S J G Lewis

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Cognitive deficits and psychosis in Parkinson's disease: a review of pathophysiology and therapeutic options
    Caroline H Williams-Gray
    Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK
    CNS Drugs 20:477-505. 2006
  2. pmc Heterogeneity of Parkinson's disease in the early clinical stages using a data driven approach
    S J G Lewis
    Cambridge Centre for Brain Repair, Forvie Site, Addenbrooke s Hospital, Cambridge, CB2 2PY, UK
    J Neurol Neurosurg Psychiatry 76:343-8. 2005
  3. ncbi request reprint Cognitive impairments in early Parkinson's disease are accompanied by reductions in activity in frontostriatal neural circuitry
    Simon J G Lewis
    Cambridge Centre for Brain Repair and Department of Neurology, University of Cambridge, Cambridge, United Kingdom CB2 2EF
    J Neurosci 23:6351-6. 2003
  4. ncbi request reprint Striatal contributions to working memory: a functional magnetic resonance imaging study in humans
    Simon J G Lewis
    Cambridge Centre for Brain Repair, Forvie Site, Addenbrooke s Hospital, Cambridge, CB2 2PY, UK
    Eur J Neurosci 19:755-60. 2004
  5. ncbi request reprint Modern therapeutic approaches in Parkinson's disease
    Simon J G Lewis
    Cambridge Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge, CB2 2PY, UK
    Expert Rev Mol Med 5:1-20. 2003
  6. ncbi request reprint Dopaminergic basis for deficits in working memory but not attentional set-shifting in Parkinson's disease
    Simon J G Lewis
    Cambridge Centre for Brain Repair, Forvie Site, Addenbrooke s Hospital, Cambridge CB2 2PY, UK
    Neuropsychologia 43:823-32. 2005
  7. pmc Saccadic latency distributions in Parkinson's disease and the effects of L-dopa
    A W Michell
    Cambridge Centre for Brain Repair, Forvie Site, Robinson Way, CB2 2PY, Cambridge, UK
    Exp Brain Res 174:7-18. 2006
  8. pmc Abnormal frontal activations related to decision-making in current and former amphetamine and opiate dependent individuals
    K D Ersche
    Department of Psychiatry, School of Clinical Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Psychopharmacology (Berl) 180:612-23. 2005
  9. ncbi request reprint The role of learned irrelevance in attentional set-shifting impairments in Parkinson's disease
    Aleksandra Slabosz
    MRC Cognition and Brain Sciences Unit, Cambridge, England
    Neuropsychology 20:578-88. 2006
  10. ncbi request reprint The use of the Actiwatch-Neurologica system to objectively assess the involuntary movements and sleep-wake activity in patients with mild-moderate Huntington's disease
    Carrie B Hurelbrink
    Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK
    J Neurol 252:642-7. 2005

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Cognitive deficits and psychosis in Parkinson's disease: a review of pathophysiology and therapeutic options
    Caroline H Williams-Gray
    Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK
    CNS Drugs 20:477-505. 2006
    ..Modafinil improves alertness in Parkinson's disease and warrants further investigation to establish its effects on cognitive performance...
  2. pmc Heterogeneity of Parkinson's disease in the early clinical stages using a data driven approach
    S J G Lewis
    Cambridge Centre for Brain Repair, Forvie Site, Addenbrooke s Hospital, Cambridge, CB2 2PY, UK
    J Neurol Neurosurg Psychiatry 76:343-8. 2005
    ..To investigate the heterogeneity of idiopathic Parkinson's disease (PD) in a data driven manner among a cohort of patients in the early clinical stages of the disease meeting established diagnostic criteria...
  3. ncbi request reprint Cognitive impairments in early Parkinson's disease are accompanied by reductions in activity in frontostriatal neural circuitry
    Simon J G Lewis
    Cambridge Centre for Brain Repair and Department of Neurology, University of Cambridge, Cambridge, United Kingdom CB2 2EF
    J Neurosci 23:6351-6. 2003
    ..Furthermore, they suggest that fMRI may provide a valuable tool for identifying patients who may benefit from targeted therapeutic strategies...
