F Y Liew

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. pmc IL-33 exacerbates antigen-induced arthritis by activating mast cells
    Damo Xu
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, 120 University Place, University of Glasgow, Glasgow G12 8TA, United Kingdom
    Proc Natl Acad Sci U S A 105:10913-8. 2008
  2. ncbi request reprint Disease-associated functions of IL-33: the new kid in the IL-1 family
    Foo Y Liew
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK
    Nat Rev Immunol 10:103-10. 2010
  3. pmc IL-33 reduces the development of atherosclerosis
    Ashley M Miller
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, Scotland, UK
    J Exp Med 205:339-46. 2008
  4. ncbi request reprint Negative regulation of toll-like receptor-mediated immune responses
    Foo Y Liew
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G11 6NT, UK
    Nat Rev Immunol 5:446-58. 2005
  5. pmc Toll-like receptor 2 signalling and inflammation
    F Y Liew
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G11 6NT, UK
    Ann Rheum Dis 64:iv104-5. 2005
  6. ncbi request reprint T(H)1 and T(H)2 cells: a historical perspective
    Foo Y Liew
    Department of Immunology and Bacteriology, University of Glasgow, UK
    Nat Rev Immunol 2:55-60. 2002
  7. pmc Cytokines and nitric oxide as effector molecules against parasitic infections
    F Y Liew
    Department of Immunology, University of Glasgow, UK
    Philos Trans R Soc Lond B Biol Sci 352:1311-5. 1997
  8. ncbi request reprint Effects of nitric oxide on the induction and differentiation of Th1 cells
    W Niedbala
    Department of Immunology, University of Glasgow, Glasgow, GB
    Eur J Immunol 29:2498-505. 1999
  9. ncbi request reprint Interleukin 27 attenuates collagen-induced arthritis
    W Niedbala
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    Ann Rheum Dis 67:1474-9. 2008
  10. ncbi request reprint IL-18 induces the differentiation of Th1 or Th2 cells depending upon cytokine milieu and genetic background
    D Xu
    Department of Immunology and Bacteriology, University of Glasgow, Glasgow, GB
    Eur J Immunol 30:3147-56. 2000

Detail Information

Publications99

  1. pmc IL-33 exacerbates antigen-induced arthritis by activating mast cells
    Damo Xu
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, 120 University Place, University of Glasgow, Glasgow G12 8TA, United Kingdom
    Proc Natl Acad Sci U S A 105:10913-8. 2008
    ..Thus, this IL-1 superfamily member represents a therapeutic target for RA...
  2. ncbi request reprint Disease-associated functions of IL-33: the new kid in the IL-1 family
    Foo Y Liew
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK
    Nat Rev Immunol 10:103-10. 2010
    ..Thus IL-33 could be a new target for therapeutic intervention across a range of diseases...
  3. pmc IL-33 reduces the development of atherosclerosis
    Ashley M Miller
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, Scotland, UK
    J Exp Med 205:339-46. 2008
    ..In conclusion, IL-33 may play a protective role in the development of atherosclerosis via the induction of IL-5 and ox-LDL antibodies...
  4. ncbi request reprint Negative regulation of toll-like receptor-mediated immune responses
    Foo Y Liew
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G11 6NT, UK
    Nat Rev Immunol 5:446-58. 2005
    ..Here, we discuss the various negative regulatory mechanisms that have evolved to attenuate TLR signalling to maintain this immunological balance...
  5. pmc Toll-like receptor 2 signalling and inflammation
    F Y Liew
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G11 6NT, UK
    Ann Rheum Dis 64:iv104-5. 2005
  6. ncbi request reprint T(H)1 and T(H)2 cells: a historical perspective
    Foo Y Liew
    Department of Immunology and Bacteriology, University of Glasgow, UK
    Nat Rev Immunol 2:55-60. 2002
    ..In this article, I attempt to trace the historical events contributing to the development of the T(H)1/T(H)2 concept, the current state of play, and briefly discuss the future prospects for the field...
  7. pmc Cytokines and nitric oxide as effector molecules against parasitic infections
    F Y Liew
    Department of Immunology, University of Glasgow, UK
    Philos Trans R Soc Lond B Biol Sci 352:1311-5. 1997
    ..Furthermore, LPG can also inhibit IL-12 synthesis, thereby indirectly blocking the induction of iNOS. The evolutionary and therapeutic implications of these findings are discussed...
  8. ncbi request reprint Effects of nitric oxide on the induction and differentiation of Th1 cells
    W Niedbala
    Department of Immunology, University of Glasgow, Glasgow, GB
    Eur J Immunol 29:2498-505. 1999
    ..These results therefore provide an additional pathway by which NO modulates the immune response and contributes to the homeostasis of the immune system...
