G D Lowe

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi request reprint How to search for the role and prevalence of defective fibrinolytic states as triggers of myocardial infarction? The haemostasis epidemiologist's view
    G D Lowe
    Vascular Medicine, University of Glasgow, UK
    Ital Heart J 2:656-7. 2001
  2. ncbi request reprint Total tooth loss and prevalent cardiovascular disease in men and women: possible roles of citrus fruit consumption, vitamin C, and inflammatory and thrombotic variables
    Gordon Lowe
    University Department of Medicine, Royal Infirmary, 10 Alexandra Parade, Glasgow, G31 2ER, UK
    J Clin Epidemiol 56:694-700. 2003
  3. ncbi request reprint C-reactive protein, fibrin D-dimer, and risk of ischemic heart disease: the Caerphilly and Speedwell studies
    G D O Lowe
    Department of Medicine, University of Glasgow, Scotland, UK
    Arterioscler Thromb Vasc Biol 24:1957-62. 2004
  4. ncbi request reprint Fibrin D-dimer, markers of coagulation activation and the risk of major ischaemic heart disease in the caerphilly study
    G D Lowe
    University Department of Medicine, Royal Infirmary, Glasgow, UK
    Thromb Haemost 86:822-7. 2001
  5. ncbi request reprint Interleukin-6, fibrin D-dimer, and coagulation factors VII and XIIa in prediction of coronary heart disease
    Gordon D O Lowe
    Department of Medicine, University of Glasgow, Glasgow, UK
    Arterioscler Thromb Vasc Biol 24:1529-34. 2004
  6. ncbi request reprint Venous and arterial thrombosis: epidemiology and risk factors at various ages
    Gordon D O Lowe
    Department of Medicine, Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, UK
    Maturitas 47:259-63. 2004
  7. ncbi request reprint Dental disease, coronary heart disease and stroke, and inflammatory markers: what are the associations, and what do they mean?
    Gordon D O Lowe
    Section of Vascular Medicine, University of Glasgow, United Kingdom
    Circulation 109:1076-8. 2004
  8. ncbi request reprint Tissue plasminogen activator antigen and coronary heart disease. Prospective study and meta-analysis
    G D O Lowe
    University Department of Medicine, Royal Infirmary, Glasgow, UK
    Eur Heart J 25:252-9. 2004
  9. ncbi request reprint The relationship between infection, inflammation, and cardiovascular disease: an overview
    G D Lowe
    Department of Medicine, University of Glasgow, Glasgow, Scotland
    Ann Periodontol 6:1-8. 2001
  10. ncbi request reprint Associations of plasma fibrinogen assays, C-reactive protein and interleukin-6 with previous myocardial infarction
    G D O Lowe
    University Department of Medicine, Royal Infirmary, Glasgow, UK
    J Thromb Haemost 1:2312-6. 2003

Collaborators

Detail Information

Publications92

  1. ncbi request reprint How to search for the role and prevalence of defective fibrinolytic states as triggers of myocardial infarction? The haemostasis epidemiologist's view
    G D Lowe
    Vascular Medicine, University of Glasgow, UK
    Ital Heart J 2:656-7. 2001
    ..3-2.2) for D-dimer. Further studies are required to establish with confidence the associations for plasminogen activator inhibitor type 1, urokinase-type plasminogen activator, and other fibrinolytic variables...
  2. ncbi request reprint Total tooth loss and prevalent cardiovascular disease in men and women: possible roles of citrus fruit consumption, vitamin C, and inflammatory and thrombotic variables
    Gordon Lowe
    University Department of Medicine, Royal Infirmary, 10 Alexandra Parade, Glasgow, G31 2ER, UK
    J Clin Epidemiol 56:694-700. 2003
    ..We evaluated the association of total tooth loss with prevalent CVD in men and women; as well as with citrus fruit consumption, plasma vitamin C, and inflammatory and thrombotic variables...
  3. ncbi request reprint C-reactive protein, fibrin D-dimer, and risk of ischemic heart disease: the Caerphilly and Speedwell studies
    G D O Lowe
    Department of Medicine, University of Glasgow, Scotland, UK
    Arterioscler Thromb Vasc Biol 24:1957-62. 2004
    ..We assessed their joint and independent associations with IHD in a large combined analysis of 2 population cohorts...
  4. ncbi request reprint Fibrin D-dimer, markers of coagulation activation and the risk of major ischaemic heart disease in the caerphilly study
    G D Lowe
    University Department of Medicine, Royal Infirmary, Glasgow, UK
    Thromb Haemost 86:822-7. 2001
    ..We suggest that further studies are required to establish the causes of increased cross-linked fibrin turnover, which is associated with incident IHD in the general population when measured by a specific assay...
