Andrew Lotery

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. pmc Genome-wide association study of primary open angle glaucoma risk and quantitative traits
    Jane Gibson
    Genetic Epidemiology and Genomic Informatics Group, Human Genetics, Faculty of Medicine, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, UK
    Mol Vis 18:1083-92. 2012
  2. doi request reprint Pharmacogenetic associations with vascular endothelial growth factor inhibition in participants with neovascular age-related macular degeneration in the IVAN Study
    Andrew J Lotery
    Clinical Neurosciences Research Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom Electronic address
    Ophthalmology 120:2637-43. 2013
  3. doi request reprint Common spectral domain OCT and electrophysiological findings in different pattern dystrophies
    Shabeeba Rashed Hannan
    Department of Ophthalmology, Southampton University Hospital, Southampton, UK
    Br J Ophthalmol 97:605-10. 2013
  4. ncbi request reprint Progress in defining the molecular biology of age related macular degeneration
    Andrew Lotery
    Clinical Neurosciences Division, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK
    Hum Genet 122:219-36. 2007
  5. pmc Burden of illness, visual impairment and health resource utilisation of patients with neovascular age-related macular degeneration: results from the UK cohort of a five-country cross-sectional study
    Andrew Lotery
    University of Southampton, Southampton Eye Unit, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Br J Ophthalmol 91:1303-7. 2007
  6. pmc Reduced secretion of fibulin 5 in age-related macular degeneration and cutis laxa
    Andrew J Lotery
    Human Genetics Division, University of Southampton, Southampton, Hampshire, United Kingdom
    Hum Mutat 27:568-74. 2006
  7. pmc Chlamydia infection status, genotype, and age-related macular degeneration
    Sam Khandhadia
    Division of Clinical Neurosciences, University of Southampton, Southampton General Hospital, Southampton, UK
    Mol Vis 18:29-37. 2012
  8. doi request reprint Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study
    Sarah Ennis
    Genetic Epidemiology and Bioinformatics Group, University of Southampton, Human Genetics Division MP 808, Southampton General Hospital, Southampton, UK
    Lancet 372:1828-34. 2008
  9. doi request reprint Determination of a gene and environment risk model for age-related macular degeneration
    Jane Gibson
    Genetic Epidemiology and Bioinformatics Group, University of Southampton, Human Genetics Division, Southampton General Hospital, Southampton, UK
    Br J Ophthalmol 94:1382-7. 2010
  10. pmc Fine-scale linkage disequilibrium mapping of age-related macular degeneration in the complement factor H gene region
    Sarah Ennis
    Genetic Epidemiology and Bioinformatics Group, Human Genetics Division MP 808, Southampton General Hospital, Southampton, UK
    Br J Ophthalmol 91:966-70. 2007

