J Little

Summary

Affiliation: University of Aberdeen
Country: UK

Publications

  1. ncbi request reprint Colon cancer and genetic variation in folate metabolism: the clinical bottom line
    Julian Little
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, UK
    J Nutr 133:3758S-3766S. 2003
  2. ncbi request reprint Smoking and orofacial clefts: a United Kingdom-based case-control study
    J Little
    University of Aberdeen, Aberdeen, Scotland
    Cleft Palate Craniofac J 41:381-6. 2004
  3. ncbi request reprint Epidemiology of neurodevelopmental disorders in children
    J Little
    Department of Medicine and Therapeutics, Epidemiology Group, Aberdeen, UK
    Prostaglandins Leukot Essent Fatty Acids 63:11-20. 2000
  4. ncbi request reprint Colorectal neoplasia and genetic polymorphisms associated with folate metabolism
    J Little
    Department of Medicine and Therapeutics, University of Aberdeen Medical School, Polwarth Building, Foresterhill, Aberdeen, Scotland, AB25 2ZD, UK
    Eur J Cancer Prev 11:105-10. 2002
  5. ncbi request reprint Cytochrome P-450 1A1 gene polymorphisms and risk of breast cancer: a HuGE review
    L F Masson
    Epidemiology Group, Department of Public Health, University of Aberdeen, Aberdeen, Scotland
    Am J Epidemiol 161:901-15. 2005
  6. pmc Psychological effects of a low-grade abnormal cervical smear test result: anxiety and associated factors
    N M Gray
    Department of General Practice and Primary Care, Foresterhill Health Centre, University of Aberdeen and Grampian University Hospitals, Aberdeen, UK
    Br J Cancer 94:1253-62. 2006
  7. ncbi request reprint N-acetyltransferase polymorphisms and colorectal cancer: a HuGE review
    N Brockton
    Department of Medicine and Therapeutics, University of Aberdeen, Scotland, United Kingdom
    Am J Epidemiol 151:846-61. 2000
  8. doi request reprint Global oral health inequalities: challenges in the prevention and management of orofacial clefts and potential solutions
    P A Mossey
    University of Dundee Dental Hospital and School, Scotland, UK
    Adv Dent Res 23:247-58. 2011
  9. pmc Lifestyle and socio-demographic factors associated with high-risk HPV infection in UK women
    S C Cotton
    Department of Public Health, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, Scotland
    Br J Cancer 97:133-9. 2007
  10. ncbi request reprint Folate and breast cancer: the role of polymorphisms in methylenetetrahydrofolate reductase (MTHFR)
    L Sharp
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill House Annex, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Cancer Lett 181:65-71. 2002

Detail Information

Publications53

  1. ncbi request reprint Colon cancer and genetic variation in folate metabolism: the clinical bottom line
    Julian Little
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, UK
    J Nutr 133:3758S-3766S. 2003
    ....
  2. ncbi request reprint Smoking and orofacial clefts: a United Kingdom-based case-control study
    J Little
    University of Aberdeen, Aberdeen, Scotland
    Cleft Palate Craniofac J 41:381-6. 2004
    ..To investigate the association between smoking and orofacial clefts in the United Kingdom...
  3. ncbi request reprint Epidemiology of neurodevelopmental disorders in children
    J Little
    Department of Medicine and Therapeutics, Epidemiology Group, Aberdeen, UK
    Prostaglandins Leukot Essent Fatty Acids 63:11-20. 2000
    ..The analytical epidemiology of other neurodevelopmental disorders is less well understood. Study design issues are discussed in relation to mental and behavioural disorders...
  4. ncbi request reprint Colorectal neoplasia and genetic polymorphisms associated with folate metabolism
    J Little
    Department of Medicine and Therapeutics, University of Aberdeen Medical School, Polwarth Building, Foresterhill, Aberdeen, Scotland, AB25 2ZD, UK
    Eur J Cancer Prev 11:105-10. 2002
  5. ncbi request reprint Cytochrome P-450 1A1 gene polymorphisms and risk of breast cancer: a HuGE review
    L F Masson
    Epidemiology Group, Department of Public Health, University of Aberdeen, Aberdeen, Scotland
    Am J Epidemiol 161:901-15. 2005
    ....