  5. ncbi request reprint Interleukin-6, fibrin D-dimer, and coagulation factors VII and XIIa in prediction of coronary heart disease
    Gordon D O Lowe
    Department of Medicine, University of Glasgow, Glasgow, UK
    Arterioscler Thromb Vasc Biol 24:1529-34. 2004
    ....
  6. ncbi request reprint Venous and arterial thrombosis: epidemiology and risk factors at various ages
    Gordon D O Lowe
    Department of Medicine, Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, UK
    Maturitas 47:259-63. 2004
    ..g. homocysteine, haemostatic and inflammatory variables) should elucidate their roles in risk prediction, including thrombotic risks of sex hormones which have effects on these variables...
  7. ncbi request reprint Dental disease, coronary heart disease and stroke, and inflammatory markers: what are the associations, and what do they mean?
    Gordon D O Lowe
    Section of Vascular Medicine, University of Glasgow, United Kingdom
    Circulation 109:1076-8. 2004
  8. ncbi request reprint Tissue plasminogen activator antigen and coronary heart disease. Prospective study and meta-analysis
    G D O Lowe
    University Department of Medicine, Royal Infirmary, Glasgow, UK
    Eur Heart J 25:252-9. 2004
    ..To determine whether circulating tissue plasminogen activator (t-PA) antigen concentrations are prospectively related to risk of coronary heart disease (CHD) in the general population...
  9. ncbi request reprint The relationship between infection, inflammation, and cardiovascular disease: an overview
    G D Lowe
    Department of Medicine, University of Glasgow, Glasgow, Scotland
    Ann Periodontol 6:1-8. 2001
    ..While control of chronic infection in the mouth, stomach or lungs is appropriate for its local effects, proving its efficacy in prevention of CVD presents a continuing challenge to medical science...
  10. ncbi request reprint Associations of plasma fibrinogen assays, C-reactive protein and interleukin-6 with previous myocardial infarction
    G D O Lowe
    University Department of Medicine, Royal Infirmary, Glasgow, UK
    J Thromb Haemost 1:2312-6. 2003
    ..Increased ratio of clottable fibrinogen to intact fibrinogen (measured by a recently developed immunoassay) has been proposed as a measure of hyperfunctional fibrinogen, and is elevated in acute MI...
  11. ncbi request reprint Hormone replacement therapy: prothrombotic vs. protective effects
    Gordon D O Lowe
    Department of Medicine, Royal Infirmary, University of Glasgow, UK
    Pathophysiol Haemost Thromb 32:329-32. 2002
    ..The overall balance of prothrombotic and protective effects varies with HRT preparations and individual women: and may be clarified by ongoing large randomised trials and case-control studies (and substudies of trials)...
  12. ncbi request reprint Prevention of venous thromboembolism after major orthopaedic surgery: is fondaparinux an advance?
    Gordon D O Lowe
    University Department of Medicine, Royal Infirmary, Glasgow G31 2ER, UK
    Lancet 362:504-5. 2003
  13. ncbi request reprint Fibrinogen and its degradation products as thrombotic risk factors
    G D Lowe
    University Department of Medicine, Royal Infirmary, 10 Alexandra Parade, Glasgow, United Kingdom
    Ann N Y Acad Sci 936:560-5. 2001
    ..Finally, the causal significance of the associations of fibrinogen and D-dimer with thrombotic events remains to be established by randomized controlled trials of reduction in their plasma levels...
  14. ncbi request reprint Specificity of haemostasis abnormalities for vascular phenotypes
    G D Lowe
    University Department of Medicine, Royal Infirmary, Glasgow, UK
    Haemostasis 28:223-7. 1998
    ..Associations between haemostatic variables and any given phenotype, e.g. (vascular) dementia, should be interpreted with caution, given the overlaps of vascular disease phenotypes, risk factors, and haemostatic variables...
  15. ncbi request reprint Plasma fibrinogen
    Gordon D O Lowe
    Department of Medicine, University of Glasgow Glasgow, Scotland, UK
    Ann Clin Biochem 41:430-40. 2004
    ..Unlike clottable fibrinogen assays, immunoassays can be performed in dipotassium edetate anticoagulated samples...
  16. ncbi request reprint Prediction of deep vein thrombosis after elective hip replacement surgery by preoperative clinical and haemostatic variables: the ECAT DVT Study. European Concerted Action on Thrombosis
    G D Lowe
    University Department of Medicine, Royal Infirmary, Glasgow, UK
    Thromb Haemost 81:879-86. 1999
    ....
  17. ncbi request reprint Prediction of postoperative deep-vein thrombosis
    G D Lowe
    Department of Medicine, University of Glasgow, UK
    Thromb Haemost 78:47-52. 1997
    ..However, the clinical utility of such tests is unproven; so at present they cannot be advocated for routine preoperative or postoperative screening...
