Ulrich F O Luhmann
Affiliation: University College London
Luhmann U, Carvalho L, Holthaus S, Cowing J, Greenaway S, Chu C, et al
. The severity of retinal pathology in homozygous Crb1rd8/rd8 mice is dependent on additional genetic factors. Hum Mol Genet. 2015;24:128-41 pubmed publisher
Herrmann P, Cowing J, Cristante E, Liyanage S, Ribeiro J, Duran Y, et al
. Cd59a deficiency in mice leads to preferential innate immune activation in the retinal pigment epithelium-choroid with age. Neurobiol Aging. 2015;36:2637-48 pubmed publisher
..This data emphasizes the particular vulnerability of the RPE-choroidal complex to dysregulation of the alternative complement pathway during aging. ..
Luhmann U, Robbie S, Munro P, Barker S, Duran Y, Luong V, et al
. The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages. Invest Ophthalmol Vis Sci. 2009;50:5934-43 pubmed publisher
..Other, previously described features of Ccl2(-/-) mice that are similar to AMD may be the result of aging alone. ..
Luhmann U, Ali R. Local vs. systemic mononuclear phagocytes in age-related macular degeneration and their regulation by CCL2-CCR2 and CX3CL1-CX3CR1 chemokine signalling. Adv Exp Med Biol. 2012;723:17-22 pubmed publisher
Luhmann U, Lange C, Robbie S, Munro P, Cowing J, Armer H, et al
. Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling. PLoS ONE. 2012;7:e35551 pubmed publisher
..These findings indicate that CCDKO mice are not a model of AMD, but a model for an inherited retinal degeneration that is differentially modulated by Ccl2-Ccr2 and Cx3cl1-Cx3cr1 chemokine signalling. ..
Luhmann U, Carvalho L, Robbie S, Cowing J, Duran Y, Munro P, et al
. Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration. Exp Eye Res. 2013;107:80-7 pubmed publisher
..In conclusion, CCL2-CCR2 and/or CX3CL1-CX3CR1 signalling defects may differentially affect the trafficking of microglia and macrophages in the retina during ageing, but do not appear to cause age-related retinal degeneration in mice. ..