Martin Lowe

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi request reprint Structure and function of the Lowe syndrome protein OCRL1
    Martin Lowe
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    Traffic 6:711-9. 2005
  2. doi request reprint Structural organization of the Golgi apparatus
    Martin Lowe
    Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    Curr Opin Cell Biol 23:85-93. 2011
  3. ncbi request reprint Targeting of the type II inositol polyphosphate 5-phosphatase INPP5B to the early secretory pathway
    Catrin Williams
    Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    J Cell Sci 120:3941-51. 2007
  4. pmc ZFPL1, a novel ring finger protein required for cis-Golgi integrity and efficient ER-to-Golgi transport
    Chi Fang Chiu
    Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Manchester, UK
    EMBO J 27:934-47. 2008
  5. pmc Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases
    Noora Hyvola
    Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester, UK
    EMBO J 25:3750-61. 2006
  6. doi request reprint Coordination of golgin tethering and SNARE assembly: GM130 binds syntaxin 5 in a p115-regulated manner
    Aipo Diao
    Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    J Biol Chem 283:6957-67. 2008
  7. pmc The PH domain proteins IPIP27A and B link OCRL1 to receptor recycling in the endocytic pathway
    Christopher J Noakes
    Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, United Kingdom
    Mol Biol Cell 22:606-23. 2011
  8. pmc Differential clathrin binding and subcellular localization of OCRL1 splice isoforms
    Rawshan Choudhury
    Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    J Biol Chem 284:9965-73. 2009
  9. ncbi request reprint Caspase-mediated cleavage of syntaxin 5 and giantin accompanies inhibition of secretory traffic during apoptosis
    Martin Lowe
    School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, Manchester, M13 9PT, UK
    J Cell Sci 117:1139-50. 2004
  10. pmc The coiled-coil membrane protein golgin-84 is a novel rab effector required for Golgi ribbon formation
    Aipo Diao
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, UK
    J Cell Biol 160:201-12. 2003

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Structure and function of the Lowe syndrome protein OCRL1
    Martin Lowe
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    Traffic 6:711-9. 2005
    ..I will then discuss possible mechanisms by which loss of OCRL1 may bring about cellular defects that manifest themselves in the pathology of Lowe syndrome...
  2. doi request reprint Structural organization of the Golgi apparatus
    Martin Lowe
    Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    Curr Opin Cell Biol 23:85-93. 2011
    ..In this review I describe recent progress in the identification and characterization of the molecular machinery that together help generate the characteristic organization of this organelle...
  3. ncbi request reprint Targeting of the type II inositol polyphosphate 5-phosphatase INPP5B to the early secretory pathway
    Catrin Williams
    Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    J Cell Sci 120:3941-51. 2007
    ..Our data suggest a role for INPP5B in retrograde ERGIC-to-ER transport and imply that it has functions distinct from those of OCRL1 within both the secretory and endocytic pathways...
  4. pmc ZFPL1, a novel ring finger protein required for cis-Golgi integrity and efficient ER-to-Golgi transport
    Chi Fang Chiu
    Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Manchester, UK
    EMBO J 27:934-47. 2008
    ..Together, these data suggest that ZFPL1 has an important function in maintaining the integrity of the cis-Golgi and that it does so through interactions with GM130...
  5. pmc Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases
    Noora Hyvola
    Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester, UK
    EMBO J 25:3750-61. 2006
    ..We conclude that rabs play a dual role in regulation of OCRL1, firstly targeting it to the Golgi apparatus and endosomes, and secondly, directly stimulating the 5-phosphatase activity of OCRL1 after membrane recruitment...
  6. doi request reprint Coordination of golgin tethering and SNARE assembly: GM130 binds syntaxin 5 in a p115-regulated manner
    Aipo Diao
    Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    J Biol Chem 283:6957-67. 2008
    ..The interactions of GM130 with syntaxin 5 and Rab1 are also regulated by mitotic phosphorylation, which is likely to contribute to the inhibition of ER to Golgi trafficking that occurs when mammalian cells enter mitosis...
  7. pmc The PH domain proteins IPIP27A and B link OCRL1 to receptor recycling in the endocytic pathway
    Christopher J Noakes
    Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, United Kingdom
    Mol Biol Cell 22:606-23. 2011
    ..Our results identify IPIP27A and B as key players in endocytic trafficking and strongly suggest that defects in this process are responsible for the pathology of Lowe syndrome and Dent disease...
  8. pmc Differential clathrin binding and subcellular localization of OCRL1 splice isoforms
    Rawshan Choudhury
    Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    J Biol Chem 284:9965-73. 2009
    ..Our results suggest that OCRL1 exists as two functional pools, one participating in clathrin-mediated trafficking events such as endocytosis and another that is much less or not involved in this process...
  9. ncbi request reprint Caspase-mediated cleavage of syntaxin 5 and giantin accompanies inhibition of secretory traffic during apoptosis
    Martin Lowe
    School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, Manchester, M13 9PT, UK
    J Cell Sci 117:1139-50. 2004
    ..The contribution that such an inhibition of trafficking may make towards the generation of an apoptotic phenotype is discussed...