  18. ncbi request reprint Thrombotic variables and risk of idiopathic venous thromboembolism in women aged 45-64 years. Relationships to hormone replacement therapy
    G Lowe
    University Department of Medicine, Royal Infirmary, Glasgow, UK
    Thromb Haemost 83:530-5. 2000
    ..However, HRT increases the risk of VTE about fourfold even in women without any thrombotic abnormalities: possible causes are discussed...
  19. ncbi request reprint Plasma lipid peroxides: relationships to cardiovascular risk factors and prevalent cardiovascular disease
    A G Rumley
    University Department of Medicine, Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER
    QJM 97:809-16. 2004
    ..The epidemiology of plasma lipid peroxides, which may play a role in atherogenesis, has not been well defined...
  20. ncbi request reprint Blood rheology, cardiovascular risk factors, and cardiovascular disease: the West of Scotland Coronary Prevention Study
    G Lowe
    Department of Medicine, University of Glasgow, UK
    Thromb Haemost 84:553-8. 2000
    ..Further studies are required to test this hypothesis...
  21. ncbi request reprint Hormone replacement therapy and cardiovascular disease: increased risks of venous thromboembolism and stroke, and no protection from coronary heart disease
    G D O Lowe
    Division of Cardiovascular and Medical Sciences, University of Glasgow, UK
    J Intern Med 256:361-74. 2004
    ..The implications for prescription are discussed, as are lessons for future evaluation of health care interventions...
  22. ncbi request reprint Circulating inflammatory markers and risks of cardiovascular and non-cardiovascular disease
    G D O Lowe
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    J Thromb Haemost 3:1618-27. 2005
    ..Markers are of little additional predictive value to current cardiovascular risk scores, and it is premature to advocate their use in screening for cardiovascular risk prior to careful evaluation of costs, risks, and benefits...
  23. ncbi request reprint Local inflammation, endothelial dysfunction and fibrinolysis in coronary heart disease
    Gordon D O Lowe
    University Department of Medicine, University of Glasgow, Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, U K
    Clin Sci (Lond) 110:327-8. 2006
    ....
  24. ncbi request reprint Fibrinogen measurement to assess the risk of arterial thrombosis in individual patients: not yet
    G D O Lowe
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    J Thromb Haemost 3:635-7. 2005
  25. ncbi request reprint C-reactive protein, fibrin D-dimer, and incident ischemic heart disease in the Speedwell study: are inflammation and fibrin turnover linked in pathogenesis?
    G D Lowe
    University Department of Medicine, Royal Infirmary, Glasgow
    Arterioscler Thromb Vasc Biol 21:603-10. 2001
    ..Further larger studies are required to test this hypothesis...
  26. ncbi request reprint Different effects of oral and transdermal hormone replacement therapies on factor IX, APC resistance, t-PA, PAI and C-reactive protein--a cross-sectional population survey
    G D Lowe
    University Department of Medicine, Glasgow Royal Infirmary, UK
    Thromb Haemost 86:550-6. 2001
    ....
  27. pmc Impact of angiotensin converting enzyme inhibition on post-coronary artery bypass interleukin 6 release
    D J Brull
    UCL Centre for Cardiovascular Genetics, Rayne Institute, London, UK Department of Medicine, Glasgow Royal Infirmary, Glasgow, UK
    Heart 87:252-5. 2002
    ..Angiotensin 1 converting enzyme (ACE) inhibitors reduce morbidity and mortality after coronary artery bypass graft surgery (CABG). This benefit may result from an anti-inflammatory action...
  28. ncbi request reprint The effects of transdermal estradiol in combination with oral norethisterone on lipoproteins, coagulation, and endothelial markers in postmenopausal women with type 2 diabetes: a randomized, placebo-controlled study
    M Perera
    Diabetes Center, West Glasgow Hospitals National Health Service Trust, University of Glasgow, Scotland
    J Clin Endocrinol Metab 86:1140-3. 2001
    ..In addition, a reduction in von Willebrand factor antigen is consistent with an improvement in endothelial function. We suggest that the regimen used in this study may have the potential to reduce CHD risk in women with type 2 diabetes...
  29. doi request reprint Sex differences in the relationship between inflammatory and hemostatic biomarkers and metabolic syndrome: British 1958 Birth Cohort
    A R Rudnicka
    Division of Population Health Sciences and Education, St George s, University of London, Cranmer Terrace, London Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    J Thromb Haemost 9:2337-44. 2011
    ..However, their associations with metabolic syndrome and its components in large populations of men and women have not been well defined...
  30. ncbi request reprint Haemostasis in ischaemic stroke and vascular dementia
    D J Stott
    Academic Section of Geriatric Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK
    Blood Coagul Fibrinolysis 12:651-7. 2001
    ..Acute ischaemic stroke is associated with transient changes in haemostatic factors; however, most abnormalities persist into the convalescent phase, and are also demonstrable in subjects with vascular dementia...
