L B Lovat
Affiliation: University College London
- Elastic scattering spectroscopy accurately detects high grade dysplasia and cancer in Barrett's oesophagusL B Lovat
National Medical Laser Centre, Department of Surgery, Royal Free and University College Medical School, University College London, UK
Gut 55:1078-83. 2006..The aim of this study was to assess the potential for elastic scattering to detect high grade dysplasia or cancer within Barrett's oesophagus...
- Elastic scattering spectroscopy for detection of dysplasia in Barrett's esophagusLaurence Lovat
National Medical Laser Centre, Institute of Surgical Studies, Royal Free and University College Medical School, 67 73 Riding House Street, London W1W 7EJ, UK
Gastrointest Endosc Clin N Am 14:507-17, ix. 2004..Even as a point measurement technique or optical biopsy, the technique may become an invaluable tool to endoscopists. This article focuses on elastic scattering spectroscopy (also known as diffuse reflectance spectroscopy)...
- Radiofrequency ablation is effective for the treatment of high-grade dysplasia in Barrett's esophagus after failed photodynamic therapyJ M Dunn
National Medical Laser Centre, Department of Surgery, University College London, London, UK
Endoscopy 43:627-30. 2011..The rate of strictures was 7 % (1/14) and there was a low rate of buried glands (0.5 % follow-up biopsies). These data suggest RFA is both safe and effective for eradication of high-grade dysplasia in patients in whom PDT has failed...
- A randomised controlled trial of ALA vs. Photofrin photodynamic therapy for high-grade dysplasia arising in Barrett's oesophagusJ M Dunn
National Medical Laser Centre, Division of Surgery and Interventional Science, University College London, 67 73 Riding House Street, London, W1W 7EJ, UK
Lasers Med Sci 28:707-15. 2013..In patients with BE length ≤ 6 cm, preliminary results show ALA-PDT is associated with significantly higher CR-HGD. In longer segments of BE, neither PDT drug is sufficiently efficacious to warrant routine use...
- Image cytometry accurately detects DNA ploidy abnormalities and predicts late relapse to high-grade dysplasia and adenocarcinoma in Barrett's oesophagus following photodynamic therapyJ M Dunn
Department of Surgery, National Medical Laser Centre, University College London, 67 73 Riding House Street, London W1W 7EJ, UK
Br J Cancer 102:1608-17. 2010..Our aim was to determine the accuracy of ICDA vs FC, and evaluate DNA ploidy as a prognostic biomarker after histologically successful treatment with photodynamic therapy (PDT)...
- Comparison of nuclear texture analysis and image cytometric DNA analysis for the assessment of dysplasia in Barrett's oesophagusJ M Dunn
Department of Surgery, National Medical Laser Centre, University College London, London, UK
Br J Cancer 105:1218-23. 2011..We aimed to evaluate NT as a marker of dysplasia in BO and compare with image cytometric DNA analysis (ICM)...
- Nd:YAG laser induces long-term remission in transfusion-dependent patients with watermelon stomachN G Mathou
National Medical Laser Centre, Department of Surgery, Royal Free and University College Medical School, UCL, 67 73 Riding House Street, W1W 7EJ, London, UK
Lasers Med Sci 18:213-8. 2004..Oestrogens were not used in these patients. Our experience shows that long-term remission from blood transfusion is seen in most patients treated with Nd:YAG laser. If bleeding recurs, further laser treatment is usually successful...
- Photodynamic therapy for cancer of the pancreasS G Bown
National Medical Laser Centre, Department of Surgery, Royal Free and University College Medical School, London, UK
Gut 50:549-57. 2002..Photodynamic therapy produces local necrosis of tissue with light after prior administration of a photosensitising agent, and in experimental studies can be tolerated by the pancreas and surrounding normal tissue...
- The biology of photodynamic therapy in the gastrointestinal tractS G Bown
Department of Surgery, National Medical Laser Centre, Royal Free and University College Medical School, University College, London, England
Gastrointest Endosc Clin N Am 10:533-50. 2000..Animal studies show that the pancreas and surrounding tissues can tolerate photodynamic therapy, justifying pilot clinical trials on percutaneous, interstitial photodynamic therapy for localized, inoperable pancreatic cancers...
- Laser augmented by brachytherapy versus laser alone in the palliation of adenocarcinoma of the oesophagus and cardia: a randomised studyG M Spencer
National Medical Laser Centre, Institute of Surgical Studies, Royal Free and University College Medical School, London, UK
Gut 50:224-7. 2002..Many patients with advanced malignant dysphagia are not suitable for definitive treatment. The best option for palliation of dysphagia varies between patients. This paper looks at a simple technique for enhancing laser recanalisation...
- Cell cycle phase abnormalities do not account for disordered proliferation in Barrett's carcinogenesisPierre Lao-Sirieix
MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, UK
Neoplasia 6:751-60. 2004..Hence, the increased proliferation seen in Barrett's carcinogenesis is due to abnormal cell cycle entry or exit, rather than a primary abnormality within the cell cycle...
- Cyclin A immunocytology as a risk stratification tool for Barrett's esophagus surveillancePierre Lao-Sirieix
Medical Research Council Cancer Cell Unit, Medical Research Council Hutchison Research Centre, Hills Road, Cambridge, UK
Clin Cancer Res 13:659-65. 2007..We hypothesized that cyclin A, which detects a proportion of proliferating cells, would be more specific. Because cytologic sampling has clinical advantages, we also evaluated the efficacy of cyclin A in endoscopic brushing samples...
- Photodynamic therapy using 5-aminolaevulinic acid for the treatment of dysplasia in Barrett's oesophagusJason Dunn
University College London Hospitals NHS Foundation Trust, National Medical Laser Centre, 67 73 Riding House Street, London W1P 7NN, UK
Expert Opin Pharmacother 9:851-8. 2008..It is used topically to treat benign and malignant skin disorders by a process called photodynamic therapy (PDT). Recently, data are emerging on its systemic use in the treatment of dysplasia in Barrett's oesophagus...