Research Topics
Genomes and GenesSpecies | Claire LewisSummaryAffiliation: University of Sheffield Country: UK Publications
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Publications
The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapiesL Bingle
Tumour Targeting Group, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield S10 2RX, UK
J Pathol 196:254-65. 2002..It also outlines the range of pro- and anti-tumour functions performed by TAMs, and the novel therapies recently devised using TAMs to stimulate host immune responses or deliver therapeutic gene constructs to solid tumours...- Multiple effects of angiopoietin-2 blockade on tumorsClaire E Lewis
Academic Unit of Inflammation and Tumour Targeting, The University of Sheffield Medical School, Sheffield, UK
Cancer Cell 19:431-3. 2011.... - Tie2-expressing monocytes and tumor angiogenesis: regulation by hypoxia and angiopoietin-2Claire E Lewis
Tumor Targeting Group, Academic Unit of Pathology, The Sir Henry Wellcome Laboratories for Medical Research, University of Sheffield Medical School, Sheffield, United Kingdom
Cancer Res 67:8429-32. 2007..Learning more about the regulation of TEMs by the tumor microenvironment may yield new strategies to ablate the tumor vasculature... 
Inflammation and breast cancer. Microenvironmental factors regulating macrophage function in breast tumours: hypoxia and angiopoietin-2Claire E Lewis
Tumour Targeting Group, Academic Unit of Pathology, Section of Infection, Inflammation and Immunity, The Sir Henry Wellcome Laboratories for Medical Research, University of Sheffield Medical School, UK
Breast Cancer Res 9:209. 2007..This in turn then recruits Tie-2-expressing monocytes into tumours from the bloodstream and inhibits their production of anti-apoptotic and anti-angiogenic cytokines...- Distinct role of macrophages in different tumor microenvironmentsClaire E Lewis
Academic Unit of Pathology, Division of Genomic Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, United Kingdom
Cancer Res 66:605-12. 2006..This review will discuss the evidence for differential regulation of TAMs in these microenvironments and provide an overview of current attempts to target or use TAMs for therapeutic purposes... - Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapiesClaire Lewis
Tumor Targeting Group, Academic Unit of Pathology, Division of Genomic Medicine, Sir Henry Wellcome Laboratories for Medical Research, University of Sheffield Medical School, Sheffield S10 2RX, UK
Am J Pathol 167:627-35. 2005..We also discuss current attempts to selectively target TAMs for destruction or to use them to deliver gene therapy specifically to hypoxic tumor sites... - Expression of Tie-2 by human monocytes and their responses to angiopoietin-2Craig Murdoch
Tumor Targeting Group, Academic Unit of Pathology, Division of Genomic Medicine, The Sir Henry Wellcome Laboratories for Medical Research, University of Sheffield Medical School, Sheffield, United Kingdom
J Immunol 178:7405-11. 2007..In sum, our data indicate that Ang-2 may recruit Tie-2(+) monocytes to tumors and sites of inflammation, modulate their release of important cytokines and stimulate them to express a proangiogenic phenotype... 
