Research Topics
Genomes and Genes
Species | Michelle LucianoSummaryAffiliation: University of Edinburgh Country: UK Publications
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Detail Information
Publications
Depressive symptoms and diet: their effects on prospective inflammation levels in the elderlyMichelle Luciano
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
Brain Behav Immun 26:717-20. 2012....- Genome-wide association uncovers shared genetic effects among personality traits and mood statesMichelle Luciano
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
Am J Med Genet B Neuropsychiatr Genet 159:684-95. 2012..The variance explained by individual SNPs was very small (up to 1%) confirming that there are no moderate/large effects of common SNPs on personality and related traits... - SNP sets and reading ability: testing confirmation of a 10-SNP set in a population sampleMichelle Luciano
Centre for Cognitive Aging and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, United Kingdom
Twin Res Hum Genet 14:228-32. 2011..Results indicate that these SNPs are not associated with reading ability in an Australian population. The results are interpreted as supporting use of much larger SNP sets in common disorders where effects are small... - Association of existing and new candidate genes for anxiety, depression and personality traits in older peopleMichelle Luciano
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, Scotland, UK
Behav Genet 40:518-32. 2010..No SNPs withstood the correction to significance level for multiple testing. Nevertheless, the results will be of importance to future meta-analyses of these candidate genes in relation to psychological distress and personality... 
Whole genome association scan for genetic polymorphisms influencing information processing speedMichelle Luciano
Centre for Cognitive Aging and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Scotland, UK
Biol Psychol 86:193-202. 2011..g., receptor binding, cellular metabolic process). These highlighted genes and pathways will be able to inform future research, including results for psychiatric disease...- Variation in the dysbindin gene and normal cognitive function in three independent population samplesM Luciano
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK
Genes Brain Behav 8:218-27. 2009..Our results therefore support involvement of the dysbindin gene in cognitive function, but further work is needed to clarify the specific functional variants involved and the cognitive abilities with which they are associated... - Testing replication of a 5-SNP set for general cognitive ability in six population samplesMichelle Luciano
Department of Psychology, MRC Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
Eur J Hum Genet 16:1388-95. 2008..01, P=0.57), indicating that this SNP set was not associated with general cognitive ability in the populations studied... - Longevity candidate genes and their association with personality traits in the elderlyMichelle Luciano
Centre for Cognitive Aging and Cognitive Epidemiology, The University of Edinburgh, UK
Am J Med Genet B Neuropsychiatr Genet 159:192-200. 2012.... - Evolutionary conserved longevity genes and human cognitive abilities in elderly cohortsLorna M Lopez
Department of Psychology, The University of Edinburgh, Edinburgh, UK
Eur J Hum Genet 20:341-7. 2012..A meta-analysis replicated the SYNJ2 association with cognitive abilities (lowest P=0.00077). SYNJ2 is a novel gene in which variation is potentially associated with cognitive abilities... - Cognitive ability at age 11 and 70 years, information processing speed, and APOE variation: the Lothian Birth Cohort 1936 studyMichelle Luciano
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, Scotland
Psychol Aging 24:129-38. 2009..05): The correlation between childhood ability and speed was lower in e4 allele carriers. APOE has an influence on nonverbal cognition in old age and interacts with childhood IQ to influence processing speed... - Genetic variants associated with altered plasma levels of C-reactive protein are not associated with late-life cognitive ability in four Scottish samplesRiccardo E Marioni
Public Health Sciences Section, Division of Community Health Sciences, Centre for Population Health Sciences, University of Edinburgh, Medical School, Teviot Place, EH8 9AG Edinburgh, Scotland, UK
Behav Genet 40:3-11. 2010..038). After correction for multiple testing and adjustment for age and sex, no statistically significant associations were found between the SNPs and cognition. CRP is unlikely to be a causal determinant of late-life cognitive ability... - Genetic associations between fibrinogen and cognitive performance in three Scottish cohortsRiccardo E Marioni
Centre for Population Health Sciences, The University of Edinburgh, Medical School, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
Behav Genet 41:691-9. 2011..These findings suggest a tentative role for fibrinogen as a determinant of late-life cognitive performance and justify further attempts at replication in older persons... - Apolipoprotein E is not related to memory abilities at 70 years of ageMichelle Luciano
Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK
Behav Genet 39:6-14. 2009..04) in the analysis not controlling for IQ. Neither of these tests was significant when a correction for multiple testing was applied. APOE e4 does not influence memory abilities in a normal population of 70-year-olds... - Genetic contributions to stability and change in intelligence from childhood to old ageIan J Deary
Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
Nature 482:212-5. 2012..62. These estimates, derived from rarely available data on lifetime cognitive measures, warrant the search for genetic causes of cognitive stability and change... - Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin timeLorna M Houlihan
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
Am J Hum Genet 86:626-31. 2010..16 x 10(-30)), KNG1 (rs710446, combined p = 9.52 x 10(-22)), and HRG (rs9898, combined p = 1.34 x 10(-11)). These three SNPs explain approximately 18% of phenotypic variance in aPTT in the Lothian Birth Cohorts... - Genetic variance in a component of the language acquisition device: ROBO1 polymorphisms associated with phonological buffer deficitsTimothy C Bates
Centre for Cognitive Aging and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
Behav Genet 41:50-7. 2011..Its functional role in neuronal migration underlying bilateral symmetry and lateralization of neuronal function further suggests a role in the evolution of human language ability... - Reverse causation in the association between C-reactive protein and fibrinogen levels and cognitive abilities in an aging sampleMichelle Luciano
Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
Psychosom Med 71:404-9. 2009..Blood inflammatory markers have been shown to predict late-life cognition, although the mechanism through which this occurs is unknown... - Genetic copy number variation and general cognitive abilityAndrew K MacLeod
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom Medical Genetics Section, Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
PLoS ONE 7:e37385. 2012..This is the first study to examine the effects of rare CNVs as called by multiple algorithms on cognition in a large non-clinical sample, and finds no effects of such variants on general cognitive ability... - Polygenic risk for schizophrenia is associated with cognitive change between childhood and old ageAndrew M McIntosh
Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom Electronic address
Biol Psychiatry 73:938-43. 2013..No study has determined whether cognitive impairments can be attributed to schizophrenia's polygenic architecture using data from GWAS... - Multivariate genetic analyses of cognition and academic achievement from two population samples of 174,000 and 166,000 school childrenCatherine M Calvin
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK
Behav Genet 42:699-710. 2012.... 
Replication of reported linkages for dyslexia and spelling and suggestive evidence for novel regions on chromosomes 4 and 17Timothy C Bates
Department of Psychology, University of Edinburgh, Edinburgh, UK
Eur J Hum Genet 15:194-203. 2007..83, respectively, whereas two regions received little support (6p23-21.3 and 11p15.5). This study also identified two novel linkages at 4p15.33-16.1 and 17p13.3, which received suggestive support (max. lod 2.08 and 1.99, respectively)...- Happiness is a personal(ity) thing: the genetics of personality and well-being in a representative sampleAlexander Weiss
Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, UK
Psychol Sci 19:205-10. 2008..These findings indicate that subjective well-being is linked to personality by common genes and that personality may form an "affective reserve" relevant to set-point maintenance and changes in set point over time... - Personality traits and inflammation in men and women in their early 70s: the Lothian Birth Cohort 1936 study of healthy agingRené Mõttus
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, Scotland, UK
Psychosom Med 75:11-9. 2013..Findings, however, have been inconsistent. This study investigates these associations in individuals who ranged in age from approximately 70 to 73 years...