G Y Lip

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. ncbi request reprint Should patients with hypertension receive antithrombotic therapy?
    G Y Lip
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    J Intern Med 249:205-14. 2001
  2. ncbi request reprint Plasma levels of vascular endothelial growth factor and its soluble receptor (SFlt-1) in essential hypertension
    F M Belgore
    University Department of Medicine, City Hospital, Birmingham, United Kingdom
    Am J Cardiol 87:805-7, A9. 2001
  3. ncbi request reprint Abnormalities of hemorheological, endothelial, and platelet function in patients with chronic heart failure in sinus rhythm: effects of angiotensin-converting enzyme inhibitor and beta-blocker therapy
    C R Gibbs
    Haemostasis, Thrombosis, and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Circulation 103:1746-51. 2001
  4. ncbi request reprint Increased soluble P-selectin in patients with haematological and breast cancer: a comparison with fibrinogen, plasminogen activator inhibitor and von Willebrand factor
    A D Blann
    University Department of Medicine, City Hospital, Birmingham, UK
    Blood Coagul Fibrinolysis 12:43-50. 2001
  5. ncbi request reprint A cross-sectional, diurnal, and follow-up study of platelet activation and endothelial dysfunction in malignant phase hypertension
    G Y Lip
    University Department of Medicine, City Hospital, Birmingham, United Kingdom
    Am J Hypertens 14:823-8. 2001
  6. ncbi request reprint A pilot study of streptokinase-induced endothelial injury and platelet activation following acute myocardial infarction
    G Y Lip
    University Department of Medicine, City Hospital, Birmingham, UK
    J Intern Med 248:316-8. 2000
  7. ncbi request reprint Effect of acute exercise on the raised plasma fibrinogen, soluble P-selectin and von Willebrand factor levels in chronic atrial fibrillation
    F L Li-Saw-Hee
    University Department of Medicine, City Hospital, Birmingham, United Kingdom
    Clin Cardiol 24:409-14. 2001
  8. ncbi request reprint Plasma vascular endothelial growth factor and its receptor Flt-1 in patients with hyperlipidemia and atherosclerosis and the effects of fluvastatin or fenofibrate
    A D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, United Kingdom
    Am J Cardiol 87:1160-3. 2001
  9. ncbi request reprint Effect of antihypertensive therapy using enalapril or losartan on haemostatic markers in essential hypertension: a pilot prospective randomised double-blind parallel group trial
    F L Li-Saw-Hee
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, B18 7QH, Birmingham, UK
    Int J Cardiol 78:241-6. 2001
  10. ncbi request reprint Age-related macular degeneration is associated with increased vascular endothelial growth factor, hemorheology and endothelial dysfunction
    P L Lip
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, England, UK
    Ophthalmology 108:705-10. 2001

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Should patients with hypertension receive antithrombotic therapy?
    G Y Lip
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    J Intern Med 249:205-14. 2001
    ..However, some of the risks of aspirin administration, namely increased incidence of major bleeding events, may possibly outweigh the benefits, especially in low-risk individuals...
  2. ncbi request reprint Plasma levels of vascular endothelial growth factor and its soluble receptor (SFlt-1) in essential hypertension
    F M Belgore
    University Department of Medicine, City Hospital, Birmingham, United Kingdom
    Am J Cardiol 87:805-7, A9. 2001
    ..This raises the possibility that abnormal angiogenesis may contribute to the pathogenesis of complications related to hypertension and merits exploration in larger studies...
  3. ncbi request reprint Abnormalities of hemorheological, endothelial, and platelet function in patients with chronic heart failure in sinus rhythm: effects of angiotensin-converting enzyme inhibitor and beta-blocker therapy
    C R Gibbs
    Haemostasis, Thrombosis, and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Circulation 103:1746-51. 2001
    ..These positive effects of ACE inhibitors may offer an explanation for the observed reduction in ischemic events in clinical trials...