  31. ncbi request reprint Fibrinogen, factor VII and PAI-1 genotypes and the risk of coronary and peripheral atherosclerosis: Edinburgh Artery Study
    A J Lee
    Institute of Medical Genetics, Yorkhill Hospitals Campus, Glasgow, UK
    Thromb Haemost 81:553-60. 1999
    ..05). These data provide evidence that a polymorphism of the P fibrinogen gene is associated with an increased risk of peripheral atherosclerosis...
  32. ncbi request reprint The incidence and mechanism of hypotension following thrombolytic therapy for acute myocardial infarction with streptokinase-containing agents--lack of relationship to pretreatment streptokinase resistance
    J D Gemmill
    Department of Medicine and Therapeutics, University of Glasgow, Western Infirmary Stobhill General Hospital, U K
    Eur Heart J 14:819-25. 1993
    ..The mechanism of hypotension remains unclear, but is not related to prior exposure to streptococcal antigen...
  33. ncbi request reprint The role of myocardial perfusion scanning, heart rate variability and D-dimers in predicting the risk of perioperative cardiac complications after peripheral vascular surgery
    N Mamode
    Department of Vascular Surgery, Medical Cardiology and Medicine, Glasgow, UK
    Eur J Vasc Endovasc Surg 22:499-508. 2001
    ..CONCLUSIONS: Preliminary screening using clinical data has limited value in risk assessment prior to vascular surgery but preoperative heart rate variability, D-dimers and thallium scanning provide modest incremental predictive value...
  34. ncbi request reprint Interleukin-6 gene -174g>c and -572g>c promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery
    D J Brull
    Division of Cardiovascular Genetics, Department of Medicine, Royal Free and University College London Medical School, London, UK
    Arterioscler Thromb Vasc Biol 21:1458-63. 2001
    ....
  35. ncbi request reprint Factor IX and thrombosis
    G D Lowe
    University Department of Medicine, Royal Infirmary, Glasgow, UK
    Br J Haematol 115:507-13. 2001
  36. doi request reprint Fetal corticotrophin-releasing hormone mRNA, but not phosphatidylserine-exposing microparticles, in maternal plasma are associated with factor VII activity in pre-eclampsia
    D J Freeman
    Reproductive and Maternal Medicine, Division of Developmental Medicine, University of Glasgow, Royal Infirmary, Glasgow, UK
    J Thromb Haemost 6:421-7. 2008
    ..Pre-eclampsia is associated with increased placental debris circulating in maternal plasma...
  37. ncbi request reprint Lipoprotein-associated phospholipase A2 as an independent predictor of coronary heart disease. West of Scotland Coronary Prevention Study Group
    C J Packard
    Department of Pathological Biochemistry, Glasgow Royal Infirmary, Scotland
    N Engl J Med 343:1148-55. 2000
    ....
  38. ncbi request reprint Effects of tumor necrosis factor blockade on cardiovascular risk factors in psoriatic arthritis: a double-blind, placebo-controlled study
    Naveed Sattar
    University of Glasgow, Glasgow, UK
    Arthritis Rheum 56:831-9. 2007
    ....
  39. ncbi request reprint Effects of venesection on leg blood flow in claudicants with high-normal haematocrit
    A R Turner
    Department of Vascular Surgery, Royal Infirmary, Glasgow
    Scott Med J 33:298-9. 1988
    ..No increase in claudication time would therefore be expected, and none was observed in the present study...
  40. ncbi request reprint Acute renal failure complicating high-dose intravenous immunoglobulin therapy for acquired haemophilia
    M D McColl
    Haemophilia Centre, Royal Infirmary, Glasgow, UK
    Haemophilia 5:124-6. 1999
    ..All patients receiving such treatment should have renal function carefully monitored both during and after the infusion...
  41. ncbi request reprint Combined prednisolone and intravenous immunoglobulin treatment for acquired factor VIII inhibitors: a 2-year review
    A C Dykes
    Haemophilia Centre, Glasgow Royal Infirmary, Glasgow, UK
    Haemophilia 7:160-3. 2001
    ..Therapy was well tolerated and responses have been maintained off treatment for 2-8 months. This is a safe, well-tolerated rapidly acting regimen with good response rates...
  42. doi request reprint Associations of plasma pro-inflammatory cytokines, fibrinogen, viscosity and C-reactive protein with cardiovascular risk factors and social deprivation: the fourth Glasgow MONICA study
    Paul Welsh
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    Br J Haematol 141:852-61. 2008
    ....
  43. ncbi request reprint Detection of mutations in ectopic factor VIII transcripts from nine haemophilia A patients and the correlation with phenotype
    S I Bidichandani
    Duncan Guthrie Institute of Medical Genetics, University of Glasgow, Yorkhill, UK
    Hum Genet 95:531-8. 1995
    ..Analysis of the sequences in the immediate vicinity of the mutations has revealed sequence features that may have had a possible role in mutagenesis...