  9. ncbi request reprint Interleukin 27 attenuates collagen-induced arthritis
    W Niedbala
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    Ann Rheum Dis 67:1474-9. 2008
    ....
  10. ncbi request reprint IL-18 induces the differentiation of Th1 or Th2 cells depending upon cytokine milieu and genetic background
    D Xu
    Department of Immunology and Bacteriology, University of Glasgow, Glasgow, GB
    Eur J Immunol 30:3147-56. 2000
    ..These data therefore provide a novel mechanism for Th2 cell development. Thus, IL-18, a cytokine constitutively expressed by cells of the innate response, is capable of inducing Th2 cell differentiation in the absence of IL-4...
  11. ncbi request reprint Mice defective in Fas are highly susceptible to Leishmania major infection despite elevated IL-12 synthesis, strong Th1 responses, and enhanced nitric oxide production
    F P Huang
    Department of Immunology, University of Glasgow, Western Infirmary, United Kingdom
    J Immunol 160:4143-7. 1998
    ..Thus, Fas expression is essential for resistance against leishmaniasis, and Fas-mediated apoptosis may form an integral part of the Th1-mediated microbicidal function...
  12. ncbi request reprint A novel pathway regulating lipopolysaccharide-induced shock by ST2/T1 via inhibition of Toll-like receptor 4 expression
    M J Sweet
    Department of Immunology and Bacteriology, University of Glasgow, Glasgow, G11 6NT, United Kingdom
    J Immunol 166:6633-9. 2001
    ..We demonstrate here a novel regulatory pathway for LPS-induced shock via the ST2-Toll-like receptor 4 route. This may be of considerable therapeutic potential for reducing the severity and pathology of inflammatory diseases...
  13. ncbi request reprint Modulation of macrophage cytokine production by ES-62, a secreted product of the filarial nematode Acanthocheilonema viteae
    H S Goodridge
    Department of Immunology and Bacteriology, University of Glasgow, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, United Kingdom
    J Immunol 167:940-5. 2001
    ..This likely contributes to the generation of immune responses with an anti-inflammatory Th2 phenotype, a well-documented feature of filarial nematode infection...
  14. ncbi request reprint Immuno-regulatory cytokines in asthma: IL-15 and IL-13 in induced sputum
    M Komai-Koma
    Department of Immunology, Western Infirmary, Glasgow, UK
    Clin Exp Allergy 31:1441-8. 2001
    ..The macrophage-derived cytokine, interleukin (IL)-15 has a number of T cell regulatory properties which might be of relevance to asthma and its treatment...
  15. ncbi request reprint Reduced incidence and severity of collagen-induced arthritis in mice lacking IL-18
    X Q Wei
    Department of Immunology and Bacteriology, University of Glasgow, Glasgow, G11 6NT, United Kingdom
    J Immunol 166:517-21. 2001
    ..These data directly demonstrate a pivotal role of IL-18 in the development of inflammatory arthritis and suggest that antagonists to IL-18 may have therapeutic potential in rheumatic diseases...
  16. ncbi request reprint Altered immune responses and susceptibility to Leishmania major and Staphylococcus aureus infection in IL-18-deficient mice
    X Q Wei
    Department of Immunology, University of Glasgow, United Kingdom
    J Immunol 163:2821-8. 1999
    ....
  17. ncbi request reprint CD4+CD25+ regulatory T cells cure murine colitis: the role of IL-10, TGF-beta, and CTLA4
    Haiying Liu
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, United Kingdom
    J Immunol 171:5012-7. 2003
    ..Furthermore, colitis can manifest independent of Th1 and Th2 responses...
  18. pmc The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice
    F P Huang
    Department of Immunology, University of Glasgow, United Kingdom
    J Exp Med 183:1447-59. 1996
    ....
  19. ncbi request reprint A role for IL-18 in neutrophil activation
    B P Leung
    Department of Immunology and Bacteriology, Western Infirmary, University of Glasgow, Glasgow, United Kingdom
    J Immunol 167:2879-86. 2001
    ..Together, these data define a novel role for IL-18 in activating neutrophils and thereby promoting early innate immune responses...
  20. ncbi request reprint Glucocorticoid-induced TNFR family-related protein (GITR) activation exacerbates murine asthma and collagen-induced arthritis
    Manish Patel
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    Eur J Immunol 35:3581-90. 2005
    ..Our results therefore provide direct evidence that GITR can modulate both Th1- and Th2-mediated inflammatory diseases, and may be a potential target for therapeutic intervention...
  21. ncbi request reprint IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation
    Mariola Kurowska-Stolarska
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
    J Immunol 183:6469-77. 2009
    ..Taken together, we demonstrate here that IL-33/ST2 plays a significant role in the amplification of AAM polarization and chemokine production which contribute to innate and Ag-induced airway inflammation...