  6. pmc Psychological effects of a low-grade abnormal cervical smear test result: anxiety and associated factors
    N M Gray
    Department of General Practice and Primary Care, Foresterhill Health Centre, University of Aberdeen and Grampian University Hospitals, Aberdeen, UK
    Br J Cancer 94:1253-62. 2006
    ....
  7. ncbi request reprint N-acetyltransferase polymorphisms and colorectal cancer: a HuGE review
    N Brockton
    Department of Medicine and Therapeutics, University of Aberdeen, Scotland, United Kingdom
    Am J Epidemiol 151:846-61. 2000
    ....
  8. doi request reprint Global oral health inequalities: challenges in the prevention and management of orofacial clefts and potential solutions
    P A Mossey
    University of Dundee Dental Hospital and School, Scotland, UK
    Adv Dent Res 23:247-58. 2011
    ..The future research agenda also requires engagement with implementation science to get research findings into practice...
  9. pmc Lifestyle and socio-demographic factors associated with high-risk HPV infection in UK women
    S C Cotton
    Department of Public Health, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, Scotland
    Br J Cancer 97:133-9. 2007
    ..In stratified analyses, current smear status and age remained associated with hrHPV infection. Data of this type are relevant to the debate on human papillomavirus (HPV) testing in screening and development of HPV vaccination programmes...
  10. ncbi request reprint Folate and breast cancer: the role of polymorphisms in methylenetetrahydrofolate reductase (MTHFR)
    L Sharp
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill House Annex, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Cancer Lett 181:65-71. 2002
    ..Patterns in risk with regard to genotype and folate combinations are broadly similar those reported for colorectal neoplasia. The roles of MTHFR and folate in breast cancer aetiology are likely to be complex...
  11. doi request reprint The role of human papillomavirus testing in the management of women with low-grade abnormalities: multicentre randomised controlled trial
    S Cotton
    Department of Public Health, University of Aberdeen, Aberdeen, UK
    BJOG 117:645-59. 2010
    ....
  12. ncbi request reprint A high frequency of the MTHFR 677C>T polymorphism in Scottish women with epilepsy: possible role in pathogenesis
    J C S Dean
    University of Aberdeen, Aberdeen, Scotland, United Kingdom
    Seizure 17:269-75. 2008
    ..The MTHFR 677C>T polymorphism may be a susceptibility factor for epilepsy, and its higher frequency in women with epilepsy may contribute to the increased risk of malformation in children of women with epilepsy...
  13. ncbi request reprint CYP17 gene polymorphisms: prevalence and associations with hormone levels and related factors. a HuGE review
    L Sharp
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, United Kingdom
    Am J Epidemiol 160:729-40. 2004
    ..Further investigation of relations between genotype and hormone levels, exogenous hormone use, and markers of hormonal status may advance understanding of hormonally mediated diseases...
  14. pmc Impact of deprivation and rural residence on treatment of colorectal and lung cancer
    N C Campbell
    Department of General Practice and Primary Care, Foresterhill Health Centre, Westburn Road, Aberdeen AB25 2AY, UK
    Br J Cancer 87:585-90. 2002
    ..03 to 1.64). These findings suggest that socio-economic status and rurality may have a minor impact on modalities of treatment for colorectal and lung cancer, but do not lead to delays between referral and treatment...
  15. ncbi request reprint Developing a questionnaire to measure the psychosocial impact of an abnormal cervical smear result and its subsequent management: the TOMBOLA (Trial of Management of Borderline and Other Low-grade Abnormal Smears) trial
    N M Gray
    Department of Public Health, University of Aberdeen, Foresterhill, Aberdeen, UK
    Qual Life Res 14:1553-62. 2005
    ..The POSM will enable comparison of the alternative management policies for low-grade cervical smears in terms of the benefits (or otherwise) perceived by the women managed by these policies...
  16. ncbi request reprint Glutathione S-transferase polymorphisms and colorectal cancer: a HuGE review
    S C Cotton
    Department of Medicine and Therapeutics, Faculty of Medicine and Medical Sciences, University of Aberdeen, Scotland
    Am J Epidemiol 151:7-32. 2000
    ..These finding require confirmation. Methods for determining GSTM1 and GSTT1 genotype are well established. Population testing is not currently justified...
