R J F Loos

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Genetic predisposition to obesity leads to increased risk of type 2 diabetes
    S Li
    MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    Diabetologia 54:776-82. 2011
  2. pmc Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies
    Marcel den Hoed
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Diabetes 59:2980-8. 2010
  3. pmc Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians
    H Li
    Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
    Diabetologia 55:981-95. 2012
  4. doi request reprint Genetic determinants of common obesity and their value in prediction
    Ruth J F Loos
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Best Pract Res Clin Endocrinol Metab 26:211-26. 2012
  5. pmc A multilevel linear mixed model of the association between candidate genes and weight and body mass index using the Framingham longitudinal family data
    Jian An Luan
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    BMC Proc 3:S115. 2009
  6. pmc Recent progress in the genetics of common obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Br J Clin Pharmacol 68:811-29. 2009
  7. doi request reprint The genetic epidemiology of melanocortin 4 receptor variants
    Ruth J F Loos
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, P O Box 285, Cambridge, CB5 8QD, United Kingdom
    Eur J Pharmacol 660:156-64. 2011
  8. doi request reprint FTO: the first gene contributing to common forms of human obesity
    R J F Loos
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Obes Rev 9:246-50. 2008
  9. pmc TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population
    Ruth J F Loos
    Medical Research Council Epidemiology Unit, Strangeways Research Laboratory, Cambridge, UK
    Diabetes 56:1943-7. 2007
  10. pmc Comment on "A common genetic variant is associated with adult and childhood obesity"
    Ruth J F Loos
    Medical Research Council Epidemiology Unit, Cambridge, UK
    Science 315:187; author reply 187. 2007

Collaborators

Detail Information

Publications55

  1. pmc Genetic predisposition to obesity leads to increased risk of type 2 diabetes
    S Li
    MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    Diabetologia 54:776-82. 2011
    ..We examined the associations of 12 obesity susceptibility loci, individually and in combination, with risk of type 2 diabetes in the population-based European Prospective Investigation of Cancer (EPIC) Norfolk cohort...
  2. pmc Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies
    Marcel den Hoed
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Diabetes 59:2980-8. 2010
    ..We examined associations of variants in these loci with anthropometric traits in children and adolescents...
  3. pmc Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians
    H Li
    Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
    Diabetologia 55:981-95. 2012
    ..To test whether there is an association of the FTO locus with obesity and type 2 diabetes, we conducted a meta-analysis of 32 populations including 96,551 East and South Asians...
  4. doi request reprint Genetic determinants of common obesity and their value in prediction
    Ruth J F Loos
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Best Pract Res Clin Endocrinol Metab 26:211-26. 2012
    ..To conclude, the most valuable contribution of GWAS-identified loci lies in their contribution to elucidating new physiological pathways that underlie obesity-susceptibility...
  5. pmc A multilevel linear mixed model of the association between candidate genes and weight and body mass index using the Framingham longitudinal family data
    Jian An Luan
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    BMC Proc 3:S115. 2009
    ..Linkage disequilibrium (LD) between the two FTO SNPs was strong (D' = 0.997, r2 = 0.875) but their haplotype was not significantly associated with either weight or BMI. The two SNPs near MC4R were in weak LD (D' = 0.487, r2 = 0.166)...
  6. pmc Recent progress in the genetics of common obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Br J Clin Pharmacol 68:811-29. 2009
    ....
  7. doi request reprint The genetic epidemiology of melanocortin 4 receptor variants
    Ruth J F Loos
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, P O Box 285, Cambridge, CB5 8QD, United Kingdom
    Eur J Pharmacol 660:156-64. 2011
    ..Of particular interest is the finding from genome-wide association studies that suggests that the region downstream of MC4R contributes to its regulation...
  8. doi request reprint FTO: the first gene contributing to common forms of human obesity
    R J F Loos
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Obes Rev 9:246-50. 2008
    ..The expectations are high but many challenges remain. Among the latter, translating new advances into useful guidelines for prevention and treatment of obesity will be the most demanding...
  9. pmc TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population
    Ruth J F Loos
    Medical Research Council Epidemiology Unit, Strangeways Research Laboratory, Cambridge, UK
    Diabetes 56:1943-7. 2007
    ....
  10. pmc Comment on "A common genetic variant is associated with adult and childhood obesity"
    Ruth J F Loos
    Medical Research Council Epidemiology Unit, Cambridge, UK
    Science 315:187; author reply 187. 2007
    ..However, we found no evidence of association between rs7566605 and body mass index in two large ethnically homogeneous population-based cohorts. On the contrary, an opposite tendency was observed...
  11. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  12. ncbi request reprint No association between polymorphisms in the INSIG1 gene and the risk of type 2 diabetes and related traits
    Magdalena Szopa
    Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Am J Clin Nutr 92:252-7. 2010
    ....