  4. ncbi request reprint Increased soluble P-selectin in patients with haematological and breast cancer: a comparison with fibrinogen, plasminogen activator inhibitor and von Willebrand factor
    A D Blann
    University Department of Medicine, City Hospital, Birmingham, UK
    Blood Coagul Fibrinolysis 12:43-50. 2001
    ..We conclude that the platelet marker soluble P-selectin is raised in both haematological and breast cancer, and is higher in the former, but is unrelated to the type or stage of breast cancer...
  5. ncbi request reprint A cross-sectional, diurnal, and follow-up study of platelet activation and endothelial dysfunction in malignant phase hypertension
    G Y Lip
    University Department of Medicine, City Hospital, Birmingham, United Kingdom
    Am J Hypertens 14:823-8. 2001
    ..These abnormalities do not undergo any significant diurnal variation and may be beneficially altered by BP reduction...
  6. ncbi request reprint A pilot study of streptokinase-induced endothelial injury and platelet activation following acute myocardial infarction
    G Y Lip
    University Department of Medicine, City Hospital, Birmingham, UK
    J Intern Med 248:316-8. 2000
    ....
  7. ncbi request reprint Effect of acute exercise on the raised plasma fibrinogen, soluble P-selectin and von Willebrand factor levels in chronic atrial fibrillation
    F L Li-Saw-Hee
    University Department of Medicine, City Hospital, Birmingham, United Kingdom
    Clin Cardiol 24:409-14. 2001
    ..Nevertheless, acute exercise does not appear to have a significant influence on endothelial dysfunction or platelet activation in patients with AF...
  8. ncbi request reprint Plasma vascular endothelial growth factor and its receptor Flt-1 in patients with hyperlipidemia and atherosclerosis and the effects of fluvastatin or fenofibrate
    A D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, United Kingdom
    Am J Cardiol 87:1160-3. 2001
    ..e., modulation of angiogenesis) by which lipid-lowering therapy may reduce cardiovascular events beyond lipid reduction alone...
  9. ncbi request reprint Effect of antihypertensive therapy using enalapril or losartan on haemostatic markers in essential hypertension: a pilot prospective randomised double-blind parallel group trial
    F L Li-Saw-Hee
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, B18 7QH, Birmingham, UK
    Int J Cardiol 78:241-6. 2001
    ..However, plasma fibrinogen and indices of platelet activation, fibrinolysis or endothelial dysfunction were not significantly affected by antihypertensive treatment with enalapril or losartan, despite satisfactory blood pressure control...
  10. ncbi request reprint Age-related macular degeneration is associated with increased vascular endothelial growth factor, hemorheology and endothelial dysfunction
    P L Lip
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, England, UK
    Ophthalmology 108:705-10. 2001
    ..The interaction between abnormal angiogenesis and the components of Virchow's triad for thrombogenesis may in part contribute to the pathogenesis of ARMD...
  11. ncbi request reprint The prevalence of pre-eclampsia and obstetric outcome in pregnancies of normotensive and hypertensive women attending a hospital specialist clinic
    C Lydakis
    University Department of Medicine, City Hospital, Birmingham
    Int J Clin Pract 55:361-7. 2001
    ..The high prevalence of PE in chronic hypertensive women (16.0%) was not statistically significant to that of normotensive women (11.9%), reflecting the referral selection of 'high risk' normotensive women to our clinic...
  12. ncbi request reprint Measurement of free and complexed soluble vascular endothelial growth factor receptor, Flt-1, in fluid samples: development and application of two new immunoassays
    F M Belgore
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Dudley Road, Birmingham B187QH, UK
    Clin Sci (Lond) 100:567-75. 2001
    ..Furthermore, these results suggest that circulating sFlt-1 may serve as a selective inhibitor of VEGF activity, and that this regulatory mechanism may be altered by pathological conditions...
  13. ncbi request reprint Increased platelet glycoprotein V levels in patients with coronary and peripheral atherosclerosis--the influence of aspirin and cigarette smoking
    A D Blann
    University Department of Medicine, City Hospital, Birmingham, UK
    Thromb Haemost 86:777-83. 2001
    ..Our data indicate that soluble gpV may be a useful new marker of platelet activation in atherosclerosis, but may be influenced by smoking status and blood pressure...