  17. pmc Long term health and neurodevelopment in children exposed to antiepileptic drugs before birth
    J C S Dean
    Department of Medical Genetics, Medical School, Foresterhill, Aberdeen AB25 2ZD, UK
    J Med Genet 39:251-9. 2002
    ..To investigate the frequency of neonatal and later childhood morbidity in children exposed to antiepileptic drugs in utero...
  18. pmc Systematic review of cancer treatment programmes in remote and rural areas
    N C Campbell
    Department of General Practice and Primary Care, Foresterhill Health Centre, Aberdeen, UK
    Br J Cancer 80:1275-80. 1999
    ..Tele-oncology, by which some consultations are conducted using televideo, may be an acceptable adjunct. Larger and more methodologically robust studies are justified and should be conducted...
  19. ncbi request reprint Maternal medication use and the risk of brain tumors in the offspring: the SEARCH international case-control study
    Amanda H Cardy
    Department of Public Health, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, United Kingdom
    Int J Cancer 118:1302-8. 2006
    ..This is the largest case-control study of CBT and maternal medications to date. Our data provide little support for an association between maternal use of medications that may form NOC and subsequent development of CBT in the offspring...
  20. ncbi request reprint Refining the management of low-grade cervical abnormalities in the UK National Health Service and defining the potential for human papillomavirus testing: a commentary on emerging evidence
    Elaine Bentley
    University of Nottingham Medical School at Derby, Derby City General Hospital, UK
    J Low Genit Tract Dis 10:26-38. 2006
  21. ncbi request reprint Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intake
    Linda Sharp
    Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen AB25 2ZD, UK
    Br J Nutr 99:379-89. 2008
    ..Investigation of particular folate vitamers (for example, tetrahydrofolate, 5,10-methylenetetrahydrofolate) may help clarify carcinogenesis pathways...
  22. ncbi request reprint Trial of management of borderline and other low-grade abnormal smears (TOMBOLA): Trial design
    Seonaidh C Cotton
    Department of Public Health, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, AB25 2ZD, UK
    Contemp Clin Trials 27:449-71. 2006
    ..This paper describes the design of the trial, and discusses the rationale underlying aspects of the design and the challenges faced in designing and implementing the trial...
  23. ncbi request reprint Colorectal cancer and genetic polymorphisms of CYP1A1, GSTM1 and GSTT1: a case-control study in the Grampian region of Scotland
    Julian Little
    Epidemiology Group, Department of Public Health, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, UK
    Int J Cancer 119:2155-64. 2006
    ..There was no evidence of interaction between CYP1A1 and smoking, and no evidence of interaction between the GSTM1 or GSTT1 polymorphisms and smoking, meat intake, green leafy vegetable intake, CYP1A1 variants or each other...
  24. ncbi request reprint Prevention of orofacial clefts: does pregnancy planning have a role?
    Peter A Mossey
    University of Dundee, Dental School, Scotland, UK
    Cleft Palate Craniofac J 44:244-50. 2007
    ..To investigate the association between pregnancy planning and orofacial clefts in the United Kingdom...
  25. doi request reprint Folate intake, markers of folate status and oral clefts: is the evidence converging?
    Candice Y Johnson
    Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Canada
    Int J Epidemiol 37:1041-58. 2008
    ..The purpose of this systematic review and meta-analysis was to assemble evidence on the role of folate in the aetiology of cleft lip with or without cleft palate (CL/P) and cleft palate only (CPO)...
  26. ncbi request reprint United Kingdom cervical cancer screening and the costs of time and travel
    Claire Woolley
    University of Nottingham, UK
    Int J Technol Assess Health Care 23:232-9. 2007
    ....
  27. ncbi request reprint Relation of childhood brain tumors to exposure of parents and children to tobacco smoke: the SEARCH international case-control study. Surveillance of Environmental Aspects Related to Cancer in Humans
    Graziella Filippini
    Neuroepidemiology Research Unit, Istituto Nazionale Neurologico C Besta, Milan, Italy
    Int J Cancer 100:206-13. 2002
    ..These results did not change considering the child's age at diagnosis, the histologic type of tumor or center...