  22. pmc Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice
    M Komai-Koma
    Institute of Infection, Immunity and Inflammation, University of Glasgow, UK
    Allergy 67:1118-26. 2012
    ..IL-33 administration increases serum IgE in mice with unknown mechanism. We tested the hypothesis that IL-33 provides an antigen-independent stimulus for IgE production and mast cell degranulation...
  23. pmc Role of interleukin 18 in rheumatoid arthritis
    F Y Liew
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G11 6NT, Scotland, UK
    Ann Rheum Dis 62:ii48-50. 2003
  24. pmc A toll for T cell costimulation
    F Y Liew
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G11 6NT, UK
    Ann Rheum Dis 63:ii76-ii78. 2004
  25. pmc The cytokine interleukin-33 mediates anaphylactic shock
    Peter N Pushparaj
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Scotland, United Kingdom
    Proc Natl Acad Sci U S A 106:9773-8. 2009
    ..This report therefore reveals a hitherto unrecognized pathophysiological role of IL-33 and suggests that IL-33 may be a potential therapeutic target for anaphylaxis, a disease of considerable unmet medical need...
  26. pmc In vivo exposure of murine dendritic cell and macrophage bone marrow progenitors to the phosphorylcholine-containing filarial nematode glycoprotein ES-62 polarizes their differentiation to an anti-inflammatory phenotype
    Helen S Goodridge
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, United Kingdom
    Immunology 113:491-8. 2004
    ..Such a finding could have important implications for the use of pathogen products or their derivatives for immunotherapy...
  27. ncbi request reprint IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells
    Wanda Niedbala
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK
    Eur J Immunol 37:3021-9. 2007
    ..Thus, IL-35 is a novel anti-inflammatory cytokine suppressing the immune response through the expansion of regulatory T cells and suppression of Th17 cell development...
  28. ncbi request reprint IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4
    Mariola Kurowska-Stolarska
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow United Kingdom
    J Immunol 181:4780-90. 2008
    ..Thus, we demonstrate here that, in the presence of Ag, IL-33 induces IL-5-producing T cells and promotes airway inflammation independent of IL-4...
  29. ncbi request reprint IL-15 induces type 1 and type 2 CD4+ and CD8+ T cells proliferation but is unable to drive cytokine production in the absence of TCR activation or IL-12 / IL-4 stimulation in vitro
    Wanda Niedbala
    Department of Immunology and Bacteriology, University of Glasgow, Glasgow G11 6NT, Scotland, GB
    Eur J Immunol 32:341-7. 2002
    ..The levels of these cells are maintained by IL-15 and they are only mobilized to carry out effector functions when subsequently confronted with specific pathogens...
  30. ncbi request reprint Role of interleukin 33 in human immunopathology
    G E J Murphy
    Glasgow Biomedical Research Centre, 120 University Place, Glasgow G12 8QQ, UK
    Ann Rheum Dis 69:i43-47. 2010
    ..In this paper the basic biology of IL33 is described together with that of its cognate receptor, ST2L, and the existing knowledge base for its potential role in mediating human pathology across a range of diseases is defined...
  31. ncbi request reprint The role of nitric oxide in parasitic diseases
    F Y Liew
    Department of Immunology, University of Glasgow
    Ann Trop Med Parasitol 87:637-42. 1993
    ..The regulatory pathways involve tyrosine kinase and protein kinase C...
  32. pmc Cell-cell interactions in synovitis. Interactions between T lymphocytes and synovial cells
    I B McInnes
    Centre for Rheumatic Diseases, Glasgow Royal Infirmary, University of Glasgow, Glasgow, UK
    Arthritis Res 2:374-8. 2000
    ..Since soluble factors thus induced may in turn contribute directly to T cell activation, positive feedback loops are likely to be created. These novel pathways represent exciting potential therapeutic targets...
  33. ncbi request reprint Immune effector mechanism in parasitic infections
    F Y Liew
    Department of Immunology, University of Glasgow, UK
    Immunol Lett 65:101-4. 1999
    ..major infection. These results show directly the critical role of the balance between Th1 and Th2 cells in cutaneous leishmaniasis...
  34. ncbi request reprint A novel therapy of murine collagen-induced arthritis with soluble T1/ST2
    Bernard P Leung
    Division of Immunology, Infection, and Inflammation and Centre for Rheumatic Diseases, Royal Infirmary, University of Glasgow, Glasgow G11 6NT, Scotland, UK
    J Immunol 173:145-50. 2004
    ..Together these results demonstrate that sST2-Fc may provide a novel approach in treating chronic autoimmune conditions by inhibiting the release of proinflammatory cytokines...
  35. ncbi request reprint Colony-stimulating factor-1 suppresses responses to CpG DNA and expression of toll-like receptor 9 but enhances responses to lipopolysaccharide in murine macrophages
    Matthew J Sweet
    Department of Immunology and Bacteriology, University of Glasgow, Glasgow, United Kingdom
    J Immunol 168:392-9. 2002
    ..Hence, CSF-1 may regulate host responses to pathogens through modulation of TLR expression. Furthermore, these results suggest that CSF-1 and CSF-1R antagonists may enhance the efficacy of CpG DNA in vivo...
