S J Lewis

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. ncbi request reprint GSTM1, GSTT1 and GSTP1 polymorphisms and lung cancer risk
    Sarah J Lewis
    School of Epidemiology and Health Sciences, University of Manchester, Manchester M13 9PT, UK
    Cancer Lett 180:165-71. 2002
  2. ncbi request reprint Meta-analysis of vitamin D receptor polymorphisms and pulmonary tuberculosis risk
    S J Lewis
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Int J Tuberc Lung Dis 9:1174-7. 2005
  3. pmc Associations between an obesity related genetic variant (FTO rs9939609) and prostate cancer risk
    Sarah J Lewis
    School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
    PLoS ONE 5:e13485. 2010
  4. doi request reprint Approaches for strengthening causal inference regarding prenatal risk factors for childhood behavioural and psychiatric disorders
    Sarah J Lewis
    School of Social and Community Medicine, University of Bristol, UK
    J Child Psychol Psychiatry 54:1095-108. 2013
  5. pmc Maternal and offspring fasting glucose and type 2 diabetes-associated genetic variants and cognitive function at age 8: a Mendelian randomization study in the Avon Longitudinal Study of Parents and Children
    Carolina Bonilla
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    BMC Med Genet 13:90. 2012
  6. pmc Association of fascin-1 with mortality, disease progression and metastasis in carcinomas: a systematic review and meta-analysis
    Vanessa Y Tan
    School of Social and Community Medicine, University of Bristol, 39 Whatley Road, Bristol BS8 2PS, UK
    BMC Med 11:52. 2013
  7. pmc Fetal alcohol exposure and IQ at age 8: evidence from a population-based birth-cohort study
    Sarah J Lewis
    School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
    PLoS ONE 7:e49407. 2012
  8. ncbi request reprint Folic acid supplementation during pregnancy may protect against depression 21 months after pregnancy, an effect modified by MTHFR C677T genotype
    S J Lewis
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Eur J Clin Nutr 66:97-103. 2012
  9. pmc The methylenetetrahydrofolate reductase C677T genotype and the risk of obesity in three large population-based cohorts
    Sarah J Lewis
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS82PR, UK
    Eur J Endocrinol 159:35-40. 2008
  10. pmc Smoking is associated with, but does not cause, depressed mood in pregnancy--a mendelian randomization study
    Sarah J Lewis
    School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
    PLoS ONE 6:e21689. 2011

Detail Information

Publications32

  1. ncbi request reprint GSTM1, GSTT1 and GSTP1 polymorphisms and lung cancer risk
    Sarah J Lewis
    School of Epidemiology and Health Sciences, University of Manchester, Manchester M13 9PT, UK
    Cancer Lett 180:165-71. 2002
    ....
  2. ncbi request reprint Meta-analysis of vitamin D receptor polymorphisms and pulmonary tuberculosis risk
    S J Lewis
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Int J Tuberc Lung Dis 9:1174-7. 2005
    ..We carried out a systematic review and meta-analysis, and found that results were inconclusive and studies were underpowered...
  3. pmc Associations between an obesity related genetic variant (FTO rs9939609) and prostate cancer risk
    Sarah J Lewis
    School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
    PLoS ONE 5:e13485. 2010
    ..Further research should confirm these findings, extend them to other BMI-related genetic variants and determine whether they are due to detection bias or obesity-related hormonal changes...
  4. doi request reprint Approaches for strengthening causal inference regarding prenatal risk factors for childhood behavioural and psychiatric disorders
    Sarah J Lewis
    School of Social and Community Medicine, University of Bristol, UK
    J Child Psychol Psychiatry 54:1095-108. 2013
    ..However, due to confounding and other limitations of traditional epidemiological studies, identification of causal risk factors has proved challenging and on the whole research in this area has not been fruitful...
  5. pmc Maternal and offspring fasting glucose and type 2 diabetes-associated genetic variants and cognitive function at age 8: a Mendelian randomization study in the Avon Longitudinal Study of Parents and Children
    Carolina Bonilla
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    BMC Med Genet 13:90. 2012
    ..These associations could be explained by confounding...
  6. pmc Association of fascin-1 with mortality, disease progression and metastasis in carcinomas: a systematic review and meta-analysis
    Vanessa Y Tan
    School of Social and Community Medicine, University of Bristol, 39 Whatley Road, Bristol BS8 2PS, UK
    BMC Med 11:52. 2013
    ..Fascin-1 is an interesting candidate biomarker for aggressive, metastatic carcinomas but data from individual studies of human tumors have not yet been pooled systematically...
  7. pmc Fetal alcohol exposure and IQ at age 8: evidence from a population-based birth-cohort study
    Sarah J Lewis
    School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
    PLoS ONE 7:e49407. 2012
    ..Associations between children's cognitive function and both maternal and child genotype at these loci can shed light on the effects of maternal alcohol consumption on offspring cognitive development...
