Research Topics
Genomes and Genes | David LydallSummaryAffiliation: University of Newcastle Country: UK Publications
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Publications
Colonyzer: automated quantification of micro-organism growth characteristics on solid agarConor Lawless
Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle Upon Tyne NE45PL, UK
BMC Bioinformatics 11:287. 2010..g. the logistic growth model). In order to parametrize such a model, a robust image analysis tool capable of capturing a wide range of cell densities from plate photographs is required...- Taming the tiger by the tail: modulation of DNA damage responses by telomeresDavid Lydall
Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, HenryWellcome Laboratory, Newcastle University, Tyne and Wear, UK
EMBO J 28:2174-87. 2009.... - Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage responseIsabelle Morin
Institute for Ageing and Health, Henry Wellcome Laboratory for Biogerontology Research, Newcastle University, Newcastle upon Tyne, UK
EMBO J 27:2400-10. 2008..We propose that Rad53-dependent Exo1 phosphorylation is involved in a negative feedback loop to limit ssDNA accumulation and DNA damage checkpoint activation... - Mrc1 protects uncapped budding yeast telomeres from exonuclease EXO1Avgi Tsolou
Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Henry Wellcome Laboratory for Biogerontology Research, Newcastle University, Newcastle upon Tyne NE4 6BE, UK
DNA Repair (Amst) 6:1607-17. 2007..Our observations show that Mrc1, a core component of the replication fork, plays an important role in telomere capping, protecting from nucleases and checkpoint pathways... - A genome wide analysis of the response to uncapped telomeres in budding yeast reveals a novel role for the NAD+ biosynthetic gene BNA2 in chromosome end protectionAmanda Greenall
Aging Research Laboratories, Institute for Aging and Health, Newcastle University, Newcastle upon Tyne, UK
Genome Biol 9:R146. 2008..In order to better understand the eukaryotic response to telomere damage, budding yeast strains harboring a temperature sensitive allele of an essential telomere capping gene (cdc13-1) were subjected to a transcriptomic study... 
Linear chromosome maintenance in the absence of essential telomere-capping proteinsMikhajlo K Zubko
Institute for Ageing and Health, Henry Wellcome Laboratory for Biogerontology Research, University of Newcastle, Newcastle upon Tyne, NE4 6BE, UK
Nat Cell Biol 8:734-40. 2006..Our results indicate that the structure of the eukaryotic telomere cap is remarkably flexible and that changes in the DNA damage response allow alternative strategies for telomere capping to evolve...- Pif1- and Exo1-dependent nucleases coordinate checkpoint activation following telomere uncappingJames M Dewar
Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle upon Tyne, Tyne and Wear, UK
EMBO J 29:4020-34. 2010..Thus, attenuation of the DDR at uncapped telomeres can circumvent the need for otherwise-essential telomere capping proteins... - Customizable views on semantically integrated networks for systems biologyJochen Weile
School of Computing Science, Faculty of Science Agriculture and Engineering, Newcastle University, Newcastle upon Tyne, UK
Bioinformatics 27:1299-306. 2011..Although well suited to computational manipulation, such integrated datasets are typically too large and complex for easy visualization and interactive exploration... - The PAL-mechanism of chromosome maintenance: causes and consequencesLaura Maringele
Wellcome Laboratory for Bio gerontology, Institute for Ageing and Health, Newcastle General Hospital, University of Newcastle, School of Clinical Medical Sciences, Newcastle upon Tyne, UK
Cell Cycle 4:747-51. 2005..This first evidence is from the budding yeast model system. We also discuss the possible involvement of the PAL-mechanism in carcinogenesis... 
Simple, non-radioactive measurement of single-stranded DNA at telomeric, sub-telomeric, and genomic loci in budding yeastJames M Dewar
Institute for Cell and Molecular Biosciences, Newcastle University, Medical School, Newcastle upon Tyne, UK
Methods Mol Biol 920:341-8. 2012..These complementary methods are useful to understand the important roles of ssDNA in yeast cells and could be readily extended to other cell types...- MRX protects telomeric DNA at uncapped telomeres of budding yeast cdc13-1 mutantsSteven S Foster
Institute for Ageing and Health, University of Newcastle, Henry Wellcome Laboratory for Biogerontology Research, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK
DNA Repair (Amst) 5:840-51. 2006..Instead, we find that Rad50 inhibits ssDNA accumulation and promotes cdc13-1 cell viability, consistent with a major role for MRX in telomere capping... - Quantitative amplification of single-stranded DNAEva Maria Holstein
Institute for Cell and Molecular Biosciences, Newcastle University, Medical School, Newcastle upon Tyne, UK
Methods Mol Biol 920:323-39. 2012..QAOS is a useful tool to gain insights into the cellular processes that involve ssDNA and the roles of proteins in regulating ssDNA production and responses to ssDNA...