Karen A Lillycrop

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. doi request reprint Breast cancer and the importance of early life nutrition
    Karen A Lillycrop
    Centre for Biological Sciences, Institute of Developmental Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, SO16 6YD, UK
    Cancer Treat Res 159:269-85. 2014
  2. doi request reprint Epigenetic mechanisms linking early nutrition to long term health
    Karen A Lillycrop
    Centre for Biological Sciences, Institute of Developmental Sciences, University of Southampton, Southampton, UK
    Best Pract Res Clin Endocrinol Metab 26:667-76. 2012
  3. doi request reprint The effect of nutrition during early life on the epigenetic regulation of transcription and implications for human diseases
    Karen A Lillycrop
    Centre for Biological Sciences, Institute of Developmental Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, UK
    J Nutrigenet Nutrigenomics 4:248-60. 2011
  4. doi request reprint Epigenetic changes in early life and future risk of obesity
    K A Lillycrop
    School of Biological Sciences, University of Southampton, Southampton, UK
    Int J Obes (Lond) 35:72-83. 2011
  5. ncbi request reprint Induction of antisense Pax-3 expression leads to the rapid morphological differentiation of neuronal cells and an altered response to the mitogenic growth factor bFGF
    F C Reeves
    Department of Biochemistry and Molecular Biology, School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK
    J Cell Sci 112:253-61. 1999
  6. doi request reprint Effect of maternal diet on the epigenome: implications for human metabolic disease
    Karen A Lillycrop
    School of Biological Sciences, Institute of Developmental Sciences, University of Southampton, Southampton, UK
    Proc Nutr Soc 70:64-72. 2011
  7. pmc Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and
    Karen A Lillycrop
    Development and Cell Biology, Biomedical Sciences Building, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Br J Nutr 97:1064-73. 2007
  8. pmc Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring
    Karen A Lillycrop
    Development and Cell Biology, Biomedical Sciences Building, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Br J Nutr 100:278-82. 2008
  9. doi request reprint Maternal protein restriction with or without folic acid supplementation during pregnancy alters the hepatic transcriptome in adult male rats
    Karen A Lillycrop
    Development and Cell Biology, University of Southampton, Bassett Crescent East, Southampton, UK
    Br J Nutr 103:1711-9. 2010
  10. pmc Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations
    Graham C Burdge
    Developmental Origins of Health and Disease Division, University of Southampton, Southampton, UK
    Br J Nutr 97:435-9. 2007

Collaborators

Detail Information

Publications38

  1. doi request reprint Breast cancer and the importance of early life nutrition
    Karen A Lillycrop
    Centre for Biological Sciences, Institute of Developmental Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, SO16 6YD, UK
    Cancer Treat Res 159:269-85. 2014
    ....
  2. doi request reprint Epigenetic mechanisms linking early nutrition to long term health
    Karen A Lillycrop
    Centre for Biological Sciences, Institute of Developmental Sciences, University of Southampton, Southampton, UK
    Best Pract Res Clin Endocrinol Metab 26:667-76. 2012
    ..This review will focus on how nutritional cues in early life can alter the epigenome, producing different phenotypes and altered disease susceptibilities...
  3. doi request reprint The effect of nutrition during early life on the epigenetic regulation of transcription and implications for human diseases
    Karen A Lillycrop
    Centre for Biological Sciences, Institute of Developmental Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, UK
    J Nutrigenet Nutrigenomics 4:248-60. 2011
    ....
  4. doi request reprint Epigenetic changes in early life and future risk of obesity
    K A Lillycrop
    School of Biological Sciences, University of Southampton, Southampton, UK
    Int J Obes (Lond) 35:72-83. 2011
    ....
  5. ncbi request reprint Induction of antisense Pax-3 expression leads to the rapid morphological differentiation of neuronal cells and an altered response to the mitogenic growth factor bFGF
    F C Reeves
    Department of Biochemistry and Molecular Biology, School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK
    J Cell Sci 112:253-61. 1999
    ..The slow onset of cell cycle arrest in the cells lacking Pax-3 argues against this transcription factor playing a direct role in the regulation of neuronal cell proliferation...
