David A Long
Affiliation: University College London
Huang J, Woolf A, Kolatsi Joannou M, Baluk P, Sandford R, Peters D, et al
. Vascular Endothelial Growth Factor C for Polycystic Kidney Diseases. J Am Soc Nephrol. 2016;27:69-77 pubmed publisher
..Overall, this study highlights VEGFC as a potential new treatment for some aspects of PKD, with the possibility for synergy with current epithelially targeted approaches. ..
Vasilopoulou E, Winyard P, Riley P, Long D. The role of thymosin-Î²4 in kidney disease. Expert Opin Biol Ther. 2015;15 Suppl 1:S187-90 pubmed publisher
..Thymosin-Î²4 is already being tested in clinical trials for heart disease and wound healing. This editorial outlines the evidence that thymosin-Î²4 may also have therapeutic benefit in CKD. ..
Long D, Kolatsi Joannou M, Price K, Dessapt Baradez C, Huang J, Papakrivopoulou E, et al
. Albuminuria is associated with too few glomeruli and too much testosterone. Kidney Int. 2013;83:1118-29 pubmed publisher
..These proteins may represent novel biomarkers and even therapeutic targets for early kidney and cardiovascular disease. ..
Gnudi L, Coward R, Long D. Diabetic Nephropathy: Perspective on Novel Molecular Mechanisms. Trends Endocrinol Metab. 2016;27:820-830 pubmed publisher
..We believe that these mechanisms offer new therapeutic targets that can be exploited to develop important renoprotective treatments for DN over the next decade. ..
Vasilopoulou E, Kolatsi Joannou M, Lindenmeyer M, White K, Robson M, Cohen C, et al
. Loss of endogenous thymosin Î²4 accelerates glomerular disease. Kidney Int. 2016;90:1056-1070 pubmed publisher
..We propose that endogenous thymosin Î²4 is a modifier of glomerular injury, likely having a protective role acting as a brake to slow disease progression. ..
BrzÃ³ska H, d Esposito A, Kolatsi Joannou M, Patel V, Igarashi P, Lei Y, et al
. Planar cell polarity genes Celsr1 and Vangl2 are necessary for kidney growth, differentiation, and rostrocaudal patterning. Kidney Int. 2016;90:1274-1284 pubmed publisher
..Thus, PCP genes are important in mammalian kidney development and have an unexpected role in rostrocaudal patterning during organogenesis. ..