Gordon D O Lowe

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. doi request reprint Common risk factors for both arterial and venous thrombosis
    Gordon D O Lowe
    Division of Cardiovascular and Medical Sciences, University of Glasgow, and Haemophilia and Thrombosis Centre, Royal Infirmary, Glasgow, UK
    Br J Haematol 140:488-95. 2008
  2. ncbi request reprint Is venous thrombosis a risk factor for arterial thrombosis?
    Gordon D O Lowe
    University of Glasgow, Royal Infirmary, Glasgow G31 2ER, UK
    Lancet 370:1742-4. 2007
  3. ncbi request reprint Coagulation factors, activation markers and risk of coronary heart disease: the Northwick Park Heart Studies
    G D O Lowe
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Royal Infirmary, Glasgow, UK
    J Thromb Haemost 6:256-8. 2008
  4. ncbi request reprint Inflammatory/hemostatic biomarkers and cardiovascular risk: coming of age?
    G D O Lowe
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Royal Infirmary, Glasgow, UK
    J Thromb Haemost 5:1125-7. 2007
  5. ncbi request reprint Coagulation, genotypes and recurrent cardiovascular events: what further studies are required?
    G D O Lowe
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Royal Infirmary, Glasgow, UK
    J Thromb Haemost 6:717-9. 2008
  6. doi request reprint Can haemostatic factors predict atherothrombosis?
    Gordon Lowe
    Institute of Cardiovascular and Medical Sciences, University of Glasgow, BHF GCRC, 126 University Place, Glasgow G12 8TA, UK
    Intern Emerg Med 6:497-501. 2011
  7. ncbi request reprint Can haematological tests predict cardiovascular risk? The 2005 Kettle Lecture
    Gordon D O Lowe
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    Br J Haematol 133:232-50. 2006
  8. ncbi request reprint Arterial disease and venous thrombosis: are they related, and if so, what should we do about it?
    G D O Lowe
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    J Thromb Haemost 4:1882-5. 2006
  9. doi request reprint Associations of inflammatory and haemostatic biomarkers with poor outcome in acute ischaemic stroke
    Paul Welsh
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    Cerebrovasc Dis 27:247-53. 2009
  10. ncbi request reprint Interleukin-6, fibrin D-dimer, and coagulation factors VII and XIIa in prediction of coronary heart disease
    Gordon D O Lowe
    Department of Medicine, University of Glasgow, Glasgow, UK
    Arterioscler Thromb Vasc Biol 24:1529-34. 2004

Detail Information

Publications87

  1. doi request reprint Common risk factors for both arterial and venous thrombosis
    Gordon D O Lowe
    Division of Cardiovascular and Medical Sciences, University of Glasgow, and Haemophilia and Thrombosis Centre, Royal Infirmary, Glasgow, UK
    Br J Haematol 140:488-95. 2008
    ..Appropriate lifestyle advice and medication (including aspirin) should then be considered...
  2. ncbi request reprint Is venous thrombosis a risk factor for arterial thrombosis?
    Gordon D O Lowe
    University of Glasgow, Royal Infirmary, Glasgow G31 2ER, UK
    Lancet 370:1742-4. 2007
  3. ncbi request reprint Coagulation factors, activation markers and risk of coronary heart disease: the Northwick Park Heart Studies
    G D O Lowe
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Royal Infirmary, Glasgow, UK
    J Thromb Haemost 6:256-8. 2008
  4. ncbi request reprint Inflammatory/hemostatic biomarkers and cardiovascular risk: coming of age?
    G D O Lowe
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Royal Infirmary, Glasgow, UK
    J Thromb Haemost 5:1125-7. 2007
  5. ncbi request reprint Coagulation, genotypes and recurrent cardiovascular events: what further studies are required?
    G D O Lowe
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Royal Infirmary, Glasgow, UK
    J Thromb Haemost 6:717-9. 2008
  6. doi request reprint Can haemostatic factors predict atherothrombosis?
    Gordon Lowe
    Institute of Cardiovascular and Medical Sciences, University of Glasgow, BHF GCRC, 126 University Place, Glasgow G12 8TA, UK
    Intern Emerg Med 6:497-501. 2011
    ..However, at present there is no sufficient evidence base for their routine measurement in prediction...
