Research Topics | Marco LondeiSummaryAffiliation: University College London Country: UK Publications
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Publications
Gliadin as a stimulator of innate responses in celiac diseaseMarco Londei
Marco Londei Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
Mol Immunol 42:913-8. 2005..We further suggest a novel way to harness the unwanted immune response to toxic prolamine, and thus indicate new potential therapeutic strategies to treat or at least control CD...
Association between innate response to gliadin and activation of pathogenic T cells in coeliac diseaseLuigi Maiuri
Institute of Child Health, University College London, London, UK
Lancet 362:30-7. 2003..Although our findings emphasise the key role of gliadin-specific T cells, they suggest a complex pathogenic situation, and show that inhibition of interleukin-15 or p38 MAP kinase might have the potential to control coeliac disease...
Role of regulatory T cells in experimental arthritis and implications for clinical useMarco Londei
Institute of Child Health, University College London, London, UK
Arthritis Res Ther 7:118-20. 2005..The second is how we can practically deliver their therapeutic activity in patients. Once these points have been addressed we will have a new and potentially very effective 'magic bullet' for the treatment of chronic autoimmune diseases...
Prevention of arthritis by interleukin 10-producing B cellsClaudia Mauri
The Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science Technology and Medicine, London W6 8 LH, United Kingdom
J Exp Med 197:489-501. 2003..Our results suggest a new role of a subset of B cells in controlling T cell differentiation and autoimmune disorders...
Gliadin as stimulator adaptive and innate immune responses in celiac diseaseMarco Londei
Autoimmunity Group, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
J Pediatr Gastroenterol Nutr 39:S729. 2004
Gliadin regulates the NK-dendritic cell cross-talk by HLA-E surface stabilizationGiuseppe Terrazzano
Department of Cellular and Molecular Biology and Pathology, University Federico II, Naples, Italy
J Immunol 179:372-81. 2007..Analysis of HLA-E expression in the small intestinal mucosa of gluten-containing diet celiac patients and organ culture experiments confirmed the in vitro data...
Altered monocyte cyclooxygenase response to lipopolysaccharide in type 1 diabetesHuriya Beyan
Department of Diabetes and Metabolic Medicine, Institute of Cell and Molecular Science, London E1 2AT, U K
Diabetes 55:3439-45. 2006..Because COX-2 response to LPS is proinflammatory, an inherited reduced response would predispose to chronic inflammatory diseases such as type 1 diabetes...
Unexpected role of surface transglutaminase type II in celiac diseaseLuigi Maiuri
Institute of Child Health, University College London, London, England
Gastroenterology 129:1400-13. 2005..It follows that inhibition of TG2 might represent an attractive strategy to curb the toxic action of gliadin. Here we studied the validity of this strategy using the organ culture approach...
A search for the holy grail: non-toxic gluten for celiac patientsMarco Londei
Gastroenterology 129:1111-3. 2005
Regulation of major histocompatibility complex class II synthesis by interleukin-10Anne-Sophie Morel
The Kennedy Institute of Rheumatology Division, Imperial College of Science, Technology and Medicine, Faculty of Medicine, London, UK
Immunology 106:229-36. 2002..A higher proportion of Ii-associated HLA-DR, coupled to increased membrane recycling, may contribute to the lower T-cell stimulatory capacity of IL-10-treated dendritic cells...
Celiac disease: in vitro and in vivo safety and palatability of wheat-free sorghum food productsCarolina Ciacci
Department of Clinical and Experimental Medicine, Federico II, Napoli, Italy
Clin Nutr 26:799-805. 2007..Thus the aim of the present study was to assess safety and tolerability of sorghum flour products in adult celiac disease patients, utilizing an in vitro and in vivo challenge...
