B J Lipworth

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. doi request reprint Targeting the small airways asthma phenotype: if we can reach it, should we treat it?
    Brian Lipworth
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, Dundee, Scotland
    Ann Allergy Asthma Immunol 110:233-9. 2013
  2. doi request reprint Tailored second-line therapy in asthmatic children with the Arg(16) genotype
    Brian J Lipworth
    Asthma and Allergy Research Group, Division of Medicine and Therapeutics, University of Dundee, Dundee DD2 4BF, Scotland, UK
    Clin Sci (Lond) 124:521-8. 2013
  3. pmc Pharmacokinetics of chlorofluorocarbon and hydrofluoroalkane metered-dose inhaler formulations of beclomethasone dipropionate
    B J Lipworth
    Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, Scotland, UK
    Br J Clin Pharmacol 48:866-8. 1999
  4. ncbi request reprint Dose-response comparison of budesonide dry powder inhalers using adenosine monophosphate bronchial challenge
    Brian J Lipworth
    Asthma and Allergy Research Group, Division of Medicine and Therapeutics, Ninewells University Hospital and Medical School, University of Dundee, Dundee, Scotland
    Ann Allergy Asthma Immunol 94:675-81. 2005
  5. ncbi request reprint Bronchodilator response to albuterol after regular formoterol and effects of acute corticosteroid administration
    B J Lipworth
    Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Chest 117:156-62. 2000
  6. ncbi request reprint Asthma and Cushing's syndrome
    A M Wilson
    Departments of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
    Chest 117:593-4. 2000
  7. ncbi request reprint Safety of inhaled and intranasal corticosteroids: lessons for the new millennium
    B J Lipworth
    Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Scotland
    Drug Saf 23:11-33. 2000
  8. ncbi request reprint The comparative safety/efficacy ratio of HFA-BDP
    B J Lipworth
    Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, UK
    Respir Med 94:S21-6. 2000
  9. ncbi request reprint Relationship between changes in quality of life and measures of lung function and bronchial hyper-responsiveness during high-dose inhaled corticosteroid treatment in uncontrolled asthma
    Linda C Orr
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Am J Respir Med 2:433-8. 2003
  10. ncbi request reprint Systemic adverse effects of inhaled corticosteroid therapy: A systematic review and meta-analysis
    B J Lipworth
    Department of Clinical Pharmacology and Therapeutics and Respiratory Medicine, Ninewells Hospital and Medical School, University of Dundee, Scotland
    Arch Intern Med 159:941-55. 1999

Collaborators

Detail Information

Publications137 found, 100 shown here

  1. doi request reprint Targeting the small airways asthma phenotype: if we can reach it, should we treat it?
    Brian Lipworth
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, Dundee, Scotland
    Ann Allergy Asthma Immunol 110:233-9. 2013
    ..To review the available methods of evaluating the small airways disease in asthma and the therapeutic strategies to achieve better control using emerging extrafine particle inhaler technologies...
  2. doi request reprint Tailored second-line therapy in asthmatic children with the Arg(16) genotype
    Brian J Lipworth
    Asthma and Allergy Research Group, Division of Medicine and Therapeutics, University of Dundee, Dundee DD2 4BF, Scotland, UK
    Clin Sci (Lond) 124:521-8. 2013
    ..In conclusion, montelukast may be suitable as tailored second-line controller therapy instead of salmeterol in asthmatic children expressing the susceptible Arg(16) genotype, a move towards a personalized medicine approach to management...
  3. pmc Pharmacokinetics of chlorofluorocarbon and hydrofluoroalkane metered-dose inhaler formulations of beclomethasone dipropionate
    B J Lipworth
    Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, Scotland, UK
    Br J Clin Pharmacol 48:866-8. 1999
    ..To compare the pharmacokinetic profile of Beclazone (beclomethasone dipropionate) in its chlorofluorocarbon (CFC)-based and CFC-free formulations...
  4. ncbi request reprint Dose-response comparison of budesonide dry powder inhalers using adenosine monophosphate bronchial challenge
    Brian J Lipworth
    Asthma and Allergy Research Group, Division of Medicine and Therapeutics, Ninewells University Hospital and Medical School, University of Dundee, Dundee, Scotland
    Ann Allergy Asthma Immunol 94:675-81. 2005
    ..Bronchial hyperresponsiveness to adenosine monophosphate, an indirect measure of airway inflammation, is a sensitive marker of inhaled corticosteroid efficacy...
  5. ncbi request reprint Bronchodilator response to albuterol after regular formoterol and effects of acute corticosteroid administration
    B J Lipworth
    Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Chest 117:156-62. 2000
    ..There is controversy about the development of bronchodilator subsensitivity after regular administration of long-acting beta(2)-agonists...
  6. ncbi request reprint Asthma and Cushing's syndrome
    A M Wilson
    Departments of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
    Chest 117:593-4. 2000
    ..Her appearance, mental state, and myopathy also improved with no loss of asthma control. This case illustrates the potential for developing clinically relevant adverse effects of inhaled corticosteroids when given at licensed doses...
  7. ncbi request reprint Safety of inhaled and intranasal corticosteroids: lessons for the new millennium
    B J Lipworth
    Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Scotland
    Drug Saf 23:11-33. 2000
    ..Prescribers of inhaled and intranasal corticosteroids should be aware of the potential for long term systemic effects. The safest way to use these drugs is to 'step-down' to achieve the lowest possible effective maintenance dosage...
