Ian R Logan

Summary

Affiliation: University of Warwick
Country: UK

Publications

  1. ncbi request reprint Analysis of the MDM2 antagonist nutlin-3 in human prostate cancer cells
    Ian R Logan
    Northern Institute for Cancer Research, Newcastle University, Paul O Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne, UK
    Prostate 67:900-6. 2007
  2. pmc Human PIRH2 enhances androgen receptor signaling through inhibition of histone deacetylase 1 and is overexpressed in prostate cancer
    Ian R Logan
    University of Newcastle upon Tyne, Northern Institute for Cancer Research, Paul O Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
    Mol Cell Biol 26:6502-10. 2006
  3. ncbi request reprint Expression of Tip60, an androgen receptor coactivator, and its role in prostate cancer development
    Kalipso Halkidou
    1Prostate Research Group, School of Surgical and Reproductive Sciences, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Oncogene 22:2466-77. 2003
  4. pmc Deubiquitinating enzyme Usp12 is a novel co-activator of the androgen receptor
    Urszula L Burska
    From the Solid Tumour Target Discovery Laboratory, Newcastle Cancer Centre, Northern Institute for Cancer Research, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Biol Chem 288:32641-50. 2013
  5. pmc Heat shock factor-1 modulates p53 activity in the transcriptional response to DNA damage
    Ian R Logan
    Northern Institute for Cancer Research, Newcastle University, Medical School, Newcastle upon Tyne, UK
    Nucleic Acids Res 37:2962-73. 2009
  6. ncbi request reprint Control of human PIRH2 protein stability: involvement of TIP60 and the proteosome
    Ian R Logan
    Northern Institute for Cancer Research, School of Surgical and Reproductive Sciences, Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Biol Chem 279:11696-704. 2004
  7. ncbi request reprint Cellular functions of TIP60
    Vasileia Sapountzi
    Northern Institute for Cancer Research, Paul O Gorman Building, Medical School, Framlington Place, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom
    Int J Biochem Cell Biol 38:1496-509. 2006
  8. ncbi request reprint Phosphorylation of Tat-interactive protein 60 kDa by protein kinase C epsilon is important for its subcellular localisation
    Vasileia Sapountzi
    Surgical Oncology Laboratory, Northern Institute for Cancer Research, Paul O Gorman Building, Framlington Place, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Int J Biochem Cell Biol 40:236-44. 2008
  9. ncbi request reprint Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor
    Luke Gaughan
    Prostate Research Group, School of Surgical Sciences, University of Newcastle upon Tyne, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Biol Chem 277:25904-13. 2002
  10. pmc Regulation of androgen receptor and histone deacetylase 1 by Mdm2-mediated ubiquitylation
    Luke Gaughan
    Prostate Research Group, Northern Institute for Cancer Research Paul, O Gorman Building University of Newcastle Upon Tyne, Medical School Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Nucleic Acids Res 33:13-26. 2005

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Analysis of the MDM2 antagonist nutlin-3 in human prostate cancer cells
    Ian R Logan
    Northern Institute for Cancer Research, Newcastle University, Paul O Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne, UK
    Prostate 67:900-6. 2007
    ..We compared the efficacy of nutlin-3 in three prostate cancer cell types and provide an insight into the mechanism of nutlin-3...
  2. pmc Human PIRH2 enhances androgen receptor signaling through inhibition of histone deacetylase 1 and is overexpressed in prostate cancer
    Ian R Logan
    University of Newcastle upon Tyne, Northern Institute for Cancer Research, Paul O Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
    Mol Cell Biol 26:6502-10. 2006
    ..0001 and 0.0004, respectively). Collectively, our data establish hPIRH2 as a key modulator of AR function, opening a new direction for targeted therapy in aggressive human prostate cancer...
  3. ncbi request reprint Expression of Tip60, an androgen receptor coactivator, and its role in prostate cancer development
    Kalipso Halkidou
    1Prostate Research Group, School of Surgical and Reproductive Sciences, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Oncogene 22:2466-77. 2003
    ..Thus, in vitro and in vivo data support a possible role for Tip60 in the molecular pathway leading to the development of androgen-independent CaP following long-term androgen deprivation therapy...
  4. pmc Deubiquitinating enzyme Usp12 is a novel co-activator of the androgen receptor
    Urszula L Burska
    From the Solid Tumour Target Discovery Laboratory, Newcastle Cancer Centre, Northern Institute for Cancer Research, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Biol Chem 288:32641-50. 2013
    ..Our data show that Usp12 acts in a pro-proliferative manner by stabilizing AR and enhancing its cellular function. ..
  5. pmc Heat shock factor-1 modulates p53 activity in the transcriptional response to DNA damage
    Ian R Logan
    Northern Institute for Cancer Research, Newcastle University, Medical School, Newcastle upon Tyne, UK
    Nucleic Acids Res 37:2962-73. 2009
    ..Our data reveal HSF1 as a key transcriptional regulator in response to genotoxic compounds widely used in the clinical setting, and suggest that HSF1 will contribute to the efficacy of these agents...
  6. ncbi request reprint Control of human PIRH2 protein stability: involvement of TIP60 and the proteosome
    Ian R Logan
    Northern Institute for Cancer Research, School of Surgical and Reproductive Sciences, Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Biol Chem 279:11696-704. 2004
    ..These results suggest that hPIRH2 activities can be controlled, at the post-translational level, in multiple ways...
  7. ncbi request reprint Cellular functions of TIP60
    Vasileia Sapountzi
    Northern Institute for Cancer Research, Paul O Gorman Building, Medical School, Framlington Place, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom
    Int J Biochem Cell Biol 38:1496-509. 2006
    ..Here, we describe how TIP60 is a multifunctional enzyme involved in multiple nuclear transactions...
  8. ncbi request reprint Phosphorylation of Tat-interactive protein 60 kDa by protein kinase C epsilon is important for its subcellular localisation
    Vasileia Sapountzi
    Surgical Oncology Laboratory, Northern Institute for Cancer Research, Paul O Gorman Building, Framlington Place, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Int J Biochem Cell Biol 40:236-44. 2008
    ..Regulation of the subcellular localisation of Tat-interactive protein 60 kDa via phosphorylation provides a novel means of controlling Tat-interactive protein 60 kDa function...
  9. ncbi request reprint Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor
    Luke Gaughan
    Prostate Research Group, School of Surgical Sciences, University of Newcastle upon Tyne, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Biol Chem 277:25904-13. 2002
    ....
  10. pmc Regulation of androgen receptor and histone deacetylase 1 by Mdm2-mediated ubiquitylation
    Luke Gaughan
    Prostate Research Group, Northern Institute for Cancer Research Paul, O Gorman Building University of Newcastle Upon Tyne, Medical School Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Nucleic Acids Res 33:13-26. 2005
    ..In all, our data indicates a novel role for Mdm2 in regulating components of the AR transcriptosome...