  36. ncbi request reprint IL-33 exacerbates eosinophil-mediated airway inflammation
    Bartosz Stolarski
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
    J Immunol 185:3472-80. 2010
    ..Taken together, this study demonstrates that the IL-33/ST2 signaling pathway activates airway eosinophils that exacerbate airway inflammation in an autocrine and paracrine manner...
  37. ncbi request reprint A novel dendritic cell-induced model of erosive inflammatory arthritis: distinct roles for dendritic cells in T cell activation and induction of local inflammation
    Bernard P Leung
    Department of Immunology and Bacteriology, University of Glasgow, Western Infirmary, Glasgow, United Kingdom
    J Immunol 169:7071-7. 2002
    ..Furthermore, this disease process is mediated through both adaptive and innate effects of DCs; first, priming of autoreactive T cells and, second, induction of local inflammation via mediators such as TNF...
  38. ncbi request reprint Chemoattraction of human T cells by IL-18
    Mousa Komai-Koma
    Division of Immunology, Infection and Inflammation, Faculty of Medicine, University of Glasgow, United Kingdom
    J Immunol 170:1084-90. 2003
    ..These data therefore demonstrate for the first time lymphocyte chemoattractant properties of a member of the IL-1 cytokine family and its relevance in inflammatory diseases...
  39. ncbi request reprint Septic arthritis following Staphylococcus aureus infection in mice lacking inducible nitric oxide synthase
    I B McInnes
    Department of Immunology, University of Glasgow, United Kingdom
    J Immunol 160:308-15. 1998
    ..These data indicate that high output NO production is not a prerequisite for severe articular destruction and imply that NO is of importance in synovial defense against staphylococcal infection...
  40. ncbi request reprint Lipid vesicle size determines the Th1 or Th2 response to entrapped antigen
    J M Brewer
    Department of Immunology, University of Strathclyde, Glasgow, Scotland
    J Immunol 161:4000-7. 1998
    ..Our results therefore indicate that macrophages respond to endocytosis of large or small vesicles by producing different patterns of cytokines that can subsequently direct the immune response toward a Th1 or a Th2 phenotype...
  41. pmc Role of interleukin 15 and interleukin 18 in inflammatory response
    F Y Liew
    Department of Immunology and Bacteriology, University of Glasgow, Glasgow G11 6NT, UK
    Ann Rheum Dis 61:ii100-2. 2002
    ..Here we present recent data mainly from our own laboratories illustrating the importance of IL15 and IL18 in the induction and perpetuation of chronic inflammation during experimental and clinical rheumatoid synovitis...
  42. ncbi request reprint A novel anti-inflammatory role for simvastatin in inflammatory arthritis
    Bernard P Leung
    Department of Immunology, Glasgow Royal Infirmary, University of Glasgow, Glasgow, United Kingdom
    J Immunol 170:1524-30. 2003
    ..These data clearly illustrate the therapeutic potential of statin-sensitive pathways in inflammatory arthritis...
  43. pmc Nitric oxide preferentially induces type 1 T cell differentiation by selectively up-regulating IL-12 receptor beta 2 expression via cGMP
    Wanda Niedbala
    Department of Immunology and Bacteriology, University of Glasgow, Glasgow G11 6NT, United Kingdom
    Proc Natl Acad Sci U S A 99:16186-91. 2002
    ..Our results also provide an example of the regulation of cytokine receptor expression by NO. The selectivity of such action via cGMP suggests that it is amenable to therapeutic intervention...
  44. pmc Nitric oxide induces CD4+CD25+ Foxp3 regulatory T cells from CD4+CD25 T cells via p53, IL-2, and OX40
    Wanda Niedbala
    Division of Immunology, Infection, and Inflammation, Glasgow Biomedical Research Centre, 120 University Place, University of Glasgow, Glasgow G12 8TA, United Kingdom
    Proc Natl Acad Sci U S A 104:15478-83. 2007
    ..Therefore, our findings uncovered a previously unrecognized function of NO via the NO-p53-IL-2-OX40-survivin signaling pathway for T cell differentiation and development...
  45. ncbi request reprint A novel anti-inflammatory role of simvastatin in a murine model of allergic asthma
    Anne McKay
    Division of Immunology, Infection, and Inflammation, Section of Respiratory Medicine, University of Glasgow, Glasgow, United Kingdom
    J Immunol 172:2903-8. 2004
    ..Simvastatin treatment did not alter serum total IgE or OVA-specific IgG1 and IgG2a levels. These data demonstrate the therapeutic potential of statin-sensitive pathways in allergic airways disease...