  7. ncbi request reprint Can haematological tests predict cardiovascular risk? The 2005 Kettle Lecture
    Gordon D O Lowe
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    Br J Haematol 133:232-50. 2006
    ..In conclusion, haematological tests have very limited roles in the prediction of cardiovascular risk, and should only be used according to evidence-based guidelines. The need for management studies is highlighted...
  8. ncbi request reprint Arterial disease and venous thrombosis: are they related, and if so, what should we do about it?
    G D O Lowe
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    J Thromb Haemost 4:1882-5. 2006
  9. doi request reprint Associations of inflammatory and haemostatic biomarkers with poor outcome in acute ischaemic stroke
    Paul Welsh
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    Cerebrovasc Dis 27:247-53. 2009
    ..Many inflammatory and haemostatic biomarkers show associations with acute ischaemic stroke outcome, but few studies compare a large range of markers...
  10. ncbi request reprint Interleukin-6, fibrin D-dimer, and coagulation factors VII and XIIa in prediction of coronary heart disease
    Gordon D O Lowe
    Department of Medicine, University of Glasgow, Glasgow, UK
    Arterioscler Thromb Vasc Biol 24:1529-34. 2004
    ....
  11. doi request reprint Activation of hemostasis and decline in cognitive function in older people
    David J Stott
    Academic Section of Geriatric Medicine, 3 Floor Queen Elizabeth Building, Royal Infirmary, Glasgow G31 2ER
    Arterioscler Thromb Vasc Biol 30:605-11. 2010
    ..To determine whether activation of hemostatic function (thrombosis and fibrinolysis) is associated with cognitive decline in older people...
  12. doi request reprint Adipocytokines and risk of stroke in older people: a nested case-control study
    David J Stott
    Division of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Scotland, UK
    Int J Epidemiol 38:253-61. 2009
    ..Inflammation may play an important role in atherothrombosis and in promoting cerebral damage after stroke. We hypothesized that plasma adipocytokine concentrations would be associated with risk of stroke in older people...
  13. doi request reprint Associations of proinflammatory cytokines with the risk of recurrent stroke
    Paul Welsh
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, UK
    Stroke 39:2226-30. 2008
    ..We studied the association of interleukin (IL)-6, IL-18, and tumor necrosis factor-alpha (TNF-alpha) with recurrent stroke in a nested case-control study derived from the Perindopril Protection Against Recurrent Stroke Study (PROGRESS)...
  14. pmc Incident venous thromboembolic events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER)
    Dilys J Freeman
    Centre of Population and Health Sciences, University of Glasgow, Glasgow, UK
    BMC Geriatr 11:8. 2011
    ..We aimed to determine the effect of pravastatin on incident VTE in older people; we also studied the impact of clinical and plasma risk variables...
  15. ncbi request reprint The association between homocysteine and myocardial infarction is independent of age, sex, blood pressure, cholesterol, smoking and markers of inflammation: the Glasgow Myocardial Infarction Study
    Mark Woodward
    The George Institute, Royal Prince Alfred Hospital, Sydney, Australia, and Department of Clinical Biochemistry, Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    Blood Coagul Fibrinolysis 17:1-5. 2006
    ..01-1.24) after the full adjustment. CONCLUSION: This study suggests that homocysteine has an effect on cardiovascular risk over and above that of inflammatory markers and the major cardiovascular risk factors...
  16. ncbi request reprint D-dimer predicts early clinical progression in ischemic stroke: confirmation using routine clinical assays
    Mark Barber
    University Section of Clinical Gerontology and Vascular Medicine, Royal Infirmary, Glasgow, UK
    Stroke 37:1113-5. 2006
    ..We wished to confirm these findings using commercially available assays and to provide data to allow the design of intervention studies...
  17. ncbi request reprint Our inability to predict thromboembolic events after prosthetic valve surgery
    Malcolm B Will
    Department of Cardiac Surgery, University of Glasgow, Glasgow, UK
    J Heart Valve Dis 15:570-80; discussion 580. 2006
    ....
  18. ncbi request reprint Oral contraceptives, hormone replacement therapy, thrombophilias and risk of venous thromboembolism: a systematic review. The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) Study
    Olivia Wu
    Department of Obstetrics and Gynaecology, University of Glasgow, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, UK
    Thromb Haemost 94:17-25. 2005
    ..However, further studies are required to establish with greater confidence the associations of these, and other, thrombophilias with venous thromboembolism among hormone users...