  44. ncbi request reprint Benefits of salmon eating on traditional and novel vascular risk factors in young, non-obese healthy subjects
    Jose J Lara
    Department of Human Nutrition, Division of Developmental Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow G31 2ER, Scotland, UK
    Atherosclerosis 193:213-21. 2007
    ..The present clinical study tested the hypothesis that oil-rich fish consumption improves CHD risk factors...
  45. doi request reprint Associations of circulating TNFalpha and IL-18 with myocardial infarction and cardiovascular risk markers: the Glasgow Myocardial Infarction Study
    Paul Welsh
    Division of Cardiovascular and Medical Sciences, University of Glasgow, UK
    Cytokine 47:143-7. 2009
    ..There are a lack of data on the associations of circulating levels of TNFalpha and IL-18 with myocardial infarction (MI), and on the extent of confounding by classical and inflammatory risk markers...
  46. ncbi request reprint Our inability to predict thromboembolic events after prosthetic valve surgery
    Malcolm B Will
    Department of Cardiac Surgery, University of Glasgow, Glasgow, UK
    J Heart Valve Dis 15:570-80; discussion 580. 2006
    ....
  47. ncbi request reprint Plasma leptin: associations with metabolic, inflammatory and haemostatic risk factors for cardiovascular disease
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Atherosclerosis 191:418-26. 2007
    ..We have examined the relationship between leptin and vascular risk factors including insulin resistance, metabolic, inflammatory and haemostatic risk factors...
  48. ncbi request reprint Can haematological tests predict cardiovascular risk? The 2005 Kettle Lecture
    Gordon D O Lowe
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    Br J Haematol 133:232-50. 2006
    ..In conclusion, haematological tests have very limited roles in the prediction of cardiovascular risk, and should only be used according to evidence-based guidelines. The need for management studies is highlighted...
  49. ncbi request reprint The association between homocysteine and myocardial infarction is independent of age, sex, blood pressure, cholesterol, smoking and markers of inflammation: the Glasgow Myocardial Infarction Study
    Mark Woodward
    The George Institute, Royal Prince Alfred Hospital, Sydney, Australia, and Department of Clinical Biochemistry, Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    Blood Coagul Fibrinolysis 17:1-5. 2006
    ..01-1.24) after the full adjustment. CONCLUSION: This study suggests that homocysteine has an effect on cardiovascular risk over and above that of inflammatory markers and the major cardiovascular risk factors...
  50. ncbi request reprint D-dimer predicts early clinical progression in ischemic stroke: confirmation using routine clinical assays
    Mark Barber
    University Section of Clinical Gerontology and Vascular Medicine, Royal Infirmary, Glasgow, UK
    Stroke 37:1113-5. 2006
    ..We wished to confirm these findings using commercially available assays and to provide data to allow the design of intervention studies...
  51. ncbi request reprint Associations of vitamin C status, fruit and vegetable intakes, and markers of inflammation and hemostasis
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, United Kingdom
    Am J Clin Nutr 83:567-74; quiz 726-7. 2006
    ..It has been suggested that a high dietary intake and high circulating concentrations of vitamin C may protect against ischemic heart disease...
  52. ncbi request reprint Reduced lung function in patients with abdominal aortic aneurysm is associated with activation of inflammation and hemostasis, not smoking or cardiovascular disease
    F Gerald R Fowkes
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, University of Edinburgh, Edinburgh, United Kingdom
    J Vasc Surg 43:474-80. 2006
    ..The aim of this study was to determine if these factors accounted for the link between aneurysms and pulmonary disease...
  53. ncbi request reprint Seven haemostatic gene polymorphisms in coronary disease: meta-analysis of 66,155 cases and 91,307 controls
    Zheng Ye
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Site, Wort s Causeway, Cambridge CB1 8RN, UK
    Lancet 367:651-8. 2006
    ..We did meta-analyses on seven such haemostatic genetic variants for which the available evidence on each comprises at least 5000 coronary disease cases and at least 5000 controls...
  54. ncbi request reprint C-reactive protein and cardiovascular disease: weighing the evidence
    Gordon D O Lowe
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, University College London, Rowland Hill Street, London NW3 2PF, United Kingdom
    Curr Atheroscler Rep 8:421-8. 2006
    ..Future clinical trials of specific CRP inhibitors now in development could directly test the contribution of CRP to pathogenesis of cardiovascular disease...
  55. doi request reprint Associations of proinflammatory cytokines with the risk of recurrent stroke
    Paul Welsh
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, UK
    Stroke 39:2226-30. 2008
    ..We studied the association of interleukin (IL)-6, IL-18, and tumor necrosis factor-alpha (TNF-alpha) with recurrent stroke in a nested case-control study derived from the Perindopril Protection Against Recurrent Stroke Study (PROGRESS)...