  46. pmc TLR2 is expressed on activated T cells as a costimulatory receptor
    Mousa Komai-Koma
    Division of Immunology, Infection, and Inflammation, University of Glasgow, Glasgow G11 6NT, United Kingdom
    Proc Natl Acad Sci U S A 101:3029-34. 2004
    ..This suggests that pathogens, via their pathogen-associated molecular patterns, may contribute directly to the perpetuation and activation of long-term T cell memory in both antigen-dependent and independent manner...
  47. doi request reprint IL-33: a Janus cytokine
    F Y Liew
    Institute of Infection, Immunity and Inflammation, University of Glasgow, 120, University Place, Glasgow G12 8TA, UK
    Ann Rheum Dis 71:i101-4. 2012
    ..In contrast, IL-33 can also exacerbate allergy and the inflammation in collagen-induced or serum-induced arthritis. Hence, IL-33 is a double-edged sword, and targeting IL-33 should be approached with caution...
  48. pmc New strategies to control inflammatory synovitis: interleukin 15 and beyond
    I B McInnes
    Centre for Rheumatic Diseases, Division of Immunology, Infection and Inflammation, Department of Medicine, University of Glasgow, UK
    Ann Rheum Dis 62:ii51-4. 2003
  49. pmc Role of nitric oxide in the regulation of T cell functions
    W Niedbala
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, 120 University Place, University of Glasgow, Glasgow G12 8TA, UK
    Ann Rheum Dis 65:iii37-40. 2006
    ....
  50. ncbi request reprint Nitric oxide mediates intestinal pathology but not immune expulsion during Trichinella spiralis infection in mice
    C E Lawrence
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    J Immunol 164:4229-34. 2000
    ..NO may therefore be an important mediator of enteropathy in both Th1- and Th2-inducing conditions...
  51. ncbi request reprint Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in mice
    Ashley M Miller
    Division of Immunology, Infection and Inflammation, GBRC, University of Glasgow, Glasgow, United Kingdom
    Circ Res 107:650-8. 2010
    ..The cytokine interleukin (IL)-33 and its receptor ST2 are expressed in adipose tissue, but their role in adipose tissue inflammation during obesity is unclear...
  52. ncbi request reprint Cytokine networks--towards new therapies for rheumatoid arthritis
    Iain B McInnes
    Centre for Rheumatic Diseases, University of Glasgow, UK
    Nat Clin Pract Rheumatol 1:31-9. 2005
    ..As therapeutic goals move from disease control towards remission induction, development of the capacity for cytokine targeting to modify the underlying immune dysregulation remains a major priority...
  53. ncbi request reprint IL-33 exacerbates autoantibody-induced arthritis
    Damo Xu
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK
    J Immunol 184:2620-6. 2010
    ....
  54. ncbi request reprint Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection
    Jose C Alves-Filho
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK
    Nat Med 16:708-12. 2010
    ..Together, our results indicate a previously undescribed mechanism of action of IL-33 and suggest a therapeutic potential of IL-33 in sepsis...
  55. ncbi request reprint TLR2 agonist ameliorates established allergic airway inflammation by promoting Th1 response and not via regulatory T cells
    Manish Patel
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, Scotland, United Kingdom
    J Immunol 174:7558-63. 2005
    ..Our results provide direct evidence that Pam3CSK4 could represent a novel therapeutic agent in allergic airways disease...
  56. pmc Differential regulation of interleukin-12 p40 and p35 induction via Erk mitogen-activated protein kinase-dependent and -independent mechanisms and the implications for bioactive IL-12 and IL-23 responses
    Helen S Goodridge
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    Immunology 109:415-25. 2003
    ....
  57. ncbi request reprint The role of innate cytokines in inflammatory response
    Foo Y Liew
    Department of Immunology and Bacteriology, University of Glasgow, Glasgow, Scotland G11 6NT, UK
    Immunol Lett 85:131-4. 2003
    ..These findings suggest that antagonists to these cytokines may have a potential therapeutic role against organ-specific autoimmune diseases...
  58. ncbi request reprint CD4+CD25+ regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice
    Damo Xu
    Department of Immunology and Bacteriology, University of Glasgow, Glasgow, Scotland, United Kingdom
    J Immunol 170:394-9. 2003
    ..Our results therefore document that CD4+CD25+ regulatory T cells suppress both Th1 and Th2 cells and that these regulatory T cells have a profound therapeutic potential against diseases induced by both Th1 and Th2 cells in vivo...
  59. ncbi request reprint A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62
    Iain B McInnes
    Department of Immunology and Center for Rheumatic Diseases, University of Glasgow, Glasgow, United Kingdom
    J Immunol 171:2127-33. 2003
    ..ES-62 represents one such mechanism. We now provide proof of concept that parasite-derived immunomodulatory strategies offer a novel therapeutic opportunity in inflammatory arthritis...