  8. ncbi request reprint The comparative safety/efficacy ratio of HFA-BDP
    B J Lipworth
    Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, UK
    Respir Med 94:S21-6. 2000
    ..8). Thus, viewing the data as a whole, it would seem that, compared to CFC-BDP and alternative inhaled corticosteroids, HFA-BDP in a dose of up to 800 microg day(-1) exhibits a favourable therapeutic ratio...
  9. ncbi request reprint Relationship between changes in quality of life and measures of lung function and bronchial hyper-responsiveness during high-dose inhaled corticosteroid treatment in uncontrolled asthma
    Linda C Orr
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Am J Respir Med 2:433-8. 2003
    ..To examine the relationship between changes in quality of life and measures of lung function and bronchial hyper-responsiveness (BHR) during treatment with high-dose inhaled corticosteroids in patients with uncontrolled asthma...
  10. ncbi request reprint Systemic adverse effects of inhaled corticosteroid therapy: A systematic review and meta-analysis
    B J Lipworth
    Department of Clinical Pharmacology and Therapeutics and Respiratory Medicine, Ninewells Hospital and Medical School, University of Dundee, Scotland
    Arch Intern Med 159:941-55. 1999
    ..To appraise the data on systemic adverse effects of inhaled corticosteroids...
  11. ncbi request reprint Effects of genetic polymorphism on ex vivo and in vivo function of beta2-adrenoceptors in asthmatic patients
    B J Lipworth
    Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
    Chest 115:324-8. 1999
    ..Genetic polymorphism determines agonist-induced down-regulation and desensitization of beta2-adrenoceptors...
  12. ncbi request reprint Effect of ciclesonide and fluticasone on hypothalamic-pituitary-adrenal axis function in adults with mild-to-moderate persistent asthma
    Brian J Lipworth
    Allergy Research Group, Department of Medicine and Therapeutics, University of Dundee, Dundee, Scotland
    Ann Allergy Asthma Immunol 94:465-72. 2005
    ..Ciclesonide (hydrofluoroalkane propellant) is a novel inhaled corticosteroid with few, if any, clinical adverse events...
  13. ncbi request reprint Bronchoprotection with formoterol via dry powder and metered-dose inhalers in patients with asthma
    Brian J Lipworth
    Department of Medicine and Therapeutics Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland
    Ann Allergy Asthma Immunol 95:283-90. 2005
    ..Objective: To evaluate the methacholine bronchoprotection afforded by formoterol, 12 microg, delivered via Clickhaler and Aerolizer dry powder inhalers and a pressurized metered-dose inhaler (pMDI) in mild-to-moderate asthmatic patients...
  14. pmc Effect of plastic spacer handling on salbutamol lung deposition in asthmatic children
    Brian J Lipworth
    Asthma and Allergy Research Group, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    Br J Clin Pharmacol 54:544-7. 2002
    ..To study the effects of electrostatics in a plastic spacer on the lung deposition of salbutamol in asthmatic children...
  15. ncbi request reprint Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease
    Brian J Lipworth
    Department of Medicine and Therapeutics, Asthma and Allergy Research Group, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Lancet 365:167-75. 2005
    ..Ultimately, clinicians will want to know whether PDE4 inhibitors are anything more than expensive "designer" theophylline, the archetypal non-selective phosphodiesterase inhibitor...
  16. ncbi request reprint 5-Lipoxygenase polymorphism and in-vivo response to leukotriene receptor antagonists
    Stephen J Fowler
    Asthma and Allergy Research Group, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Eur J Clin Pharmacol 58:187-90. 2002
    ..To determine whether genetic polymorphisms of the core promoter region of the 5-lipoxygenase gene contribute to the clinical response to leukotriene receptor antagonists...
  17. ncbi request reprint Evaluation of salmeterol or montelukast as second-line therapy for asthma not controlled with inhaled corticosteroids
    A M Wilson
    Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Chest 119:1021-6. 2001
    ..CONCLUSIONS: Montelukast and salmeterol exhibited significant improvements in asthma control when given as second-line therapy. Montelukast also produced significant effects on AMP challenge and EOS suggesting anti-inflammatory activity...
  18. ncbi request reprint Effects of topical corticosteroid and combined mediator blockade on domiciliary and laboratory measurements of nasal function in seasonal allergic rhinitis
    A M Wilson
    Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
    Ann Allergy Asthma Immunol 87:344-9. 2001
    ..36). CONCLUSIONS: Both treatments were effective in managing allergic rhinitis symptoms, and patients' symptoms were more closely associated with domiciliary measurements of nasal flow than laboratory measurements of nasal function...
  19. ncbi request reprint Effects of low dose fluticasone/salmeterol combination on surrogate inflammatory markers in moderate persistent asthma
    G P Currie
    Asthma and Allergy Research Group Department of Pathology, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Allergy 58:602-7. 2003
    ..We wished to examine the effects of low dose fluticasone/salmeterol combination on different commonly used inflammatory markers in moderate persistent asthma...
  20. ncbi request reprint Effects of mediator antagonism on mannitol and adenosine monophosphate challenges
    G P Currie
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    Clin Exp Allergy 33:783-8. 2003
    ..Airway hyper-responsiveness (AHR) to indirect stimuli is a useful non-invasive surrogate inflammatory marker in the evaluation of asthma, while histamine and cysteinyl leukotrienes are important inflammatory mediators...