  56. ncbi request reprint Relative value of inflammatory, hemostatic, and rheological factors for incident myocardial infarction and stroke: the Edinburgh Artery Study
    Ioanna Tzoulaki
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
    Circulation 115:2119-27. 2007
    ....
  57. ncbi request reprint Cognitive decline and markers of inflammation and hemostasis: the Edinburgh Artery Study
    Snorri B Rafnsson
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, Medical School, University of Edinburgh, Edinburgh, UK
    J Am Geriatr Soc 55:700-7. 2007
    ..To determine whether circulating markers of activated inflammation and hemostasis are associated with cognitive decline in older people...
  58. ncbi request reprint Adipokines and risk of type 2 diabetes in older men
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Diabetes Care 30:1200-5. 2007
    ..The aim was to assess the relationship between adipokines, including interleukin (IL)-6, leptin, and adiponectin, with development of type 2 diabetes and assess the role of obesity and insulin resistance in these relationships...
  59. ncbi request reprint Is venous thrombosis a risk factor for arterial thrombosis?
    Gordon D O Lowe
    University of Glasgow, Royal Infirmary, Glasgow G31 2ER, UK
    Lancet 370:1742-4. 2007
  60. doi request reprint Tissue plasminogen activator, von Willebrand factor, and risk of type 2 diabetes in older men
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill St, London NW3 2PF, UK
    Diabetes Care 31:995-1000. 2008
    ....
  61. doi request reprint Common risk factors for both arterial and venous thrombosis
    Gordon D O Lowe
    Division of Cardiovascular and Medical Sciences, University of Glasgow, and Haemophilia and Thrombosis Centre, Royal Infirmary, Glasgow, UK
    Br J Haematol 140:488-95. 2008
    ..Appropriate lifestyle advice and medication (including aspirin) should then be considered...
  62. ncbi request reprint Diurnal, seasonal, and blood-processing patterns in levels of circulating fibrinogen, fibrin D-dimer, C-reactive protein, tissue plasminogen activator, and von Willebrand factor in a 45-year-old population
    Alicja R Rudnicka
    Division of Community Health Sciences, St George s, University of London Cranmer Terrace, London, SW17 0RE, United Kingdom
    Circulation 115:996-1003. 2007
    ....
  63. ncbi request reprint Inflammatory, haemostatic, and rheological markers for incident peripheral arterial disease: Edinburgh Artery Study
    Ioanna Tzoulaki
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
    Eur Heart J 28:354-62. 2007
    ..However, their role in peripheral arterial disease (PAD) is not well established and some of them, including the pro-inflammatory cytokine interleukin-6 (IL-6), have not been examined before in prospective epidemiological studies...
  64. ncbi request reprint Association between plasma IL-6, the IL6 -174G>C gene variant and the metabolic syndrome in type 2 diabetes mellitus
    Jeffrey W Stephens
    Diabetes Research Group, The Medical School, Swansea University, Swansea SA2 8PP, UK
    Mol Genet Metab 90:422-8. 2007
    ..Further prospective work is required to explore the effect of this gene variant in relation to obesity, the metabolic syndrome and 'prediabetes'...
  65. ncbi request reprint Relationships of inflammatory and haemostatic markers with social class: results from a population-based study of older men
    Sheena Ramsay
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Atherosclerosis 197:654-61. 2008
    ..The effect of socio-economic gradient on the factor VIII-vWF complex, APC resistance, plasma viscosity and platelet count merits further study...
  66. pmc The association between elevated levels of inflammation biomarkers and coronary artery disease and death
    Gordon D O Lowe
    University of Glasgow, Division of Cardiovascular and Medical Sciences, Glasgow Royal Infirmary, Glasgow, Scotland
    CMAJ 174:479-80. 2006
  67. ncbi request reprint Hemostatic factors, inflammatory markers, and progressive peripheral atherosclerosis: the Edinburgh Artery Study
    Ioanna Tzoulaki
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, School of Medicine and Veterinary Medicine, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    Am J Epidemiol 163:334-41. 2006
    ..Since D-dimer and fibrinogen are acute phase reactants, these data support the hypothesis that inflammation is more related to atherosclerosis than is hypercoagulation...
  68. ncbi request reprint Extent of regression dilution for established and novel coronary risk factors: results from the British Regional Heart Study
    Jonathan R Emberson
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, NW3 2PF, UK
    Eur J Cardiovasc Prev Rehabil 11:125-34. 2004
    ..We examine the extent of this bias for established and novel risk factors for coronary heart disease (CHD) and consider the consequences for CHD prevention...
