R M Lewis

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. ncbi Effects of maternal iron restriction in the rat on hypoxia-induced gene expression and fetal metabolite levels
    R M Lewis
    Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, UK
    Br J Nutr 85:193-201. 2001
  2. doi Umbilical venous-arterial plasma composition differences suggest differential incorporation of fatty acids in NEFA and cholesteryl ester pools
    Rohan M Lewis
    Institute of Developmental Sciences, Faculty of Medicine, University of Southampton, UK
    Br J Nutr 106:463-7. 2011
  3. ncbi L-serine uptake by human placental microvillous membrane vesicles
    R M Lewis
    Centre for Developmental Origins of Health and Disease, University of Southampton, Level F MP887, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK
    Placenta 28:445-52. 2007
  4. ncbi Low serine hydroxymethyltransferase activity in the human placenta has important implications for fetal glycine supply
    Rohan M Lewis
    Centre for the Developmental Origins of Health and Disease, University of Southampton, Princess Anne Hospital, SO16 5YA Southampton, United Kingdom
    J Clin Endocrinol Metab 90:1594-8. 2005
  5. ncbi Long-term programming of blood pressure by maternal dietary iron restriction in the rat
    Rohan M Lewis
    Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, CB2 2QR, UK
    Br J Nutr 88:283-90. 2002
  6. ncbi Effects of maternal iron restriction on placental vascularization in the rat
    R M Lewis
    Department of Clinical Biochemistry, University of Cambridge, Box 232 Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Placenta 22:534-9. 2001
  7. ncbi Effects of maternal iron restriction in the rat on blood pressure, glucose tolerance, and serum lipids in the 3-month-old offspring
    R M Lewis
    Department of Clinical Biochemistry, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK
    Metabolism 50:562-7. 2001
  8. pmc Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone mass
    R M Lewis
    Institute of Developmental Sciences, University of Southampton and Southampton University Hospitals NHS Trust, UK
    Bone 50:337-42. 2012
  9. pmc Facilitated transporters mediate net efflux of amino acids to the fetus across the basal membrane of the placental syncytiotrophoblast
    J K Cleal
    Institute of Developmental Sciences, University of Southampton, Mail point 887, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    J Physiol 589:987-97. 2011
  10. doi Comparison of L-serine uptake by human placental microvillous membrane vesicles and placental villous fragments
    A P Brand
    Institute of Developmental Sciences, University of Southampton, School of Medicine, UK
    Placenta 31:456-9. 2010