Angiopoietin-2 regulates gene expression in TIE2-expressing monocytes and augments their inherent proangiogenic functionsSeth B Coffelt
Academic Unit of Inflammation and Tumour Targeting, University of Sheffield Medical School, Sheffield, United Kingdom
Cancer Res 70:5270-80. 2010..As such, the ANG-2-TEM axis may represent a new target for antiangiogenic cancer therapies...- Elusive identities and overlapping phenotypes of proangiogenic myeloid cells in tumorsSeth B Coffelt
Medical School, University of Sheffield, Sheffield, S10 2RX, UK
Am J Pathol 176:1564-76. 2010..quot; Here we review the findings of various attempts to phenotype the myeloid cells involved and discuss the therapeutic implications of correctly identifying-and thus being able to target-this proangiogenic force in tumors... - Neutrophils: key mediators of tumour angiogenesisSimon Tazzyman
Tumour Targeting Group, Academic Unit of Pathology, Medical School, University of Sheffield, Sheffield, UK
Int J Exp Pathol 90:222-31. 2009..We also discuss possible future chemotherapeutic strategies that are aimed at limiting tumour angiogenesis by inhibiting neutrophil recruitment... - Hypoxia regulates macrophage functions in inflammationCraig Murdoch
Tumor Targeting Group, Academic Unit of Pathology, Division of Genomic Medicine, The Henry Wellcome Laboratories for Medical Research, University of Sheffield Medical School, Sheffield S10 2RX
J Immunol 175:6257-63. 2005..In the present study, we outline and compare the phenotypic responses of macrophages to hypoxia in different diseased states and the implications of these for their progression and treatment... - Macrophage migration and gene expression in response to tumor hypoxiaCraig Murdoch
Tumor Targeting Group, Academic Unit of Pathology, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield S10 2RX, United Kingdom
Int J Cancer 117:701-8. 2005..In this way, the responses of macrophages to tumor hypoxia can be exploited to deliver potent antitumor agents to these poorly vascularized, and thus largely inaccessible, areas of tumors... - Tumor-associated macrophages: effectors of angiogenesis and tumor progressionSeth B Coffelt
Academic Unit of Pathology, Medical School, University of Sheffield, Sheffield, UK
Biochim Biophys Acta 1796:11-8. 2009..We also discuss recent attempts to both target/destroy TAMs and exploit them as delivery vehicles for anti-cancer gene therapy... - Alphastatin, a 24-amino acid fragment of human fibrinogen, is a potent new inhibitor of activated endothelial cells in vitro and in vivoCarolyn A Staton
Tumor Targeting Group, University of Sheffield Medical School, Sheffield, S10 2RX, United Kingdom
Blood 103:601-6. 2004..Taken together, these data indicate that alphastatin is a potent new antiangiogenic agent in vitro and antivascular agent in vivo... - Effects of hypoxia on transcription factor expression in human monocytes and macrophagesLaila Elbarghati
Tumour Targeting Group, Academic Unit of Pathology, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK
Immunobiology 213:899-908. 2008..Taken together, these findings indicate that a number of transcription factors work together in a tightly regulated fashion to control macrophage activities in ischaemic areas of diseased tissues... - Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapyBernard Burke
Tumor Targeting Group, Section of Oncology and Pathology, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield, United Kingdom
Am J Pathol 163:1233-43. 2003..The hypoxia up-regulated genes identified could be important for the survival and functioning of macrophages in hypoxic diseased tissues, and their promoters could prove useful in macrophage-delivered gene therapy... - The role of myeloid cells in the promotion of tumour angiogenesisCraig Murdoch
Department of Oral and Maxillofacial Surgery, School of Clinical Dentistry, Beech Hill Road, University of Sheffield, Sheffield, UK
Nat Rev Cancer 8:618-31. 2008..We also discuss the therapeutic implications of recent findings that specific myeloid cell populations modulate the responses of tumours to agents such as chemotherapy and some anti-angiogenic therapies... - Hemostatic regulators of tumor angiogenesis: a source of antiangiogenic agents for cancer treatment?Martina E Daly
Academic Unit of Hematology, School of Medicine and Biomedical Sciences, Sheffield, United Kingdom
J Natl Cancer Inst 95:1660-73. 2003..Finally, we review the results of recent clinical trials involving angiogenesis inhibitors and the evidence that antiangiogenic therapy may be associated with hemostatic complications... - The role of fibrinogen and related fragments in tumour angiogenesis and metastasisCarolyn A Staton
Tumour Targeting Group, University of Sheffield Medical School, Sheffield, S10 2RX, UK
Expert Opin Biol Ther 3:1105-20. 2003..In this review, the evidence for the ability of fibrinogen and various protein/peptide fragment derivatives to modulate angiogenic mechanisms in vitro and to affect tumour growth and metastasis in vivo is discussed... - Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxiaHsin Yu Fang