  69. ncbi request reprint Hemostatic function and progressing ischemic stroke: D-dimer predicts early clinical progression
    Mark Barber
    University Section of Clinical Gerontology and Vascular Medicine, Royal Infirmary, Glasgow, UK
    Stroke 35:1421-5. 2004
    ..We hypothesized that activation of the coagulation system is an important contributor in some cases of deterioration. We aimed to characterize alterations in circulating hemostatic markers in patients with progressing stroke...
  70. ncbi request reprint C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease
    John Danesh
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
    N Engl J Med 350:1387-97. 2004
    ..We report data from a large study of C-reactive protein and other circulating inflammatory markers, as well as updated meta-analyses, to evaluate their relevance to the prediction of coronary heart disease...
  71. ncbi request reprint Relationship of the platelet glycoprotein PlA and fibrinogen T/G+1689 polymorphisms with peripheral arterial disease and ischaemic heart disease
    Felicity B Smith
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Department of Community Health Sciences, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Thromb Res 112:209-16. 2003
    ..This study determined the risk of peripheral arterial disease and ischaemic heart disease associated with polymorphisms of fibrinogen T/G(+1689) and platelet glycoprotein Pl(A) genes and the effects of cigarette smoking and fibrinogen...
  72. ncbi request reprint Endothelial dysfunction and inflammation in asymptomatic proteinuria
    Karen E Paisley
    Institute of Biomedical and Clinical Science, Peninsula Medical School, and Renal Unit, Royal Devon and Exeter Hospital, Exeter, United Kingdom
    Kidney Int 63:624-33. 2003
    ..Vascular risk and chronic inflammation are associated. This study investigates whether the increased vascular permeability in proteinuria reflects systemic endothelial dysfunction and chronic inflammation...
  73. ncbi request reprint Interleukin-6 -174G>C polymorphism and risk of coronary heart disease in West of Scotland coronary prevention study (WOSCOPS)
    Federica Basso
    Centre for Cardiovascular Genetics, BHF Laboratories, Royal Free and University College London Medical School, London, UK
    Arterioscler Thromb Vasc Biol 22:599-604. 2002
    ..These results demonstrate the importance of the inflammatory system in determining the risk of CHD and support the nonlipid effect of statins on risk...
  74. ncbi request reprint C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study
    Dilys J Freeman
    Department of Obstetrics and Gynaecology, University of Glasgow, Glasgow, UK
    Diabetes 51:1596-600. 2002
    ..They also add to the notion that low-grade inflammation is important in the pathogenesis of type 2 diabetes...
  75. ncbi request reprint Association of the factor XII 46C>T polymorphism with risk of coronary heart disease (CHD) in the WOSCOPS study
    Francesco Zito
    Centre for Cardiovascular Genetics, Royal Free and University College London Medical School, London WC1E 6JJ, UK
    Atherosclerosis 165:153-8. 2002
    ..To evaluate the contribution of the 46C>T polymorphism of the Factor XII (FXII) gene to risk for coronary heart disease (CHD) in the West of Scotland Coronary Prevention Study (WOSCOPS) of men with high cholesterol...
  76. ncbi request reprint Influence of socioeconomic status and job control on plasma fibrinogen responses to acute mental stress
    Andrew Steptoe
    Department of Epidemiology and Public Health, University College London, United Kingdom
    Psychosom Med 65:137-44. 2003
    ..This study assessed the influence of socioeconomic status, job control, and social isolation on fibrinogen responses to acute stress...
  77. ncbi request reprint Does sticky blood predict a sticky end? Associations of blood viscosity, haematocrit and fibrinogen with mortality in the West of Scotland
    Mark Woodward
    Institute for International Health, University of Sydney, Australia
    Br J Haematol 122:645-50. 2003
    ..However, the significance of this association, and the extent to which viscosity is associated with mortality, remain to be established in larger studies and meta-analyses...
  78. ncbi request reprint C-reactive protein: associations with haematological variables, cardiovascular risk factors and prevalent cardiovascular disease
    Mark Woodward
    Institute for International Health, University of Sydney, Australia
    Br J Haematol 122:135-41. 2003
    ....
  79. ncbi request reprint Resonance-thrombography indices of the haemostatic process in relation to risk of incident coronary heart disease: 9 years follow-up in the Caerphilly Prospective Heart Disease Study
    Shicheng Yu
    Department of Epidemiology and Public Health, Queen s University Belfast, Belfast, UK
    Br J Haematol 126:385-91. 2004
    ..Additional adjustment for fibrinogen, viscosity, white cell count and fibrin d-dimer either reduced these associations to non-significance (AF) or to borderline significance (r)...
  80. ncbi request reprint Virchow's triad revisited: abnormal flow
    Gordon D O Lowe
    Professor of Vascular Medicine, University Department of Medicine Royal Infirmary, Glasgow, UK
    Pathophysiol Haemost Thromb 33:455-7. 2003
    ..There is increasing evidence that regular exercise and avoidance of immobility reduces the risk of both arterial and venous thrombosis and also has systemic antithrombotic and anti-inflammatory effects. So: "Go with the flow!"..