  8. ncbi request reprint Folic acid supplementation during pregnancy may protect against depression 21 months after pregnancy, an effect modified by MTHFR C677T genotype
    S J Lewis
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Eur J Clin Nutr 66:97-103. 2012
    ..As low folate status has been implicated in depression, high folate intake, in the form of supplements, during pregnancy might offer protection against depression during pregnancy and postpartum...
  9. pmc The methylenetetrahydrofolate reductase C677T genotype and the risk of obesity in three large population-based cohorts
    Sarah J Lewis
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS82PR, UK
    Eur J Endocrinol 159:35-40. 2008
    ..We sought to determine whether MTHFR C677T genotype was associated with obesity...
  10. pmc Smoking is associated with, but does not cause, depressed mood in pregnancy--a mendelian randomization study
    Sarah J Lewis
    School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
    PLoS ONE 6:e21689. 2011
    ....
  11. doi request reprint Body composition at age 9 years, maternal folate intake during pregnancy and methyltetrahydrofolate reductase (MTHFR) C677T genotype
    Sarah J Lewis
    Department of Social Medicine, University of Bristol, 39 Whatley Road, Bristol BS8 2PS, UK
    Br J Nutr 102:493-6. 2009
    ..We also looked at maternal and offspring's MTHFR C677T genotype in relation to offspring body composition. We found no evidence to support the hypothesis that intra-uterine exposure to folate influences childhood body composition...
  12. ncbi request reprint Meta-analyses of observational and genetic association studies of folate intakes or levels and breast cancer risk
    Sarah J Lewis
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    J Natl Cancer Inst 98:1607-22. 2006
    ....
  13. ncbi request reprint The thermolabile variant of MTHFR is associated with depression in the British Women's Heart and Health Study and a meta-analysis
    S J Lewis
    Department of Social Medicine, University of Bristol, Whiteladies Road, Bristol, UK
    Mol Psychiatry 11:352-60. 2006
    ..36 (95% CI: 1.11, 1.67, P=0.003). Since this genotype influences the functioning of the folate metabolic pathway, these findings suggest that folate or its derivatives may be causally related to risk of depression...
  14. ncbi request reprint Methodological problems in genetic association studies of longevity--the apolipoprotein E gene as an example
    Sarah J Lewis
    International Centre for Health and Society, Department of Epidemiology and Public Health, University College London, London, UK
    Int J Epidemiol 33:962-70. 2004
    ..Such studies are based on two assumptions; (a) initial relative allele frequencies in the different age cohorts are similar, and (b) the risk of mortality conferred by genotypes does not depend on year of birth...
  15. ncbi request reprint A meta-analysis of the MTHFR C677T polymorphism and schizophrenia risk
    Sarah J Lewis
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 135:2-4. 2005
    ..Larger studies of this issue are required, together with studies of maternal genotype which could identify whether maternal folate status during pregnancy is important...
  16. ncbi request reprint Alcohol, ALDH2, and esophageal cancer: a meta-analysis which illustrates the potentials and limitations of a Mendelian randomization approach
    Sarah J Lewis
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:1967-71. 2005
    ..The two different processes operating as a result of the ALDH2 genotype have implications for the interpretation of studies using the Mendelian randomization paradigm...
  17. pmc Meta-analysis of MTHFR 677C->T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate?
    Sarah J Lewis
    Department of Social Medicine, University of Bristol, Bristol BS8 2PR
    BMJ 331:1053. 2005
    ..To investigate the association between the MTHFR 677C-->T polymorphism and coronary heart disease, assessing small study bias and heterogeneity between studies...
  18. doi request reprint Genetic variants in the vitamin d receptor are associated with advanced prostate cancer at diagnosis: findings from the prostate testing for cancer and treatment study and a systematic review
    Lina Chen
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Cancer Epidemiol Biomarkers Prev 18:2874-81. 2009
    ..84; 95% confidence interval, 0.71-1.00; P(unadjusted) = 0.050; P(adjusted) = 0.014). Our finding provides some support for the hypothesis that low levels of vitamin D may increase the risk of prostate cancer progression...
  19. doi request reprint PTGS2-899G>C and prostate cancer risk: a population-based nested case-control study (ProtecT) and a systematic review with meta-analysis
    A Murad
    Department of Social Medicine, University of Bristol, Bristol, UK
    Prostate Cancer Prostatic Dis 12:296-300. 2009
    ..20). A meta-analysis of three studies also found little evidence that rs20417 alters risk (pooled OR(CC & GC v GG)=1.04, 95% CI=0.93-1.17), making it unlikely that rs20417 contributes in any major way to prostate cancer aetiology...
  20. pmc Circulating folate, vitamin B12, homocysteine, vitamin B12 transport proteins, and risk of prostate cancer: a case-control study, systematic review, and meta-analysis
    Simon M Collin
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Cancer Epidemiol Biomarkers Prev 19:1632-42. 2010
    ..Disturbed folate metabolism is associated with an increased risk of some cancers. Our objective was to determine whether blood levels of folate, vitamin B(12), and related metabolites were associated with prostate cancer risk...