  19. doi request reprint Vascular dysfunction and alteration of novel and classic cardiovascular risk factors in mothers of growth restricted offspring
    Malini G Kanagalingam
    Reproductive and Maternal Medicine, University of Glasgow, Glasgow, United Kingdom
    Atherosclerosis 205:244-50. 2009
    ..However, whether established or putative novel cardiovascular risk factors including vascular and metabolic function are disrupted in women who delivered small for gestational age (SGA) offspring is unknown...
  20. doi request reprint Tissue plasminogen activator antigen predicts medium-term left ventricular end-systolic volume after acute myocardial infarction
    Robin A P Weir
    Cardiology Department, Western Infirmary, Glasgow, Scotland, UK
    J Thromb Thrombolysis 29:421-8. 2010
    ..This novel link between the coagulation-fibrinolysis system and matrix turnover merits further study in understanding the pathophysiology of adverse ventricular remodeling after AMI...
  21. ncbi request reprint Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease
    David J Stott
    Division of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom
    Am J Clin Nutr 82:1320-6. 2005
    ..Homocysteine is an independent risk factor for vascular disease and is associated with dementia in older people. Potential mechanisms include altered endothelial and hemostatic function...
  22. ncbi request reprint Hemostatic and rheological variables and risk of cardiovascular disease
    Gordon D O Lowe
    University Department of Medicine, Royal Infirmary, Glasgow, United Kingdom
    Semin Vasc Med 2:429-39. 2002
    ....
  23. ncbi request reprint Hemostatic function and progressing ischemic stroke: D-dimer predicts early clinical progression
    Mark Barber
    University Section of Clinical Gerontology and Vascular Medicine, Royal Infirmary, Glasgow, UK
    Stroke 35:1421-5. 2004
    ..We hypothesized that activation of the coagulation system is an important contributor in some cases of deterioration. We aimed to characterize alterations in circulating hemostatic markers in patients with progressing stroke...
  24. pmc The association between elevated levels of inflammation biomarkers and coronary artery disease and death
    Gordon D O Lowe
    University of Glasgow, Division of Cardiovascular and Medical Sciences, Glasgow Royal Infirmary, Glasgow, Scotland
    CMAJ 174:479-80. 2006
  25. ncbi request reprint Dental disease, coronary heart disease and stroke, and inflammatory markers: what are the associations, and what do they mean?
    Gordon D O Lowe
    Section of Vascular Medicine, University of Glasgow, United Kingdom
    Circulation 109:1076-8. 2004
  26. ncbi request reprint Plasma fibrinogen
    Gordon D O Lowe
    Department of Medicine, University of Glasgow Glasgow, Scotland, UK
    Ann Clin Biochem 41:430-40. 2004
    ..Unlike clottable fibrinogen assays, immunoassays can be performed in dipotassium edetate anticoagulated samples...
  27. ncbi request reprint C-reactive protein, fibrin D-dimer, and risk of ischemic heart disease: the Caerphilly and Speedwell studies
    G D O Lowe
    Department of Medicine, University of Glasgow, Scotland, UK
    Arterioscler Thromb Vasc Biol 24:1957-62. 2004
    ..We assessed their joint and independent associations with IHD in a large combined analysis of 2 population cohorts...
  28. ncbi request reprint Associations of plasma fibrinogen assays, C-reactive protein and interleukin-6 with previous myocardial infarction
    G D O Lowe
    University Department of Medicine, Royal Infirmary, Glasgow, UK
    J Thromb Haemost 1:2312-6. 2003
    ..Increased ratio of clottable fibrinogen to intact fibrinogen (measured by a recently developed immunoassay) has been proposed as a measure of hyperfunctional fibrinogen, and is elevated in acute MI...
  29. ncbi request reprint Tissue plasminogen activator antigen and coronary heart disease. Prospective study and meta-analysis
    G D O Lowe
    University Department of Medicine, Royal Infirmary, Glasgow, UK
    Eur Heart J 25:252-9. 2004
    ..To determine whether circulating tissue plasminogen activator (t-PA) antigen concentrations are prospectively related to risk of coronary heart disease (CHD) in the general population...