  21. pmc Dose-response for adrenal suppression with hydrofluoroalkane formulations of fluticasone propionate and beclomethasone dipropionate
    S J Fowler
    Asthma and Allergy Research Group, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY
    Br J Clin Pharmacol 52:93-5. 2001
    ..This suggests that the greater glucocorticoid potency of HFA-FP may be offset by the greater lung bioavailability of HFA-BDP...
  22. ncbi request reprint Differential anti-inflammatory effects of large and small particle size inhaled corticosteroids in asthma
    D Menzies
    Asthma and Allergy Research Group, University of Dundee, Dundee, UK
    Allergy 62:661-7. 2007
    ..There is little data comparing their effects on inflammation. We have evaluated the effects of HFA-BDP and CFC-BDP on pulmonary and systemic markers of asthmatic inflammation...
  23. ncbi request reprint Relationship between airway hyperresponsiveness to mannitol and adenosine monophosphate
    G P Currie
    Asthma and Allergy Research Group, Ninewells University Hospital and Medical School, Dundee, UK
    Allergy 58:762-6. 2003
    ..We investigated the putative relationship in AHR between inhaled adenosine monophosphate and mannitol...
  24. ncbi request reprint Combined mediator blockade or topical steroid for treating the unified allergic airway
    M L Barnes
    Asthma and Allergy Research Group, Department of Medicine and Therapeutics, Ninewells Hospital and Perth Royal Infirmary, University of Dundee, Dundee, UK
    Allergy 62:73-80. 2007
    ..Asthma and allergic rhinitis are manifestations of a single unified allergic airway, for which the best treatment is uncertain...
  25. doi request reprint Steroid sparing effects of intranasal corticosteroids in asthma and allergic rhinitis
    A Nair
    Asthma and Allergy Research Group, Department of Medicine and Therapeutics, Ninewells Hospital and Medical School and Perth Royal Infirmary, University of Dundee, Dundee, UK
    Allergy 65:359-67. 2010
    ..We conducted a dose ranging study in asthma and persistent allergic rhinitis to evaluate if intranasal corticosteroids exhibit a sparing effect on the dose of inhaled corticosteroid...
  26. doi request reprint Disconnect between standardized field-based testing and mannitol challenge in Scottish elite swimmers
    K L Clearie
    Asthma and Allergy Research Group, Department of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Clin Exp Allergy 40:731-7. 2010
    ..Elite swimmers have high rates of rhinoconjunctivitis and exercise-induced bronchoconstriction. Moreover, exposure to chlorine and chlorine metabolites is known to induce bronchial hyper-reactivity...
  27. ncbi request reprint A comparison of topical budesonide and oral montelukast in seasonal allergic rhinitis and asthma
    A M Wilson
    Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    Clin Exp Allergy 31:616-24. 2001
    ..Both treatments significantly reduced allergic rhinitis symptoms...
  28. ncbi request reprint Butterbur, a herbal remedy, confers complementary anti-inflammatory activity in asthmatic patients receiving inhaled corticosteroids
    D K C Lee
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Clin Exp Allergy 34:110-4. 2004
    ..The effects of butterbur (BB), a herbal remedy, as add-on therapy to inhaled corticosteroids in patients with atopic asthma is currently unknown...
  29. ncbi request reprint Functional antagonism with formoterol and salmeterol in asthmatic patients expressing the homozygous glycine-16 beta(2)-adrenoceptor polymorphism
    B J Lipworth
    Asthma and Allergy Research Group, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
    Chest 118:321-8. 2000
    ..The homozygous glycine-16 polymorphism of the beta(2)-adrenoceptor occurs in approximately 40% of patients and is known to predispose to agonist-induced downregulation and desensitization...
  30. ncbi request reprint Effects of montelukast on surrogate inflammatory markers in corticosteroid-treated patients with asthma
    Graeme P Currie
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Am J Respir Crit Care Med 167:1232-8. 2003
    ..Further studies are required to evaluate whether these effects of montelukast translate into clinical benefits...
  31. doi request reprint Airway dysfunction in nasal polyposis: a spectrum of asthmatic disease?
    P A Williamson
    Asthma and Allergy Research Group, Centre for Cardiovascular and Lung Biology, Division of Medical Sciences, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    Clin Exp Allergy 41:1379-85. 2011
    ..Chronic rhinosinusitis with nasal polyposis (CRSwNP) represents an interesting model to investigate the existence of a non-allergic unified airway. The factors associated with airway dysfunction in CRSwNP are not fully understood...
  32. doi request reprint Supervised step-down of inhaled corticosteroids in the community--an observational study
    K L Clearie
    Asthma and Allergy Research Group, Ninewells Hospital, University of Dundee, Dundee DD1 9SY, UK
    Respir Med 105:558-65. 2011
    ..Current asthma guidelines recommend step-down of inhaled corticosteroids (ICS) to the minimum dose required for control of symptoms...
  33. ncbi request reprint Pharmacokinetics, efficacy and adverse effects of sublingual salbutamol in patients with asthma
    B J Lipworth
    Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, UK
    Eur J Clin Pharmacol 37:567-71. 1989
    ..These results show that sublingual administration of salbutamol tablet has no clinical benefit over the oral route...
  34. ncbi request reprint Airway and systemic effects of hydrofluoroalkane formulations of high-dose ciclesonide and fluticasone in moderate persistent asthma
    Daniel K C Lee
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Chest 127:851-60. 2005
    ..There are no data comparing the relative effects of high-dose ciclesonide (CIC) and fluticasone propionate (FP) on airway and systemic outcomes in patients with moderate persistent asthma...