  13. pmc Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response
    C Langenberg
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Diabetologia 52:1537-42. 2009
    ....
  14. pmc Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth
    Cathy E Elks
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge, United Kingdom
    PLoS Med 7:e1000284. 2010
    ..Exploration of these genotype associations in children may provide insights into the timing of weight changes leading to adult obesity...
  15. ncbi request reprint Absence of association between the INSIG2 gene polymorphism (rs7566605) and obesity in the European Youth Heart Study (EYHS)
    Karani S Vimaleswaran
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Obesity (Silver Spring) 17:1453-7. 2009
    ..There was also no evidence of interaction between genotype and physical activity (P = 0.95). Despite an adequately powered study, our findings suggest that rs7566605 is not associated with obesity-related traits and lipids in the EYHS...
  16. pmc Evaluation of common genetic variants identified by GWAS for early onset and morbid obesity in population-based samples
    M den Hoed
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Int J Obes (Lond) 37:191-6. 2013
    ..Meta-analysis of case-control genome-wide association studies (GWAS) for early onset and morbid obesity identified four variants in/near the PRL, PTER, MAF and NPC1 genes...
  17. ncbi request reprint Physical activity energy expenditure may mediate the relationship between plasma leptin levels and worsening insulin resistance independently of adiposity
    P W Franks
    Medical Research Council Epidemiology Unit, Cambridge, UK
    J Appl Physiol (1985) 102:1921-6. 2007
    ..Hyperleptinemia predicts a relative decline in PAEE and worsening insulin resistance, possibly via shared molecular pathways...
  18. doi request reprint Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene
    Karani S Vimaleswaran
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge CB2 0QQ, United Kingdom
    Am J Clin Nutr 90:425-8. 2009
    ..Intronic variation in the FTO (fat mass and obesity-associated) gene has been unequivocally associated with increased body mass index (BMI; in kg/m(2)) and the risk of obesity in populations of different ethnicity...
  19. pmc Common genetic determinants of glucose homeostasis in healthy children: the European Youth Heart Study
    Clara Kelliny
    Medical Research Council Epidemiology Unit, Addenbrooke s Hospital, Institute of Metabolic Science, Cambridge, U K
    Diabetes 58:2939-45. 2009
    ..The goal of this study was to investigate whether the effects of common genetic variants associated with fasting glucose in adults are detectable in healthy children...
  20. ncbi request reprint Association between serotonin 5-HT-2C receptor gene (HTR2C) polymorphisms and obesity- and mental health-related phenotypes in a large population-based cohort
    K S Vimaleswaran
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Int J Obes (Lond) 34:1028-33. 2010
    ..We aimed to analyse whether variation in the HTR2C is associated with obesity- and mental health-related phenotypes in a large population-based cohort...
  21. pmc Polymorphisms in the gene encoding sterol regulatory element-binding factor-1c are associated with type 2 diabetes
    A H Harding
    MRC Epidemiology Unit, Cambridge, UK
    Diabetologia 49:2642-8. 2006
    ..The present study aimed to replicate our previously reported association in a larger case-control study and to examine an additional five SREBF1c SNPs for their association with diabetes risk and plasma glucose concentrations...
  22. ncbi request reprint The ADRB3 Trp64Arg variant and BMI: a meta-analysis of 44 833 individuals
    N Kurokawa
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Int J Obes (Lond) 32:1240-9. 2008
    ..The association between the Trp64Arg variant in the ADRB3 and body mass index (BMI) has been widely examined, but previous studies have been small and results have been inconsistent...
  23. doi request reprint Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies
    Shengxu Li
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Am J Clin Nutr 91:184-90. 2010
    ..Large-scale genome-wide association studies have identified 12 genetic loci that are robustly associated with body mass index (BMI)...
  24. pmc Genetic predisposition influences plasma lipids of participants on habitual diet, but not the response to reductions in dietary intake of saturated fatty acids
    C G Walker
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
    Atherosclerosis 215:421-7. 2011
    ..SNPs identified from genome-wide association studies associate with lipid risk markers of cardiovascular disease. This study investigated whether these SNPs altered the plasma lipid response to diet in the 'RISCK' study cohort...
  25. pmc Associations between the pubertal timing-related variant in LIN28B and BMI vary across the life course
    Ken K Ong
    Medical Research Council MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Clin Endocrinol Metab 96:E125-9. 2011
    ..The common C allele of rs314276 in LIN28B has been robustly associated with earlier age at menarche in girls and associated with earlier timing of other pubertal traits in both sexes...
  26. pmc Epidemiological study designs to investigate gene-behavior interactions in the context of human obesity
    Nicholas J Wareham
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Obesity (Silver Spring) 16:S66-71. 2008
    ..It is clear from power calculations that an approach based on enhancing precision of measurement of diet and physical activity is critical...