Collaborators

Detail Information

Publications30

  1. pmc Genome-wide association study of primary open angle glaucoma risk and quantitative traits
    Jane Gibson
    Genetic Epidemiology and Genomic Informatics Group, Human Genetics, Faculty of Medicine, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, UK
    Mol Vis 18:1083-92. 2012
    ..Few genes have been detected that influence POAG susceptibility and other genes are therefore likely to be involved. We analyzed carefully characterized POAG cases in a genome-wide association study (GWAS)...
  2. doi request reprint Pharmacogenetic associations with vascular endothelial growth factor inhibition in participants with neovascular age-related macular degeneration in the IVAN Study
    Andrew J Lotery
    Clinical Neurosciences Research Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom Electronic address
    Ophthalmology 120:2637-43. 2013
    ..The objectives were to replicate 3 reported pharmacogenetic associations of response in nAMD and to test for novel associations...
  3. doi request reprint Common spectral domain OCT and electrophysiological findings in different pattern dystrophies
    Shabeeba Rashed Hannan
    Department of Ophthalmology, Southampton University Hospital, Southampton, UK
    Br J Ophthalmol 97:605-10. 2013
    ..2) To correlate visual acuity (VA) with central macular thickness (CMT), the electrooculogram (EOG) and pattern electroretinogram (PERG)...
  4. ncbi request reprint Progress in defining the molecular biology of age related macular degeneration
    Andrew Lotery
    Clinical Neurosciences Division, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK
    Hum Genet 122:219-36. 2007
    ..This review will give an insight into these developments and will summarise our current knowledge of the molecular biology of AMD...
  5. pmc Burden of illness, visual impairment and health resource utilisation of patients with neovascular age-related macular degeneration: results from the UK cohort of a five-country cross-sectional study
    Andrew Lotery
    University of Southampton, Southampton Eye Unit, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Br J Ophthalmol 91:1303-7. 2007
    ..Quantitative data regarding the impact of neovascular age-related macular degeneration (NV-AMD) on individuals and society is a prerequisite for rational decision-making processes when evaluating alternative treatments for the disease...
  6. pmc Reduced secretion of fibulin 5 in age-related macular degeneration and cutis laxa
    Andrew J Lotery
    Human Genetics Division, University of Southampton, Southampton, Hampshire, United Kingdom
    Hum Mutat 27:568-74. 2006
    ..Such knowledge may ultimately lead to the development of novel therapies for this common disease...
  7. pmc Chlamydia infection status, genotype, and age-related macular degeneration
    Sam Khandhadia
    Division of Clinical Neurosciences, University of Southampton, Southampton General Hospital, Southampton, UK
    Mol Vis 18:29-37. 2012
    ....
  8. doi request reprint Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study
    Sarah Ennis
    Genetic Epidemiology and Bioinformatics Group, University of Southampton, Human Genetics Division MP 808, Southampton General Hospital, Southampton, UK
    Lancet 372:1828-34. 2008
    ..Variants in complement 3 (C3) and an HLA locus containing both factor B and C2 genes have also been implicated. We aimed to identify further genetic risk factors for this disease...
  9. doi request reprint Determination of a gene and environment risk model for age-related macular degeneration
    Jane Gibson
    Genetic Epidemiology and Bioinformatics Group, University of Southampton, Human Genetics Division, Southampton General Hospital, Southampton, UK
    Br J Ophthalmol 94:1382-7. 2010
    ..In the current study we interrogated the genomic region in linkage disequilibrium (LD) with the SERPING1 gene, and modelled the contribution to disease of known genetic and environmental AMD risk factors...
  10. pmc Fine-scale linkage disequilibrium mapping of age-related macular degeneration in the complement factor H gene region
    Sarah Ennis
    Genetic Epidemiology and Bioinformatics Group, Human Genetics Division MP 808, Southampton General Hospital, Southampton, UK
    Br J Ophthalmol 91:966-70. 2007
    ..To present results from a nested association study of the complement factor H (CFH) gene region using a novel methodology that uses a high-resolution genetic linkage disequilibrium map to estimate a point location for a causal mutation...
  11. ncbi request reprint The molecular genetics of congenital idiopathic nystagmus
    James Self
    University of Southampton, Southampton, UK
    Semin Ophthalmol 21:87-90. 2006
    ..If linkage experiments are used to find "nystagmus genes," their power will depend heavily on accurate phenotyping to avoid misdiagnosis due to masquerading conditions and phenotypic variations within pedigrees...
  12. doi request reprint Generation of light-sensitive photoreceptor phenotypes by genetic modification of human adult ocular stem cells with Crx
    Catherine Jomary
    Clinical Neurosciences Division, University of Southampton, South Laboratory and Pathology Block, Southampton General Hospital, Southampton, United Kingdom
    Invest Ophthalmol Vis Sci 51:1181-9. 2010
    ..This study compared the effect of the transcription factor Crx (cone, rod homeobox) on the differentiation of human adult corneal (hCSC) and retinal (hRSC) stem cells into functional photoreceptors...
  13. doi request reprint Oxidation and age-related macular degeneration: insights from molecular biology
    Sam Khandhadia
    Clinical Neurosciences Division, School of Medicine, University of Southampton, UK
    Expert Rev Mol Med 12:e34. 2010
    ..This article reviews the role of oxidative stress in AMD and the potential therapies that might have a role in preventing the blindness resulting from this disease...
  14. pmc Ranibizumab (Lucentis) versus bevacizumab (Avastin): modelling cost effectiveness
    James Raftery
    Wessex Institute for Health R and D, Medical School, University of Southampton, Southampton, UK
    Br J Ophthalmol 91:1244-6. 2007
