L B Lovat

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Elastic scattering spectroscopy accurately detects high grade dysplasia and cancer in Barrett's oesophagus
    L B Lovat
    National Medical Laser Centre, Department of Surgery, Royal Free and University College Medical School, University College London, UK
    Gut 55:1078-83. 2006
  2. ncbi request reprint Elastic scattering spectroscopy for detection of dysplasia in Barrett's esophagus
    Laurence Lovat
    National Medical Laser Centre, Institute of Surgical Studies, Royal Free and University College Medical School, 67 73 Riding House Street, London W1W 7EJ, UK
    Gastrointest Endosc Clin N Am 14:507-17, ix. 2004
  3. doi request reprint Radiofrequency ablation is effective for the treatment of high-grade dysplasia in Barrett's esophagus after failed photodynamic therapy
    J M Dunn
    National Medical Laser Centre, Department of Surgery, University College London, London, UK
    Endoscopy 43:627-30. 2011
  4. doi request reprint A randomised controlled trial of ALA vs. Photofrin photodynamic therapy for high-grade dysplasia arising in Barrett's oesophagus
    J M Dunn
    National Medical Laser Centre, Division of Surgery and Interventional Science, University College London, 67 73 Riding House Street, London, W1W 7EJ, UK
    Lasers Med Sci 28:707-15. 2013
  5. pmc Image cytometry accurately detects DNA ploidy abnormalities and predicts late relapse to high-grade dysplasia and adenocarcinoma in Barrett's oesophagus following photodynamic therapy
    J M Dunn
    Department of Surgery, National Medical Laser Centre, University College London, 67 73 Riding House Street, London W1W 7EJ, UK
    Br J Cancer 102:1608-17. 2010
  6. pmc Comparison of nuclear texture analysis and image cytometric DNA analysis for the assessment of dysplasia in Barrett's oesophagus
    J M Dunn
    Department of Surgery, National Medical Laser Centre, University College London, London, UK
    Br J Cancer 105:1218-23. 2011
  7. ncbi request reprint Nd:YAG laser induces long-term remission in transfusion-dependent patients with watermelon stomach
    N G Mathou
    National Medical Laser Centre, Department of Surgery, Royal Free and University College Medical School, UCL, 67 73 Riding House Street, W1W 7EJ, London, UK
    Lasers Med Sci 18:213-8. 2004
  8. pmc Photodynamic therapy for cancer of the pancreas
    S G Bown
    National Medical Laser Centre, Department of Surgery, Royal Free and University College Medical School, London, UK
    Gut 50:549-57. 2002
  9. ncbi request reprint The biology of photodynamic therapy in the gastrointestinal tract
    S G Bown
    Department of Surgery, National Medical Laser Centre, Royal Free and University College Medical School, University College, London, England
    Gastrointest Endosc Clin N Am 10:533-50. 2000
  10. pmc Laser augmented by brachytherapy versus laser alone in the palliation of adenocarcinoma of the oesophagus and cardia: a randomised study
    G M Spencer
    National Medical Laser Centre, Institute of Surgical Studies, Royal Free and University College Medical School, London, UK
    Gut 50:224-7. 2002

Collaborators

  • Rebecca Fitzgerald
  • S G Bown
  • M R Novelli
  • P Sasieni
  • W R Lees
  • J M Dunn
  • M R Banks
  • G D MacKenzie
  • S Thorpe
  • D Oukrif
  • Pierre Lao-Sirieix
  • M Rodriguez-Justo
  • A Winstanley
  • C A Mosse
  • Jason Dunn
  • N G Mathou
  • S M Thorpe
  • G M Spencer
  • S Green
  • R Haidry
  • T Hveem
  • M Pretorius
  • B Nielsen
  • H E Danielsen
  • F Albregtsen
  • P S Rabinovitch
  • Rebecca Brais
  • Nicholas Coleman
  • G M Blackman
  • J Solano
  • J S Tobias