  27. ncbi request reprint Association between birth weight and visceral fat in adults
    Emanuella De Lucia Rolfe
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom
    Am J Clin Nutr 92:347-52. 2010
    ..Several studies reported inverse associations between birth weight and central adiposity in adults. However, few studies investigated the contributions of different abdominal fat compartments...
  28. pmc Association of variants in the PCSK1 gene with obesity in the EPIC-Norfolk study
    Tuomas O Kilpeläinen
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Hum Mol Genet 18:3496-501. 2009
    ..68 for BMI and obesity, respectively). In conclusion, our data suggest that the PCSK1 rs6232 and rs6235 SNPs are not major contributors to common obesity in the general population. However, the effect of rs6232 may be age-dependent...
  29. pmc Habitual energy expenditure modifies the association between NOS3 gene polymorphisms and blood pressure
    Karani S Vimaleswaran
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Am J Hypertens 21:297-302. 2008
    ..Thus, energy expenditure may modify the association between the genetic variation at NOS3 and blood pressure...
  30. ncbi request reprint Rapid infancy weight gain and subsequent obesity: systematic reviews and hopeful suggestions
    Ken K Ong
    Medical Research Council Epidemiology Unit, Cambridge, UK
    Acta Paediatr 95:904-8. 2006
    ..Further evidence is needed, and we will need to rigorously test the benefits and risks of any interventions. However, the concept of "healthy" rapid catch-up infancy growth is an attractive prospect...
  31. pmc LDL-cholesterol concentrations: a genome-wide association study
    Manjinder S Sandhu
    Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK
    Lancet 371:483-91. 2008
    ..We therefore did a genome-wide association study of LDL-cholesterol concentrations...
  32. pmc The contribution of prenatal environment and genetic factors to the association between birth weight and adult grip strength
    Charlotte L Ridgway
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom
    PLoS ONE 6:e17955. 2011
    ....
  33. doi request reprint Progress in the genetics of common obesity and type 2 diabetes
    Karani S Vimaleswaran
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Expert Rev Mol Med 12:e7. 2010
    ..This will require integration of genetic epidemiological methods with functional genomics and proteomics. However, the use of these novel insights for genetic screening and personalised treatment lies some way off in the future...
  34. pmc Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
    Cathy E Elks
    Medical Research Council MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 42:1077-85. 2010
    ..Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing...
  35. doi request reprint Progress in the genetics of common obesity: size matters
    Shengxu Li
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Curr Opin Lipidol 19:113-21. 2008
    ..We conclude by speculating about the way forward in the near future...
  36. ncbi request reprint Genetic and environmental determination of tracking in subcutaneous fat distribution during adolescence
    Maarten W Peeters
    Department of Biomedical Kinesiology, Faculty of Kinesiology and Rehabilitation Sciences Epidemiology Unit, Strangeways Research Laboratory, Cambridge, United Kingdom
    Am J Clin Nutr 86:652-60. 2007
    ..The distribution of fat and adipose tissue is an important predictor of disease risk. Variation in fat distribution during adolescence is correlated with fat distribution in adulthood...
  37. ncbi request reprint Adiponectin and adiponectin receptor gene variants in relation to resting metabolic rate, respiratory quotient, and adiposity-related phenotypes in the Quebec Family Study
    Ruth J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 85:26-34. 2007
    ..Despite adiponectin's presumed role in fatty acid oxidation and energy homeostasis, little is known about the effect of gene variants on substrate oxidation, energy expenditure, and adiposity-related phenotypes...
  38. ncbi request reprint MC4R marker associated with stature in children and young adults: a longitudinal study
    Nicola Santoro
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, LA 70808 4124, USA
    J Pediatr Endocrinol Metab 18:859-63. 2005
    ..These results suggest that DNA sequence variation in the MC4R locus may contribute to the gain in body height from childhood to adulthood...
  39. ncbi request reprint Gene-diet interactions on body weight changes
    Ruth J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Am Diet Assoc 105:S29-34. 2005
    ..This growing body of research may help in the development of antiobesity treatments and perhaps genetic tests to predict the risk for obesity...
  40. ncbi request reprint Calcium intake is associated with adiposity in Black and White men and White women of the HERITAGE Family Study
    Ruth J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA
    J Nutr 134:1772-8. 2004
    ..04). No significant associations were found in Black women. Low Ca(2+) intake may be associated with higher adiposity, particularly in men and White women...
  41. ncbi request reprint The influence of maternal BMI and age in twin pregnancies on insulin resistance in the offspring
    Ruth J F Loos
    Center for Human Genetics, Faculty of Medicine, Katholieke Universiteit Leuven, Belgium
    Diabetes Care 25:2191-6. 2002
    ..We have carried out a twin study to distinguish among maternal influences, which affect both twins; fetoplacental influences, which are unique to each twin; and the genetic factors that may underlie this association...
