M Lyon

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. Uchimura K, Morimoto Tomita M, Bistrup A, Li J, Lyon M, Gallagher J, et al. HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1. BMC Biochem. 2006;7:2 pubmed
    ..Our results validate Sulf-2 as a new tool for deciphering the sulfation requirements in the interaction of protein ligands with heparin/HSPGs and expand the range of potential biological activities of this enzyme. ..
  2. request reprint
    Lyon M, Deakin J, Rahmoune H, Fernig D, Nakamura T, Gallagher J. Hepatocyte growth factor/scatter factor binds with high affinity to dermatan sulfate. J Biol Chem. 1998;273:271-8 pubmed
    ..This is the first described example of a high affinity interaction between a growth factor and DS, and is likely to have significant implications for the biological activity of this paracrine-acting factor. ..

Detail Information

Publications2

  1. Uchimura K, Morimoto Tomita M, Bistrup A, Li J, Lyon M, Gallagher J, et al. HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1. BMC Biochem. 2006;7:2 pubmed
    ..Our results validate Sulf-2 as a new tool for deciphering the sulfation requirements in the interaction of protein ligands with heparin/HSPGs and expand the range of potential biological activities of this enzyme. ..
  2. request reprint
    Lyon M, Deakin J, Rahmoune H, Fernig D, Nakamura T, Gallagher J. Hepatocyte growth factor/scatter factor binds with high affinity to dermatan sulfate. J Biol Chem. 1998;273:271-8 pubmed
    ..This is the first described example of a high affinity interaction between a growth factor and DS, and is likely to have significant implications for the biological activity of this paracrine-acting factor. ..