Y K Loke

Summary

Affiliation: University of East Anglia
Country: UK

Publications

  1. pmc Benefits and harms of extending the duration of dual antiplatelet therapy after percutaneous coronary intervention with drug-eluting stents: a meta-analysis
    Chun Shing Kwok
    Institute of Cardiovascular Sciences, University of Manchester, Manchester Royal Infirmary, Manchester M13 9WL, UK
    ScientificWorldJournal 2014:794078. 2014
  2. pmc Risk prediction models for mortality in community-acquired pneumonia: a systematic review
    Chun Shing Kwok
    Norfolk and Norwich University Hospital, Colney Lane, Norwich NR4 7UY, UK
    Biomed Res Int 2013:504136. 2013
  3. ncbi request reprint Systematic review evaluating cardiovascular events of the 5-alpha reductase inhibitor - Dutasteride
    Y K Loke
    Norwich Medical School, University of East Anglia, Norwich, UK
    J Clin Pharm Ther 38:405-15. 2013
  4. pmc Drug safety assessment in clinical trials: methodological challenges and opportunities
    Sonal Singh
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Trials 13:138. 2012
  5. doi request reprint Chronic obstructive pulmonary disease and mortality from pneumonia: meta-analysis
    Y K Loke
    Norwich Medical School, University of East Anglia, Norwich, UK
    Int J Clin Pract 67:477-87. 2013
  6. ncbi request reprint Association of obstructive sleep apnea with risk of serious cardiovascular events: a systematic review and meta-analysis
    Yoon K Loke
    Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich Research Park, Norwich, United Kingdom
    Circ Cardiovasc Qual Outcomes 5:720-8. 2012
  7. pmc Impact of health literacy in patients with chronic musculoskeletal disease--systematic review
    Yoon K Loke
    Norwich Medical School, University of East Anglia, Norwich, Norfolk, United Kingdom
    PLoS ONE 7:e40210. 2012
  8. doi request reprint Systematic review of consistency between adherence to cardiovascular or diabetes medication and health literacy in older adults
    Yoon K Loke
    Norwich Medical School, University of East Anglia, Norwich, UK
    Ann Pharmacother 46:863-72. 2012
  9. pmc Adverse drug reactions
    Yoon K Loke
    Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK
    Br J Clin Pharmacol 73:908-11. 2012
  10. pmc Internet treatment of sexually transmitted infections - a public health hazard?
    Roberto Vivancos
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ, UK
    BMC Public Health 7:333. 2007

