David Lydall

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. pmc Colonyzer: automated quantification of micro-organism growth characteristics on solid agar
    Conor Lawless
    Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle Upon Tyne NE45PL, UK
    BMC Bioinformatics 11:287. 2010
  2. pmc Taming the tiger by the tail: modulation of DNA damage responses by telomeres
    David Lydall
    Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, HenryWellcome Laboratory, Newcastle University, Tyne and Wear, UK
    EMBO J 28:2174-87. 2009
  3. pmc Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response
    Isabelle Morin
    Institute for Ageing and Health, Henry Wellcome Laboratory for Biogerontology Research, Newcastle University, Newcastle upon Tyne, UK
    EMBO J 27:2400-10. 2008
  4. pmc Mrc1 protects uncapped budding yeast telomeres from exonuclease EXO1
    Avgi Tsolou
    Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Henry Wellcome Laboratory for Biogerontology Research, Newcastle University, Newcastle upon Tyne NE4 6BE, UK
    DNA Repair (Amst) 6:1607-17. 2007
  5. pmc A genome wide analysis of the response to uncapped telomeres in budding yeast reveals a novel role for the NAD+ biosynthetic gene BNA2 in chromosome end protection
    Amanda Greenall
    Aging Research Laboratories, Institute for Aging and Health, Newcastle University, Newcastle upon Tyne, UK
    Genome Biol 9:R146. 2008
  6. ncbi request reprint Linear chromosome maintenance in the absence of essential telomere-capping proteins
    Mikhajlo K Zubko
    Institute for Ageing and Health, Henry Wellcome Laboratory for Biogerontology Research, University of Newcastle, Newcastle upon Tyne, NE4 6BE, UK
    Nat Cell Biol 8:734-40. 2006
  7. pmc Pif1- and Exo1-dependent nucleases coordinate checkpoint activation following telomere uncapping
    James M Dewar
    Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle upon Tyne, Tyne and Wear, UK
    EMBO J 29:4020-34. 2010
  8. pmc Customizable views on semantically integrated networks for systems biology
    Jochen Weile
    School of Computing Science, Faculty of Science Agriculture and Engineering, Newcastle University, Newcastle upon Tyne, UK
    Bioinformatics 27:1299-306. 2011
  9. ncbi request reprint The PAL-mechanism of chromosome maintenance: causes and consequences
    Laura Maringele
    Wellcome Laboratory for Bio gerontology, Institute for Ageing and Health, Newcastle General Hospital, University of Newcastle, School of Clinical Medical Sciences, Newcastle upon Tyne, UK
    Cell Cycle 4:747-51. 2005
  10. doi request reprint Simple, non-radioactive measurement of single-stranded DNA at telomeric, sub-telomeric, and genomic loci in budding yeast
    James M Dewar
    Institute for Cell and Molecular Biosciences, Newcastle University, Medical School, Newcastle upon Tyne, UK
    Methods Mol Biol 920:341-8. 2012