Academic Unit of Inflammation and Tumour Targeting, Faculty of Medicine, Dentistry and Health, University of Sheffield, Beech Hill Road, Sheffield, United Kingdom
Blood 114:844-59. 2009..Further studies using experimental mouse models are now warranted to investigate the role of such macrophage responses in the progression of various diseased tissues, such as malignant tumors... - Expression of HIF-1alpha by human macrophages: implications for the use of macrophages in hypoxia-regulated cancer gene therapyBernard Burke
Tumour Targeting Group, Academic Unit of Pathology, Section of Oncology and Pathology, Division of Genomic Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK
J Pathol 196:204-12. 2002.... - Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissuesCraig Murdoch
Tumor Targeting Group, Academic Unit of Pathology, Division of Genomic Medicine, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, United Kingdom
Blood 104:2224-34. 2004.... - Current methods for assaying angiogenesis in vitro and in vivoCarolyn A Staton
Tumour Targeting Group University of Sheffield Medical School, Sheffield, UK
Int J Exp Pathol 85:233-48. 2004.... - Angiogenesis inhibitors found within the haemostasis pathwayCarolyn A Staton
Microcirculation Research Group, University of Sheffield Medical School, Sheffield, S10 2RX, UK
J Cell Mol Med 9:286-302. 2005.... - Use of bacteria in anti-cancer therapiesRachel M Ryan
Tumour Targeting Group, Division of Genomic Medicine, University of Sheffield, UK
Bioessays 28:84-94. 2006..Here, we review the evidence for the success of these in pre-clinical models and clinical trials, as single modality treatments and in combination with conventional cancer therapies... - Macrophage-based anti-cancer therapy: modelling different modes of tumour targetingSteven D Webb
Centre for Mathematical Medicine, School of Mathematical Sciences, University of Nottingham, Nottingham, NG7 2RD, UK
Bull Math Biol 69:1747-76. 2007..We conclude that effective targeting of hypoxic tumour cells may require the use of drugs with limited mobility or whose action does not depend on cell proliferation... - Plasticity in tumor-promoting inflammation: impairment of macrophage recruitment evokes a compensatory neutrophil responseJessica C Pahler
Department of Biochemistry and Biophysics, Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA
Neoplasia 10:329-40. 2008..If such tumor-promoting macrophages are suppressed, MMP-9(+) neutrophils are then recruited, providing alternative paracrine support for tumor angiogenesis and progression... - Plasticity of macrophage function during tumor progression: regulation by distinct molecular mechanismsSubhra K Biswas
Singapore Immunology Network, Biomedical Sciences Institutes, Agency for Science, Technology and Research, Singapore
J Immunol 180:2011-7. 2008..In this review, we discuss the evidence for this plasticity of macrophage functions, the specific signaling mechanisms that may be regulating it, and the new targets for anticancer therapies highlighted by these findings... - Tie2-expressing monocytes: regulation of tumor angiogenesis and therapeutic implicationsMichele De Palma
Angiogenesis and Tumor Targeting Research Unit and San Raffaele Telethon Institute for Gene Therapy, San Raffaele Scientific Institute, Via Olgettina, Milan, Italy
Trends Immunol 28:519-24. 2007.... - Mathematical modelling of the use of macrophages as vehicles for drug delivery to hypoxic tumour sitesMarkus R Owen
Mathematical Biology Group, Department of Mathematical Sciences, Loughborough University, Loughborough, LE11 3TU, UK
J Theor Biol 226:377-91. 2004..In summary, this paper illustrates how mathematical models may be used to investigate promising macrophage-based therapies... - Hypoxia-induced secretion of macrophage migration-inhibitory factor from MCF-7 breast cancer cells is regulated in a hypoxia-inducible factor-independent mannerMona Larsen
Laboratory of Experimental Oncology, Institute of Molecular Pathology, University of Copenhagen, Copenhagen, Denmark
Cancer Lett 265:239-49. 2008..However, inhibition of transcription and translation significantly decreased MIF production, suggesting that hypoxia-induced secretion of MIF in MCF-7 cells is via an alternative pathway... - Anoxic induction of ATF-4 through HIF-1-independent pathways of protein stabilization in human cancer cellsKurosh Ameri
Cancer Research UK, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
Blood 103:1876-82. 2004..Thus, this study demonstrates a novel HIF-1alpha-independent anoxic mechanism that regulates ATF-4 induction at the protein stability level in tumor cells... - A multiphase model describing vascular tumour growthChristopher J W Breward
Mathematical Institute, 24 29 St Giles, Oxford OX1 3LB, UK
Bull Math Biol 65:609-40. 2003..The model is able to reproduce tumour structure that is found in vivo in certain cases. Our framework can be easily modified to incorporate the effect of other phases, or to include the effect of drugs...