  14. ncbi request reprint A pilot study of homocyst(e)ine levels in essential hypertension: relationship to von Willebrand factor, an index of endothelial damage
    G Y Lip
    University Department of Medicine, City Hospital, Birmingham, UK
    Am J Hypertens 14:627-31. 2001
    ....
  15. ncbi request reprint Endothelial integrity, soluble adhesion molecules and platelet markers in type 1 diabetes mellitus
    A D Blann
    University Department of Medicine, City Hospital, Birmingham, UK
    Diabet Med 15:634-42. 1998
    ....
  16. ncbi request reprint Plasma von Willebrand factor, fibrinogen and soluble P-selectin levels in paroxysmal, persistent and permanent atrial fibrillation. Effects of cardioversion and return of left atrial function
    F L Li-Saw-Hee
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Eur Heart J 22:1741-7. 2001
    ..Cardioversion of persistent atrial fibrillation did not significantly alter indices of hypercoagulability even after 3 months maintenance of sinus rhythm, despite the return of atrial systole...
  17. ncbi request reprint Paroxysmal atrial fibrillation
    G Y Lip
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    QJM 94:665-78. 2001
    ..Evidence for antithrombotic therapy is also based on epidemiological studies and subgroup analyses of the large randomized trials...
  18. ncbi request reprint Hypertension and the prothrombotic state
    G Y Lip
    University Department of Medicine, City Hospital, Birmingham, UK
    J Hum Hypertens 14:687-90. 2000
    ..Further work is needed to examine the mechanisms leading to this phenomenon, the potential prognostic and treatment implications, and the possible value of measuring these parameters in routine clinical practice...
  19. ncbi request reprint Prothrombotic factors, endothelial function and left ventricular hypertrophy in isolated systolic hypertension compared with systolic-diastolic hypertension
    G Y Lip
    University Department of Medicine, City Hospital, Birmingham, UK
    J Hypertens 17:1203-7. 1999
    ..We hypothesized that patients with ISH would exhibit a prothrombotic state similar to that seen in SDH. A secondary hypothesis was that individuals with ISH had similar echocardiographic parameters to those seen in SDH...
  20. ncbi request reprint Effect of aortic valve replacement on plasma soluble P-selectin, von Willebrand factor, and fibrinogen
    I R Goldsmith
    University Department of Medicine, City Hospital, Birmingham, United Kingdom
    Am J Cardiol 87:107-10, A9. 2001
    ....
  21. doi request reprint What is the most effective and safest delivery of thromboprophylaxis in atrial fibrillation?
    G Y H Lip
    University of Birmingham, Centre for Cardiovascular Sciences, City Hospital, Birmingham, B18 7QH England, UK
    J R Coll Physicians Edinb 42:35-44. 2012
    ....
  22. ncbi request reprint Differences in free and total tissue factor pathway inhibitor, and tissue factor in peripheral artery disease compared to healthy controls
    A D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University, Department of Medicine, City Hospital, B18 7QH, Birmingham, UK
    Atherosclerosis 152:29-34. 2000
    ..21, P=0.178). We suggest that reduced levels of total TFPI and raised levels of TF may contribute to the process of atherogenesis and the increased risk of thrombosis among patients with cardiovascular disease...
  23. ncbi request reprint Serum urate is associated with baseline renal dysfunction but not survival or deterioration in renal function in malignant phase hypertension
    G Y Lip
    University Department of Medicine, City Hospital, Birmingham, UK
    J Hypertens 18:97-101. 2000
    ..There has been speculation whether serum uric acid levels are an independent prognostic factor in patients with hypertension...
  24. ncbi request reprint Changes in renal function with percutaneous transluminal coronary angioplasty
    G Y Lip
    Department of Cardiology, City Hospital, Birmingham, UK
    Int J Cardiol 70:127-31. 1999
    ....
  25. ncbi request reprint Does heart failure confer a hypercoagulable state? Virchow's triad revisited
    G Y Lip
    University Department of Medicine, City Hospital, Birmingham, United
    J Am Coll Cardiol 33:1424-6. 1999
    ....