  81. ncbi request reprint Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease
    David J Stott
    Division of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom
    Am J Clin Nutr 82:1320-6. 2005
    ..Homocysteine is an independent risk factor for vascular disease and is associated with dementia in older people. Potential mechanisms include altered endothelial and hemostatic function...
  82. ncbi request reprint The need for risk factor assessment in atherothrombotic vascular disease
    Gordon D O Lowe
    Department of Medicine, Royal Infirmary, Glasgow, Scotland
    Semin Vasc Med 2:231-2. 2002
    ..g., blood pressure, serum cholesterol). Emerging potential risk factors include markers of infection, inflammation, and thrombosis; their possible roles in causation and in risk prediction require much further study...
  83. ncbi request reprint Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis
    John Danesh
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, England
    JAMA 294:1799-809. 2005
    ..Plasma fibrinogen levels may be associated with the risk of coronary heart disease (CHD) and stroke...
  84. ncbi request reprint Associations of inflammatory and hemostatic variables with the risk of recurrent stroke
    Mark Woodward
    George Institute for International Health, University of Sydney, Australia
    Stroke 36:2143-7. 2005
    ..Little has been published on the associations of these variables with recurrent stroke. We studied such associations in a nested case-control study derived from the Perindopril Protection Against Recurrent Stroke Study (PROGRESS)...
  85. ncbi request reprint Oral contraceptives, hormone replacement therapy, thrombophilias and risk of venous thromboembolism: a systematic review. The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) Study
    Olivia Wu
    Department of Obstetrics and Gynaecology, University of Glasgow, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, UK
    Thromb Haemost 94:17-25. 2005
    ..However, further studies are required to establish with greater confidence the associations of these, and other, thrombophilias with venous thromboembolism among hormone users...
  86. ncbi request reprint C-reactive protein, interleukin-6, and soluble adhesion molecules as predictors of progressive peripheral atherosclerosis in the general population: Edinburgh Artery Study
    Ioanna Tzoulaki
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, University of Edinburgh, Edinburgh, EH8 9AG, Scotland
    Circulation 112:976-83. 2005
    ..We therefore studied inflammatory markers as predictors of peripheral atherosclerotic progression, measured by the ankle-brachial index (ABI) at 3 consecutive time points over 12 years...
  87. ncbi request reprint The metabolic syndrome and insulin resistance: relationship to haemostatic and inflammatory markers in older non-diabetic men
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    Atherosclerosis 181:101-8. 2005
    ..We have examined the cross-sectional relationship between insulin resistance, the metabolic syndrome and haemostatic and inflammatory markers...
  88. ncbi request reprint Associations of fibrinogen and C-reactive protein with prevalent and incident coronary heart disease are attenuated by adjustment for confounding factors. British Women's Heart and Health Study
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, UK
    Thromb Haemost 93:955-63. 2005
    ..We conclude that fibrinogen and CRP predict CHD but may not be causally related to it...
  89. ncbi request reprint Associations between cigarette smoking, pipe/cigar smoking, and smoking cessation, and haemostatic and inflammatory markers for cardiovascular disease
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill St, London NW3 2PF, UK
    Eur Heart J 26:1765-73. 2005
    ..To examine the associations between cigarette smoking, pipe/cigar smoking, and years since quitting smoking, and inflammatory and haemostatic markers...
  90. ncbi request reprint Cardiovascular risk parameters in men with ankylosing spondylitis in comparison with non-inflammatory control subjects: relevance of systemic inflammation
    Hiren Divecha
    Centre for Rheumatic Diseases, Glasgow Royal Infirmary, Scotland, UK
    Clin Sci (Lond) 109:171-6. 2005
    ..In conclusion, men with AS have perturbances in several CHD risk factors, which appear to be driven principally by systemic inflammatory mediators. Inflammation-driven atherogenesis potentially contributes to the excess CHD risk in AS...
  91. ncbi request reprint Association of C-reactive protein with blood pressure and hypertension: life course confounding and mendelian randomization tests of causality
    George Davey Smith
    Department of Social Medicine, University of Bristol, Bristol, UK
    Arterioscler Thromb Vasc Biol 25:1051-6. 2005
    ..C-reactive protein (CRP) has repeatedly been associated with blood pressure and prevalent and incident hypertension, but whether a causal link exists is uncertain...
  92. ncbi request reprint On the route to combined evidence from OC and HRT/ERT
    Sven O Skouby
    Department of Obstetrics and Gynecology, Frederiksberg Hospital, University of Copenhagen, DK 2000 Copenhagen F, Denmark
    Eur J Contracept Reprod Health Care 7:185-98. 2002