  60. ncbi request reprint A novel negative regulator for IL-1 receptor and Toll-like receptor 4
    Foo Y Liew
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G11 6NT, UK
    Immunol Lett 96:27-31. 2005
    ..The results provide a molecular explanation for the role of ST2 in T(H)2 responses since inhibition of TLRs will promote a T(H)2 response and also identify ST2 as a key regulator of endotoxin tolerance...
  61. ncbi request reprint The role of innate mediators in inflammatory response
    Foo Y Liew
    Department of Immunology and Bacteriology, University of Glasgow, G11 6NT, UK
    Mol Immunol 38:887-90. 2002
    ..Here we present recent data mainly from our own laboratory illustrating the important role of IL-15 and -18 in the induction and perpetuation of chronic inflammation during experimental and clinical rheumatoid synovitis...
  62. pmc Interleukin-18: a therapeutic target in rheumatoid arthritis?
    Iain B McInnes
    Division of Immunology, Infection and Inflammation, University of Glasgow, UK
    Arthritis Res Ther 7:38-41. 2005
    ..The aim of this article is to briefly review the biology of, and experimental approaches to IL-18 neutralisation, together with speculation as to the relative merits of IL-18 as an alternative to existing targets...
  63. ncbi request reprint Interleukin-18 levels in induced sputum are reduced in asthmatic and normal smokers
    A McKay
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    Clin Exp Allergy 34:904-10. 2004
    ..As such, it may have a regulatory role in asthma by modifying Th2 lymphocyte responses. Cigarette smoking may amplify the airway inflammation associated with asthma...
  64. ncbi request reprint Altered immune responses in mice lacking inducible nitric oxide synthase
    X Q Wei
    Department of Immunology, University of Glasgow, UK
    Nature 375:408-11. 1995
    ..The mutant mice showed reduced nonspecific inflammatory response to carrageenin, and were resistant to lipopolysaccharide-induced mortality...
  65. pmc Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells
    Haiying Liu
    Division of Immunology, Infection, and Inflammation, University of Glasgow, Glasgow G11 6NT, United Kingdom
    Proc Natl Acad Sci U S A 103:7048-53. 2006
    ..In the process, BLP also expands the Tregs, which recover their suppressive activity when the infection has subsided, in time to limit potential autoimmunity that might result from the overactivated effectors...
  66. ncbi request reprint IL-33 is a chemoattractant for human Th2 cells
    Mousa Komai-Koma
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK
    Eur J Immunol 37:2779-86. 2007
    ..These data therefore demonstrate that IL-33 is a selective Th2 chemoattractant associated with the pro-inflammatory property of this novel cytokine...
  67. ncbi request reprint A TLR2 ligand suppresses inflammation by modulation of chemokine receptors and redirection of leukocyte migration
    Clive S McKimmie
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow Biomedical Research Centre, Glasgow, United Kingdam
    Blood 113:4224-31. 2009
    ..These data highlight a novel role for TLR ligands, such as BLP, in regulating leukocyte retention and migration away from innate immune lesions via discrete constitutive and inflammatory chemokine receptor regulation...
  68. ncbi request reprint Galectin-3 deficiency reduces the severity of experimental autoimmune encephalomyelitis
    Hui Rong Jiang
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK
    J Immunol 182:1167-73. 2009
    ....
  69. ncbi request reprint Expression and alternative processing of IL-18 in human neutrophils
    Susan E Robertson
    CRD, Division of Immunology, Infection and Inflammation, Glasgow Royal Infirmary, Glasgow, UK
    Eur J Immunol 36:722-31. 2006
    ..Through cytosolic, membrane or secretory expression of such processing enzymes, together with generation of IL-18 itself, neutrophils likely play a critical role in regulating IL-18 activities during early innate immune responses...
  70. ncbi request reprint Apolipoprotein E-deficient mice are resistant to the development of collagen-induced arthritis
    Darren L Asquith
    University of Glasgow, Glasgow, UK
    Arthritis Rheum 62:472-7. 2010
    ..To determine whether elevated serum lipid levels resulting from feeding animals a high-fat diet can affect the inflammatory process in C57BL/6 (B6) wild-type (WT) and B6 ApoE(-/-) mouse models of collagen-induced arthritis (CIA)...
  71. ncbi request reprint Expression and function of Toll-like receptor on T cells
    Damo Xu
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G11 6NT, Scotland, UK
    Cell Immunol 233:85-9. 2005
    ..This suggests that pathogens, via their PAMPs, may contribute directly to the perpetuation and activation of long term T cell memory in both antigen dependent and independent manner...
  72. ncbi request reprint Animal models of rheumatoid arthritis
    Darren L Asquith
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, Scotland, UK
    Eur J Immunol 39:2040-4. 2009
    ..Here, we describe these animal models and discuss their advantages and limitations...
