Graziano Lolli

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
    Graziano Lolli
    Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, Oxford, UK
    Cell Cycle 4:572-7. 2005
  2. pmc Binding to DNA of the RNA-polymerase II C-terminal domain allows discrimination between Cdk7 and Cdk9 phosphorylation
    Graziano Lolli
    Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Nucleic Acids Res 37:1260-8. 2009
  3. pmc The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation
    Sonja Baumli
    Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, Oxford, UK
    EMBO J 27:1907-18. 2008
  4. ncbi request reprint Recognition of Cdk2 by Cdk7
    Graziano Lolli
    Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
    Proteins 67:1048-59. 2007
  5. ncbi request reprint The crystal structure of human CDK7 and its protein recognition properties
    Graziano Lolli
    Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, Rex Richards Building, Oxford, OX1 3QU, United Kingdom
    Structure 12:2067-79. 2004

Detail Information

Publications5

  1. ncbi request reprint CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
    Graziano Lolli
    Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, Oxford, UK
    Cell Cycle 4:572-7. 2005
    ..We review the role of CAK in different biological processes and evaluate the biological evidence for CDK7 as a possible pharmacological target...
  2. pmc Binding to DNA of the RNA-polymerase II C-terminal domain allows discrimination between Cdk7 and Cdk9 phosphorylation
    Graziano Lolli
    Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Nucleic Acids Res 37:1260-8. 2009
    ..CTD dissociates from DNA following phosphorylation by Cdk7, allowing transcription initiation. The CTD then becomes accessible for further phosphorylation by Cdk9 that drives the transition to transcription elongation...
  3. pmc The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation
    Sonja Baumli
    Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, Oxford, UK
    EMBO J 27:1907-18. 2008
    ..We show that CDK9/CycT1 autophosphorylates on Thr186 in the activation segment and three C-terminal phosphorylation sites. Autophosphorylation on all sites occurs in cis...
  4. ncbi request reprint Recognition of Cdk2 by Cdk7
    Graziano Lolli
    Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
    Proteins 67:1048-59. 2007
    ..Further experiments demonstrate that cyclin A hydrophobic pocket is not a recruitment site for Cdk7...
  5. ncbi request reprint The crystal structure of human CDK7 and its protein recognition properties
    Graziano Lolli
    Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, Rex Richards Building, Oxford, OX1 3QU, United Kingdom
    Structure 12:2067-79. 2004
    ..The functional properties of the enzyme against CDK2 and CTD as substrates are characterized through kinase assays. Experiments confirm that CDK7 is not a substrate for kinase-associated phosphatase...