Detail Information

Publications13

  1. pmc Elastic scattering spectroscopy accurately detects high grade dysplasia and cancer in Barrett's oesophagus
    L B Lovat
    National Medical Laser Centre, Department of Surgery, Royal Free and University College Medical School, University College London, UK
    Gut 55:1078-83. 2006
    ..The aim of this study was to assess the potential for elastic scattering to detect high grade dysplasia or cancer within Barrett's oesophagus...
  2. ncbi request reprint Elastic scattering spectroscopy for detection of dysplasia in Barrett's esophagus
    Laurence Lovat
    National Medical Laser Centre, Institute of Surgical Studies, Royal Free and University College Medical School, 67 73 Riding House Street, London W1W 7EJ, UK
    Gastrointest Endosc Clin N Am 14:507-17, ix. 2004
    ..Even as a point measurement technique or optical biopsy, the technique may become an invaluable tool to endoscopists. This article focuses on elastic scattering spectroscopy (also known as diffuse reflectance spectroscopy)...
  3. doi request reprint Radiofrequency ablation is effective for the treatment of high-grade dysplasia in Barrett's esophagus after failed photodynamic therapy
    J M Dunn
    National Medical Laser Centre, Department of Surgery, University College London, London, UK
    Endoscopy 43:627-30. 2011
    ..The rate of strictures was 7 % (1/14) and there was a low rate of buried glands (0.5 % follow-up biopsies). These data suggest RFA is both safe and effective for eradication of high-grade dysplasia in patients in whom PDT has failed...
  4. doi request reprint A randomised controlled trial of ALA vs. Photofrin photodynamic therapy for high-grade dysplasia arising in Barrett's oesophagus
    J M Dunn
    National Medical Laser Centre, Division of Surgery and Interventional Science, University College London, 67 73 Riding House Street, London, W1W 7EJ, UK
    Lasers Med Sci 28:707-15. 2013
    ..In patients with BE length ≤ 6 cm, preliminary results show ALA-PDT is associated with significantly higher CR-HGD. In longer segments of BE, neither PDT drug is sufficiently efficacious to warrant routine use...
  5. pmc Image cytometry accurately detects DNA ploidy abnormalities and predicts late relapse to high-grade dysplasia and adenocarcinoma in Barrett's oesophagus following photodynamic therapy
    J M Dunn
    Department of Surgery, National Medical Laser Centre, University College London, 67 73 Riding House Street, London W1W 7EJ, UK
    Br J Cancer 102:1608-17. 2010
    ..Our aim was to determine the accuracy of ICDA vs FC, and evaluate DNA ploidy as a prognostic biomarker after histologically successful treatment with photodynamic therapy (PDT)...
  6. pmc Comparison of nuclear texture analysis and image cytometric DNA analysis for the assessment of dysplasia in Barrett's oesophagus
    J M Dunn
    Department of Surgery, National Medical Laser Centre, University College London, London, UK
    Br J Cancer 105:1218-23. 2011
    ..We aimed to evaluate NT as a marker of dysplasia in BO and compare with image cytometric DNA analysis (ICM)...
  7. ncbi request reprint Nd:YAG laser induces long-term remission in transfusion-dependent patients with watermelon stomach
    N G Mathou
    National Medical Laser Centre, Department of Surgery, Royal Free and University College Medical School, UCL, 67 73 Riding House Street, W1W 7EJ, London, UK
    Lasers Med Sci 18:213-8. 2004
    ..Oestrogens were not used in these patients. Our experience shows that long-term remission from blood transfusion is seen in most patients treated with Nd:YAG laser. If bleeding recurs, further laser treatment is usually successful...
  8. pmc Photodynamic therapy for cancer of the pancreas
    S G Bown
    National Medical Laser Centre, Department of Surgery, Royal Free and University College Medical School, London, UK
    Gut 50:549-57. 2002
    ..Photodynamic therapy produces local necrosis of tissue with light after prior administration of a photosensitising agent, and in experimental studies can be tolerated by the pancreas and surrounding normal tissue...
  9. ncbi request reprint The biology of photodynamic therapy in the gastrointestinal tract
    S G Bown
    Department of Surgery, National Medical Laser Centre, Royal Free and University College Medical School, University College, London, England
    Gastrointest Endosc Clin N Am 10:533-50. 2000
    ..Animal studies show that the pancreas and surrounding tissues can tolerate photodynamic therapy, justifying pilot clinical trials on percutaneous, interstitial photodynamic therapy for localized, inoperable pancreatic cancers...
  10. pmc Laser augmented by brachytherapy versus laser alone in the palliation of adenocarcinoma of the oesophagus and cardia: a randomised study
    G M Spencer
    National Medical Laser Centre, Institute of Surgical Studies, Royal Free and University College Medical School, London, UK
    Gut 50:224-7. 2002
    ..Many patients with advanced malignant dysphagia are not suitable for definitive treatment. The best option for palliation of dysphagia varies between patients. This paper looks at a simple technique for enhancing laser recanalisation...
  11. pmc Cell cycle phase abnormalities do not account for disordered proliferation in Barrett's carcinogenesis
    Pierre Lao-Sirieix
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, UK
    Neoplasia 6:751-60. 2004
    ..Hence, the increased proliferation seen in Barrett's carcinogenesis is due to abnormal cell cycle entry or exit, rather than a primary abnormality within the cell cycle...
  12. ncbi request reprint Cyclin A immunocytology as a risk stratification tool for Barrett's esophagus surveillance
    Pierre Lao-Sirieix
    Medical Research Council Cancer Cell Unit, Medical Research Council Hutchison Research Centre, Hills Road, Cambridge, UK
    Clin Cancer Res 13:659-65. 2007
    ..We hypothesized that cyclin A, which detects a proportion of proliferating cells, would be more specific. Because cytologic sampling has clinical advantages, we also evaluated the efficacy of cyclin A in endoscopic brushing samples...
  13. doi request reprint Photodynamic therapy using 5-aminolaevulinic acid for the treatment of dysplasia in Barrett's oesophagus
    Jason Dunn
    University College London Hospitals NHS Foundation Trust, National Medical Laser Centre, 67 73 Riding House Street, London W1P 7NN, UK
    Expert Opin Pharmacother 9:851-8. 2008
    ..It is used topically to treat benign and malignant skin disorders by a process called photodynamic therapy (PDT). Recently, data are emerging on its systemic use in the treatment of dysplasia in Barrett's oesophagus...