Emyr Lloyd-Evans

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium
    Emyr Lloyd-Evans
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, UK
    Nat Med 14:1247-55. 2008
  2. ncbi Lipids on trial: the search for the offending metabolite in Niemann-Pick type C disease
    Emyr Lloyd-Evans
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Traffic 11:419-28. 2010
  3. ncbi Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking
    Margarida Ruas
    Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK
    Curr Biol 20:703-9. 2010
  4. ncbi Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease
    Anthony J Morgan
    Department of Pharmacology, University of Oxford, U K
    Biochem J 439:349-74. 2011
  5. ncbi Beneficial effects of substrate reduction therapy in a mouse model of GM1 gangliosidosis
    Elena Elliot-Smith
    Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Mol Genet Metab 94:204-11. 2008
  6. ncbi Endolysosomal calcium regulation and disease
    Emyr Lloyd-Evans
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Biochem Soc Trans 38:1458-64. 2010

Collaborators

Detail Information

Publications6

  1. ncbi Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium
    Emyr Lloyd-Evans
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, UK
    Nat Med 14:1247-55. 2008
    ..This unique calcium phenotype represents a new target for therapeutic intervention, as elevation of cytosolic calcium with curcumin normalized NPC1 disease cellular phenotypes and prolonged survival of the NPC1 mouse...
  2. ncbi Lipids on trial: the search for the offending metabolite in Niemann-Pick type C disease
    Emyr Lloyd-Evans
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Traffic 11:419-28. 2010
    ..We review the potential role of each of the individual storage lipids in initiating the pathogenic cascade and propose a model of NPC1 and NPC2 function based on the current knowledge...
  3. ncbi Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking
    Margarida Ruas
    Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK
    Curr Biol 20:703-9. 2010
    ..We propose that NAADP regulates endolysosomal Ca(2+) storage and release via TPCs and coordinates endoplasmic reticulum Ca(2+) release in a role that impacts on Ca(2+) signaling in health and disease [6]...
  4. ncbi Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease
    Anthony J Morgan
    Department of Pharmacology, University of Oxford, U K
    Biochem J 439:349-74. 2011
    ..These developments underscore a new central role for the endolysosomal system in cellular Ca2+ regulation and signalling...
  5. ncbi Beneficial effects of substrate reduction therapy in a mouse model of GM1 gangliosidosis
    Elena Elliot-Smith
    Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Mol Genet Metab 94:204-11. 2008
    ..However, functional improvement was greatest with NB-DNJ treatment which may potentially be caused by novel anti-inflammatory properties of NB-DNJ...
  6. ncbi Endolysosomal calcium regulation and disease
    Emyr Lloyd-Evans
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Biochem Soc Trans 38:1458-64. 2010
    ..In the present review, we provide a summary of the current knowledge on mechanisms of calcium homoeostasis within the endolysosomal system and how these mechanisms may be affected in human metabolic disorders...