Genomes and Genes
Andrew C Lin
Affiliation: University of Oxford
- Cytoplasmic polyadenylation and cytoplasmic polyadenylation element-dependent mRNA regulation are involved in Xenopus retinal axon developmentAndrew C Lin
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK
Neural Dev 4:8. 2009..Control of poly(A) tail length by cytoplasmic polyadenylation element (CPE) binding protein 1 (CPEB1) is a conserved mechanism for mRNA-specific translational regulation that could be involved in regulating translation in axons...
- Local translation and directional steering in axonsAndrew C Lin
Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, UK
EMBO J 26:3729-36. 2007..This article reviews recent findings in local axonal translation and discusses how new protein synthesis may function in growth cone guidance, with a comparative view toward models of local translation in other systems...
- Function and regulation of local axonal translationAndrew C Lin
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
Curr Opin Neurobiol 18:60-8. 2008..We discuss possible rationales for local axonal translation, including distinct properties of nascent proteins, precise localization, and axonal autonomy...
- Asymmetrical beta-actin mRNA translation in growth cones mediates attractive turning to netrin-1Kin-Mei Leung
Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
Nat Neurosci 9:1247-56. 2006..Our data suggest that newly synthesized beta-actin, concentrated near sites of signal reception, provides the directional bias for polymerizing actin in the direction of an attractive stimulus...