  6. doi request reprint Effect of maternal diet on the epigenome: implications for human metabolic disease
    Karen A Lillycrop
    School of Biological Sciences, Institute of Developmental Sciences, University of Southampton, Southampton, UK
    Proc Nutr Soc 70:64-72. 2011
    ....
  7. pmc Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and
    Karen A Lillycrop
    Development and Cell Biology, Biomedical Sciences Building, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Br J Nutr 97:1064-73. 2007
    ..These findings suggest that induction in the offspring of altered epigenetic regulation of the hepatic GR1(10) promoter, and hence metabolic phenotype, may be due to reduced Dnmt1 expression...
  8. pmc Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring
    Karen A Lillycrop
    Development and Cell Biology, Biomedical Sciences Building, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Br J Nutr 100:278-82. 2008
    ..These data show for the first time that prenatal nutrition induces differential changes to the methylation of individual CpG dinucleotides in juvenile rats which persist in adults...
  9. doi request reprint Maternal protein restriction with or without folic acid supplementation during pregnancy alters the hepatic transcriptome in adult male rats
    Karen A Lillycrop
    Development and Cell Biology, University of Southampton, Bassett Crescent East, Southampton, UK
    Br J Nutr 103:1711-9. 2010
    ..The present findings show that the pattern of induced changes in the adult liver transcriptome were dependent on maternal protein and folic acid intakes during pregnancy...
  10. pmc Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations
    Graham C Burdge
    Developmental Origins of Health and Disease Division, University of Southampton, Southampton, UK
    Br J Nutr 97:435-9. 2007
    ..This may represent a mechanism for the transmission of induced phenotypes between generations..
  11. doi request reprint Non-imprinted epigenetics in fetal and postnatal development and growth
    Keith M Godfrey
    MRC Lifecourse Epidemiology Unit, Southampton General Hospital, Southampton, UK
    Nestle Nutr Inst Workshop Ser 71:57-63. 2013
    ..Elucidation of epigenetic processes may enable early intervention strategies to improve early development and growth...
  12. pmc The nature of the growth pattern and of the metabolic response to fasting in the rat are dependent upon the dietary protein and folic acid intakes of their pregnant dams and post-weaning fat consumption
    Graham C Burdge
    Institute of Human Nutrition, University of Southampton, Southampton, SO16 6YD, UK
    Br J Nutr 99:540-9. 2008
    ..Prevention by increased folic acid intake of an altered metabolic phenotype by maternal protein-restriction may be at the expense of somatic growth...
  13. pmc Maternal fat intake in rats alters 20:4n-6 and 22:6n-3 status and the epigenetic regulation of Fads2 in offspring liver
    Samuel P Hoile
    Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK
    J Nutr Biochem 24:1213-20. 2013
    ..Thus, epigenetic regulation of Fads2 may contribute to short- and long-term regulation of PUFA synthesis...
  14. pmc Progressive, transgenerational changes in offspring phenotype and epigenotype following nutritional transition
    Graham C Burdge
    Academic Unit of Human Development and Health, Faculty of Medicine, Institute of Developmental Sciences, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    PLoS ONE 6:e28282. 2011
    ..The transgenerational effects on phenotype were associated with altered DNA methylation of specific genes in a manner consistent with induction de novo of epigenetic marks in each generation...
  15. pmc Epigenetic regulation of transcription: a mechanism for inducing variations in phenotype (fetal programming) by differences in nutrition during early life?
    Graham C Burdge
    DOHaD Research Division, University of Southampton, Bassett Cresent East, Southampton, UK
    Br J Nutr 97:1036-46. 2007
    ..The demonstration of altered epigenetic regulation of genes in phenotype induction suggests the possibility of interventions to modify long-term disease risk associated with unbalanced nutrition in early life...
  16. pmc Tissue-specific 5' heterogeneity of PPARα transcripts and their differential regulation by leptin
    Emma S Garratt
    Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
    PLoS ONE 8:e67483. 2013
    ..Such complexity in the regulation of PPARα may allow the expression of PPARα to be finely regulated in response to environmental factors. ..
  17. doi request reprint Increasing the folic acid content of maternal or post-weaning diets induces differential changes in phosphoenolpyruvate carboxykinase mRNA expression and promoter methylation in rats
    Samuel P Hoile
    Academic Unit of Human Development and Health, Faculty of Medicine, Institute of Developmental Sciences, Southampton General Hospital, Tremona Road, Southampton, UK
    Br J Nutr 108:852-7. 2012
    ..Together, these findings show that both the period during the life course and sex influence the effect of increased exposure to folic acid on the epigenetic regulation of PEPCK and glucose homeostasis...