Collaborators

Detail Information

Publications12

  1. pmc Colonyzer: automated quantification of micro-organism growth characteristics on solid agar
    Conor Lawless
    Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle Upon Tyne NE45PL, UK
    BMC Bioinformatics 11:287. 2010
    ..g. the logistic growth model). In order to parametrize such a model, a robust image analysis tool capable of capturing a wide range of cell densities from plate photographs is required...
  2. pmc Taming the tiger by the tail: modulation of DNA damage responses by telomeres
    David Lydall
    Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, HenryWellcome Laboratory, Newcastle University, Tyne and Wear, UK
    EMBO J 28:2174-87. 2009
    ....
  3. pmc Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response
    Isabelle Morin
    Institute for Ageing and Health, Henry Wellcome Laboratory for Biogerontology Research, Newcastle University, Newcastle upon Tyne, UK
    EMBO J 27:2400-10. 2008
    ..We propose that Rad53-dependent Exo1 phosphorylation is involved in a negative feedback loop to limit ssDNA accumulation and DNA damage checkpoint activation...
  4. pmc Mrc1 protects uncapped budding yeast telomeres from exonuclease EXO1
    Avgi Tsolou
    Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Henry Wellcome Laboratory for Biogerontology Research, Newcastle University, Newcastle upon Tyne NE4 6BE, UK
    DNA Repair (Amst) 6:1607-17. 2007
    ..Our observations show that Mrc1, a core component of the replication fork, plays an important role in telomere capping, protecting from nucleases and checkpoint pathways...
  5. pmc A genome wide analysis of the response to uncapped telomeres in budding yeast reveals a novel role for the NAD+ biosynthetic gene BNA2 in chromosome end protection
    Amanda Greenall
    Aging Research Laboratories, Institute for Aging and Health, Newcastle University, Newcastle upon Tyne, UK
    Genome Biol 9:R146. 2008
    ..In order to better understand the eukaryotic response to telomere damage, budding yeast strains harboring a temperature sensitive allele of an essential telomere capping gene (cdc13-1) were subjected to a transcriptomic study...
  6. ncbi request reprint Linear chromosome maintenance in the absence of essential telomere-capping proteins
    Mikhajlo K Zubko
    Institute for Ageing and Health, Henry Wellcome Laboratory for Biogerontology Research, University of Newcastle, Newcastle upon Tyne, NE4 6BE, UK
    Nat Cell Biol 8:734-40. 2006
    ..Our results indicate that the structure of the eukaryotic telomere cap is remarkably flexible and that changes in the DNA damage response allow alternative strategies for telomere capping to evolve...
  7. pmc Pif1- and Exo1-dependent nucleases coordinate checkpoint activation following telomere uncapping
    James M Dewar
    Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle upon Tyne, Tyne and Wear, UK
    EMBO J 29:4020-34. 2010
    ..Thus, attenuation of the DDR at uncapped telomeres can circumvent the need for otherwise-essential telomere capping proteins...
  8. pmc Customizable views on semantically integrated networks for systems biology
    Jochen Weile
    School of Computing Science, Faculty of Science Agriculture and Engineering, Newcastle University, Newcastle upon Tyne, UK
    Bioinformatics 27:1299-306. 2011
    ..Although well suited to computational manipulation, such integrated datasets are typically too large and complex for easy visualization and interactive exploration...
  9. ncbi request reprint The PAL-mechanism of chromosome maintenance: causes and consequences
    Laura Maringele
    Wellcome Laboratory for Bio gerontology, Institute for Ageing and Health, Newcastle General Hospital, University of Newcastle, School of Clinical Medical Sciences, Newcastle upon Tyne, UK
    Cell Cycle 4:747-51. 2005
    ..This first evidence is from the budding yeast model system. We also discuss the possible involvement of the PAL-mechanism in carcinogenesis...
  10. doi request reprint Simple, non-radioactive measurement of single-stranded DNA at telomeric, sub-telomeric, and genomic loci in budding yeast
    James M Dewar
    Institute for Cell and Molecular Biosciences, Newcastle University, Medical School, Newcastle upon Tyne, UK
    Methods Mol Biol 920:341-8. 2012
    ..These complementary methods are useful to understand the important roles of ssDNA in yeast cells and could be readily extended to other cell types...
  11. ncbi request reprint MRX protects telomeric DNA at uncapped telomeres of budding yeast cdc13-1 mutants
    Steven S Foster
    Institute for Ageing and Health, University of Newcastle, Henry Wellcome Laboratory for Biogerontology Research, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK
    DNA Repair (Amst) 5:840-51. 2006
    ..Instead, we find that Rad50 inhibits ssDNA accumulation and promotes cdc13-1 cell viability, consistent with a major role for MRX in telomere capping...
  12. doi request reprint Quantitative amplification of single-stranded DNA
    Eva Maria Holstein
    Institute for Cell and Molecular Biosciences, Newcastle University, Medical School, Newcastle upon Tyne, UK
    Methods Mol Biol 920:323-39. 2012
    ..QAOS is a useful tool to gain insights into the cellular processes that involve ssDNA and the roles of proteins in regulating ssDNA production and responses to ssDNA...