  26. ncbi request reprint Microalbuminuria and cardiovascular risk
    C Lydakis
    University Department of Medicine, City Hospital, Birmingham, UK
    QJM 91:381-91. 1998
    ..Nevertheless, further information on the value of microalbuminuria in other atherosclerotic vascular complications, such as ischaemic heart disease, stroke and peripheral artery disease is still needed...
  27. ncbi request reprint Atrial fibrillation amongst the Indo-Asian general practice population. The West Birmingham Atrial Fibrillation Project
    G Y Lip
    University Department of Medicine, City Hospital, Birmingham, UK
    Int J Cardiol 65:187-92. 1998
    ..More information on the clinical epidemiology of AF in non-caucasian groups is still needed and urgently required, in view of the public health implications of this common cardiac arrhythmia...
  28. ncbi request reprint Abnormal haemorheology, endothelial function and thrombogenesis in relation to hypertension in acute (ictus < 12 h) stroke patients: the West Birmingham Stroke Project
    G Y Lip
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Blood Coagul Fibrinolysis 12:307-15. 2001
    ..This is despite the known hypercoagulable state found in hypertension and the relationship of haemostatic abnormalities to vascular complications...
  29. ncbi request reprint Management of hypertension in pregnancy
    N A Chung
    University Department of Medicine, City Hospital, Birmingham, England
    Am J Cardiovasc Drugs 1:253-62. 2001
    ..This will reduce blood pressure, but hypertension per se may still persist post partum requiring short term therapy...
  30. ncbi request reprint The endothelium in atherothrombotic disease: assessment of function, mechanisms and clinical implications
    A D Blann
    University Department of Medicine, City Hospital, Birmingham, UK
    Blood Coagul Fibrinolysis 9:297-306. 1998
    ....
  31. ncbi request reprint The measurement of blood pressure and the detection of hypertension in children and adolescents
    G Y Lip
    University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    J Hum Hypertens 15:419-23. 2001
    ..Simplified, shortened and updated guidelines on hypertension in paediatric practice and research are needed...
  32. ncbi request reprint Resistant hypertension and the Birmingham Hypertension Square
    D C Felmeden
    University Department of Medicine, City Hospital, Birmingham B18 7QH, UK. am.ac.uk
    Curr Hypertens Rep 3:203-8. 2001
    ..The use of the Birmingham Hypertension Square for the optimum choice of add-in drugs for the treatment of resistant hypertension may aid management...
  33. ncbi request reprint Soluble intercelluar adhesion molecule-1, E-selectin, vascular cell adhesion molecule-1 and von Willebrand factor in stroke
    A Blann
    University Department of Medicine, City Hospital, Birmingham, UK
    Blood Coagul Fibrinolysis 10:277-84. 1999
    ..These changes may perhaps be part of the complex pathophysiological responses to infarction and repair of brain tissue following stroke...
  34. ncbi request reprint Antihypertensive therapy and cancer risk
    D C Felmeden
    University Department of Medicine, City Hospital, Birmingham, England
    Drug Saf 24:727-39. 2001
    ..Until further solid data are available from prospective clinical trials, we suggest that the management of hypertension should continue according to current treatment guidelines with little fear of any substantial cancer risk...
  35. ncbi request reprint Do patients with de novo hypertension differ from patients with previously known hypertension when malignant phase hypertension occurs?
    G Y Lip
    University Department of Medicine, City Hospital, Birmingham, England
    Am J Hypertens 13:934-9. 2000
    ..6549). We suggest that MHT can occur de novo in patients without previously known hypertension, and the clinical characteristics and prognosis in such patients were similar to MHT patients with previously known hypertension...
  36. ncbi request reprint Renal cell carcinoma and malignant phase hypertension
    P S Wong
    Department of Medicine, City Hospital, Birmingham, UK
    Blood Press 10:16-21. 2001
    ..Hypertension was found in 43% of the renal carcinoma patients and 20% of the local population, also a clear excess. The mechanism of the association between renal cancer and malignant and non-malignant hypertension is unclear...
