Pamela A Lochhead

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi Activation-loop autophosphorylation is mediated by a novel transitional intermediate form of DYRKs
    Pamela A Lochhead
    The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, Scotland, United Kingdom
    Cell 121:925-36. 2005
  2. ncbi A chaperone-dependent GSK3beta transitional intermediate mediates activation-loop autophosphorylation
    Pamela A Lochhead
    The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow, G61 1BD
    Mol Cell 24:627-33. 2006
  3. ncbi dDYRK2 and Minibrain interact with the chromatin remodelling factors SNR1 and TRX
    Ross Kinstrie
    The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, Scotland, UK
    Biochem J 398:45-54. 2006
  4. ncbi dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila
    Pamela A Lochhead
    The Beatson Institute for Cancer Research, Cancer Research UK, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
    Biochem J 374:381-91. 2003
  5. ncbi Insulin regulation of insulin-like growth factor-binding protein-1 gene expression is dependent on the mammalian target of rapamycin, but independent of ribosomal S6 kinase activity
    Satish Patel
    Division of Cellular Signalling, School of Life Sciences, Wellcome Trust Biocentre Medical Sciences Institute Complex, Dow Street, University of Dundee, Dundee DD1 5EH, United Kingdom
    J Biol Chem 277:9889-95. 2002

Collaborators

Detail Information

Publications5

  1. ncbi Activation-loop autophosphorylation is mediated by a novel transitional intermediate form of DYRKs
    Pamela A Lochhead
    The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, Scotland, United Kingdom
    Cell 121:925-36. 2005
    ..The intermediate's characteristics are lost upon completion of translation, making the critical tyrosine autophosphorylation a "one-off" inceptive event. This mechanism is likely to be shared with other kinases...
  2. ncbi A chaperone-dependent GSK3beta transitional intermediate mediates activation-loop autophosphorylation
    Pamela A Lochhead
    The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow, G61 1BD
    Mol Cell 24:627-33. 2006
    ....
  3. ncbi dDYRK2 and Minibrain interact with the chromatin remodelling factors SNR1 and TRX
    Ross Kinstrie
    The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, Scotland, UK
    Biochem J 398:45-54. 2006
    ..This is the first instance of phosphorylation of SNR1 or any of its homologues and implicates the DYRK family of kinases with a role in chromatin remodelling...
  4. ncbi dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila
    Pamela A Lochhead
    The Beatson Institute for Cancer Research, Cancer Research UK, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
    Biochem J 374:381-91. 2003
    ..Finally, dDYRK2 is active at all stages of fly development, with elevated levels observed during embryogenesis and pupation...
  5. ncbi Insulin regulation of insulin-like growth factor-binding protein-1 gene expression is dependent on the mammalian target of rapamycin, but independent of ribosomal S6 kinase activity
    Satish Patel
    Division of Cellular Signalling, School of Life Sciences, Wellcome Trust Biocentre Medical Sciences Institute Complex, Dow Street, University of Dundee, Dundee DD1 5EH, United Kingdom
    J Biol Chem 277:9889-95. 2002
    ..Therefore, although the insulin-responsive sequence of the G6Pase gene promoter is related to that of the IGFBP-1 promoter, the signaling pathways that mediate suppression of these genes are distinct...