  30. ncbi request reprint Fibrinogen measurement to assess the risk of arterial thrombosis in individual patients: not yet
    G D O Lowe
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    J Thromb Haemost 3:635-7. 2005
  31. ncbi request reprint Circulating inflammatory markers and risks of cardiovascular and non-cardiovascular disease
    G D O Lowe
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    J Thromb Haemost 3:1618-27. 2005
    ..Markers are of little additional predictive value to current cardiovascular risk scores, and it is premature to advocate their use in screening for cardiovascular risk prior to careful evaluation of costs, risks, and benefits...
  32. ncbi request reprint Effects of moderate weight loss on anginal symptoms and indices of coagulation and fibrinolysis in overweight patients with angina pectoris
    C R Hankey
    Department of Human Nutrition, University of Glasgow, Glasgow, UK
    Eur J Clin Nutr 56:1039-45. 2002
    ..To evaluate the effects of moderate weight loss, in overweight patients with angina, on plasma coagulation, fibrinolytic indicies and pain frequency...
  33. ncbi request reprint Plasma lipid peroxides: relationships to cardiovascular risk factors and prevalent cardiovascular disease
    A G Rumley
    University Department of Medicine, Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER
    QJM 97:809-16. 2004
    ..The epidemiology of plasma lipid peroxides, which may play a role in atherogenesis, has not been well defined...
  34. ncbi request reprint Dementia in subjects with atrial fibrillation: hemostatic function and the role of anticoagulation
    M Barber
    University Section of Clinical Gerontology and Vascular Medicine and Department of Haematology, Royal Infirmary, Glasgow, UK
    J Thromb Haemost 2:1873-8. 2004
    ..Atrial fibrillation (AF) is associated with cognitive impairment and dementia, perhaps through encouraging a prothrombotic state and cardioembolism...
  35. ncbi request reprint Hormone replacement therapy and cardiovascular disease: increased risks of venous thromboembolism and stroke, and no protection from coronary heart disease
    G D O Lowe
    Division of Cardiovascular and Medical Sciences, University of Glasgow, UK
    J Intern Med 256:361-74. 2004
    ..The implications for prescription are discussed, as are lessons for future evaluation of health care interventions...
  36. ncbi request reprint The need for risk factor assessment in atherothrombotic vascular disease
    Gordon D O Lowe
    Department of Medicine, Royal Infirmary, Glasgow, Scotland
    Semin Vasc Med 2:231-2. 2002
    ..g., blood pressure, serum cholesterol). Emerging potential risk factors include markers of infection, inflammation, and thrombosis; their possible roles in causation and in risk prediction require much further study...
  37. ncbi request reprint Local inflammation, endothelial dysfunction and fibrinolysis in coronary heart disease
    Gordon D O Lowe
    University Department of Medicine, University of Glasgow, Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, U K
    Clin Sci (Lond) 110:327-8. 2006
    ....
  38. ncbi request reprint Prevention of venous thromboembolism after major orthopaedic surgery: is fondaparinux an advance?
    Gordon D O Lowe
    University Department of Medicine, Royal Infirmary, Glasgow G31 2ER, UK
    Lancet 362:504-5. 2003
  39. ncbi request reprint Fibrin D-dimer and cardiovascular risk
    Gordon D O Lowe
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom
    Semin Vasc Med 5:387-98. 2005
    ..Harmonization of results from different assays would increase clinical utility...
  40. ncbi request reprint Hormone replacement therapy: prothrombotic vs. protective effects
    Gordon D O Lowe
    Department of Medicine, Royal Infirmary, University of Glasgow, UK
    Pathophysiol Haemost Thromb 32:329-32. 2002
    ..The overall balance of prothrombotic and protective effects varies with HRT preparations and individual women: and may be clarified by ongoing large randomised trials and case-control studies (and substudies of trials)...
  41. ncbi request reprint Effects of older age on fibrin D-dimer, C-reactive protein, and other hemostatic and inflammatory variables in men aged 60-79 years
    A Rumley
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Royal Infirmary, 10 Alexandra Parade, Glasgow, UK
    J Thromb Haemost 4:982-7. 2006
    ..However, there is a lack of data from large population studies for reliable estimates of reference ranges...
  42. ncbi request reprint C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study
    Dilys J Freeman
    Department of Obstetrics and Gynaecology, University of Glasgow, Glasgow, UK
    Diabetes 51:1596-600. 2002
    ..They also add to the notion that low-grade inflammation is important in the pathogenesis of type 2 diabetes...