  18. pmc Epigenetic gene promoter methylation at birth is associated with child's later adiposity
    Keith M Godfrey
    Institute of Developmental Sciences, University of Southampton, Southampton, UK
    Diabetes 60:1528-34. 2011
    ..In animal models, maternal diet alters offspring body composition, accompanied by epigenetic changes in metabolic control genes. Little is known about whether such processes operate in humans...
  19. doi request reprint Epigenetics: are there implications for personalised nutrition?
    Graham C Burdge
    Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Tremona Road, Southampton, UK
    Curr Opin Clin Nutr Metab Care 15:442-7. 2012
    ..Findings from animal models and human cohorts are discussed in the context of whether or not epigenetics may be an important factor in the progress towards the goal of personalised nutrition...
  20. doi request reprint Childhood Bone Mineral Content Is Associated With Methylation Status of the RXRA Promoter at Birth
    Nicholas C Harvey
    Medical Research Council MRC Lifecourse Epidemiology Unit, University of Southampton, UK National Institute for Health Research NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service NHS Foundation Trust, Southampton General Hospital, Southampton, UK
    J Bone Miner Res 29:600-7. 2014
    ..The potential mechanistic and functional significance of this finding remains a subject for further investigation. © 2014 American Society for Bone and Mineral Research. ..
  21. doi request reprint Nutrition, epigenetics, and developmental plasticity: implications for understanding human disease
    Graham C Burdge
    Institute of Human Nutrition, University of Southampton School of Medicine, Southampton, SO16 6YD, United Kingdom
    Annu Rev Nutr 30:315-39. 2010
    ..The purpose of this review is to discuss recent advances in understanding the mechanism that underlies the early life origins of disease and to place these studies in a broader life-course context...
  22. pmc Evaluation of methylation status of the eNOS promoter at birth in relation to childhood bone mineral content
    Nicholas C Harvey
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK
    Calcif Tissue Int 90:120-7. 2012
    ..This supports a role for eNOS in bone growth and metabolism and implies that its contribution may at least in part occur during early skeletal development...
  23. pmc Nutrition in early life, and risk of cancer and metabolic disease: alternative endings in an epigenetic tale?
    Graham C Burdge
    Institute of Human Nutrition, Southampton General Hospital, Tremona Road, Southampton, UK
    Br J Nutr 101:619-30. 2009
    ..However, the induction of specific disease risk is dependent upon the nature of the environmental challenge and interactions between the susceptibility set by the altered epigenome and the environment throughout the life course...
  24. ncbi request reprint Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring
    Karen A Lillycrop
    Development and Cell Biology, University of Southampton, UK
    J Nutr 135:1382-6. 2005
    ..Epigenetic regulation of gene transcription provides a strong candidate mechanism for fetal programming...
  25. pmc Correction of unexpected distributions of P values from analysis of whole genome arrays by rectifying violation of statistical assumptions
    Sheila J Barton
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK
    BMC Genomics 14:161. 2013
    ....
  26. ncbi request reprint Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease
    Keith M Godfrey
    Centre for Developmental Origins of Health and Disease, University of Southampton, UK
    Pediatr Res 61:5R-10R. 2007
    ..Future research into epigenetic processes may permit us to develop intervention strategies...
  27. ncbi request reprint Sex, but not maternal protein or folic acid intake, determines the fatty acid composition of hepatic phospholipids, but not of triacylglycerol, in adult rats
    G C Burdge
    Institute of Human Nutrition, Institute of Developmental Sciences Building, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, UK
    Prostaglandins Leukot Essent Fatty Acids 78:73-9. 2008
    ..These results suggest that sex differences in liver phospholipid fatty acid composition may reflect primary differences in the specificity of phospholipid biosynthesis...
  28. doi request reprint Folic acid supplementation in pregnancy: Are there devils in the detail?