  28. ncbi request reprint Fetal anticonvulsant syndromes and polymorphisms in MTHFR, MTR, and MTRR
    John Dean
    Department of Medical Genetics, Clinical Genetics Centre, University of Aberdeen, Aberdeen, Scotland, United Kingdom
    Am J Med Genet A 143:2303-11. 2007
    ..MTR 2756A > G and MTRR 66A > G genotype frequencies in children with FACS and neurodevelopmental disorder were different from those in healthy blood donor controls...
  29. ncbi request reprint How many genes underlie the occurrence of common complex diseases in the population?
    Quanhe Yang
    National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention CDC, Atlanta, GA 30333, USA
    Int J Epidemiol 34:1129-37. 2005
    ..It is not clear how many genes are necessary to account for an appreciable population-attributable fraction of these diseases...
  30. ncbi request reprint The role of cytokine gene polymorphisms in colorectal cancer and their interaction with aspirin use in the northeast of Scotland
    Mairi Macarthur
    Department of Medicine and Therapeutics, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:1613-8. 2005
    ..These results suggest that host genetics may play a role in predicting response to chemopreventive strategies. Confirmation of these findings in other populations is required...
  31. ncbi request reprint Asymptomatic colorectal neoplasia and fecal characteristics: a case-control study of subjects participating in the nottingham fecal occult blood screening trial
    Julian Little
    Epidemiology Group, Department of Medicine and Therapeutics, Aberdeen University Medical School, United Kingdom
    Dis Colon Rectum 45:1233-41. 2002
    ..We sought to test hypotheses relating to fecal bile acids, calcium, and pH in a large sample of asymptomatic subjects who had participated in fecal occult blood screening...
  32. ncbi request reprint Reporting, appraising, and integrating data on genotype prevalence and gene-disease associations
    Julian Little
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, Scotland
    Am J Epidemiol 156:300-10. 2002
    ....
  33. ncbi request reprint Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review
    Linda Sharp
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Scotland, UK
    Am J Epidemiol 159:423-43. 2004
    ..Overall, the roles of folate-pathway genes, folate, and related dietary factors in colorectal neoplasia are complex. Research priorities are suggested...
  34. pmc Tobacco smoking and oral clefts: a meta-analysis
    Julian Little
    Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill, Scotland
    Bull World Health Organ 82:213-8. 2004
    ..To examine the association between maternal smoking and non-syndromic orofacial clefts in infants...
  35. ncbi request reprint Associations between two common variants C677T and A1298C in the methylenetetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (strand breaks, misincorporated uracil, and DNA methylation status) in human lymphocytes in vivo
    Sabrina Narayanan
    Division of Cellular Integrity, Rowett Research Institute, Bucksburn, Aberdeen, United Kingdom
    Cancer Epidemiol Biomarkers Prev 13:1436-43. 2004
    ....
  36. ncbi request reprint Low dose aspirin, COX-inhibition and chemoprevention of colorectal cancer
    Robert Benamouzig
    Department of Gastro enterology, Hopital Avicenne, 125 rue de Stalingrad, 93009 Bobigny Cedex, France
    Curr Top Med Chem 5:493-503. 2005
    ..Four RCTs of the effect of aspirin on adenoma recurrence are available. Other trials are currently underway...
  37. ncbi request reprint Folate, DNA stability and colo-rectal neoplasia
    Susan J Duthie
    Division of Cellular Integrity, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    Proc Nutr Soc 63:571-8. 2004
    ..Evidence from animal and human studies is presented here in support of folate acting to maintain genomic stability through both these mechanisms...
  38. ncbi request reprint Occupational risk factors for low grade and high grade glioma: results from an international case control study of adult brain tumours
    Brigitte Schlehofer
    Unit of Environmental Epidemiology, German Cancer Research Centre, Heidelberg, Germany
    Int J Cancer 113:116-25. 2005
    ..Although some other point estimates were elevated, they lacked statistical significance. The results do not provide evidence of a strong association between occupational exposures and glioma development...