Detail Information

Publications32

  1. pmc Benefits and harms of extending the duration of dual antiplatelet therapy after percutaneous coronary intervention with drug-eluting stents: a meta-analysis
    Chun Shing Kwok
    Institute of Cardiovascular Sciences, University of Manchester, Manchester Royal Infirmary, Manchester M13 9WL, UK
    ScientificWorldJournal 2014:794078. 2014
    ..The optimal duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) is unclear...
  2. pmc Risk prediction models for mortality in community-acquired pneumonia: a systematic review
    Chun Shing Kwok
    Norfolk and Norwich University Hospital, Colney Lane, Norwich NR4 7UY, UK
    Biomed Res Int 2013:504136. 2013
    ..Several models have been developed to predict the risk of mortality in community-acquired pneumonia (CAP). This study aims to systematically identify and evaluate the performance of published risk prediction models for CAP...
  3. ncbi request reprint Systematic review evaluating cardiovascular events of the 5-alpha reductase inhibitor - Dutasteride
    Y K Loke
    Norwich Medical School, University of East Anglia, Norwich, UK
    J Clin Pharm Ther 38:405-15. 2013
    ..Our objective was to perform a meta-analysis to assess the risk of cardiovascular adverse events with the use of dutasteride for the prevention or treatment of prostatic disease...
  4. pmc Drug safety assessment in clinical trials: methodological challenges and opportunities
    Sonal Singh
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Trials 13:138. 2012
    ..Regulatory and academic partnerships should be fostered to provide an independent and transparent evaluation of drug safety...
  5. doi request reprint Chronic obstructive pulmonary disease and mortality from pneumonia: meta-analysis
    Y K Loke
    Norwich Medical School, University of East Anglia, Norwich, UK
    Int J Clin Pract 67:477-87. 2013
    ..We also assessed the effect of inhaled corticosteroids (ICS) on pneumonia mortality in COPD...
  6. ncbi request reprint Association of obstructive sleep apnea with risk of serious cardiovascular events: a systematic review and meta-analysis
    Yoon K Loke
    Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich Research Park, Norwich, United Kingdom
    Circ Cardiovasc Qual Outcomes 5:720-8. 2012
    ..The relationship between obstructive sleep apnea (OSA) and cardiovascular events remains unclear. We conducted a systematic review to determine the incident risk of cardiovascular events among patients with OSA...
  7. pmc Impact of health literacy in patients with chronic musculoskeletal disease--systematic review
    Yoon K Loke
    Norwich Medical School, University of East Anglia, Norwich, Norfolk, United Kingdom
    PLoS ONE 7:e40210. 2012
    ..To estimate the prevalence of low health literacy, and evaluate the impact of low health literacy on outcomes in patients with chronic musculoskeletal conditions...
  8. doi request reprint Systematic review of consistency between adherence to cardiovascular or diabetes medication and health literacy in older adults
    Yoon K Loke
    Norwich Medical School, University of East Anglia, Norwich, UK
    Ann Pharmacother 46:863-72. 2012
    ..To review the relationship between health literacy and adherence to cardiovascular/diabetes medication...
  9. pmc Adverse drug reactions
    Yoon K Loke
    Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK
    Br J Clin Pharmacol 73:908-11. 2012
    ....
  10. pmc Internet treatment of sexually transmitted infections - a public health hazard?
    Roberto Vivancos
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ, UK
    BMC Public Health 7:333. 2007
    ..We conducted an internet search to determine the availability of treatments for STIs and the nature of information provided by vendors of these treatments...
  11. pmc Identifying systematic reviews of the adverse effects of health care interventions
    Su Golder
    Centre for Reviews and Dissemination CRD, University of York, York, YO10 5DD, UK
    BMC Med Res Methodol 6:22. 2006
    ..In order to carry out a methodological research survey of systematic reviews of adverse effects we needed to retrieve a sample of systematic reviews in which the primary outcome is an adverse effect or effects...
  12. pmc Extent of publication bias in different categories of research cohorts: a meta-analysis of empirical studies
    Fujian Song
    School of Medicine, Health Policy and Practice, University of East Anglia, Earlham Road, Norwich NR4 7TJ, UK
    BMC Med Res Methodol 9:79. 2009
    ..We conducted a meta-analysis to ascertain the strength and consistency of the association between study results and formal publication...
  13. pmc Room for improvement? A survey of the methods used in systematic reviews of adverse effects
    Su Golder
    Centre for Reviews and Dissemination, University of York, York, YO10 5DD, UK
    BMC Med Res Methodol 6:3. 2006
    ..Although the methods for conducting systematic reviews of efficacy are well established, there is much less guidance on how systematic reviews of adverse effects should be performed...
  14. doi request reprint Value of severity scales in predicting mortality from community-acquired pneumonia: systematic review and meta-analysis
    Yoon K Loke
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, Norfolk, UK
    Thorax 65:884-90. 2010
    ..Several scoring systems have been used to predict mortality in patients with community-acquired pneumonia. The properties of commonly used risk stratification scales were systematically reviewed...
  15. pmc Assessing the benefit-harm balance at the bedside
    Yoon Kong Loke
    School of Medicine, Health Policy and Practice University of East Anglia, Norwich NR4 7TJ
    BMJ 329:7-8. 2004
  16. pmc Systematic reviews of adverse effects: framework for a structured approach
    Yoon K Loke
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK
    BMC Med Res Methodol 7:32. 2007
    ..A detailed discussion of why, how and when to include adverse effects in a systematic review, is required...
  17. ncbi request reprint Meta-analysis: gastrointestinal bleeding due to interaction between selective serotonin uptake inhibitors and non-steroidal anti-inflammatory drugs