  35. pmc Comparison of combination inhalers vs inhaled corticosteroids alone in moderate persistent asthma
    Daniel K C Lee
    Asthma and Allergy Research Group, Department of Clinical Pharmacology, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY
    Br J Clin Pharmacol 56:494-500. 2003
    ....
  36. ncbi request reprint Comparative in vivo lung delivery of hydrofluoroalkane-salbutamol formulation via metered-dose inhaler alone, with plastic spacer, or with cardboard tube
    S J Fowler
    Asthma and Allergy Research Group, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Chest 119:1018-20. 2001
    ..If a spacer is required for reasons other than increasing delivered drug dose, then the addition of a readily available cardboard tube will fulfill many of the required functions with no expense to the patient...
  37. ncbi request reprint Effects of levocetirizine as add-on therapy to fluticasone in seasonal allergic rhinitis
    M L Barnes
    Asthma and Allergy Research Group, Department of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Clin Exp Allergy 36:676-84. 2006
    ..Addition of H(1) antagonists to intranasal corticosteroid treatment of allergic rhinitis (AR) is common in clinical practice and recommended by guidelines, despite some evidence that the additive benefits are negligible...
  38. ncbi request reprint Montelukast protects against nasal lysine-aspirin challenge in patients with aspirin-induced asthma
    D K C Lee
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Eur Respir J 24:226-30. 2004
    ..Nasal lysine-aspirin challenge appeared to be a reproducible and safe method in assessing patients with aspirin-induced asthma...
  39. ncbi request reprint A placebo-controlled evaluation of butterbur and fexofenadine on objective and subjective outcomes in perennial allergic rhinitis
    D K C Lee
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Clin Exp Allergy 34:646-9. 2004
    ..There are presently no placebo-controlled data regarding the effects of butterbur (BB) on subjective and objective outcomes in patients with perennial allergic rhinitis...
  40. pmc Airway and systemic effects of hydrofluoroalkane fluticasone and beclomethasone in patients with asthma
    G P Currie
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, UK
    Thorax 57:865-8. 2002
    ..We examined the airway and systemic effects of hydrofluoroalkane-134a fluticasone propionate (FLU-HFA) and beclomethasone dipropionate (BEC-HFA) at recommended labelled doses...
  41. ncbi request reprint Addition of fexofenadine to inhaled corticosteroid therapy to reduce inflammatory biomarkers in atopic asthma
    Tom C Fardon
    Asthma and Allergy Research Group, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland
    Ann Allergy Asthma Immunol 95:259-65. 2005
    ....
  42. ncbi request reprint Effects of high-dose inhaled fluticasone propionate on the hypothalamic-pituitary-adrenal axis in asthmatic patients with severely impaired lung function
    Daniel K C Lee
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland
    Ann Allergy Asthma Immunol 93:253-8. 2004
    ..The effects of high-dose fluticasone propionate therapy on dynamic cortisol stimulation in severe asthma are unknown...
  43. ncbi request reprint Relative lung delivery of fluticasone propionate via large volume spacer or nebuliser in healthy volunteers
    O J Dempsey
    Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
    Eur J Clin Pharmacol 57:637-41. 2001
    ..This suggests that a very little of the labelled nebulised dose is respirable. Other factors such as patient preference, cost and compliance will determine the inhaler device that is chosen...
  44. ncbi request reprint Comparative effects of desloratadine, fexofenadine, and levocetirizine on nasal adenosine monophosphate challenge in patients with perennial allergic rhinitis
    D K C Lee
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Clin Exp Allergy 34:650-3. 2004
    ..However, further long-term studies will be required to study their comparative effects on nasal symptoms, quality of life, as well as on nasal inflammatory cells...
  45. pmc Cross tolerance to salbutamol occurs independently of beta2 adrenoceptor genotype-16 in asthmatic patients receiving regular formoterol or salmeterol
    D K C Lee
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Thorax 59:662-7. 2004
    ..A study was undertaken to evaluate the Arg-16 and Gly-16 genotypes for the acute salbutamol response following methacholine bronchial challenge between the first and last doses of formoterol (FM) and salmeterol (SM) combination inhalers...
  46. ncbi request reprint Airway-stabilizing effect of long-acting beta2-agonists as add-on therapy to inhaled corticosteroids
    G P Currie
    Asthma and Allergy Research Group, Department of Public Health and Epidemiology, Ninewells University Hospital and Medical School, University of Dundee, UK
    QJM 96:435-40. 2003
    ..The protection afforded by long-acting beta(2)-agonists against bronchoconstrictor stimuli can be regarded as a surrogate for their stabilizing effects on airway smooth muscle...
  47. ncbi request reprint A proof-of-concept study to assess the putative dose response to topical corticosteroid in persistent allergic rhinitis using adenosine monophosphate challenge
    M L Barnes
    Asthma and Allergy Research Group, Department of Medicine and Therapeutics, Ninewells Hospital and Perth Royal Infirmary, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Clin Exp Allergy 37:696-703. 2007
    ..The aim of this proof-of-concept study was to assess whether nasal adenosine monophosphate (AMP) challenge may be used to quantify dose response to topical fluticasone propionate (FP) in persistent allergic rhinitis (PER)...
  48. doi request reprint Effect of levocetirizine on nasal provocation testing with adenosine monophosphate compared with allergen challenge in allergic rhinitis
    S Vaidyanathan
    Asthma and Allergy Research Group, Department of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Clin Exp Allergy 39:409-16. 2009
    ..End-organ hyperreactivity is an important feature of the allergic airway. There are no data directly comparing the responsiveness to treatment of different nasal provocation tests (NPT)...