  4. ncbi request reprint Striatal contributions to working memory: a functional magnetic resonance imaging study in humans
    Simon J G Lewis
    Cambridge Centre for Brain Repair, Forvie Site, Addenbrooke s Hospital, Cambridge, CB2 2PY, UK
    Eur J Neurosci 19:755-60. 2004
    ..These results suggest an essential and specific role for the caudate nucleus in executive function, which may underlie the cognitive disturbances observed in frontostriatal neurodegenerative disorders such as Parkinson's disease...
  5. ncbi request reprint Modern therapeutic approaches in Parkinson's disease
    Simon J G Lewis
    Cambridge Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge, CB2 2PY, UK
    Expert Rev Mol Med 5:1-20. 2003
    ..In this review, we discuss the emerging new therapies in PD in terms of neuroprotective agents, drugs designed to control symptoms more effectively, and finally curative cell therapies...
  6. ncbi request reprint Dopaminergic basis for deficits in working memory but not attentional set-shifting in Parkinson's disease
    Simon J G Lewis
    Cambridge Centre for Brain Repair, Forvie Site, Addenbrooke s Hospital, Cambridge CB2 2PY, UK
    Neuropsychologia 43:823-32. 2005
    ..These results confirm that working memory deficits in PD are both psychologically specific and related to dopamine depletion. It is anticipated that greater understanding of these mechanisms will lead to future therapeutic improvements...
  7. pmc Saccadic latency distributions in Parkinson's disease and the effects of L-dopa
    A W Michell
    Cambridge Centre for Brain Repair, Forvie Site, Robinson Way, CB2 2PY, Cambridge, UK
    Exp Brain Res 174:7-18. 2006
    ....
  8. pmc Abnormal frontal activations related to decision-making in current and former amphetamine and opiate dependent individuals
    K D Ersche
    Department of Psychiatry, School of Clinical Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Psychopharmacology (Berl) 180:612-23. 2005
    ..We sought to investigate this possibility using functional neuroimaging...
  9. ncbi request reprint The role of learned irrelevance in attentional set-shifting impairments in Parkinson's disease
    Aleksandra Slabosz
    MRC Cognition and Brain Sciences Unit, Cambridge, England
    Neuropsychology 20:578-88. 2006
    ....
  10. ncbi request reprint The use of the Actiwatch-Neurologica system to objectively assess the involuntary movements and sleep-wake activity in patients with mild-moderate Huntington's disease
    Carrie B Hurelbrink
    Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK
    J Neurol 252:642-7. 2005
    ..These results demonstrate that the Actiwatch-Neurologica activity monitor can be used to objectively assess movements in HD patients during periods of high activity as well as during sleep...
  11. ncbi request reprint Using executive heterogeneity to explore the nature of working memory deficits in Parkinson's disease
    Simon J G Lewis
    Cambridge Centre for Brain Repair, Forvie Site, Addenbrooke s Hospital, University of Cambridge, CB2 2PY, UK
    Neuropsychologia 41:645-54. 2003
    ..The results also suggest that performance on the Tower of London task may prove to be a useful discriminant variable in defining the nature of cognitive heterogeneity in Parkinson's disease...
  12. ncbi request reprint L-DOPA disrupts activity in the nucleus accumbens during reversal learning in Parkinson's disease
    Roshan Cools
    Department of Experimental Psychology, Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 32:180-9. 2007
    ..These data concur with evidence from studies with experimental animals and indicate an important role for the human nucleus accumbens in the dopaminergic modulation of reversal learning...
  13. ncbi request reprint Biomarkers and Parkinson's disease
    A W Michell
    Cambridge Centre for Brain Repair, Forvie Site, Robinson Way, CB2 2PY, UK
    Brain 127:1693-705. 2004
    ..In this review we discuss the current potential biomarkers for Parkinson's disease, highlight the problems with their use, and conclude with a discussion of future alternatives...
  14. ncbi request reprint Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease
    An Goris
    Department of Clinical Neurosciences Neurology Unit, University of Cambridge, Cambridge, United Kingdom
    Ann Neurol 62:145-53. 2007
    ..We investigated the genetic basis of susceptibility to and cognitive heterogeneity of this disease...
  15. pmc X-linked adrenoleukodystrophy presenting as autosomal dominant pure hereditary spastic paraparesis
    C J Shaw-Smith
    Department of Medical Genetics, University of Cambridge, UK
    J Neurol Neurosurg Psychiatry 75:686-8. 2004
    ..This report illustrates the importance of assaying very long chain fatty acids (VLCFAs) in any HSP family where there is no male to male transmission...