  43. ncbi request reprint A specific elevation in tissue plasminogen activator antigen in women with polycystic ovarian syndrome
    Christopher J G Kelly
    Department of Medicine and Therapeutics, University of Glasgow, Glasgow G31 2ER, Scotland, UK
    J Clin Endocrinol Metab 87:3287-90. 2002
    ..We suggest that elevated t-PA and dysfibrinolysis may be a factor in the increased cardiovascular morbidity seen in PCOS...
  44. ncbi request reprint Venous and arterial thrombosis: epidemiology and risk factors at various ages
    Gordon D O Lowe
    Department of Medicine, Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, UK
    Maturitas 47:259-63. 2004
    ..g. homocysteine, haemostatic and inflammatory variables) should elucidate their roles in risk prediction, including thrombotic risks of sex hormones which have effects on these variables...
  45. pmc Measurement of thrombosis and its prevention
    Gordon D O Lowe
    University Department of Medicine, Royal Infirmary, Alexandra Parade, Glasgow G31 2ER
    Br J Clin Pharmacol 54:96-100. 2002
  46. doi request reprint Serum matrix metalloproteinase-9 and coronary heart disease: a prospective study in middle-aged men
    P Welsh
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow
    QJM 101:785-91. 2008
    ..Matrix metalloproteinase-9 (MMP-9) has a potential role in arterial plaque rupture, but its relation to risk of coronary heart disease (CHD) is uncertain...
  47. ncbi request reprint Glucocorticoids and insulin sensitivity: dissociation of insulin's metabolic and vascular actions
    C G Perry
    University Department of Medicine, Western Infirmary, University of Glasgow, Glasgow, Scotland, United Kingdom
    J Clin Endocrinol Metab 88:6008-14. 2003
    ..This implies that, using this model, there is physiological uncoupling of the effects of insulin in different tissues...
  48. ncbi request reprint Virchow's triad revisited: abnormal flow
    Gordon D O Lowe
    Professor of Vascular Medicine, University Department of Medicine Royal Infirmary, Glasgow, UK
    Pathophysiol Haemost Thromb 33:455-7. 2003
    ..There is increasing evidence that regular exercise and avoidance of immobility reduces the risk of both arterial and venous thrombosis and also has systemic antithrombotic and anti-inflammatory effects. So: "Go with the flow!"..
  49. ncbi request reprint Screening for thrombophilia in high-risk situations: systematic review and cost-effectiveness analysis. The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) study
    O Wu
    Division of Developmental Medicine, University of Glasgow, UK
    Health Technol Assess 10:1-110. 2006
    ..To evaluate the relative cost-effectiveness of universal and selective VTE history-based screening for thrombophilia compared with no screening in the three high-risk patient groups...
  50. ncbi request reprint Blood interactions with plasticised poly (vinyl chloride): influence of surface modification
    Xiaobin Zhao
    Bioengineering Unit, University of Strathclyde, Glasgow, UK
    J Mater Sci Mater Med 19:713-9. 2008
    ..The blood compatibility assessment confirms the importance of surface modification for the improvement of blood compatibility...
  51. ncbi request reprint Thrombophilia in pregnancy: a systematic review
    L Robertson
    Department of Obstetrics and Gynaecology, University of Glasgow, UK
    Br J Haematol 132:171-96. 2006
    ..There is also a lack of controlled trials of antithrombotic intervention to prevent pregnancy complications. Thus, at present, universal screening for thrombophilia in pregnancy cannot be justified clinically...
  52. ncbi request reprint C-reactive protein and cardiovascular disease: weighing the evidence
    Gordon D O Lowe
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, University College London, Rowland Hill Street, London NW3 2PF, United Kingdom
    Curr Atheroscler Rep 8:421-8. 2006
    ..Future clinical trials of specific CRP inhibitors now in development could directly test the contribution of CRP to pathogenesis of cardiovascular disease...
  53. ncbi request reprint Association between plasma IL-6, the IL6 -174G>C gene variant and the metabolic syndrome in type 2 diabetes mellitus
    Jeffrey W Stephens
    Diabetes Research Group, The Medical School, Swansea University, Swansea SA2 8PP, UK
    Mol Genet Metab 90:422-8. 2007
    ..Further prospective work is required to explore the effect of this gene variant in relation to obesity, the metabolic syndrome and 'prediabetes'...
