David Lydall

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. pmc Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response
    Isabelle Morin
    Institute for Ageing and Health, Henry Wellcome Laboratory for Biogerontology Research, Newcastle University, Newcastle upon Tyne, UK
    EMBO J 27:2400-10. 2008
  2. pmc Mrc1 protects uncapped budding yeast telomeres from exonuclease EXO1
    Avgi Tsolou
    Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Henry Wellcome Laboratory for Biogerontology Research, Newcastle University, Newcastle upon Tyne NE4 6BE, UK
    DNA Repair (Amst) 6:1607-17. 2007
  3. pmc Pif1- and Exo1-dependent nucleases coordinate checkpoint activation following telomere uncapping
    James M Dewar
    Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle upon Tyne, Tyne and Wear, UK
    EMBO J 29:4020-34. 2010
  4. pmc Survival and growth of yeast without telomere capping by Cdc13 in the absence of Sgs1, Exo1, and Rad9
    Hien Ping Ngo
    Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS Genet 6:e1001072. 2010
  5. pmc Quantitative fitness analysis shows that NMD proteins and many other protein complexes suppress or enhance distinct telomere cap defects
    Stephen Gregory Addinall
    Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom
    PLoS Genet 7:e1001362. 2011
  6. pmc Genome-wide analysis to identify pathways affecting telomere-initiated senescence in budding yeast
    Hsin Yu Chang
    Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, United Kingdom
    G3 (Bethesda) 1:197-208. 2011
  7. pmc Colonyzer: automated quantification of micro-organism growth characteristics on solid agar
    Conor Lawless
    Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle Upon Tyne NE45PL, UK
    BMC Bioinformatics 11:287. 2010
  8. pmc Taming the tiger by the tail: modulation of DNA damage responses by telomeres
    David Lydall
    Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, HenryWellcome Laboratory, Newcastle University, Tyne and Wear, UK
    EMBO J 28:2174-87. 2009
  9. pmc Exo1 and Rad24 differentially regulate generation of ssDNA at telomeres of Saccharomyces cerevisiae cdc13-1 mutants
    Mikhajlo K Zubko
    School of Clinical Medical Sciences Gerontology, University of Newcastle, Henry Wellcome Laboratory for Biogerontology Research, Newcastle upon Tyne, NE4 6BE, UK
    Genetics 168:103-15. 2004
  10. ncbi request reprint MRX protects telomeric DNA at uncapped telomeres of budding yeast cdc13-1 mutants
    Steven S Foster
    Institute for Ageing and Health, University of Newcastle, Henry Wellcome Laboratory for Biogerontology Research, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK
    DNA Repair (Amst) 5:840-51. 2006

