Neil A Mabbott

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Identification of novel genes selectively expressed in the follicle-associated epithelium from the meta-analysis of transcriptomics data from multiple mouse cell and tissue populations
    Atsushi Kobayashi
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK
    DNA Res 19:407-22. 2012
  2. pmc The diverse roles of mononuclear phagocytes in prion disease pathogenesis
    Gwennaelle J Wathne
    The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Midlothian, UK
    Prion 6:124-33. 2012
  3. pmc Follicular dendritic cell-specific prion protein (PrP) expression alone is sufficient to sustain prion infection in the spleen
    Laura McCulloch
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Midlothian, United Kingdom
    PLoS Pathog 7:e1002402. 2011
  4. pmc M cell-depletion blocks oral prion disease pathogenesis
    D S Donaldson
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Edinburgh, UK
    Mucosal Immunol 5:216-25. 2012
  5. pmc The functional maturation of M cells is dramatically reduced in the Peyer's patches of aged mice
    A Kobayashi
    The Roslin Institute and the Royal Dick School of Veterinary Sciences, University of Edinburgh, Edinburgh, UK
    Mucosal Immunol 6:1027-37. 2013
  6. pmc An expression atlas of human primary cells: inference of gene function from coexpression networks
    Neil A Mabbott
    The Roslin Institute and Royal Dick School of Veterinary Studies, The University of Edinburgh, Easter Bush, Midlothian, Edinburgh EH25 9RG, UK
    BMC Genomics 14:632. 2013
  7. pmc Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium
    N A Mabbott
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Easter Bush, Midlothian, Scotland, UK
    Mucosal Immunol 6:666-77. 2013
  8. pmc Prion pathogenesis and secondary lymphoid organs (SLO): tracking the SLO spread of prions to the brain
    Neil A Mabbott
    The Roslin Institute and Royal Dick School of Veterinary Studies, Midlothian, UK
    Prion 6:322-33. 2012
  9. ncbi request reprint Meta-analysis of lineage-specific gene expression signatures in mouse leukocyte populations
    Neil A Mabbott
    The Roslin Institute and Royal Dick School of Veterinary Studies, The University of Edinburgh, Roslin Biocentre, Roslin, Midlothian, UK
    Immunobiology 215:724-36. 2010
  10. pmc Expression of mesenchyme-specific gene signatures by follicular dendritic cells: insights from the meta-analysis of microarray data from multiple mouse cell populations
    Neil A Mabbott
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Easter Bush, Midlothian, UK
    Immunology 133:482-98. 2011