  49. ncbi request reprint Step-down therapy with low-dose fluticasone-salmeterol combination or medium-dose hydrofluoroalkane 134a-beclomethasone alone
    Stephen J Fowler
    Asthma and Allergy Research Group, Department of Clinical Pharmacology and Therapeutic, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland
    J Allergy Clin Immunol 109:929-35. 2002
    ..Options for step-down therapy include use of inhaled corticosteroids alone or in combination with a long-acting beta2-agonist...
  50. pmc Effects of fluticasone vs. fluticasone/salmeterol on airway calibre and airway hyperresponsiveness in mild persistent asthma
    Graeme P Currie
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Br J Clin Pharmacol 56:11-7. 2003
    ..We set out to evaluate effects on airway hyperresponsiveness (AHR) and airway calibre using hydrofluoroalkane fluticasone/salmeterol (FP/SM) vs. double the dose of fluticasone alone (FP)...
  51. ncbi request reprint A proof of concept study to evaluate stepping down the dose of fluticasone in combination with salmeterol and tiotropium in severe persistent asthma
    Tom Fardon
    Asthma and Allergy Research Group, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Respir Med 101:1218-28. 2007
    ..Addition of salmeterol/tiotropium to half the dose of fluticasone afforded small, but significant improvements in pulmonary function. These effects were not associated with commensurate changes in subjective symptoms or quality of life...
  52. pmc Leukotriene C4 synthase polymorphisms and responsiveness to leukotriene antagonists in asthma
    Graeme P Currie
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    Br J Clin Pharmacol 56:422-6. 2003
    ..Our aim is to evaluate whether responsiveness to leukotriene receptor antagonists was determined by expression of the variant (C) or wild-type (A) polymorphism of this enzyme...
  53. pmc Effects of hydrofluoroalkane formulations of ciclesonide 400 microg once daily vs fluticasone 250 microg twice daily on methacholine hyper-responsiveness in mild-to-moderate persistent asthma
    Daniel K C Lee
    Asthma and Allergy Research Group, Department of Clinical Pharmacology, Ninewells Hospital and Medical School, University of Dundee, Dundee DDI 9SY, Scotland, UK
    Br J Clin Pharmacol 58:26-33. 2004
    ....
  54. ncbi request reprint Allergen sensitization and bronchial hyper-responsiveness to adenosine monophosphate in asthmatic patients
    G P Currie
    Asthma and Allergy Research Group, Ninewells University Hospital and Medical School, Dundee, Scotland, UK
    Clin Exp Allergy 33:1405-8. 2003
    ..Indirect bronchoprovocation using adenosine monophosphate (AMP) is related to atopic phenotype expression...
  55. ncbi request reprint Electrocardiographic changes induced by inhaled salbutamol after treatment with bendrofluazide: effects of replacement therapy with potassium, magnesium and triamterene
    B J Lipworth
    Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, Scotland, U K
    Clin Sci (Lond) 78:255-9. 1990
    ..Supplementation with potassium and magnesium had no effect on electrocardiographic changes, and the addition of triamterene to bendrofluazide only attenuated electrocardiographic responses in some subjects...
  56. ncbi request reprint Effects of fexofenadine and desloratadine on subjective and objective measures of nasal congestion in seasonal allergic rhinitis
    A M Wilson
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    Clin Exp Allergy 32:1504-9. 2002
    ....
  57. ncbi request reprint Effects of intranasal corticosteroid on nasal adenosine monophosphate challenge in persistent allergic rhinitis
    M L Barnes
    The Asthma and Allergy Research Group, The University of Dundee, Dundee, UK
    Allergy 61:1319-25. 2006
    ..Response to a single dose nasal adenosine monophosphate challenge has been used as a surrogate inflammatory marker for allergic rhinitis. Attenuation of response following intranasal corticosteroid would further validate the challenge...
  58. ncbi request reprint Comparative cutoff points for adenosine monophosphate and methacholine challenge testing
    Tom C Fardon
    Asthma and Allergy Research Group, Department of Clinical Pharmacology, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland
    Ann Allergy Asthma Immunol 93:365-72. 2004
    ..Current use of the PC20 (provocation concentration that causes a decrease in forced expiratory volume in 1 second of 20%) cutoff point for bronchial challenge precludes its use in patients with more severe airflow obstruction...
  59. ncbi request reprint Repeated dosing effects of mediator antagonists in inhaled corticosteroid-treated atopic asthmatic patients
    Daniel K C Lee
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Chest 125:1372-7. 2004
    ..The anti-inflammatory effects of repeated dosing with mediator antagonists as add-on therapy to that with inhaled corticosteroids (ICSs) in patients with asthma remain to be fully established...
  60. ncbi request reprint A comparison of 2 extrafine hydrofluoroalkane-134a-beclomethasone formulations on methacholine hyperresponsiveness
    Tom C Fardon
    Asthma and Allergy Research Group, Division of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland
    Ann Allergy Asthma Immunol 96:422-30. 2006
    ..Thus, extrafine particle formulations of inhaled corticosteroids are of clinical interest...
  61. ncbi request reprint Adenosine monophosphate bronchial provocation and the actions of asthma therapy
    D K C Lee
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Clin Exp Allergy 33:287-94. 2003
  62. ncbi request reprint A comparison of once daily fexofenadine versus the combination of montelukast plus loratadine on domiciliary nasal peak flow and symptoms in seasonal allergic rhinitis
    A M Wilson
    Asthma and Allergy Research Group, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
    Clin Exp Allergy 32:126-32. 2002
    ....