  39. ncbi request reprint [The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies]
    Erik von Elm
    Institute of Social and Preventive Medicine ISPM, University of Bern, Berna, Suiza
    Rev Esp Salud Publica 82:251-9. 2008
    ..We hope that the STROBE statement will contribute to improving the quality of reporting of observational studies...
  40. ncbi request reprint Polymorphisms of adrenergic receptors and the risk of heart failure
    Julian Little
    N Engl J Med 348:468-70; author reply 468-70. 2003
  41. ncbi request reprint [The Strengthening the Reporting of Observational Studies in Epidemiology [STROBE] statement: guidelines for reporting observational studies]
    Erik von Elm
    Institute of Social and Preventive Medicine ISPM, University of Bern, Berna, Switzerland
    Gac Sanit 22:144-50. 2008
    ..We hope that the STROBE statement will contribute to improving the quality of reporting of observational studies...
  42. doi request reprint Genome-wide association studies for complex traits: consensus, uncertainty and challenges
    Mark I McCarthy
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Rev Genet 9:356-69. 2008
    ....
  43. ncbi request reprint Daily soluble aspirin and prevention of colorectal adenoma recurrence: one-year results of the APACC trial
    Robert Benamouzig
    Department of Gastroenterology, Avicenne Hospital, AP HP, Paris 13 University, Bobigny Cedex, France
    Gastroenterology 125:328-36. 2003
    ..Epidemiologic and experimental studies have suggested that aspirin intake reduces the risk for colorectal carcinogenesis. However, the available data are not sufficient to serve as the basis for firm recommendations...
  44. ncbi request reprint Mendelian randomisation: a new spin or real progress?
    Julian Little
    Office of Genomics and Disease Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Lancet 362:930-1. 2003
  45. ncbi request reprint Assessment of cumulative evidence on genetic associations: interim guidelines
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Int J Epidemiol 37:120-32. 2008
    ..Future empirical research and consensus development are needed to develop an integrated model for combining epidemiological and biological evidence in the rapidly evolving field of investigation of genetic factors...
  46. ncbi request reprint An epidemiologic assessment of genomic profiling for measuring susceptibility to common diseases and targeting interventions
    Muin J Khoury
    Office of Genomics and Disease Prevention, Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Genet Med 6:38-47. 2004
    ....
  47. ncbi request reprint Turning the pump handle: evolving methods for integrating the evidence on gene-disease association
    Julian P T Higgins
    Am J Epidemiol 166:863-6. 2007
  48. pmc CYP17 and breast cancer: no overall effect, but what about interactions?
    Julian Little
    Canada Research Chair in Human Genome Epidemiology, Department of Epidemiology and Community Medicine, University of Ottawa, Ontario, Canada
    Breast Cancer Res 7:238-42. 2005
    ....
  49. ncbi request reprint A road map for efficient and reliable human genome epidemiology
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, and Biomedical Research Institute, Foundation for Research and Technology Hellas, Ioannina 45110, Greece
    Nat Genet 38:3-5. 2006
    ..Systematic reviews will be expanded to include more meta-analyses of individual-level data and prospective meta-analyses. Field synopses will offer regularly updated overviews...
  50. ncbi request reprint The emergence of epidemiology in the genomics age
    Muin J Khoury
    Office of Genomics and Disease Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Int J Epidemiol 33:936-44. 2004
  51. ncbi request reprint On the synthesis and interpretation of consistent but weak gene-disease associations in the era of genome-wide association studies
    Muin J Khoury
    National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Int J Epidemiol 36:439-45. 2007
    ..Efforts by the Human Genome Epidemiology Network (HuGENet) are currently ongoing to streamline and operationalize these criteria for data on genetic associations with common diseases...
  52. ncbi request reprint The epidemiologic approach to pharmacogenomics
    Julian Little
    Department of Epidemiology and Community Medicine, University of Ottawa, 451 Smyth Rd, Ottawa, Ontario K1H 8M5, Canada
    Am J Pharmacogenomics 5:1-20. 2005
    ....
  53. pmc Reporting of systematic reviews: the challenge of genetic association studies
    Muin J Khoury
    PLoS Med 4:e211. 2007