    ..Continued unlicensed use of bevacizumab raises ethical, legal and policy questions. Public pressure may be the most potent weapon in persuading Genentech to license bevacizumab for AMD...
  15. ncbi request reprint Association of HLA class I and class II polymorphisms with age-related macular degeneration
    Srini V Goverdhan
    Human Genetics Division, University of Southampton, Duthie Building, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Invest Ophthalmol Vis Sci 46:1726-34. 2005
    ..To evaluate whether HLA genotypes are associated with age-related macular degeneration (AMD)...
  16. doi request reprint Characterisation of mouse limbal neurosphere cells: a potential cell source of functional neurons
    Xiaoli Chen
    Clinical and Experimental Sciences, Clinical Neurosciences Research Group, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
    Br J Ophthalmol 96:1431-7. 2012
    ..To characterise the origin, ultrastructure and functional properties of corneal limbal neurospheres (LNS)...
  17. ncbi request reprint A review of the molecular genetics of congenital Idiopathic Nystagmus (CIN)
    James Self
    Clinical Neurosciences Division, University of Southampton, Southampton, United Kingdom
    Ophthalmic Genet 28:187-91. 2007
    ....
  18. ncbi request reprint Allelic variation of the FRMD7 gene in congenital idiopathic nystagmus
    James E Self
    Clinical Neurosciences Division, University of Southampton, Southampton, England
    Arch Ophthalmol 125:1255-63. 2007
    ..To perform a genotype-phenotype correlation study in an X-linked congenital idiopathic nystagmus pedigree (pedigree 1) and to assess the allelic variance of the FRMD7 gene in congenital idiopathic nystagmus...
  19. doi request reprint Age-related macular degeneration is associated with the HLA-Cw*0701 Genotype and the natural killer cell receptor AA haplotype
    Srinivas V Goverdhan
    Division of Clinical Neurosciences, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    Invest Ophthalmol Vis Sci 49:5077-82. 2008
    ..To determine the association of human leukocyte antigen (HLA) C and its cognate killer cell immunoglobulin-like receptor (KIR) ligands with age-related macular degeneration (AMD)...
  20. doi request reprint The chemistry of retinal transplantation: the influence of polymer scaffold properties on retinal cell adhesion and control
    Andrew J Treharne
    School of Chemistry, University of Southampton, UK
    Br J Ophthalmol 95:768-73. 2011
    ....
  21. doi request reprint Optimisation of polymer scaffolds for retinal pigment epithelium (RPE) cell transplantation
    Heather A J Thomson
    Clinical Neurosciences Division, Southampton General Hospital, Southampton SO16 6YD, UK
    Br J Ophthalmol 95:563-8. 2011
    ..To evaluate a variety of copolymers as suitable scaffolds to facilitate retinal pigment epithelium (RPE) transplantation...
  22. ncbi request reprint Autosomal dominant early onset aponeurotic ptosis and corneal limbal vascularization in a three-generation family
    Andre R Ismail
    Southampton Eye Unit, Southampton, United Kingdom
    Ophthal Plast Reconstr Surg 23:484-6. 2007
    ..A novel phenotype in a 3-generation family with early-onset aponeurotic ptosis and corneal limbal vascularization is described. Karyotype analysis was normal in the proband, and autosomal dominant transmission is demonstrated...
  23. ncbi request reprint Missense variations in the fibulin 5 gene and age-related macular degeneration
    Edwin M Stone
    Center for Macular Degeneration, University of Iowa, Carver College of Medicine, Iowa City 52242, USA
    N Engl J Med 351:346-53. 2004
    ..The study of a rare mendelian form of macular degeneration implicated fibulin genes in the pathogenesis of more common forms of this disease. We evaluated five fibulin genes in a large series of patients with AMD...
  24. ncbi request reprint Case of Stargardt disease caused by uniparental isodisomy
    John H Fingert
    Dept of Ophthalmology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Arch Ophthalmol 124:744-5. 2006
  25. pmc Idiopathic juxtafoveolar retinal telangiectasis in monozygotic twins
    Shabeeba R Hannan
    Southampton Eye Unit, Tremona Road, Southampton SO16 6YD, UK
    Br J Ophthalmol 91:1729-30. 2007
  26. pmc Retinal pigment epithelial tear following intravitreal bevacizumab for choroidal neovascular membrane due to age-related macular degeneration
    Shabeeba R Hannan
    Br J Ophthalmol 91:977-8. 2007
  27. ncbi request reprint Adeno-associated virus type 5: transduction efficiency and cell-type specificity in the primate retina
    Andrew J Lotery
    Department of Ophthalmology, Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
    Hum Gene Ther 14:1663-71. 2003
    ..Our results support the utility of AAV5 for rod photoreceptor degeneration therapies...
  28. ncbi request reprint Genetics update of macular diseases
    Mina Chung
    Department of Ophthalmology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 549, Rochester, NY 14642, USA
    Ophthalmol Clin North Am 15:459-65. 2002
    ..Further insight into the biochemical processes that cause macular dystrophies, including AMD, will contribute to our ability to develop treatments that will become increasingly vital in the years to come...
  29. ncbi request reprint Electroretinographic abnormalities in parents of patients with Leber congenital amaurosis who have heterozygous GUCY2D mutations
    Robert K Koenekoop
    McGill Ocular Genetics Laboratory, Montreal Children s Hospital, McGill University, Montreal, Quebec, Canada
    Arch Ophthalmol 120:1325-30. 2002
    ..In the future, LCA may become treatable by gene and/or pharmacological intervention, and these therapies will likely be gene specific, giving major significance to rapid gene identification and gene-phenotype studies...
  30. ncbi request reprint Gene transfer to the nonhuman primate retina with recombinant feline immunodeficiency virus vectors
    Andrew J Lotery
    Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Hum Gene Ther 13:689-96. 2002
    ..rFIV vectors have therapeutic potential and could be exploited to develop gene therapy for the human eye...