  54. ncbi request reprint Inflammatory, haemostatic, and rheological markers for incident peripheral arterial disease: Edinburgh Artery Study
    Ioanna Tzoulaki
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
    Eur Heart J 28:354-62. 2007
    ..However, their role in peripheral arterial disease (PAD) is not well established and some of them, including the pro-inflammatory cytokine interleukin-6 (IL-6), have not been examined before in prospective epidemiological studies...
  55. ncbi request reprint Diurnal, seasonal, and blood-processing patterns in levels of circulating fibrinogen, fibrin D-dimer, C-reactive protein, tissue plasminogen activator, and von Willebrand factor in a 45-year-old population
    Alicja R Rudnicka
    Division of Community Health Sciences, St George s, University of London Cranmer Terrace, London, SW17 0RE, United Kingdom
    Circulation 115:996-1003. 2007
    ....
  56. ncbi request reprint On the route to combined evidence from OC and HRT/ERT
    Sven O Skouby
    Department of Obstetrics and Gynecology, Frederiksberg Hospital, University of Copenhagen, DK 2000 Copenhagen F, Denmark
    Eur J Contracept Reprod Health Care 7:185-98. 2002
  57. doi request reprint Tissue plasminogen activator, von Willebrand factor, and risk of type 2 diabetes in older men
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill St, London NW3 2PF, UK
    Diabetes Care 31:995-1000. 2008
    ....
  58. pmc Long-term interleukin-6 levels and subsequent risk of coronary heart disease: two new prospective studies and a systematic review
    John Danesh
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
    PLoS Med 5:e78. 2008
    ..We updated a systematic review to put the new findings in context...
  59. ncbi request reprint Cognitive decline and markers of inflammation and hemostasis: the Edinburgh Artery Study
    Snorri B Rafnsson
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, Medical School, University of Edinburgh, Edinburgh, UK
    J Am Geriatr Soc 55:700-7. 2007
    ..To determine whether circulating markers of activated inflammation and hemostasis are associated with cognitive decline in older people...
  60. ncbi request reprint Relationships of inflammatory and haemostatic markers with social class: results from a population-based study of older men
    Sheena Ramsay
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Atherosclerosis 197:654-61. 2008
    ..The effect of socio-economic gradient on the factor VIII-vWF complex, APC resistance, plasma viscosity and platelet count merits further study...
  61. ncbi request reprint Relative value of inflammatory, hemostatic, and rheological factors for incident myocardial infarction and stroke: the Edinburgh Artery Study
    Ioanna Tzoulaki
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
    Circulation 115:2119-27. 2007
    ....
  62. ncbi request reprint Adipokines and risk of type 2 diabetes in older men
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Diabetes Care 30:1200-5. 2007
    ..The aim was to assess the relationship between adipokines, including interleukin (IL)-6, leptin, and adiponectin, with development of type 2 diabetes and assess the role of obesity and insulin resistance in these relationships...
  63. ncbi request reprint Plasma leptin: associations with metabolic, inflammatory and haemostatic risk factors for cardiovascular disease
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Atherosclerosis 191:418-26. 2007
    ..We have examined the relationship between leptin and vascular risk factors including insulin resistance, metabolic, inflammatory and haemostatic risk factors...
  64. ncbi request reprint C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease
    John Danesh
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
    N Engl J Med 350:1387-97. 2004
    ..We report data from a large study of C-reactive protein and other circulating inflammatory markers, as well as updated meta-analyses, to evaluate their relevance to the prediction of coronary heart disease...
  65. ncbi request reprint Interleukin-6 -174G>C polymorphism and risk of coronary heart disease in West of Scotland coronary prevention study (WOSCOPS)
    Federica Basso
    Centre for Cardiovascular Genetics, BHF Laboratories, Royal Free and University College London Medical School, London, UK
    Arterioscler Thromb Vasc Biol 22:599-604. 2002
    ..These results demonstrate the importance of the inflammatory system in determining the risk of CHD and support the nonlipid effect of statins on risk...