    Y K Loke
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK
    Aliment Pharmacol Ther 27:31-40. 2008
    ....
  18. pmc Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis
    Yoon K Loke
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK
    CMAJ 180:32-9. 2009
    ..Rosiglitazone and pioglitazone may increase the incidence of fractures. We aimed to determine systematically the risk of fractures associated with thiazolidinedione therapy and to evaluate the effect of the therapy on bone density...
  19. doi request reprint Risk of fractures with inhaled corticosteroids in COPD: systematic review and meta-analysis of randomised controlled trials and observational studies
    Yoon K Loke
    School of Medicine, University of East Anglia, Norwich NR4 7TJ, UK
    Thorax 66:699-708. 2011
    ..The effect of inhaled corticosteroids (ICS) on fracture risk in patients with chronic obstructive pulmonary disease (COPD) remains uncertain. The aim of this study was to evaluate the association between ICS and fractures in COPD...
  20. pmc Comparative cardiovascular effects of thiazolidinediones: systematic review and meta-analysis of observational studies
    Yoon Kong Loke
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ, UK
    BMJ 342:d1309. 2011
    ..To determine the comparative effects of the thiazolidinediones (rosiglitazone and pioglitazone) on myocardial infarction, congestive heart failure, and mortality in patients with type 2 diabetes...
  21. doi request reprint Dabigatran and rivaroxaban for prevention of venous thromboembolism--systematic review and adjusted indirect comparison
    Y K Loke
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK
    J Clin Pharm Ther 36:111-24. 2011
    ..Dabigatran and rivaroxaban are new oral anticoagulants for thromboprophylaxis after elective orthopaedic surgery. We aimed to systematically compare their relative benefits and harms through meta-analysis, and adjusted indirect comparison...
  22. doi request reprint Bisphosphonates and atrial fibrillation: systematic review and meta-analysis
    Yoon Kong Loke
    School of Medicine, University of East Anglia, Norwich, UK
    Drug Saf 32:219-28. 2009
    ..Bisphosphonates are widely used in osteoporosis, but there have been concerns about a potential link between bisphosphonate therapy and atrial fibrillation...
  23. ncbi request reprint The potassium-channel syndrome: does it exist?
    Yoon K Loke
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ, UK
    Lancet 365:1834-6. 2005
  24. pmc Case reports of suspected adverse drug reactions--systematic literature survey of follow-up
    Yoon Kong Loke
    School of Medicine, Health Policy, and Practice, University of East Anglia, Norwich NR4 7TJ
    BMJ 332:335-9. 2006
    ..To determine whether anecdotal reports of suspected adverse drug reactions are valuable early warning signals...
  25. doi request reprint Risk of myocardial infarction and cardiovascular death associated with inhaled corticosteroids in COPD
    Y K Loke
    Dept of Clinical Pharmacology, University of East Anglia, Norwich, UK
    Eur Respir J 35:1003-21. 2010
    ..These conflicting findings need to be clarified through further research...
  26. doi request reprint Atrial fibrillation and incidence of dementia: a systematic review and meta-analysis
    C S Kwok
    Stroke Research Group, Gunthorpe Acute Stroke Unit, Academic Department of Medicine for the Elderly, Norfolk and Norwich University Hospital, Norwich, Norfolk, UK
    Neurology 76:914-22. 2011
    ..Previous systematic reviews that examined whether atrial fibrillation (AF) is associated with dementia have relied on different study designs (including retrospective ones) and did not evaluate risk using meta-analysis...
  27. pmc Measures used to treat contrast-induced nephropathy: overview of reviews
    C S Kwok
    Norfolk and Norwich University Hospital, Norwich, UK
    Br J Radiol 86:20120272. 2013
    ..Despite many interventions that have been tried, controversy remains regarding the efficacy of interventions for contrast-induced nephropathy (CIN), so we aimed to evaluate the best evidence from recent meta-analyses...
  28. pmc Methodological problems in the use of indirect comparisons for evaluating healthcare interventions: survey of published systematic reviews
    Fujian Song
    Faculty of Health, University of East Anglia, Norwich NR4 7TJ
    BMJ 338:b1147. 2009
    ..To investigate basic assumptions and other methodological problems in the application of indirect comparison in systematic reviews of competing healthcare interventions...
  29. doi request reprint Meta-analysis: the effects of proton pump inhibitors on cardiovascular events and mortality in patients receiving clopidogrel
    C S Kwok
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, Norfolk, UK
    Aliment Pharmacol Ther 31:810-23. 2010
    ..Recent studies have suggested an adverse interaction between proton pump inhibitors (PPI) and clopidogrel...
  30. doi request reprint Dissemination and publication of research findings: an updated review of related biases
    F Song
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK
    Health Technol Assess 14:iii, ix-xi, 1-193. 2010
    ....
  31. pmc Is there evidence for biased reporting of published adverse effects data in pharmaceutical industry-funded studies?
    Su Golder
    CRD, University of York, York and School of Medicine, University of East Anglia, Norwich, UK
    Br J Clin Pharmacol 66:767-73. 2008
    ..To investigate whether adverse effects data for the sponsor's product are presented more favourably in pharmaceutical industry-funded studies than in non-industry-funded studies...
  32. pmc Aspirin for the prevention of cardiovascular disease: calculating benefit and harm in the individual patient
    Yoon Kong Loke
    Department of Clinical Pharmacology, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE
    Br J Clin Pharmacol 55:282-7. 2003
    ..To estimate the absolute reduction in the risk of cardiovascular events and absolute increase in gastrointestinal haemorrhage associated with aspirin for individuals with different baseline risks...