Collaborators

Detail Information

Publications31

  1. pmc Identification of novel genes selectively expressed in the follicle-associated epithelium from the meta-analysis of transcriptomics data from multiple mouse cell and tissue populations
    Atsushi Kobayashi
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK
    DNA Res 19:407-22. 2012
    ..This study provides new insight into the FAE transcriptome. Further characterization of the candidate genes identified here will aid the identification of novel regulators of cell function in the FAE...
  2. pmc The diverse roles of mononuclear phagocytes in prion disease pathogenesis
    Gwennaelle J Wathne
    The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Midlothian, UK
    Prion 6:124-33. 2012
    ..Current data suggest these cells may exhibit a diverse range of roles in TSE disease from the transport or destruction of TSE agents in lymphoid tissues, to mediators or protectors of neuropathology in the brain...
  3. pmc Follicular dendritic cell-specific prion protein (PrP) expression alone is sufficient to sustain prion infection in the spleen
    Laura McCulloch
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Midlothian, United Kingdom
    PLoS Pathog 7:e1002402. 2011
    ..The demonstration that Prnp-ablation only on FDC blocked splenic prion accumulation without apparent consequences for FDC status represents a novel opportunity to prevent neuroinvasion by modulation of PrP(C) expression on FDC...
  4. pmc M cell-depletion blocks oral prion disease pathogenesis
    D S Donaldson
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Edinburgh, UK
    Mucosal Immunol 5:216-25. 2012
    ..Furthermore, in the absence of M cells at the time of oral exposure, neuroinvasion and disease development are likewise blocked. These data suggest M cells are important sites of prion uptake from the gut lumen into Peyer's patches...
  5. pmc The functional maturation of M cells is dramatically reduced in the Peyer's patches of aged mice
    A Kobayashi
    The Roslin Institute and the Royal Dick School of Veterinary Sciences, University of Edinburgh, Edinburgh, UK
    Mucosal Immunol 6:1027-37. 2013
    ..Our study demonstrates that ageing dramatically impedes the functional maturation of M cells, revealing an important ageing-related defect in the mucosal immune system's ability to sample lumenal antigens...
  6. pmc An expression atlas of human primary cells: inference of gene function from coexpression networks
    Neil A Mabbott
    The Roslin Institute and Royal Dick School of Veterinary Studies, The University of Edinburgh, Easter Bush, Midlothian, Edinburgh EH25 9RG, UK
    BMC Genomics 14:632. 2013
    ..Here we have combined a large number of publically available microarray datasets derived from human primary cells and analysed large correlation graphs of these data...
  7. pmc Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium
    N A Mabbott
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Easter Bush, Midlothian, Scotland, UK
    Mucosal Immunol 6:666-77. 2013
    ....
  8. pmc Prion pathogenesis and secondary lymphoid organs (SLO): tracking the SLO spread of prions to the brain
    Neil A Mabbott
    The Roslin Institute and Royal Dick School of Veterinary Studies, Midlothian, UK
    Prion 6:322-33. 2012
    ....
  9. ncbi request reprint Meta-analysis of lineage-specific gene expression signatures in mouse leukocyte populations
    Neil A Mabbott
    The Roslin Institute and Royal Dick School of Veterinary Studies, The University of Edinburgh, Roslin Biocentre, Roslin, Midlothian, UK
    Immunobiology 215:724-36. 2010
    ....
  10. pmc Expression of mesenchyme-specific gene signatures by follicular dendritic cells: insights from the meta-analysis of microarray data from multiple mouse cell populations
    Neil A Mabbott
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Easter Bush, Midlothian, UK
    Immunology 133:482-98. 2011
    ..Together, these data suggest FDC are a specialized mesenchymal cell population within the germinal centres of lymphoid tissues...
  11. doi request reprint The effects of host age on follicular dendritic cell status dramatically impair scrapie agent neuroinvasion in aged mice
    Karen L Brown
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Roslin, United Kingdom
    J Immunol 183:5199-207. 2009
    ..Furthermore, the inefficient neuroinvasion in aged individuals may lead to significant levels of subclinical TSE disease in the population...
  12. doi request reprint Defining the anatomical localisation of subsets of the murine mononuclear phagocyte system using integrin alpha X (Itgax, CD11c) and colony stimulating factor 1 receptor (Csf1r, CD115) expression fails to discriminate dendritic cells from macrophages
    Barry M Bradford
    The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK
    Immunobiology 216:1228-37. 2011
    ..These results suggest more cautious interpretation of Itgax-dependent experimentation and direct equation with uniquely DC-mediated activities, particularly in the functioning of non-lymphoid MNPs within the intestinal lamina propria...
  13. pmc Follicular dendritic cell dedifferentiation by treatment with an inhibitor of the lymphotoxin pathway dramatically reduces scrapie susceptibility
    Neil A Mabbott
    Neuropathogenesis Unit, Institute for Animal Health, Edinburgh EH9 3JF, Scotland, United Kingdom
    J Virol 77:6845-54. 2003
    ..Although manipulation of FDCs may offer a potential approach for early intervention in peripherally acquired TSEs, these data suggest that the duration of the treatment window may vary widely depending on the route of exposure...
  14. pmc Follicular dendritic cell dedifferentiation reduces scrapie susceptibility following inoculation via the skin
    Joanne Mohan
    Institute for Animal Health, Ogston Building, Edinburgh, United Kingdom
    Immunology 114:225-34. 2005
    ..Together these data show that FDCs are essential for the accumulation of PrP(Sc) and infectivity within lymphoid tissues and subsequent neuroinvasion following TSE exposure via the skin...
  15. ncbi request reprint Role of the GALT in scrapie agent neuroinvasion from the intestine
    Bridget R Glaysher
    Neuropathogenesis Unit, Institute for Animal Health, Ogston Building, West Mains Road, Edinburgh, United Kingdom
    J Immunol 178:3757-66. 2007
    ..In conclusion, these data demonstrate that following oral exposure TSE agent accumulation upon FDCs within lymphoid tissue within the intestine itself is critically required for efficient neuroinvasion...
  16. ncbi request reprint In vivo depletion of CD11c+ cells impairs scrapie agent neuroinvasion from the intestine