  66. ncbi request reprint Relationship of the platelet glycoprotein PlA and fibrinogen T/G+1689 polymorphisms with peripheral arterial disease and ischaemic heart disease
    Felicity B Smith
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Department of Community Health Sciences, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Thromb Res 112:209-16. 2003
    ..This study determined the risk of peripheral arterial disease and ischaemic heart disease associated with polymorphisms of fibrinogen T/G(+1689) and platelet glycoprotein Pl(A) genes and the effects of cigarette smoking and fibrinogen...
  67. ncbi request reprint Does sticky blood predict a sticky end? Associations of blood viscosity, haematocrit and fibrinogen with mortality in the West of Scotland
    Mark Woodward
    Institute for International Health, University of Sydney, Australia
    Br J Haematol 122:645-50. 2003
    ..However, the significance of this association, and the extent to which viscosity is associated with mortality, remain to be established in larger studies and meta-analyses...
  68. ncbi request reprint C-reactive protein: associations with haematological variables, cardiovascular risk factors and prevalent cardiovascular disease
    Mark Woodward
    Institute for International Health, University of Sydney, Australia
    Br J Haematol 122:135-41. 2003
    ....
  69. ncbi request reprint Guidelines on fibrinogen assays
    Ian J Mackie
    Haematology Department, University College London, Sheffield, UK
    Br J Haematol 121:396-404. 2003
  70. ncbi request reprint Distributions of C-reactive protein measured by high-sensitivity assays in apparently healthy men and women from different populations in Europe
    Armin Imhof
    Department of Internal Medicine II, Cardiology, University of Ulm, Germany
    Clin Chem 49:669-72. 2003
  71. ncbi request reprint Endothelial dysfunction and inflammation in asymptomatic proteinuria
    Karen E Paisley
    Institute of Biomedical and Clinical Science, Peninsula Medical School, and Renal Unit, Royal Devon and Exeter Hospital, Exeter, United Kingdom
    Kidney Int 63:624-33. 2003
    ..Vascular risk and chronic inflammation are associated. This study investigates whether the increased vascular permeability in proteinuria reflects systemic endothelial dysfunction and chronic inflammation...
  72. ncbi request reprint Influence of socioeconomic status and job control on plasma fibrinogen responses to acute mental stress
    Andrew Steptoe
    Department of Epidemiology and Public Health, University College London, United Kingdom
    Psychosom Med 65:137-44. 2003
    ..This study assessed the influence of socioeconomic status, job control, and social isolation on fibrinogen responses to acute stress...
  73. ncbi request reprint Association of the factor XII 46C>T polymorphism with risk of coronary heart disease (CHD) in the WOSCOPS study
    Francesco Zito
    Centre for Cardiovascular Genetics, Royal Free and University College London Medical School, London WC1E 6JJ, UK
    Atherosclerosis 165:153-8. 2002
    ..To evaluate the contribution of the 46C>T polymorphism of the Factor XII (FXII) gene to risk for coronary heart disease (CHD) in the West of Scotland Coronary Prevention Study (WOSCOPS) of men with high cholesterol...
  74. ncbi request reprint Resonance-thrombography indices of the haemostatic process in relation to risk of incident coronary heart disease: 9 years follow-up in the Caerphilly Prospective Heart Disease Study
    Shicheng Yu
    Department of Epidemiology and Public Health, Queen s University Belfast, Belfast, UK
    Br J Haematol 126:385-91. 2004
    ..Additional adjustment for fibrinogen, viscosity, white cell count and fibrin d-dimer either reduced these associations to non-significance (AF) or to borderline significance (r)...
  75. ncbi request reprint Association of C-reactive protein with blood pressure and hypertension: life course confounding and mendelian randomization tests of causality
    George Davey Smith
    Department of Social Medicine, University of Bristol, Bristol, UK
    Arterioscler Thromb Vasc Biol 25:1051-6. 2005
    ..C-reactive protein (CRP) has repeatedly been associated with blood pressure and prevalent and incident hypertension, but whether a causal link exists is uncertain...
  76. ncbi request reprint Associations between cigarette smoking, pipe/cigar smoking, and smoking cessation, and haemostatic and inflammatory markers for cardiovascular disease
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill St, London NW3 2PF, UK
    Eur Heart J 26:1765-73. 2005
    ..To examine the associations between cigarette smoking, pipe/cigar smoking, and years since quitting smoking, and inflammatory and haemostatic markers...