  63. pmc The arginine-16 beta2-adrenoceptor polymorphism predisposes to bronchoprotective subsensitivity in patients treated with formoterol and salmeterol
    Daniel K C Lee
    Asthma and Allergy Research Group, Department of Clinical Pharmacology, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Br J Clin Pharmacol 57:68-75. 2004
    ..The relationship between beta2-adrenoceptor polymorphisms and bronchoprotective response with long-acting beta2-adrenoceptor agonists is unknown...
  64. pmc Dose-response to salbutamol via a novel palm sized nebuliser (Aerodose Inhaler), conventional nebuliser (Pari LC Plus) and metered dose inhaler (Ventolin Evohaler) in moderate to severe asthmatics
    Brian J Lipworth
    Department of Medicine and Therapeutics, Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee Scotland, DD1 9SY, UK
    Br J Clin Pharmacol 59:5-13. 2005
    ..Mountain View, USA) vs Pari LC Plus jet nebulizer (Pari LC Plus; Pari GmbH, Starnberg, Germany) and Ventolin Evohaler HFA pMDI (Evohaler; Allen & Hanburys [GlaxoSmithkline], Uxbridge, UK)...
  65. pmc Add-on therapy with montelukast or formoterol in patients with the glycine-16 beta2-receptor genotype
    Erika J Sims
    Department of Clinical Pharmacology and Therapeutics, Asthma and Allergy Research Group, Ninewells University Hospital and Medical School, Dundee, UK
    Br J Clin Pharmacol 56:104-11. 2003
    ....
  66. pmc Systemic bioavailability of hydrofluoroalkane (HFA) formulations of fluticasone/salmeterol in healthy volunteers via pMDI alone and spacer
    Karine L Clearie
    Asthma and Allergy Research Group, Division of Medical Sciences, Ninewells Hospital and Medical School, University of Dundee, DD1 9SY, UK
    Br J Clin Pharmacol 69:637-44. 2010
    ..To compare a test version of HFA fluticasone/salmeterol (FP/SM) combination inhaler (Neolab, UK) with the reference product Seretide (GlaxoSmithKline, UK)...
  67. ncbi request reprint A novel breath-actuated integrated vortex spacer device increases relative lung bioavailability of fluticasone/salmeterol in combination
    Arun Nair
    Asthma and Allergy Research Group, Department of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Ninewells Avenue, Dundee, Scotland, UK
    Pulm Pharmacol Ther 22:305-10. 2009
    ....
  68. ncbi request reprint Effects of adding either a leukotriene receptor antagonist or low-dose theophylline to a low or medium dose of inhaled corticosteroid in patients with persistent asthma
    Owen J Dempsey
    Asthma and Allergy Research Group, Section of Vascular Medicine and Biology, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Chest 122:151-9. 2002
    ..To evaluate the effect of adding zafirlukast or low-dose theophylline to a beclomethasone dipropionate (BDP) extra-fine hydrofluoroalkane aerosol on bronchial hyperresponsiveness as the primary outcome variable...
  69. pmc Antagonism of long-acting beta2-adrenoceptor agonism
    Brian J Lipworth
    Asthma and Allergy Research Group, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY UK
    Br J Clin Pharmacol 54:231-45. 2002
    ..It would therefore make more sense to first of all optimize the dose of anti-inflammatory therapy with inhaled corticosteroid and to then consider adding a long-acting beta2-adrenoceptor agonist for patients who are poorly controlled...
  70. pmc Arginine-16 beta2 adrenoceptor genotype predisposes to exacerbations in young asthmatics taking regular salmeterol
    C N A Palmer
    Asthma and Allergy Research Group, Division of Medicine and Therapeutics, Ninewells Hospital, Dundee, UK
    Thorax 61:940-4. 2006
    ..We studied the effect of this polymorphic variation on asthma exacerbations in children and young adults and its relation to long acting beta(2) agonists...
  71. ncbi request reprint Comparison of parameters of in vitro lymphocyte beta 2-adrenoceptor function in normal and asthmatic subjects
    D M Newnham
    Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Scotland, UK
    Eur J Clin Pharmacol 45:535-8. 1993
    ..24 vs 4.85. Thus, parameters of beta 2-AR function are unaltered in asthmatic patients who have not been exposed to beta 2-agonists, suggesting that asthma is not associated with an endogenous defect of beta 2-AR...
  72. ncbi request reprint Butterbur, a herbal remedy, attenuates adenosine monophosphate induced nasal responsiveness in seasonal allergic rhinitis
    D K C Lee
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Clin Exp Allergy 33:882-6. 2003
    ..However, no placebo-controlled studies have been performed to evaluate the effectiveness of BB on objective outcomes such as nasal provocation testing in seasonal allergic rhinitis (SAR)...
  73. ncbi request reprint Hypokalemic and ECG sequelae of combined beta-agonist/diuretic therapy. Protection by conventional doses of spironolactone but not triamterene
    B J Lipworth
    Department of Clinical Pharmacology, Ninewells Hospital, Dundee, Scotland
    Chest 98:811-5. 1990
    ..These findings may be important in the prevention of a potentially dangerous interaction in susceptible patients taking this combination of drugs...
