    Barry M Bradford
    The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK
    Immunobiology 216:1228-37. 2011
    ..These results suggest more cautious interpretation of Itgax-dependent experimentation and direct equation with uniquely DC-mediated activities, particularly in the functioning of non-lymphoid MNPs within the intestinal lamina propria...
  12. doi request reprint Identification of co-expressed gene signatures in mouse B1, marginal zone and B2 B-cell populations
    Neil A Mabbott
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Midlothian, UK
    Immunology 141:79-95. 2014
    ..These data showed that mouse and human germinal centre B cells shared similar transcriptional features, whereas mouse B1 B cells were distinct from proposed human B1 B cells...
  13. doi request reprint Salmonella transforms follicle-associated epithelial cells into M cells to promote intestinal invasion
    Amin Tahoun
    The Roslin Institute and Royal School of Veterinary Studies, University of Edinburgh, Edinburgh EH25 9RG, UK
    Cell Host Microbe 12:645-56. 2012
    ..Thus, via the activity of a single secreted effector, S. Typhimurium transforms primed epithelial cells into M cells to promote host colonization and invasion...
  14. pmc Follicular dendritic cell-specific prion protein (PrP) expression alone is sufficient to sustain prion infection in the spleen
    Laura McCulloch
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Midlothian, United Kingdom
    PLoS Pathog 7:e1002402. 2011
    ..The demonstration that Prnp-ablation only on FDC blocked splenic prion accumulation without apparent consequences for FDC status represents a novel opportunity to prevent neuroinvasion by modulation of PrP(C) expression on FDC...
  15. pmc The diverse roles of mononuclear phagocytes in prion disease pathogenesis
    Gwennaelle J Wathne
    The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Midlothian, UK
    Prion 6:124-33. 2012
    ..Current data suggest these cells may exhibit a diverse range of roles in TSE disease from the transport or destruction of TSE agents in lymphoid tissues, to mediators or protectors of neuropathology in the brain...
  16. pmc Prion disease and the innate immune system
    Barry M Bradford
    The Roslin Institute and Royal Dick School of Veterinary Studies, The University of Edinburgh, Easter Bush Campus, Midlothian, EH25 9RG, UK
    Viruses 4:3389-419. 2012
    ..We present here a review of the current knowledge regarding the role of the innate immune system in prion pathogenesis...
  17. pmc B cell-specific S1PR1 deficiency blocks prion dissemination between secondary lymphoid organs
    Simon W F Mok
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Midlothian EH25 9RG, United Kingdom
    J Immunol 188:5032-40. 2012
    ....
  18. doi request reprint Evidence of subclinical prion disease in aged mice following exposure to bovine spongiform encephalopathy
    Karen L Brown
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Edinburgh, UK
    J Gen Virol 95:231-43. 2014
    ....
  19. ncbi request reprint Complement component C5 is not involved in scrapie pathogenesis
    Neil A Mabbott
    Institute for Animal Health, Neuropathoqenesis Unit, Ogston Building, West Mains Road, Edinburgh EH9 3JF, Scotland, UK
    Immunobiology 209:545-9. 2004
    ..Furthermore, the severity of the neuropathology was not significantly different between C5-deficient and C5-sufficient mice. These data show that C5, and the MAC, are not involved in TSE pathogenesis...
  20. ncbi request reprint Follicular dendritic cells as targets for intervention in transmissible spongiform encephalopathies
    Neil A Mabbott
    Neuropathogenesis Unit, Institute for Animal Health, Ogston Building, Edinburgh, EH9 3JF, Scotland, UK
    Semin Immunol 14:285-93. 2002
    ..The identification of FDCs as critical for TSE pathogenesis provides a cellular target to which therapies can be specifically directed...