  77. ncbi request reprint Associations of vitamin C status, fruit and vegetable intakes, and markers of inflammation and hemostasis
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, United Kingdom
    Am J Clin Nutr 83:567-74; quiz 726-7. 2006
    ..It has been suggested that a high dietary intake and high circulating concentrations of vitamin C may protect against ischemic heart disease...
  78. ncbi request reprint Reduced lung function in patients with abdominal aortic aneurysm is associated with activation of inflammation and hemostasis, not smoking or cardiovascular disease
    F Gerald R Fowkes
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, University of Edinburgh, Edinburgh, United Kingdom
    J Vasc Surg 43:474-80. 2006
    ..The aim of this study was to determine if these factors accounted for the link between aneurysms and pulmonary disease...
  79. ncbi request reprint Seven haemostatic gene polymorphisms in coronary disease: meta-analysis of 66,155 cases and 91,307 controls
    Zheng Ye
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Site, Wort s Causeway, Cambridge CB1 8RN, UK
    Lancet 367:651-8. 2006
    ..We did meta-analyses on seven such haemostatic genetic variants for which the available evidence on each comprises at least 5000 coronary disease cases and at least 5000 controls...
  80. ncbi request reprint Hemostatic factors, inflammatory markers, and progressive peripheral atherosclerosis: the Edinburgh Artery Study
    Ioanna Tzoulaki
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, School of Medicine and Veterinary Medicine, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    Am J Epidemiol 163:334-41. 2006
    ..Since D-dimer and fibrinogen are acute phase reactants, these data support the hypothesis that inflammation is more related to atherosclerosis than is hypercoagulation...
  81. ncbi request reprint Cardiovascular risk parameters in men with ankylosing spondylitis in comparison with non-inflammatory control subjects: relevance of systemic inflammation
    Hiren Divecha
    Centre for Rheumatic Diseases, Glasgow Royal Infirmary, Scotland, UK
    Clin Sci (Lond) 109:171-6. 2005
    ..In conclusion, men with AS have perturbances in several CHD risk factors, which appear to be driven principally by systemic inflammatory mediators. Inflammation-driven atherogenesis potentially contributes to the excess CHD risk in AS...
  82. ncbi request reprint Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis
    John Danesh
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, England
    JAMA 294:1799-809. 2005
    ..Plasma fibrinogen levels may be associated with the risk of coronary heart disease (CHD) and stroke...
  83. ncbi request reprint Associations of inflammatory and hemostatic variables with the risk of recurrent stroke
    Mark Woodward
    George Institute for International Health, University of Sydney, Australia
    Stroke 36:2143-7. 2005
    ..Little has been published on the associations of these variables with recurrent stroke. We studied such associations in a nested case-control study derived from the Perindopril Protection Against Recurrent Stroke Study (PROGRESS)...
  84. ncbi request reprint C-reactive protein, interleukin-6, and soluble adhesion molecules as predictors of progressive peripheral atherosclerosis in the general population: Edinburgh Artery Study
    Ioanna Tzoulaki
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, University of Edinburgh, Edinburgh, EH8 9AG, Scotland
    Circulation 112:976-83. 2005
    ..We therefore studied inflammatory markers as predictors of peripheral atherosclerotic progression, measured by the ankle-brachial index (ABI) at 3 consecutive time points over 12 years...
  85. ncbi request reprint The metabolic syndrome and insulin resistance: relationship to haemostatic and inflammatory markers in older non-diabetic men
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    Atherosclerosis 181:101-8. 2005
    ..We have examined the cross-sectional relationship between insulin resistance, the metabolic syndrome and haemostatic and inflammatory markers...
  86. ncbi request reprint Associations of fibrinogen and C-reactive protein with prevalent and incident coronary heart disease are attenuated by adjustment for confounding factors. British Women's Heart and Health Study
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, UK
    Thromb Haemost 93:955-63. 2005
    ..We conclude that fibrinogen and CRP predict CHD but may not be causally related to it...
  87. ncbi request reprint Physical activity and hemostatic and inflammatory variables in elderly men
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free Hospital School of Medicine, London, UK
    Circulation 105:1785-90. 2002
    ..Hemostatic and inflammatory markers have been linked with risk of cardiovascular disease. We therefore examined the relationship between physical activity and hemostatic and inflammatory variables...