Ulrich F O Luhmann

Summary

Affiliation: University College London
Country: UK

Publications

  1. Luhmann U, Carvalho L, Holthaus S, Cowing J, Greenaway S, Chu C, et al. The severity of retinal pathology in homozygous Crb1rd8/rd8 mice is dependent on additional genetic factors. Hum Mol Genet. 2015;24:128-41 pubmed publisher
  2. Herrmann P, Cowing J, Cristante E, Liyanage S, Ribeiro J, Duran Y, et al. Cd59a deficiency in mice leads to preferential innate immune activation in the retinal pigment epithelium-choroid with age. Neurobiol Aging. 2015;36:2637-48 pubmed publisher
    ..This data emphasizes the particular vulnerability of the RPE-choroidal complex to dysregulation of the alternative complement pathway during aging. ..
  3. Luhmann U, Robbie S, Munro P, Barker S, Duran Y, Luong V, et al. The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages. Invest Ophthalmol Vis Sci. 2009;50:5934-43 pubmed publisher
    ..Other, previously described features of Ccl2(-/-) mice that are similar to AMD may be the result of aging alone. ..
  4. Luhmann U, Ali R. Local vs. systemic mononuclear phagocytes in age-related macular degeneration and their regulation by CCL2-CCR2 and CX3CL1-CX3CR1 chemokine signalling. Adv Exp Med Biol. 2012;723:17-22 pubmed publisher
  5. Luhmann U, Lange C, Robbie S, Munro P, Cowing J, Armer H, et al. Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling. PLoS ONE. 2012;7:e35551 pubmed publisher
    ..These findings indicate that CCDKO mice are not a model of AMD, but a model for an inherited retinal degeneration that is differentially modulated by Ccl2-Ccr2 and Cx3cl1-Cx3cr1 chemokine signalling. ..
  6. Luhmann U, Carvalho L, Robbie S, Cowing J, Duran Y, Munro P, et al. Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration. Exp Eye Res. 2013;107:80-7 pubmed publisher
    ..In conclusion, CCL2-CCR2 and/or CX3CL1-CX3CR1 signalling defects may differentially affect the trafficking of microglia and macrophages in the retina during ageing, but do not appear to cause age-related retinal degeneration in mice. ..