  73. ncbi request reprint Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1
    Clive S McKimmie
    Division of Immunology, Grasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
    J Immunol 181:8171-81. 2008
    ..These data therefore alter our models of in vivo D6 function and suggest possible discrete, and novel, roles for D6 on lymphatic endothelial cells and leukocytes...
  74. ncbi request reprint Prior elevation of IL-18 promotes rapid early IFN-gamma production during staphylococcal infection
    Shauna Culshaw
    Department of Immunology and Bacteriology, Western Infirmary, Glasgow, UK
    Eur J Immunol 35:1438-44. 2005
    ....
  75. ncbi request reprint Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1
    Clive S McKimmie
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
    J Immunol 181:3353-63. 2008
    ..These data therefore alter our models of in vivo D6 function and suggest possible discrete, and novel, roles for D6 on lymphatic endothelial cells and leukocytes...
  76. pmc Regulation of phagosomal iron release from murine macrophages by nitric oxide
    Victoriano Mulero
    Department of Immunology and Bacteriology, Western Infirmary, University of Glasgow, Glasgow, UK
    Biochem J 365:127-32. 2002
    ....
  77. pmc IL-15, a survival factor for kidney epithelial cells, counteracts apoptosis and inflammation during nephritis
    Michiya Shinozaki
    Laboratory of Molecular Autoimmune Disease, Renal Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Clin Invest 109:951-60. 2002
    ..Taken together, we suggest that IL-15 is a therapeutic for tubulointerstitial and glomerular kidney diseases...
  78. ncbi request reprint Coordinated and distinct roles for IFN-alpha beta, IL-12, and IL-15 regulation of NK cell responses to viral infection
    Khuong B Nguyen
    Deparment of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA
    J Immunol 169:4279-87. 2002
    ....
  79. ncbi request reprint Antitumor effect of interleukin (IL)-12 in the absence of endogenous IFN-gamma: a role for intrinsic tumor immunogenicity and IL-15
    Giorgia Gri
    Immunotherapy and Gene Therapy Unit, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, 20133 Milan, Italy
    Cancer Res 62:4390-7. 2002
    ....
  80. pmc Treatment with soluble interleukin-15Ralpha exacerbates intracellular parasitic infection by blocking the development of memory CD8+ T cell response
    Imtiaz A Khan
    Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Science Center, New Orleans, LA 70112, USA
    J Exp Med 195:1463-70. 2002
    ..gondii challenge. To our knowledge, this is the first demonstration of the important role of host IL-15 in the development of antigen-specific memory CD8+ T cells against an intracellular infection...
  81. ncbi request reprint Interleukin-18 is regulated by parathyroid hormone and is required for its bone anabolic actions
    Liza J Raggatt
    Department of Physiology and Biophysics, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Biol Chem 283:6790-8. 2008
    ..These data characterize the PTH regulation of IL-18 expression in osteoblastic cells and suggest that this cytokine is involved in the anabolic actions of PTH...
  82. ncbi request reprint Altered response to inflammatory cytokines in hepatic energy metabolism in inducible nitric oxide synthase knockout mice
    Takahiro Kitano
    Third Department of Internal Medicine, Kansai Medical University, Miroguchi 570 8506, Japan
    J Hepatol 36:759-65. 2002
    ..The present study focuses on the involvement of NO produced by inducible nitric oxide synthase (iNOS) in glycogen synthesis and energy metabolism stimulated by insulin...
  83. ncbi request reprint IL-15 mediates antigen-induced neutrophil migration by triggering IL-18 production
    Waldiceu A Verri
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Eur J Immunol 37:3373-80. 2007
    ....
  84. ncbi request reprint Antigen-induced inflammatory mechanical hypernociception in mice is mediated by IL-18
    Waldiceu A Verri
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Avenida Bandeirantes, 3900, 14049 900 Ribeirao Preto, Sao Paulo, Brazil
    Brain Behav Immun 21:535-43. 2007
    ..Thus, IL-18 and IL-18-downstream mediators demonstrated herein might constitute targets to inhibit antigen-induced inflammatory pain...
  85. ncbi request reprint IL-12, but not IL-18, is critical to neutrophil activation and resistance to polymicrobial sepsis induced by cecal ligation and puncture
    Susana E Moreno
    Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    J Immunol 177:3218-24. 2006
    ..Our data therefore provide further insight into the defense mechanism against this critical area of infectious disease...
  86. ncbi request reprint A fork in the pathway to inflammation and arthritis
    Foo Y Liew
    Nat Med 11:601-2. 2005
  87. ncbi request reprint ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance
    Elizabeth K Brint
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Nat Immunol 5:373-9. 2004
    ..Thus, these results provide a molecular explanation for the function of ST2 in T(H)2 responses, as inhibition of TLRs promotes a T(H)2 response, and also identify ST2 as a key regulator of endotoxin tolerance...