    Graham C Burdge
    Academic Unit of Human Development and Health, Faculty of Medicine, Institute of Developmental Sciences Building MP887, Southampton General Hospital, University of Southampton, Tremona Road, Southampton SO16 6YD, UK
    Br J Nutr 108:1924-30. 2012
    ..Nevertheless, such effects should be investigated thoroughly in order to support firm conclusions about the risk of unanticipated long-term negative effects of maternal FA supplementation in humans...
  29. pmc Effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart
    Joanne L Slater-Jefferies
    Institute of Human Nutrition, University of Southampton School of Medicine, Institute of Developmental Sciences Building, MP887, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Prostaglandins Leukot Essent Fatty Acids 83:219-23. 2010
    ..These findings suggest that sex is an important factor in determining the incorporation of dietary fatty acids into cardiac lipids. This may have implications for sex differences in susceptibility to heart disease...
  30. doi request reprint Effect of sex hormones on n-3 polyunsaturated fatty acid biosynthesis in HepG2 cells and in human primary hepatocytes
    Charlene M Sibbons
    Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK
    Prostaglandins Leukot Essent Fatty Acids 90:47-54. 2014
    ..These findings show that progesterone increases n-3 PUFA biosynthesis by up-regulating the mRNA expression of genes involved in this pathway, possibly via changes in the epigenetic regulation of FADS2. ..
  31. doi request reprint Differential Pathways to Adult Metabolic Dysfunction following Poor Nutrition at Two Critical Developmental Periods in Sheep
    Kirsten R Poore
    Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
    PLoS ONE 9:e90994. 2014
    ..Such changes may increase later life obesity and dyslipidaemia risk. ..
  32. doi request reprint Fatty acids and epigenetics
    Graham C Burdge
    aAcademic Unit of Human Development and Health, Faculty of Medicine bCentre for Biological Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, UK
    Curr Opin Clin Nutr Metab Care 17:156-61. 2014
    ..The purpose of this review is to assess the findings of recent studies on the effects of fatty acids on epigenetic process and the role of epigenetics in regulating fatty acid metabolism...
  33. ncbi request reprint Dissection of the functional interaction between p53 and the embryonic proto-oncoprotein PAX3
    Timothy J Underwood
    Cancer Sciences Division, School of Medicine, University of Southampton, UK
    FEBS Lett 581:5831-5. 2007
    ....
  34. pmc Lysophosphatidic acid attenuates the cytotoxic effects and degree of peroxisome proliferator-activated receptor gamma activation induced by 15-deoxyDelta12,14-prostaglandin J2 in neuroblastoma cells
    Helen A Rodway
    Division of Biochemistry and Molecular Biology, School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Biochem J 382:83-91. 2004
    ..These data suggest that the serum lysolipid LPA modulates the degree of PPARgamma activation and the precise cellular response to 15dPGJ2 via activation of a G(i)/phosphoinositide 3-kinase/MAPK pathway...
  35. ncbi request reprint The expression of the developmentally regulated proto-oncogene Pax-3 is modulated by N-Myc
    Robert G Harris
    Department of Biochemistry and Molecular Biology, School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, United Kingdom
    J Biol Chem 277:34815-25. 2002
    ..These results suggest that the Myc family of transcription factors may modulate Pax-3 expression in vivo...
  36. pmc Bridging the gap between epigenetics research and nutritional public health interventions
    Graham C Burdge
    Institute of Human Nutrition, University of Southampton School of Medicine, Institute of Developmental Sciences Building MP887, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
    Genome Med 2:80. 2010
    ..Despite the early stage of knowledge in this field and the intellectual, technological and financial challenges, epigenetic research has substantial potential for public health benefits...
  37. ncbi request reprint Nerve growth factor induces the expression of the LIM homeodomain transcription factor Isl-1 with the kinetics of an immediate early gene in adult rat dorsal root ganglion
    H L Jameson
    Division of Biochemistry and Molecular Biology, School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK
    Neurosci Lett 309:130-4. 2001
    ..In contrast, Rlim and Lim-3mRNA induction by NGF required protein synthesis. The role of LIM-homeodomain genes in mediating responses to NGF in adult sensory neurons is discussed...
  38. ncbi request reprint Regulation of cellular processes by PPARgamma ligands in neuroblastoma cells is modulated by the level of retinoblastoma protein expression
    V C Emmans
    Development and Cell Biology, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Biochem Soc Trans 32:840-2. 2004
    ....