  37. ncbi request reprint Peripheral vascular disease and hypertension: a forgotten association?
    A Makin
    University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    J Hum Hypertens 15:447-54. 2001
    ..There is therefore an obvious need for such outcome studies, especially since the two conditions are commonly encountered together...
  38. doi request reprint Omega-3 polyunsaturated acids and cardiovascular disease: notable ethnic differences or unfulfilled promise?
    J V Patel
    Haemostasis, Thrombosis and Vascular Biology Unit, University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, England, UK
    J Thromb Haemost 8:2095-104. 2010
    ..Future epidemiological research into the efficacy of omega-3 PUFA in cardiovascular disease should consider the influence of ethnicity...
  39. ncbi request reprint Managing atrial fibrillation in the Accident and Emergency department
    E Williams
    University Department of Medicine and. Accident and Emergency Department, City Hospital, Birmingham, UK
    QJM 94:609-14. 2001
    ..Given the current evolution of A&E as an acute speciality, A&E clinicians should at least initiate management of patients with AF and be prepared to care for them for some time in A&E...
  40. ncbi request reprint The impact of coronary heart disease in determining use of hormone replacement therapy in a general practice population
    B S Chin
    University Department of Medicine, City Hospital, Birmingham
    Int J Clin Pract 55:515-8. 2001
    ..This is contrary to previous presumptions that selection and prevention bias were the explanation for the apparent cardioprotective effects of HRT...
  41. ncbi request reprint Plasma levels of vascular endothelial growth factor (VEGF) and its receptor, Flt-1, in haematological cancers: a comparison with breast cancer
    F M Belgore
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, Birmingham, United Kingdom
    Am J Hematol 66:59-61. 2001
    ..0238). There was no difference in levels of sFlt-1. Our data point to changes in levels of plasma VEGF, but not sFlt-1, in haematological cancer that may have pathophysiological consequences...
  42. ncbi request reprint Unstable angina following acute MI in a patient with bilateral coronary artery fistulae: an unusual presentation of coronary steal?
    B Chin
    University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    Int J Clin Pract 55:342-3. 2001
    ..The possibility of a coronary steal syndrome contributing to her unstable angina arises in view of the presence of bilateral coronary artery fistulae between two atherosclerotic coronary arteries and the main pulmonary artery...
  43. ncbi request reprint Effects of acute exercise on hemorheological, endothelial, and platelet markers in patients with chronic heart failure in sinus rhythm
    C R Gibbs
    Haemostasis, Thrombosis, and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, United Kingdom
    Clin Cardiol 24:724-9. 2001
    ..Although moderate exercise should be encouraged in patients with CHF, vigorous exercise should probably be avoided in view of its potential prothrombotic effects in this high-risk group of patients...
  44. ncbi request reprint Atenolol and fetal growth in pregnancies complicated by hypertension
    C Lydakis
    University Department of Medicine, City Hospital, Birmingham, United Kingdom
    Am J Hypertens 12:541-7. 1999
    ..In conclusion, atenolol should be avoided in the early stages of pregnancy and given with caution at the later stages, as it is associated with fetal growth retardation, which is related to duration of treatment...
  45. ncbi request reprint New pharmacological strategies for the treatment of heart failure
    B S Chin
    University Department of Medicine, City Hospital, Birmingham
    Curr Opin Investig Drugs 2:923-8. 2001
    ..Clinical trials will ascertain if these new strategies in the treatment of heart failure will ultimately be successful in the management of these patients...
  46. pmc Left internal mammary graft stenosis and restenosis following angioplasty and stenting
    C G Spencer
    University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    Heart 86:E9. 2001
    ..He subsequently developed multiple stenoses in the LIMA graft which required coronary augioplasty and stenting, on more than one occasion, in view of very rapid restenosis within the LIMA graft...
  47. ncbi request reprint Relationship between plasma markers of endothelial cell integrity and the Framingham cardiovascular disease risk-factor scores in apparently healthy individuals
    A D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, The City Hospital, Birmingham, UK
    Blood Coagul Fibrinolysis 13:513-8. 2002
    ....