  88. ncbi request reprint IL-33, a potent inducer of adaptive immunity to intestinal nematodes
    Neil E Humphreys
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, United Kingdom
    J Immunol 180:2443-9. 2008
    ..Thus, the ability of IL-33 to induce Th2 responses has functional relevance in the context of intestinal helminth infection, particularly during the initiation of the response...
  89. ncbi request reprint IL-18 enhances collagen-induced arthritis by recruiting neutrophils via TNF-alpha and leukotriene B4
    Claudio A Canetti
    Department of Pharmacology, School of Medicine Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil
    J Immunol 171:1009-15. 2003
    ..Together, these findings provide a novel mechanism whereby IL-18 can promote inflammatory diseases...
  90. ncbi request reprint Immunological mechanisms and clinical implications of regulatory T cell deficiency in a systemic autoimmune disorder: roles of IL-2 versus IL-15
    Cui Hong Yang
    Department of Pathology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
    Eur J Immunol 38:1664-76. 2008
    ..These findings thus provide a clear causal relationship and immunological mechanism underlying Treg deficiency and systemic autoimmunity...
  91. ncbi request reprint Targeting interleukin-15 in patients with rheumatoid arthritis: a proof-of-concept study
    Bo Baslund
    Rigshospitalet, Copenhagen, Denmark
    Arthritis Rheum 52:2686-92. 2005
    ....
  92. pmc IL-1beta-driven ST2L expression promotes maturation resistance in rapamycin-conditioned dendritic cells
    Heth R Turnquist
    Thomas E Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Immunol 181:62-72. 2008
    ..This work identifies a novel mechanism through which a clinically important immunosuppressant impedes the capacity of DC to mature and consequently stimulate effector/adaptive T cell responses...
  93. ncbi request reprint ST2, an IL-1R family member, attenuates inflammation and lethality after intestinal ischemia and reperfusion
    Caio T Fagundes
    Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Av Antonio Carlos, 6627 Pampulha, 31270 901 Belo Horizonte, MG, Brazil
    J Leukoc Biol 81:492-9. 2007
    ..These results also demonstrate that sST2-Fc may provide a novel, complementary approach in treating ischemic reperfusion injury...
  94. pmc IL-15 mediates immune inflammatory hypernociception by triggering a sequential release of IFN-gamma, endothelin, and prostaglandin
    Waldiceu A Verri
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Avenida Bandeirantes 3900, 14049 900 Ribeirao Preto, Sao Paulo, Brazil
    Proc Natl Acad Sci U S A 103:9721-5. 2006
    ....
  95. ncbi request reprint Interleukin-18 induces mechanical hypernociception in rats via endothelin acting on ETB receptors in a morphine-sensitive manner
    Waldiceu A Verri
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Avenida Bandeirantes 3900, 14049 900 Ribeirao Preto, Sao Paulo, Brazil
    J Pharmacol Exp Ther 310:710-7. 2004
    ..Therefore, inhibition of the endothelin ET(B) receptor could be beneficial on controlling inflammatory hypernociception of diseases in which IL-18 plays a role in their pathogenesis...
  96. ncbi request reprint CXCR2-specific chemokines mediate leukotriene B4-dependent recruitment of neutrophils to inflamed joints in mice with antigen-induced arthritis
    Renata Grespan
    University of Sao Paulo, Sao Paulo, Brazil
    Arthritis Rheum 58:2030-40. 2008
    ..To investigate the mechanism underlying neutrophil migration into the articular cavity in experimental arthritis and, by extension, human inflammatory synovitis...
  97. ncbi request reprint IL-18 is a key proximal mediator of contact hypersensitivity and allergen-induced Langerhans cell migration in murine epidermis
    Christos Antonopoulos
    St John s Institute of Dermatology, King s College London, London, United Kingdom
    J Leukoc Biol 83:361-7. 2008
    ..These data indicate that IL-18 is a key proximal mediator of LC migration and CHS, acting upstream of IL-1 beta and TNF-alpha, and may play a central role in regulation of cutaneous immune responses...
  98. ncbi request reprint Role of IL-18 in overt pain-like behaviour in mice
    Waldiceu A Verri
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Avenida Bandeirantes, 3900, 14049 900 Ribeirao Preto, Sao Paulo, Brazil
    Eur J Pharmacol 588:207-12. 2008
    ..To conclude, these results further advance the understanding of the physiopathology of overt pain-like behaviour, and suggest for the first time a role for IL-18 in writhing response in mice...
  99. pmc IL-33 mediates antigen-induced cutaneous and articular hypernociception in mice
    Waldiceu A Verri
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes, 3900, 14049 900 Ribeirao Preto, Sao Paulo, Brazil
    Proc Natl Acad Sci U S A 105:2723-8. 2008
    ....