Edward J Louis
Affiliation: University of Nottingham
- Isolation and analysis of the genetic diversity of repertoires of VSG expression site containing telomeres from Trypanosoma brucei gambiense, T. b. brucei and T. equiperdumRosanna Young
Peter Medawar Building for Pathogen Research, University of Oxford, South Parks Road, Oxford, OX1 3SY, UK
BMC Genomics 9:385. 2008..We have previously developed a method to selectively isolate sets of trypanosome BES containing telomeres using Transformation associated recombination (TAR) cloning in yeast...
- Saccharomyces cerevisiae: gene annotation and genome variability, state of the art through comparative genomicsEd Louis
Institute of Genetics, Queens Medical Centre, University of Nottingham, Nottingham, UK
Methods Mol Biol 759:31-40. 2011....
- Repressive and non-repressive chromatin at native telomeres in Saccharomyces cerevisiaeEsther R Loney
Institute of Genetics, University of Nottingham, Nottingham, UK
Epigenetics Chromatin 2:18. 2009..CONCLUSION: Our data identifies chromatin features that correlate with the silencing state and indicate that an array of phased nucleosomes is not sufficient for full repression...
- In Saccharomyces cerevisiae, yKu and subtelomeric core X sequences repress homologous recombination near telomeres as part of the same pathwayMarcus E Marvin
Institute of Genetics, University of Nottingham, Medical School, Queens Medical Centre, Nottingham, UK
Genetics 183:441-51, 1SI-12SI. 2009..Furthermore, core X bestowed this protection as part of the same pathway as yKu. Our findings implicate a role for both yKu and core X in stabilizing the genome against recombination events involving telomeric sequences...
- Segregating YKU80 and TLC1 alleles underlying natural variation in telomere properties in wild yeastGianni Liti
Institute of Genetics, Queen s Medical Centre, University of Nottingham, Nottingham, United Kingdom
PLoS Genet 5:e1000659. 2009..Furthermore, we propose that sequence divergence within the Ku heterodimer generates negative epistasis within one of the allelic combinations (American-YKU70 and European-YKU80) resulting in very short telomeres...
- Population genomics of domestic and wild yeastsGianni Liti
Institute of Genetics, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
Nature 458:337-41. 2009....
- Assessing the complex architecture of polygenic traits in diverged yeast populationsFrancisco A Cubillos
Centre for Genetics and Genomics, Queen s Medical Centre, University of Nottingham, Nottingham, UK
Mol Ecol 20:1401-13. 2011..This set of recombinant strains is a powerful tool for investigating the complex architecture of polygenic traits...
- Apparent ploidy effects on silencing are post-transcriptional at HML and telomeres in Saccharomyces cerevisiaeJenny M McLaughlan
Centre for Genetics and Genomics, Queen s Medical Centre, University of Nottingham, Nottingham, United Kingdom
PLoS ONE 7:e39044. 2012..The post-transcriptional effects seen in this study, illustrate the often ignored need to measure RNA levels when assaying transcriptional silencing in Saccharomyces cerevisiae...
- The association of yKu with subtelomeric core X sequences prevents recombination involving telomeric sequencesMarcus E Marvin
Institute of Genetics, University of Nottingham, Medical School, Queen s Medical Centre, Nottingham, UK
Genetics 183:453-67, 1SI-13SI. 2009..We believe our findings support our hypothesis that yKu and core X play a pivotal role in maintaining genome stability through nuclear architecture by mediating a defensive fold-back structure at yeast chromosome ends...
- High-resolution mapping of complex traits with a four-parent advanced intercross yeast populationFrancisco A Cubillos
Centre for Genetics and Genomics, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, United Kingdom
Genetics 195:1141-55. 2013..SGRP-4X is a deeply characterized resource that provides a framework for powerful and high-resolution genetic analysis of yeast phenotypes and serves as a test bed for testing avenues to attack human complex traits. ..
- Generation of a large set of genetically tractable haploid and diploid Saccharomyces strainsFrancisco A Cubillos
Queen s Medical Centre, Institute of Genetics, University of Nottingham, Nottingham, UK
FEMS Yeast Res 9:1217-25. 2009..Three versions of each strain (haploid Mat a and Mat alpha and diploid Mat a/alpha all as ura3::KanMX-Barcode) are available through the National Culture Yeast Collection...
- Sequence diversity, reproductive isolation and species concepts in SaccharomycesGianni Liti
Institute of Genetics, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, United Kingdom
Genetics 174:839-50. 2006..There is molecular evidence of recent introgression from S. cerevisiae into the European population of S. paradoxus, supporting the idea that in nature the boundary between these species is fuzzy...
- Yeast evolution and comparative genomicsGianni Liti
Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
Annu Rev Microbiol 59:135-53. 2005..Future work on population genomics and experimental evolution will keep yeast at the forefront of studies in genome evolution...