  42. pmc Lamin A/C polymorphisms, type 2 diabetes, and the metabolic syndrome: case-control and quantitative trait studies
    Jose L Mesa
    Medical Research Center Epidemiology Unit, Cambridge, U K
    Diabetes 56:884-9. 2007
    ..Thus, it appears unlikely that variation at LMNA substantially increases the risk of type 2 diabetes or related traits in U.K. Europids...
  43. pmc A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    Timothy M Frayling
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter, UK
    Science 316:889-94. 2007
    ..67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass...
  44. pmc Evaluating the role of LPIN1 variation in insulin resistance, body weight, and human lipodystrophy in U.K. Populations
    Katherine A Fawcett
    Metabolic Disease Group, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, U K
    Diabetes 57:2527-33. 2008
    ..We aimed to conduct a comprehensive association study to clarify the influence of common LPIN1 variation on adiposity and insulin sensitivity in U.K. populations and to examine the role of LPIN1 mutations in insulin resistance syndromes...
  45. ncbi request reprint Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population
    Huaixing Li
    Key Laboratory of Systems Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes 57:264-8. 2008
    ..However, their effects in other ethnic populations remain to be elucidated...
  46. ncbi request reprint Association of lipin 1 gene polymorphisms with measures of energy and glucose metabolism
    Ruth J F Loos
    Pennington Biomedical Research Center, Human Genomics Laboratory, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Obesity (Silver Spring) 15:2723-32. 2007
    ..Lpin1 was identified as the mutated gene in the fatty liver dystrophy mouse, which exhibits lipin deficiency and features of human lipodystrophy...
  47. pmc Genome-wide association analysis identifies 20 loci that influence adult height
    Michael N Weedon
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter EX1 2LU, UK
    Nat Genet 40:575-83. 2008
    ..Finally, our results provide insights into the genetic architecture of a classic quantitative trait...
  48. pmc The Gly482Ser genotype at the PPARGC1A gene and elevated blood pressure: a meta-analysis involving 13,949 individuals
    Karani Santhanakrishnan Vimaleswaran
    Department of Public Health and Clinical Medicine, Umea University Hospital, Umea, Sweden
    J Appl Physiol (1985) 105:1352-8. 2008
    ..41; DBP, P = 0.51). Our findings suggest that the PPARGC1A Ser482 allele may be associated with higher blood pressure, but this is only apparent in younger adults...
  49. ncbi request reprint Growth in peak aerobic power during adolescence
    Christina A Geithner
    Department of Exercise Science, Gonzaga University, Spokane, WA 99258, USA
    Med Sci Sports Exerc 36:1616-24. 2004
    ..To model the growth of peak aerobic power during adolescence in both sexes followed longitudinally from 10 to 18 yr...
  50. ncbi request reprint Determinants of birthweight and intrauterine growth in liveborn twins
    Ruth J F Loos
    Faculty of Medicine, Centre for Human Genetics, Katholieke Universiteit Leven, Leuven, Belgium
    Paediatr Perinat Epidemiol 19:15-22. 2005
    ..Gestation is the main determinant of birthweight. Other placental and maternal factors have a modest but significant influence on prenatal growth...
  51. ncbi request reprint Clustering of metabolic risk factors in young adults: genes and environment
    Maarten W Peeters
    Faculty of Kinesiology and Rehabilitation Sciences, Department of Biomedical Kinesiology, Research Center for Exercise and Health, Katholieke Universiteit Leuven, Leuven, Belgium
    Atherosclerosis 200:168-76. 2008
    ..The aim of this study therefore was to study the heritabilities of the MRFs and the genetic and environmental correlations between the MRFs...
  52. ncbi request reprint Two ethnic-specific polymorphisms in the human Agouti-related protein gene are associated with macronutrient intake
    Ruth J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 82:1097-101. 2005
    ..Exogenous administration of AGRP in rodents predisposes to high fat and high sugar intakes...
  53. ncbi request reprint PGC-1alpha gene and physical activity in type 2 diabetes mellitus
    Paul W Franks
    Genetic Epidemiology and Clinical Research Group, Institute of Public Health and Clinical Medicine, Umea University Hospital, Umea, Sweden
    Exerc Sport Sci Rev 34:171-5. 2006
    ..Thus, PGC-1alpha sequence variation may interact with physical activity to modify diabetes risk via changes in oxidative energy metabolism...
  54. ncbi request reprint Genome-wide linkage scan for the metabolic syndrome in the HERITAGE Family Study
    Ruth J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 88:5935-43. 2003
    ..Some of these chromosomal regions harbor promising potential candidate genes...