    Claudine R Raymond
    Roslin Institute Neuropathogenesis Unit and Royal Dick School of Veterinary Sciences, Edinburgh, UK
    J Immunol 179:7758-66. 2007
    ..In conclusion, these data demonstrate that migratory CD11c(+) DCs play a key role in the translocation of the scrapie agent from the gut lumen to the GALT from which neuroinvasion subsequently occurs...
  17. ncbi request reprint Evidence of subclinical prion disease in aged mice following exposure to bovine spongiform encephalopathy
    Karen L Brown
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Edinburgh, UK
    J Gen Virol 95:231-43. 2014
    ....
  18. doi request reprint Determining the role of mononuclear phagocytes in prion neuroinvasion from the skin
    Gwennaelle J Wathne
    University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK
    J Leukoc Biol 91:817-28. 2012
    ..Therefore, together, these data suggest that the propagation of prions from the skin to the draining LN occurs via dermal classical DCs, independently of langerin(+) cells...
  19. pmc Skin-derived dendritic cells acquire and degrade the scrapie agent following in vitro exposure
    Joanne Mohan
    Institute for Animal Health, Edinburgh, UK
    Immunology 116:122-33. 2005
    ..In conclusion, although LCs or DCs have the potential to acquire the scrapie agent within the epidermis our data suggest it is unlikely that they become activated and stimulated to transport the agent to the draining lymph node...
  20. pmc Ablation of the cellular prion protein, PrPC, specifically on follicular dendritic cells has no effect on their maturation or function
    Laura McCulloch
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Midlothian, UK
    Immunology 138:246-57. 2013
    ..These data clearly demonstrate that PrP(C) expression is dispensable for the functional maturation of FDC and their ability to maintain antigen-specific antibody responses and affinity maturation...
  21. pmc The effects of host age on the transport of complement-bound complexes to the spleen and the pathogenesis of intravenous scrapie infection
    Karen L Brown
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Roslin, Midlothian, United Kingdom
    J Virol 86:25-35. 2012
    ..This study is the first to suggest that the effects of aging on the microarchitecture and the function of the splenic marginal zone significantly influence the pathogenesis of an important pathogen...
  22. doi request reprint Salmonella transforms follicle-associated epithelial cells into M cells to promote intestinal invasion
    Amin Tahoun
    The Roslin Institute and Royal School of Veterinary Studies, University of Edinburgh, Edinburgh EH25 9RG, UK
    Cell Host Microbe 12:645-56. 2012
    ..Thus, via the activity of a single secreted effector, S. Typhimurium transforms primed epithelial cells into M cells to promote host colonization and invasion...
  23. pmc Isolated lymphoid follicle maturation induces the development of follicular dendritic cells
    Bridget R Glaysher
    Institute for Animal Health, Ogston Building, West Mains Road, Edinburgh, UK
    Immunology 120:336-44. 2007
    ..Taken together, these data imply that the induction of germinal centres and FDC networks within mature ILFs in response to PP deficiency provides an important compensatory mechanism...
  24. pmc Identification of co-expressed gene signatures in mouse B1, marginal zone and B2 B-cell populations
    Neil A Mabbott
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Midlothian, UK
    Immunology 141:79-95. 2014
    ..These data showed that mouse and human germinal centre B cells shared similar transcriptional features, whereas mouse B1 B cells were distinct from proposed human B1 B cells...
  25. pmc B cell-specific S1PR1 deficiency blocks prion dissemination between secondary lymphoid organs
    Simon W F Mok
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Midlothian EH25 9RG, United Kingdom
    J Immunol 188:5032-40. 2012
    ....
  26. ncbi request reprint Follicular dendritic cells as targets for intervention in transmissible spongiform encephalopathies
    Neil A Mabbott
    Neuropathogenesis Unit, Institute for Animal Health, Ogston Building, Edinburgh, EH9 3JF, Scotland, UK
    Semin Immunol 14:285-93. 2002
    ..The identification of FDCs as critical for TSE pathogenesis provides a cellular target to which therapies can be specifically directed...
  27. pmc Temporary blockade of the tumor necrosis factor receptor signaling pathway impedes the spread of scrapie to the brain
    Neil A Mabbott
    Neuropathogenesis Unit, Institute for Animal Health, Edinburgh EH9 3JF, Scotland, United Kingdom
    J Virol 76:5131-9. 2002
    ..We conclude that treatments that specifically inhibit the TNFR signaling pathway may present an opportunity for early intervention in peripherally transmitted TSEs...
  28. ncbi request reprint Complement component C5 is not involved in scrapie pathogenesis
    Neil A Mabbott
    Institute for Animal Health, Neuropathoqenesis Unit, Ogston Building, West Mains Road, Edinburgh EH9 3JF, Scotland, UK
    Immunobiology 209:545-9. 2004
    ..Furthermore, the severity of the neuropathology was not significantly different between C5-deficient and C5-sufficient mice. These data show that C5, and the MAC, are not involved in TSE pathogenesis...
  29. pmc Prion disease and the innate immune system
    Barry M Bradford
    The Roslin Institute and Royal Dick School of Veterinary Studies, The University of Edinburgh, Easter Bush Campus, Midlothian, EH25 9RG, UK
    Viruses 4:3389-419. 2012
    ..We present here a review of the current knowledge regarding the role of the innate immune system in prion pathogenesis...
  30. pmc Peripheral prion disease pathogenesis is unaltered in the absence of sialoadhesin (Siglec-1/CD169)
    Barry M Bradford
    The Roslin Institute and R D SVS, University of Edinburgh, Midlothian, UK
    Immunology 143:120-9. 2014
    ..Hence, although an intact marginal zone is important for the efficient uptake and delivery of prions into the B-cell follicles of the spleen, this is not influenced by sialoadhesin expression by the MNP within it. ..
  31. ncbi request reprint Human prion diseases and the risk of their transmission during anatomical dissection
    Barry M Bradford
    The Roslin Institute and R D SVS The University of Edinburgh, Midlothian EH25 9RG, United Kingdom
    Clin Anat 27:821-32. 2014
    ..In this review, we aim to summarize the current knowledge on human prion disease relevant to those working with human tissues in the context of anatomical dissection. Clin. Anat. 27:821-832, 2014. © 2014 Wiley Periodicals, Inc. ..