  74. pmc Pharmacokinetics and systemic beta2-adrenoceptor-mediated responses to inhaled salbutamol
    S J Fowler
    Asthma and Allergy Research Group, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, UK
    Br J Clin Pharmacol 51:359-62. 2001
    ..Consequently it is suggested that potassium or tremor responses may be used to evaluate the relative lung delivery of salbutamol from different inhaler devices...
  75. ncbi request reprint Leukotriene-receptor antagonists
    B J Lipworth
    Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, UK
    Lancet 353:57-62. 1999
    ..Here I overview the clinical pharmacology of leukotriene antagonists and appraise the published data from clinical trials, and look at the appropriate position of these agents in asthma management guidelines...
  76. ncbi request reprint Adrenal suppression with dry powder formulations of fluticasone propionate and mometasone furoate
    Tom C Fardon
    Asthma and Allergy Research Group, Department of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom
    Am J Respir Crit Care Med 170:960-6. 2004
    ..Our data refute the assertion that MF has negligible systemic bioavailability and a lower potential for systemic adverse effects compared with FP...
  77. doi request reprint Effect of aspirin on airway inflammation and pulmonary function in patients with persistent asthma
    Daniel Menzies
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, Dundee, United Kingdom
    J Allergy Clin Immunol 121:1184-1189.e4. 2008
    ..Aside from patients with known aspirin-sensitive asthma, physicians have avoided the use of aspirin in asthmatic patients in general because it was believed that this agent might precipitate worsening of their condition...
  78. ncbi request reprint Effects of fluticasone plus salmeterol versus twice the dose of fluticasone in asthmatic patients
    Graeme P Currie
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, DD1 9SY Dundee, Scotland, UK
    Eur J Clin Pharmacol 59:11-5. 2003
    ..Since it is unclear how this translates into effects on surrogate inflammatory markers, we evaluated the anti-inflammatory activity of fluticasone plus salmeterol in combination versus twice the dose of fluticasone alone...
  79. ncbi request reprint Comparative efficacy and anti-inflammatory profile of once-daily therapy with leukotriene antagonist or low-dose inhaled corticosteroid in patients with mild persistent asthma
    Owen J Dempsey
    Asthma and Allergy Research Group, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, United Kingdom
    J Allergy Clin Immunol 109:68-74. 2002
    ..Current guidelines advocate the use of preventative anti-inflammatory therapy for mild persistent asthma...
  80. ncbi request reprint Therapeutic ratio of hydrofluoroalkane and chlorofluorocarbon formulations of fluticasone propionate
    Stephen J Fowler
    Asthma and Allergy Research Group, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    Chest 122:618-23. 2002
    ..To compare the therapeutic ratio of chlorofluorocarbon (CFC) and hydrofluoroalkane-134a (HFA) formulations of fluticasone propionate (FP)...
  81. doi request reprint Relationships between impulse oscillometry, spirometry and dyspnoea in COPD
    W J Anderson
    Asthma and Allergy Research Group, University of Dundee, Dundee, Scotland, UK
    J R Coll Physicians Edinb 42:111-5. 2012
    ..We hypothesised that impulse oscillometry (IOS), a non-effort-dependent measure of central and peripheral airway mechanics, could correlate to dyspnoea in COPD...
  82. doi request reprint The minimal clinically important difference in allergic rhinitis
    M L Barnes
    Asthma and Allergy Research Group, Department of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
    Clin Exp Allergy 40:242-50. 2010
    ..There are few reports of calculated MCIDs in the Rhinology literature...
  83. pmc The effects of frusemide and triamterene on the hypokalaemic and electrocardiographic responses to inhaled terbutaline
    D M Newnham
    Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, Scotland
    Br J Clin Pharmacol 32:630-2. 1991
    ..These results show that the hypokalaemic response to terbutaline was additive to that of frusemide, and that triamterene attenuated the hypokalaemic response to frusemide, but not terbutaline...
  84. ncbi request reprint The skin vasoconstrictor assay does not correlate significantly to airway or systemic responsiveness to inhaled budesonide in asthmatic patients
    Andrew M Wilson
    Asthma and Allergy Research Group, Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
    Eur J Clin Pharmacol 58:643-7. 2003
    ..The aim was to a assess whether skin vasoconstrictor assay might predict airway and systemic tissue responsiveness to inhaled budesonide in patients with asthma...
  85. ncbi request reprint Does bronchial hyperresponsiveness in asthma matter?
    Graeme P Currie
    Chest Clinic C, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, Scotland, UK
    J Asthma 41:247-58. 2004
    ....
  86. ncbi request reprint Dose response of inhaled corticosteroids on bronchial hyperresponsiveness: a meta-analysis
    Graeme P Currie
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom
    Ann Allergy Asthma Immunol 90:194-8. 2003
    ..There is a relatively steep dose-response curve for effects of inhaled corticosteroids on conventional airway markers of asthmatic disease control...
  87. doi request reprint Paradoxical trough effects of triple therapy with budesonide/formoterol and tiotropium bromide on pulmonary function outcomes in COPD
    Peter A Williamson
    Asthma and Allergy Research Group, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland
    Chest 138:595-604. 2010
    ..Impulse oscillometry (IOS) and body plethysmography (PLETH) are more sensitive than spirometry to assess inhaled therapies in COPD...
  88. pmc An evaluation of short-term corticosteroid response in perennial allergic rhinitis using histamine and adenosine monophosphate nasal challenge
    Andrew M Wilson
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Br J Clin Pharmacol 55:354-9. 2003
    ..Adenosine monophosphate (AMP) challenge has been shown to be a good inflammatory surrogate in the lower airways, but it has not been properly evaluated as a nasal challenge test...