Collaborators

Detail Information

Publications24

  1. pmc Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response
    Isabelle Morin
    Institute for Ageing and Health, Henry Wellcome Laboratory for Biogerontology Research, Newcastle University, Newcastle upon Tyne, UK
    EMBO J 27:2400-10. 2008
    ..We propose that Rad53-dependent Exo1 phosphorylation is involved in a negative feedback loop to limit ssDNA accumulation and DNA damage checkpoint activation...
  2. pmc Mrc1 protects uncapped budding yeast telomeres from exonuclease EXO1
    Avgi Tsolou
    Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Henry Wellcome Laboratory for Biogerontology Research, Newcastle University, Newcastle upon Tyne NE4 6BE, UK
    DNA Repair (Amst) 6:1607-17. 2007
    ..Our observations show that Mrc1, a core component of the replication fork, plays an important role in telomere capping, protecting from nucleases and checkpoint pathways...
  3. pmc Pif1- and Exo1-dependent nucleases coordinate checkpoint activation following telomere uncapping
    James M Dewar
    Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle upon Tyne, Tyne and Wear, UK
    EMBO J 29:4020-34. 2010
    ..Thus, attenuation of the DDR at uncapped telomeres can circumvent the need for otherwise-essential telomere capping proteins...
  4. pmc Survival and growth of yeast without telomere capping by Cdc13 in the absence of Sgs1, Exo1, and Rad9
    Hien Ping Ngo
    Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS Genet 6:e1001072. 2010
    ..Our results reveal the plasticity of the telomere cap and indicate that the essential role of telomere capping is to counteract specific aspects of the DDR...
  5. pmc Quantitative fitness analysis shows that NMD proteins and many other protein complexes suppress or enhance distinct telomere cap defects
    Stephen Gregory Addinall
    Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom
    PLoS Genet 7:e1001362. 2011
    ..QFA is a sensitive, high-throughput method that will also be useful to understand other aspects of microbial cell biology...
  6. pmc Genome-wide analysis to identify pathways affecting telomere-initiated senescence in budding yeast
    Hsin Yu Chang
    Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, United Kingdom
    G3 (Bethesda) 1:197-208. 2011
    ..Our dataset is complementary to other high-throughput studies relevant to telomere biology, genetic stability, and DNA damage responses...
  7. pmc Colonyzer: automated quantification of micro-organism growth characteristics on solid agar
    Conor Lawless
    Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle Upon Tyne NE45PL, UK
    BMC Bioinformatics 11:287. 2010
    ..g. the logistic growth model). In order to parametrize such a model, a robust image analysis tool capable of capturing a wide range of cell densities from plate photographs is required...
  8. pmc Taming the tiger by the tail: modulation of DNA damage responses by telomeres
    David Lydall
    Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, HenryWellcome Laboratory, Newcastle University, Tyne and Wear, UK
    EMBO J 28:2174-87. 2009
    ....
  9. pmc Exo1 and Rad24 differentially regulate generation of ssDNA at telomeres of Saccharomyces cerevisiae cdc13-1 mutants
    Mikhajlo K Zubko
    School of Clinical Medical Sciences Gerontology, University of Newcastle, Henry Wellcome Laboratory for Biogerontology Research, Newcastle upon Tyne, NE4 6BE, UK
    Genetics 168:103-15. 2004
    ..We conclude that Rad24 and Exo1 regulate nucleases with different properties at uncapped telomeres and propose a model to explain our findings...
  10. ncbi request reprint MRX protects telomeric DNA at uncapped telomeres of budding yeast cdc13-1 mutants
    Steven S Foster
    Institute for Ageing and Health, University of Newcastle, Henry Wellcome Laboratory for Biogerontology Research, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK
    DNA Repair (Amst) 5:840-51. 2006
    ..Instead, we find that Rad50 inhibits ssDNA accumulation and promotes cdc13-1 cell viability, consistent with a major role for MRX in telomere capping...
  11. pmc A genome wide analysis of the response to uncapped telomeres in budding yeast reveals a novel role for the NAD+ biosynthetic gene BNA2 in chromosome end protection
    Amanda Greenall
    Aging Research Laboratories, Institute for Aging and Health, Newcastle University, Newcastle upon Tyne, UK
    Genome Biol 9:R146. 2008
    ..In order to better understand the eukaryotic response to telomere damage, budding yeast strains harboring a temperature sensitive allele of an essential telomere capping gene (cdc13-1) were subjected to a transcriptomic study...
  12. ncbi request reprint Linear chromosome maintenance in the absence of essential telomere-capping proteins
