R M Lewis

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. pmc Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone mass
    R M Lewis
    Institute of Developmental Sciences, University of Southampton and Southampton University Hospitals NHS Trust, UK
    Bone 50:337-42. 2012
  2. doi Maternal muscle mass may influence system A activity in human placenta
    R M Lewis
    Institute of Developmental Sciences, School of Medicine, University of Southampton, UK
    Placenta 31:418-22. 2010
  3. pmc Facilitated transporters mediate net efflux of amino acids to the fetus across the basal membrane of the placental syncytiotrophoblast
    J K Cleal
    Institute of Developmental Sciences, University of Southampton, Mail point 887, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    J Physiol 589:987-97. 2011
  4. doi Comparison of L-serine uptake by human placental microvillous membrane vesicles and placental villous fragments
    A P Brand
    Institute of Developmental Sciences, University of Southampton, School of Medicine, UK
    Placenta 31:456-9. 2010
  5. doi Review: Modelling placental amino acid transfer--from transporters to placental function
    R M Lewis
    University of Southampton, Southampton General Hospital, Faculty of Medicine, MP 887, Tremona Road, Southampton SO14 6BD, UK
    Placenta 34:S46-51. 2013
  6. ncbi L-serine uptake by human placental microvillous membrane vesicles
    R M Lewis
    Centre for Developmental Origins of Health and Disease, University of Southampton, Level F MP887, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK
    Placenta 28:445-52. 2007
  7. doi Computational modelling of amino acid transfer interactions in the placenta
    B G Sengers
    University of Southampton, UK
    Exp Physiol 95:829-40. 2010
  8. doi Review: Placenta, evolution and lifelong health
    R M Lewis
    University of Southampton, Faculty of Medicine, Southampton, UK
    Placenta 33:S28-32. 2012
  9. doi The mechanisms and regulation of placental amino acid transport to the human foetus
    J K Cleal
    The Institute of Developmental Sciences, University of Southampton, Southampton, UK
    J Neuroendocrinol 20:419-26. 2008
  10. ncbi Effects of maternal iron restriction in the rat on hypoxia-induced gene expression and fetal metabolite levels
    R M Lewis
    Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, UK
    Br J Nutr 85:193-201. 2001

Detail Information

Publications13

  1. pmc Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone mass
    R M Lewis
    Institute of Developmental Sciences, University of Southampton and Southampton University Hospitals NHS Trust, UK
    Bone 50:337-42. 2012
    ..The results suggest that placental PHLDA2 may provide a biomarker for suboptimal skeletal growth in pregnancies uncomplicated by overt fetal growth restriction...
  2. doi Maternal muscle mass may influence system A activity in human placenta
    R M Lewis
    Institute of Developmental Sciences, School of Medicine, University of Southampton, UK
    Placenta 31:418-22. 2010
    ..This alteration may affect fetal development, altering fetal body composition, with long-term consequences...
  3. pmc Facilitated transporters mediate net efflux of amino acids to the fetus across the basal membrane of the placental syncytiotrophoblast
    J K Cleal
    Institute of Developmental Sciences, University of Southampton, Mail point 887, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    J Physiol 589:987-97. 2011
    ..Consistent with a role in placental amino acid transfer capacity and fetal growth TAT1 and LAT3 mRNA expression showed positive associations with infant size at birth...
  4. doi Comparison of L-serine uptake by human placental microvillous membrane vesicles and placental villous fragments
    A P Brand
    Institute of Developmental Sciences, University of Southampton, School of Medicine, UK
    Placenta 31:456-9. 2010
    ..This study suggests that uptake of L-serine into MVM vesicles and villous fragments via Systems A and L is comparable, but that this is not true for all components of L-serine uptake...
  5. doi Review: Modelling placental amino acid transfer--from transporters to placental function
    R M Lewis
    University of Southampton, Southampton General Hospital, Faculty of Medicine, MP 887, Tremona Road, Southampton SO14 6BD, UK
    Placenta 34:S46-51. 2013
    ..This model may also allow the development of strategies to optimise placental transfer in pathologies associated with impaired amino acid transfer such as fetal growth restriction...
  6. ncbi L-serine uptake by human placental microvillous membrane vesicles
    R M Lewis
    Centre for Developmental Origins of Health and Disease, University of Southampton, Level F MP887, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK
    Placenta 28:445-52. 2007
    ..Further studies are now required to define the fate of L-serine taken up by the placenta and its importance for the fetus...
  7. doi Computational modelling of amino acid transfer interactions in the placenta
    B G Sengers
    University of Southampton, UK
    Exp Physiol 95:829-40. 2010
    ..Ultimately, this approach will allow physiological simulations of amino acid transfer. This will enhance our understanding of these complex systems and placental function in health and disease...
  8. doi Review: Placenta, evolution and lifelong health
    R M Lewis
    University of Southampton, Faculty of Medicine, Southampton, UK
    Placenta 33:S28-32. 2012
    ....
  9. doi The mechanisms and regulation of placental amino acid transport to the human foetus
    J K Cleal
    The Institute of Developmental Sciences, University of Southampton, Southampton, UK
    J Neuroendocrinol 20:419-26. 2008
    ..Understanding the mechanisms and regulation of amino acid transport is necessary to understand the causes of intrauterine growth restriction in human pregnancy...
  10. ncbi Effects of maternal iron restriction in the rat on hypoxia-induced gene expression and fetal metabolite levels
    R M Lewis
    Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, UK
    Br J Nutr 85:193-201. 2001
    ..These changes in fetal metabolism may contribute to fetal growth retardation in this model. This study does not support the hypothesis that the Fe-restricted fetus is hypoxic...
  11. ncbi Effects of maternal iron restriction on placental vascularization in the rat
    R M Lewis
    Department of Clinical Biochemistry, University of Cambridge, Box 232 Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Placenta 22:534-9. 2001
    ..These changes in placental vascularization may contribute to the fetal growth retardation observed in iron-restricted litters...
  12. pmc What factors determine placental glucose transfer kinetics?
    P E Day
    Institute of Developmental Sciences, University of Southampton, Faculty of Medicine, Southampton SO16 6YD, United Kingdom
    Placenta 34:953-8. 2013
    ..This study investigates the relationship between maternal and fetal glucose concentrations and transfer across the placenta...
  13. doi The placental exposome: placental determinants of fetal adiposity and postnatal body composition
    R M Lewis
    University of Southampton, Southampton, UK
    Ann Nutr Metab 63:208-15. 2013
    ....