  89. pmc Single and short-term dosing effects of levocetirizine on adenosine monophosphate bronchoprovocation in atopic asthma
    Daniel K C Lee
    Asthma and Allergy Research Group, Department of Clinical Pharmacology, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Br J Clin Pharmacol 58:34-9. 2004
    ..We evaluated single and short-term dosing effects of a modern histamine H1-receptor antagonist, levocetirizine, given at the usual clinically recommended dose, on the primary outcome of AMP bronchoprovocation...
  90. ncbi request reprint Eosinophils from patients with asthma express higher levels of the pan-leucocyte receptor CD45 and the isoform CD45RO
    M G Blaylock
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen Medical School, Aberdeen, UK
    Clin Exp Allergy 33:936-41. 2003
    ..Comparisons were made between expression of CD45, CD45RA, CD45RB and CD45RO by eosinophils from asthmatic patients and non-asthmatic atopic and non-atopic, non-asthmatic control subjects...
  91. ncbi request reprint Effects of leukotriene receptor antagonist therapy in patients with chronic rhinosinusitis in a real life rhinology clinic setting
    A M Wilson
    Asthma and Allergy Research Group, Department of Clinical Pharmacology and Therapeutics, University of Dundee, Dundee, Scotland, UK
    Rhinology 39:142-6. 2001
    ..In conclusion, montelukast may be a useful therapeutic option in addition to standard therapy (i.e. intra-nasal corticosteroids or anti-histamines) when treating patients with chronic rhinosinusitis in a real life clinical setting...
  92. doi request reprint Filaggrin null mutations are associated with increased asthma exacerbations in children and young adults
    K Basu
    Maternal and Child Health Sciences, Ninewells Hospital and Medical School, Dundee, UK
    Allergy 63:1211-7. 2008
    ..Our objective was to study the role of FLG null alleles in asthma exacerbations...
  93. ncbi request reprint Evaluation of the importance of head and probe stabilisation in acoustic rhinometry
    A M Wilson
    Asthma and Allergy Research Group, Department of Clinical Pharmacology and Therapeutics, University of Dundee, Scotland, UK
    Rhinology 39:93-7. 2001
    ..Instrument fixation or examiner performed test is also preferable to allowing the patient to position the probe. The repeatability of the probe-stand method was similar to the examiner-performed method...
  94. ncbi request reprint Dose-response of inhaled drugs in asthma. An update
    D J Clark
    Department of Clinical Pharmacology, Ninewells Hospital and Medical School, University of Dundee, Scotland
    Clin Pharmacokinet 32:58-74. 1997
    ....
  95. doi request reprint Airway and systemic effects of soluble and suspension formulations of nebulized budesonide in asthmatic children
    Kaninika Basu
    Maternal and Child Health Sciences, Ninewells Hospital and Medical School, Dundee, Scotland
    Ann Allergy Asthma Immunol 103:436-41. 2009
    ..Using cyclodextrin with budesonide enables it to be formulated in a solution for nebulization...
  96. ncbi request reprint Evaluation of an abbreviated adenosine monophosphate bronchial challenge
    Tom C Fardon
    Asthma and Allergy Research Group, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
    Chest 127:2222-5. 2005
    ..We wished to know whether an abbreviated challenge at the final threshold dose would produce the same fall in FEV1 as a full, conventional dose-response challenge...
  97. ncbi request reprint Bronchoprotective effects of leukotriene receptor antagonists in asthma: a meta-analysis
    Graeme P Currie
    Asthma and Allergy Research Group, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland
    Chest 122:146-50. 2002
    ..Since bronchial hyperresponsiveness is a noninvasive surrogate marker of asthmatic airway inflammation, we evaluated the bronchoprotection afforded by leukotriene receptor antagonists (LTRAs)...
  98. pmc A proof of concept study to evaluate putative benefits of montelukast in moderate persistent asthmatics
    Graeme P Currie
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Br J Clin Pharmacol 55:609-15. 2003
    ..The latter was done to dissociate the effects of montelukast from ICS...
  99. ncbi request reprint Comparative in vivo bioactivity of modern H1-antihistamines on AMP challenge in atopic asthma
    Daniel K C Lee
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    J Allergy Clin Immunol 111:337-41. 2003
    ..Modern H(1)-antihistamines differ in their in vitro binding affinity, but their comparative in vivo bioactivity in asthmatic airways is unknown...
  100. pmc The presence of emphysema does not affect the systemic bioactivity of inhaled fluticasone in severe chronic obstructive pulmonary disease
    Daniel K C Lee
    Asthma and Allergy Research Group, Department of Clinical Pharmacology, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    Br J Clin Pharmacol 57:388-92. 2004
    ..To assess the systemic bioactivity of fluticasone proprionate (FP) 2000 micro g daily on sensitive adrenal and bone markers in severe chronic obstructive pulmonary disease (COPD) patients with or without significant emphysema...
  101. ncbi request reprint Second-line controller therapy for persistent asthma uncontrolled on inhaled corticosteroids: the step 3 dilemma
    Brian J Lipworth
    Department of Clinical Pharmacology and Therapeutics, Asthma and Allergy Research Group, Ninewells University Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Drugs 62:2315-32. 2002
    ..For the patient whose lung function is less impaired, with evidence of ongoing BHR where bronchoprotection is needed (e.g. exercise, allergen, cold air), or when there is concomitant allergic rhinitis, then an LTA would be more suitable...