Research Topics
Species | Michael LondonSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Dendritic computationMichael London
Wolfson Institute for Biomedical Research and Department of Physiology, University College London, London WC1E 6BT, UK
Annu Rev Neurosci 28:503-32. 2005..We discuss why these dendritic properties may be essential for the computations performed by the neuron and the network and provide theoretical and experimental examples to support this view...
Predicting the synaptic information efficacy in cortical layer 5 pyramidal neurons using a minimal integrate-and-fire modelMichael London
Department of Physiology, Wolfson Institute for Biomedical Research, University College London, Gower Street, London, WC1E 6BT, UK
Biol Cybern 99:393-401. 2008....
Tonic inhibition enhances fidelity of sensory information transmission in the cerebellar cortexIan Duguid
Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK
J Neurosci 32:11132-43. 2012..These results suggest that under basal conditions the level of tonic inhibition in vivo enhances the fidelity of sensory information transmission through the input layer of the cerebellar cortex...
Sensitivity to perturbations in vivo implies high noise and suggests rate coding in cortexMichael London
Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
Nature 466:123-7. 2010..However, in our in vivo recordings, we found that such events were very rare. Our findings are thus consistent with the idea that cortex is likely to use primarily a rate code...
Local and global effects of I(h) distribution in dendrites of mammalian neuronsKamilla Angelo
Wolfson Institute for Biomedical Research and Department of Physiology, University College London, London WC1E 6BT, United Kingdom
J Neurosci 27:8643-53. 2007....
The site of action potential initiation in cerebellar Purkinje neuronsBeverley A Clark
Wolfson Institute for Biomedical Research, Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
Nat Neurosci 8:137-9. 2005..Here we use recordings from visualized rat cerebellar Purkinje cell axons to localize the site of initiation to a well-defined anatomical structure: the first node of Ranvier, which normally forms at the first axonal branch point...
The information efficacy of a synapseMichael London
Department of Neurobiology Institute of Life Sciences and Center for Neural Computation, Hebrew University, Jerusalem 91904, Israel
Nat Neurosci 5:332-40. 2002..Systematic exploration of the effect of synaptic and dendritic parameters on the SIE offers a fresh look at the synapse as a communication device and a quantitative measure of how much the dendritic synapse informs the axon...
Rebuilding dendritic democracy. Focus on "equalization of synaptic efficacy by activity- and timing-dependent synaptic plasticity"Arnd Roth
J Neurophysiol 91:1941-2. 2004
Conducting synaptic music in dendritesMichael London
Nat Neurosci 7:904-5. 2004