    Mikhajlo K Zubko
    Institute for Ageing and Health, Henry Wellcome Laboratory for Biogerontology Research, University of Newcastle, Newcastle upon Tyne, NE4 6BE, UK
    Nat Cell Biol 8:734-40. 2006
    ..Our results indicate that the structure of the eukaryotic telomere cap is remarkably flexible and that changes in the DNA damage response allow alternative strategies for telomere capping to evolve...
  13. ncbi request reprint Detecting repair intermediates in vivo: effects of DNA damage response genes on single-stranded DNA accumulation at uncapped telomeres in budding yeast
    Mikhajlo K Zubko
    Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom
    Methods Enzymol 409:285-300. 2006
    ....
  14. pmc The yeast copper response is regulated by DNA damage
    Kangzhen Dong
    Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom
    Mol Cell Biol 33:4041-50. 2013
    ..This study has therefore identified a novel regulatory relationship between cellular redox, copper homeostasis, and the DNA damage response in yeast. ..
  15. pmc Telomerase- and recombination-independent immortalization of budding yeast
    Laura Maringele
    University of Newcastle, School of Clinical Medical Sciences Gerontology, Newcastle upon Tyne, NE4 6BE, United Kingdom
    Genes Dev 18:2663-75. 2004
    ..For the first time, we show that large palindromes form as a natural consequence of postsenescence growth and that they become essential for immortalization in the absence of telomerase activity...
  16. ncbi request reprint The PAL-mechanism of chromosome maintenance: causes and consequences
    Laura Maringele
    Wellcome Laboratory for Bio gerontology, Institute for Ageing and Health, Newcastle General Hospital, University of Newcastle, School of Clinical Medical Sciences, Newcastle upon Tyne, UK
    Cell Cycle 4:747-51. 2005
    ..This first evidence is from the budding yeast model system. We also discuss the possible involvement of the PAL-mechanism in carcinogenesis...
  17. ncbi request reprint Chromatin and the DNA damage response
    David Lydall
    Institute of Cell and Molecular Biosciences, University of Newcastle, Henry Wellcome Building, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK
    DNA Repair (Amst) 4:1195-207. 2005
    ..It seems likely that these two communities will increasingly share common questions and interests...
  18. pmc Customizable views on semantically integrated networks for systems biology
    Jochen Weile
    School of Computing Science, Faculty of Science Agriculture and Engineering, Newcastle University, Newcastle upon Tyne, UK
    Bioinformatics 27:1299-306. 2011
    ..Although well suited to computational manipulation, such integrated datasets are typically too large and complex for easy visualization and interactive exploration...
  19. pmc Pentose phosphate pathway function affects tolerance to the G-quadruplex binder TMPyP4
    Elizabeth J Andrew
    Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom
    PLoS ONE 8:e66242. 2013
    ..Our results have implications for the usefulness and mechanism of action of TMPyP4...
  20. ncbi request reprint Quantitative amplification of single-stranded DNA
    Eva Maria Holstein
    Institute for Cell and Molecular Biosciences, Newcastle University, Medical School, Newcastle upon Tyne, UK
    Methods Mol Biol 920:323-39. 2012
    ..QAOS is a useful tool to gain insights into the cellular processes that involve ssDNA and the roles of proteins in regulating ssDNA production and responses to ssDNA...
  21. ncbi request reprint Pulsed-field gel electrophoresis of budding yeast chromosomes
    Laura Maringele
    University of Newcastle, School of Clinical Medical Sciences Newcastle General Hospital, Newcastle upon Tyne, UK
    Methods Mol Biol 313:65-73. 2006
    ..Finally, we describe how the separated chromosomes can be visualized and photographed...
  22. ncbi request reprint Simple, non-radioactive measurement of single-stranded DNA at telomeric, sub-telomeric, and genomic loci in budding yeast
    James M Dewar
    Institute for Cell and Molecular Biosciences, Newcastle University, Medical School, Newcastle upon Tyne, UK
    Methods Mol Biol 920:341-8. 2012
    ..These complementary methods are useful to understand the important roles of ssDNA in yeast cells and could be readily extended to other cell types...
  23. ncbi request reprint Interplay between nonsense-mediated mRNA decay and DNA damage response pathways reveals that Stn1 and Ten1 are the key CST telomere-cap components
    Eva Maria Holstein
    Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne NE2 4HH, UK
    Cell Rep 7:1259-69. 2014
    ..Our data support a model that Stn1 and Ten1 can function in a Cdc13-independent manner and have implications for the function of CST components across eukaryotes. ..