  10. pmc The coiled-coil membrane protein golgin-84 is a novel rab effector required for Golgi ribbon formation
    Aipo Diao
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, UK
    J Cell Biol 160:201-12. 2003
    ..Our results suggest that golgin-84 plays a key role in the assembly and maintenance of the Golgi ribbon in mammalian cells...
  11. doi request reprint Phosphorylation and membrane dissociation of the ARF exchange factor GBF1 in mitosis
    Yuichi Morohashi
    University of Manchester, UK
    Biochem J 427:401-12. 2010
    ....
  12. pmc Lowe syndrome protein OCRL1 interacts with clathrin and regulates protein trafficking between endosomes and the trans-Golgi network
    Rawshan Choudhury
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Mol Biol Cell 16:3467-79. 2005
    ..These findings suggest a role for OCRL1 in clathrin-mediated trafficking of proteins from endosomes to the TGN and that defects in this pathway might contribute to the Lowe syndrome phenotype...
  13. pmc Impaired neural development in a zebrafish model for Lowe syndrome
    Irene Barinaga Rementeria Ramirez
    University of Manchester, The Michael Smith Building, Manchester M13 9PT, UK
    Hum Mol Genet 21:1744-59. 2012
    ..Our results indicate a novel role for OCRL1 in neural development, and support a model whereby dysregulation of phosphoinositide metabolism and clathrin-mediated membrane traffic leads to the neurological symptoms of Lowe syndrome...
  14. ncbi request reprint Cell biology. The Golgi goes fission
    Aipo Diao
    School of Biological Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Science 305:48-9. 2004
  15. pmc Alpine pathways of membrane traffic
    Martin Lowe
    School of Biological Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    EMBO Rep 5:561-4. 2004
  16. ncbi request reprint Protein kinase D: activation for Golgi carrier formation
    Yashoda Ghanekar
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, UK
    Trends Cell Biol 15:511-4. 2005
    ..These findings indicate the existence of a kinase signaling cascade at the TGN that regulates carrier fission and suggest a mechanism by which cargo might direct the formation of its transport carriers...
  17. doi request reprint Golgins and GRASPs: holding the Golgi together
    Irene Barinaga Rementeria Ramirez
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    Semin Cell Dev Biol 20:770-9. 2009
    ....
  18. ncbi request reprint Inheritance and biogenesis of organelles in the secretory pathway
    Martin Lowe
    Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    Nat Rev Mol Cell Biol 8:429-39. 2007
    ..The different mechanisms by which organelles are inherited in yeasts, protozoa and metazoans probably reflect the differences in the structure and copy number of these organelles...
  19. doi request reprint Measurement of phosphoinositides in the zebrafish Danio rerio
    David R Jones
    Cancer Research UK Inositide Laboratory, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK
    Nat Protoc 8:1058-72. 2013
    ..All the procedures described herein will take up to 10 working days...
  20. ncbi request reprint Golgi complex: biogenesis de novo?
    Martin Lowe
    School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, M13 9PT, Manchester, UK
    Curr Biol 12:R166-7. 2002
    ..Recent studies have shown that Golgi structural proteins are more dynamic than previously thought, suggesting that self-assembly of the Golgi complex may be possible...
  21. ncbi request reprint Membranes and motors
    Martin Lowe
    School of Biological Sciences, University of Manchester, Manchester, UK
    Trends Cell Biol 12:543-4. 2002
    ..Presentations covered a broad range of topics relating to the dynamics of protein transport along both the exocytic and endocytic pathways of eukaryotic cells...
  22. pmc Caspase-mediated cleavage of the stacking protein GRASP65 is required for Golgi fragmentation during apoptosis
    Jon D Lane
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Cell Biol 156:495-509. 2002
    ..Our results suggest that GRASP65 is an important structural component required for maintenance of Golgi apparatus integrity...
  23. ncbi request reprint Convergence of cell cycle regulation and growth factor signals on GRASP65
    Shin ichiro Yoshimura
    Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Japan
    J Biol Chem 280:23048-56. 2005
    ..The convergence of cell cycle regulation and growth factor signals on GRASP65 Ser-277 suggests that GRASP65 may function as a signal integrator controlling the cell growth...
  24. ncbi request reprint Dissecting the role of the ARF guanine nucleotide exchange factor GBF1 in Golgi biogenesis and protein trafficking
    Tomasz Szul
    Department of Cell Biology, University of Alabama at Birmingham, 1918 University Blvd, Birmingham, AL 35924, USA
    J Cell Sci 120:3929-40. 2007
    ..However, the trafficking of transmembrane proteins through the existing pathway requires GBF1-mediated ARF activation and COPI recruitment...
  25. ncbi request reprint Signalling for secretion
    Yashoda Ghanekar
    Nat Cell Biol 7:851-3. 2005