  21. doi request reprint Associations of folate, vitamin B12, homocysteine, and folate-pathway polymorphisms with prostate-specific antigen velocity in men with localized prostate cancer
    Simon M Collin
    School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
    Cancer Epidemiol Biomarkers Prev 19:2833-8. 2010
    ..We investigated whether these and other elements of folate metabolism were associated with prostate-specific antigen (PSA) velocity (PSAV) as a proxy measure of prostate cancer progression in men with localized prostate cancer...
  22. doi request reprint Association of folate-pathway gene polymorphisms with the risk of prostate cancer: a population-based nested case-control study, systematic review, and meta-analysis
    Simon M Collin
    Department of Social Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS United Kingdom
    Cancer Epidemiol Biomarkers Prev 18:2528-39. 2009
    ..Our meta-analysis suggests that known common folate-pathway single nucleotide polymorphisms do not have significant effects on susceptibility to prostate cancer...
  23. pmc A non-synonymous variant in ADH1B is strongly associated with prenatal alcohol use in a European sample of pregnant women
    Luisa Zuccolo
    Department of Social Medicine, University of Bristol, Bristol, UK
    Hum Mol Genet 18:4457-66. 2009
    ..We confirmed the established association of rs1229984 with reduced alcohol consumption over the life-course, contributing new evidence of an effect before and during pregnancy...
  24. pmc Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with spinal BMD in 9-year-old children
    Colin D Steer
    Department of Community Based Medicine, University of Bristol, Bristol, United Kingdom
    J Bone Miner Res 24:117-24. 2009
    ..To the extent that these findings reflect known influences of C677T MTHFR genotype on plasma homocysteine levels, our results suggest that the latter is an important regulator of spinal BMD in childhood...
  25. ncbi request reprint No APOEepsilon4 effect on coronary heart disease risk in a cohort with low smoking prevalence: the Whitehall II study
    Philippa J Talmud
    British Heart Foundation Laboratories, Department of Medicine, Centre for Cardiovascular Genetics, Rayne Building, University College London, 5 University Street, London WC1E 6JF, UK
    Atherosclerosis 177:105-12. 2004
    ..This supports the context dependency of the epsilon4 risk effect, but the low smoking incidence in the Whitehall men reduced our ability to examine a smoking:genotype interaction...
  26. pmc Alcohol intake and blood pressure: a systematic review implementing a Mendelian randomization approach
    Lina Chen
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    PLoS Med 5:e52. 2008
    ..We hypothesise that this polymorphism may influence the risk of hypertension by affecting alcohol drinking behaviour...
  27. doi request reprint Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis
    Lina Chen
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 147:814-21. 2008
    ..89-1.26, P = 0.537) comparing MM with VV genotypes and an OR of 0.97 (95% CI: 0.89-1.05, P = 0.403) comparing MV with VV genotypes. Our findings suggest that BDNF genotype does not exert a major influence on the development of depression...
  28. ncbi request reprint Maternal iron levels early in pregnancy are not associated with offspring IQ score at age 8, findings from a Mendelian randomization study
    S J Lewis
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Eur J Clin Nutr 68:496-502. 2014
    ..Iron is fundamental to many basic biological functions, and animal studies suggest that iron deficiency early in life can have a lasting impact on the developing brain...
  29. ncbi request reprint Associations between smoking, GST genotypes and N7-methylguanine levels in DNA extracted from bronchial lavage cells
    Sarah J Lewis
    Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E 6BT, UK
    Mutat Res 559:11-8. 2004
    ..1)x10(-7) versus (2.64+/-3.89)x10(-7) N7-MedGp/dGp, P=0.02). N7-MeG adduct levels in DNA isolated from lung tissue thus reflect exposure to cigarette smoke, and genetic variation in carcinogen-metabolising enzymes may modify these levels...
  30. ncbi request reprint Association between lung cancer risk and single nucleotide polymorphisms in the first intron and codon 178 of the DNA repair gene, O6-alkylguanine-DNA alkyltransferase
    Philip A J Crosbie
    Cancer Research UK Carcinogenesis Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, United Kingdom
    Int J Cancer 122:791-5. 2008
    ..These results suggest that the R allele may protect against lung cancer, specifically in heavy smokers, an effect that may result from this polymorphism affecting the function of the MGMT protein and/or levels in MGMT activity...
  31. ncbi request reprint Quantitative trait locus analysis reveals two intragenic sites that influence O6-alkylguanine-DNA alkyltransferase activity in peripheral blood mononuclear cells
    Geoffrey P Margison
    Cancer Research UK Carcinogenesis Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK
    Carcinogenesis 26:1473-80. 2005
    ..These findings suggest that further investigations of the potential epidemiological and clinical significance of inherited differences in MGMT expression and activity are warranted...
  32. ncbi request reprint Turning the pump handle: evolving methods for integrating the evidence on gene-disease association
    Julian P T Higgins
    Am J Epidemiol 166:863-6. 2007