Collaborators

Detail Information

Publications23

  1. ncbi Effects of maternal iron restriction in the rat on hypoxia-induced gene expression and fetal metabolite levels
    R M Lewis
    Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, UK
    Br J Nutr 85:193-201. 2001
    ..These changes in fetal metabolism may contribute to fetal growth retardation in this model. This study does not support the hypothesis that the Fe-restricted fetus is hypoxic...
  2. doi Umbilical venous-arterial plasma composition differences suggest differential incorporation of fatty acids in NEFA and cholesteryl ester pools
    Rohan M Lewis
    Institute of Developmental Sciences, Faculty of Medicine, University of Southampton, UK
    Br J Nutr 106:463-7. 2011
    ..The present study demonstrates differential enrichment across the placenta of fatty acids into specific lipid pools in the fetal circulation. Such partitioning may facilitate supply of individual fatty acids to specific fetal tissues...
  3. ncbi L-serine uptake by human placental microvillous membrane vesicles
    R M Lewis
    Centre for Developmental Origins of Health and Disease, University of Southampton, Level F MP887, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK
    Placenta 28:445-52. 2007
    ..Further studies are now required to define the fate of L-serine taken up by the placenta and its importance for the fetus...
  4. ncbi Low serine hydroxymethyltransferase activity in the human placenta has important implications for fetal glycine supply
    Rohan M Lewis
    Centre for the Developmental Origins of Health and Disease, University of Southampton, Princess Anne Hospital, SO16 5YA Southampton, United Kingdom
    J Clin Endocrinol Metab 90:1594-8. 2005
    ..The low activity of SHMT in the human and rat placenta suggests that, unlike in the sheep, placental conversion of serine to glycine is not a major source of fetal glycine in these species...
  5. ncbi Long-term programming of blood pressure by maternal dietary iron restriction in the rat
    Rohan M Lewis
    Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, CB2 2QR, UK
    Br J Nutr 88:283-90. 2002
    ..Both cardiac hypertrophy and decreased serum triacylglycerol have also been observed in Fe-restricted fetuses, suggesting that these changes may be initiated in utero...
  6. ncbi Effects of maternal iron restriction on placental vascularization in the rat
    R M Lewis
    Department of Clinical Biochemistry, University of Cambridge, Box 232 Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Placenta 22:534-9. 2001
    ..These changes in placental vascularization may contribute to the fetal growth retardation observed in iron-restricted litters...
  7. ncbi Effects of maternal iron restriction in the rat on blood pressure, glucose tolerance, and serum lipids in the 3-month-old offspring
    R M Lewis
    Department of Clinical Biochemistry, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK
    Metabolism 50:562-7. 2001
    ..It is thus speculated that the long-term effects of maternal dietary restriction may result from common fetal metabolic responses to this restriction...
  8. pmc Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone mass
    R M Lewis
    Institute of Developmental Sciences, University of Southampton and Southampton University Hospitals NHS Trust, UK
    Bone 50:337-42. 2012
    ..The results suggest that placental PHLDA2 may provide a biomarker for suboptimal skeletal growth in pregnancies uncomplicated by overt fetal growth restriction...
  9. pmc Facilitated transporters mediate net efflux of amino acids to the fetus across the basal membrane of the placental syncytiotrophoblast
    J K Cleal
    Institute of Developmental Sciences, University of Southampton, Mail point 887, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    J Physiol 589:987-97. 2011
    ..Consistent with a role in placental amino acid transfer capacity and fetal growth TAT1 and LAT3 mRNA expression showed positive associations with infant size at birth...
  10. doi Comparison of L-serine uptake by human placental microvillous membrane vesicles and placental villous fragments
    A P Brand
    Institute of Developmental Sciences, University of Southampton, School of Medicine, UK
    Placenta 31:456-9. 2010
    ..This study suggests that uptake of L-serine into MVM vesicles and villous fragments via Systems A and L is comparable, but that this is not true for all components of L-serine uptake...
  11. pmc What factors determine placental glucose transfer kinetics?
    P E Day
    Institute of Developmental Sciences, University of Southampton, Faculty of Medicine, Southampton SO16 6YD, United Kingdom
    Placenta 34:953-8. 2013
    ..This study investigates the relationship between maternal and fetal glucose concentrations and transfer across the placenta...
  12. doi Review: Modelling placental amino acid transfer--from transporters to placental function
    R M Lewis
    University of Southampton, Southampton General Hospital, Faculty of Medicine, MP 887, Tremona Road, Southampton SO14 6BD, UK
    Placenta 34:S46-51. 2013
    ..This model may also allow the development of strategies to optimise placental transfer in pathologies associated with impaired amino acid transfer such as fetal growth restriction...
  13. doi Maternal muscle mass may influence system A activity in human placenta
    R M Lewis
    Institute of Developmental Sciences, School of Medicine, University of Southampton, UK
    Placenta 31:418-22. 2010
    ..This alteration may affect fetal development, altering fetal body composition, with long-term consequences...
  14. ncbi Placental composition and surface area but not vascularization are altered by maternal protein restriction in the rat
    C B Doherty
    Department of Clinical Biochemistry, University of Cambridge, Box 232 Addenbrooke s Hospital, Hills Rd, UK
    Placenta 24:34-8. 2003
    ..This study found that maternal protein restriction is associated with an increase in placental size, and that this enlargement is accompanied by increases in some, but not all, structural correlates of function...
  15. ncbi Computational modelling of amino acid transfer interactions in the placenta
    B G Sengers
    University of Southampton, UK
    Exp Physiol 95:829-40. 2010
    ..Ultimately, this approach will allow physiological simulations of amino acid transfer. This will enhance our understanding of these complex systems and placental function in health and disease...
  16. doi The mechanisms and regulation of placental amino acid transport to the human foetus
    J K Cleal
    The Institute of Developmental Sciences, University of Southampton, Southampton, UK
    J Neuroendocrinol 20:419-26. 2008
    ..Understanding the mechanisms and regulation of amino acid transport is necessary to understand the causes of intrauterine growth restriction in human pregnancy...
  17. ncbi Effect of maternal iron restriction during pregnancy on renal morphology in the adult rat offspring
    S J M Lisle
    Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    Br J Nutr 90:33-9. 2003
    ..42, n 28, P<0.05) and 16 months of age (r-0.64, n 28, P<0.05). Therefore, in rats, maternal Fe restriction causes hypertension in the adult offspring that may be due, in part, to a deficit in nephron number...
  18. doi Review: Placenta, evolution and lifelong health
    R M Lewis
    University of Southampton, Faculty of Medicine, Southampton, UK
    Placenta 33:S28-32. 2012
    ....
  19. pmc Partitioning of glutamine synthesised by the isolated perfused human placenta between the maternal and fetal circulations
    P E L Day
    University of Southampton, Faculty of Medicine, Human Development and Health, United Kingdom
    Placenta 34:1223-31. 2013
    ..The objective of this study was to investigate the role of glutamate/glutamine metabolism by the isolated perfused human placenta in the provision of glutamine to the fetus...
  20. ncbi Maternal dietary iron restriction modulates hepatic lipid metabolism in the fetuses
    Junlong Zhang
    Endocrinology and Metabolism Unit, Developmental Origins of Health and Disease Division, School of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Am J Physiol Regul Integr Comp Physiol 288:R104-11. 2005
    ....
  21. doi The placental exposome: placental determinants of fetal adiposity and postnatal body composition
    R M Lewis
    University of Southampton, Southampton, UK
    Ann Nutr Metab 63:208-15. 2013
    ....
  22. pmc Modification of fetal plasma amino acid composition by placental amino acid exchangers in vitro
    Jane K Cleal
    DOHaD Division, University of Southampton, Southampton, UK
    J Physiol 582:871-82. 2007
    ..This study demonstrates that these transporters have the capacity to exchange micromolar amounts of specific amino acids, and suggests that they play an important role in regulating fetal plasma amino acid composition...
  23. ncbi Quantitated transcript haplotypes (QTH) of AGTR1, reduced abundance of mRNA haplotypes containing 1166C (rs5186:A>C), and relevance to metabolic syndrome traits
    Mohammad R Abdollahi
    Human Genetics Division, Southampton General Hospital, University of Southampton, Southampton, United Kingdom
    Hum Mutat 28:365-73. 2007
    ..Differential abundance of AGTR1 mRNA haplotypes may mediate clinical phenotypic observations of the AGTR1 genotype...